{"id":"https://openalex.org/W4401016874","doi":"https://doi.org/10.1109/tnnls.2024.3424784","title":"Oscillatory Dynamics and Regulatory Mechanisms of the p53\u2013Per2 Network in DNA-Damaged Cells","display_name":"Oscillatory Dynamics and Regulatory Mechanisms of the p53\u2013Per2 Network in DNA-Damaged Cells","publication_year":2024,"publication_date":"2024-07-26","ids":{"openalex":"https://openalex.org/W4401016874","doi":"https://doi.org/10.1109/tnnls.2024.3424784","pmid":"https://pubmed.ncbi.nlm.nih.gov/39058613"},"language":"en","primary_location":{"id":"doi:10.1109/tnnls.2024.3424784","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2024.3424784","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078527003","display_name":"Conghua Wang","orcid":"https://orcid.org/0000-0001-7563-9720"},"institutions":[{"id":"https://openalex.org/I126924076","display_name":"Chongqing Normal University","ror":"https://ror.org/01dcw5w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I126924076"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Conghua Wang","raw_affiliation_strings":["National Center for Applied Mathematics, Chongqing Normal University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0001-7563-9720","affiliations":[{"raw_affiliation_string":"National Center for Applied Mathematics, Chongqing Normal University, Chongqing, China","institution_ids":["https://openalex.org/I126924076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368742","display_name":"Yuan Zhang","orcid":"https://orcid.org/0000-0002-8963-9526"},"institutions":[{"id":"https://openalex.org/I4210143338","display_name":"Yuxi Normal University","ror":"https://ror.org/048fp0x47","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210143338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Zhang","raw_affiliation_strings":["Department of Mathematics, Yuxi Normal University, Yuxi, China"],"raw_orcid":"https://orcid.org/0000-0002-8963-9526","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Yuxi Normal University, Yuxi, China","institution_ids":["https://openalex.org/I4210143338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017808266","display_name":"Jinde Cao","orcid":"https://orcid.org/0000-0003-3133-7119"},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinde Cao","raw_affiliation_strings":["School of Mathematics, Southeast University, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0003-3133-7119","affiliations":[{"raw_affiliation_string":"School of Mathematics, Southeast University, Nanjing, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054239457","display_name":"Zhichun Yang","orcid":"https://orcid.org/0000-0001-9104-6618"},"institutions":[{"id":"https://openalex.org/I126924076","display_name":"Chongqing Normal University","ror":"https://ror.org/01dcw5w74","country_code":"CN","type":"education","lineage":["https://openalex.org/I126924076"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhichun Yang","raw_affiliation_strings":["School of Mathematical Sciences, Chongqing Normal University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0001-9104-6618","affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences, Chongqing Normal University, Chongqing, China","institution_ids":["https://openalex.org/I126924076"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5104,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.79919722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"36","issue":"5","first_page":"9725","last_page":"9732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13811","display_name":"Earth Systems and Cosmic Evolution","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/1902","display_name":"Atmospheric Science"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13811","display_name":"Earth Systems and Cosmic Evolution","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/1902","display_name":"Atmospheric Science"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11520","display_name":"Advanced Thermodynamics and Statistical Mechanics","score":0.9294000267982483,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/per2","display_name":"PER2","score":0.915829598903656},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.6755263209342957},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6447093486785889},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5217793583869934},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5143259763717651},{"id":"https://openalex.org/keywords/mdm2","display_name":"Mdm2","score":0.497894287109375},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.47488921880722046},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.45723211765289307},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.40810030698776245},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"Circadian clock","score":0.3936818242073059},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3829411268234253},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3424021005630493},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2271377146244049},{"id":"https://openalex.org/keywords/clock","display_name":"CLOCK","score":0.09908092021942139}],"concepts":[{"id":"https://openalex.org/C2779064383","wikidata":"https://www.wikidata.org/wiki/Q15323251","display_name":"PER2","level":5,"score":0.915829598903656},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6755263209342957},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6447093486785889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5217793583869934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5143259763717651},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.497894287109375},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47488921880722046},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.45723211765289307},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.40810030698776245},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.3936818242073059},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3829411268234253},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3424021005630493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2271377146244049},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.09908092021942139}],"mesh":[{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056950","descriptor_name":"Period Circadian Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tnnls.2024.3424784","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2024.3424784","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},{"id":"pmid:39058613","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39058613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on neural networks and learning systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6000000238418579}],"awards":[{"id":"https://openalex.org/G1425535763","display_name":"\u8109\u51b2\u6cdb\u51fd\u5fae\u5206\u65b9\u7a0b\u4e0e\u6d4b\u5ea6\u6cdb\u51fd\u5fae\u5206\u65b9\u7a0b\u7684\u52a8\u529b\u5b66\u7814\u7a76","funder_award_id":"11971081","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6925672444","display_name":null,"funder_award_id":"cstc2024ycjh-bgzxm0046","funder_id":"https://openalex.org/F4320321135","funder_display_name":"Chongqing University"},{"id":"https://openalex.org/G8061904289","display_name":null,"funder_award_id":"62363034","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321135","display_name":"Chongqing University","ror":"https://ror.org/023rhb549"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1965143151","https://openalex.org/W2022811243","https://openalex.org/W2030945597","https://openalex.org/W2033853356","https://openalex.org/W2038304337","https://openalex.org/W2050981751","https://openalex.org/W2056530510","https://openalex.org/W2058313832","https://openalex.org/W2058631780","https://openalex.org/W2066218351","https://openalex.org/W2068371312","https://openalex.org/W2070102480","https://openalex.org/W2102930268","https://openalex.org/W2142484802","https://openalex.org/W2158005145","https://openalex.org/W2161548459","https://openalex.org/W2167008303","https://openalex.org/W2405518992","https://openalex.org/W2554221761","https://openalex.org/W2782855149","https://openalex.org/W2787678106","https://openalex.org/W2901222362","https://openalex.org/W2913966474","https://openalex.org/W2950076541","https://openalex.org/W3013758148","https://openalex.org/W3033881971","https://openalex.org/W3046336797","https://openalex.org/W3110285363","https://openalex.org/W3117600953","https://openalex.org/W3126193027","https://openalex.org/W3136254756","https://openalex.org/W4297502053","https://openalex.org/W4307232021","https://openalex.org/W4317659805","https://openalex.org/W4320005521","https://openalex.org/W4387187999","https://openalex.org/W4392763897"],"related_works":["https://openalex.org/W1973760267","https://openalex.org/W3022220350","https://openalex.org/W2029346439","https://openalex.org/W2147780884","https://openalex.org/W4200589358","https://openalex.org/W2141996773","https://openalex.org/W2125360342","https://openalex.org/W1841263569","https://openalex.org/W2344071048","https://openalex.org/W2199426892"],"abstract_inverted_index":{"Circadian":[0],"rhythm":[1,26,152],"disruptions":[2],"are":[3,156],"linked":[4],"to":[5,44,68,73,95],"increased":[6],"cancer":[7,197],"risk":[8],"and":[9,29,71,144,185,199],"unfavorable":[10],"prognosis":[11],"in":[12,52,140],"patients":[13],"with":[14,121,127],"cancer,":[15],"highlighting":[16],"the":[17,21,24,30,38,46,49,59,63,76,88,96,105,122,128,131,134,141,150,179],"critical":[18],"role":[19],"of":[20,48,62,78,90,99,107,115,124,130,136,147,153,182],"interplay":[22],"between":[23],"circadian":[25,151,180],"factor":[27],"Per2":[28,91,100,148],"tumor":[31],"suppressor":[32],"p53.":[33],"This":[34,191],"brief":[35],"presents,":[36],"for":[37],"first":[39],"time,":[40],"a":[41,173],"mathematical":[42],"model":[43,56],"capture":[45],"dynamics":[47],"p53-Per2":[50],"network":[51],"DNA-damaged":[53,154,183],"cells.":[54],"The":[55],"accurately":[57],"describes":[58],"different":[60],"stages":[61],"process":[64],"from":[65],"unstressed":[66],"cells":[67,155,184],"cellular":[69],"repair":[70,189],"finally":[72],"apoptosis":[74],"as":[75],"degree":[77],"DNA":[79],"damage":[80],"increases.":[81],"Furthermore,":[82],"it":[83],"is":[84,163],"found":[85,164],"that":[86,165],"increasing":[87,126],"inhibition":[89,106],"by":[92,103,109,159],"p53":[93,117],"leads":[94],"phase":[97],"advance":[98],"oscillations,":[101],"whereas":[102],"modulating":[104],"Mdm2":[108],"Per2,":[110],"an":[111],"independent":[112],"amplitude":[113],"modulation":[114,125],"active":[116],"can":[118,168],"be":[119],"achieved,":[120],"range":[123],"strength":[129],"inhibition.":[132],"Moreover,":[133],"effects":[135],"time":[137,166],"delays":[138,167],"inherent":[139],"transcription,":[142],"translation,":[143],"nuclear":[145],"translocation":[146],"on":[149],"quantitatively":[157],"investigated":[158],"theoretical":[160],"analyses.":[161],"It":[162],"induce":[169],"stable":[170],"oscillations":[171],"through":[172],"supercritical":[174],"Hopf":[175],"bifurcation,":[176],"thereby":[177],"maintaining":[178],"function":[181],"enhancing":[186],"their":[187],"DNA-damage":[188],"capacity.":[190],"study":[192],"proposes":[193],"new":[194],"insights":[195],"into":[196],"prevention":[198],"treatment":[200],"strategies.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}
