{"id":"https://openalex.org/W3092462318","doi":"https://doi.org/10.1109/tnnls.2020.3025912","title":"Graph-Based Function Perturbation Analysis for Observability of Multivalued Logical Networkss","display_name":"Graph-Based Function Perturbation Analysis for Observability of Multivalued Logical Networkss","publication_year":2020,"publication_date":"2020-10-06","ids":{"openalex":"https://openalex.org/W3092462318","doi":"https://doi.org/10.1109/tnnls.2020.3025912","mag":"3092462318","pmid":"https://pubmed.ncbi.nlm.nih.gov/33021945"},"language":"en","primary_location":{"id":"doi:10.1109/tnnls.2020.3025912","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2020.3025912","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100683178","display_name":"Shuling Wang","orcid":"https://orcid.org/0000-0002-3517-2588"},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuling Wang","raw_affiliation_strings":["School of Mathematics and Statistics, Shandong Normal University, Jinan, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100453276","display_name":"Haitao Li","orcid":"https://orcid.org/0000-0001-5322-5375"},"institutions":[{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Li","raw_affiliation_strings":["School of Mathematics and Statistics, Shandong Normal University, Jinan, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, Shandong Normal University, Jinan, China","institution_ids":["https://openalex.org/I28006308"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100683178"],"corresponding_institution_ids":["https://openalex.org/I28006308"],"apc_list":null,"apc_paid":null,"fwci":1.1599,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.77867529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"32","issue":"11","first_page":"4839","last_page":"4848"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/observability","display_name":"Observability","score":0.9492028951644897},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5705143213272095},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.5384357571601868},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5112478733062744},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.47891438007354736},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.45551955699920654},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3696401119232178},{"id":"https://openalex.org/keywords/discrete-mathematics","display_name":"Discrete mathematics","score":0.2991856038570404},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.26809364557266235}],"concepts":[{"id":"https://openalex.org/C36299963","wikidata":"https://www.wikidata.org/wiki/Q1369844","display_name":"Observability","level":2,"score":0.9492028951644897},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5705143213272095},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.5384357571601868},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5112478733062744},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.47891438007354736},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.45551955699920654},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3696401119232178},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.2991856038570404},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.26809364557266235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tnnls.2020.3025912","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2020.3025912","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},{"id":"pmid:33021945","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33021945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on neural networks and learning systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1162643442","display_name":null,"funder_award_id":"61873150","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G242850823","display_name":null,"funder_award_id":"JQ201613","funder_id":"https://openalex.org/F4320334121","funder_display_name":"Natural Science Fund for Distinguished Young Scholars of Shandong Province"},{"id":"https://openalex.org/G2533198692","display_name":null,"funder_award_id":"62073202","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334121","display_name":"Natural Science Fund for Distinguished Young Scholars of Shandong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W821019010","https://openalex.org/W1501711530","https://openalex.org/W1887006513","https://openalex.org/W1950304859","https://openalex.org/W1987454097","https://openalex.org/W1991720013","https://openalex.org/W2002124892","https://openalex.org/W2012641411","https://openalex.org/W2013548638","https://openalex.org/W2030061216","https://openalex.org/W2030235975","https://openalex.org/W2033041501","https://openalex.org/W2045865989","https://openalex.org/W2049480816","https://openalex.org/W2052716795","https://openalex.org/W2057151473","https://openalex.org/W2076687919","https://openalex.org/W2077895748","https://openalex.org/W2090408760","https://openalex.org/W2143549867","https://openalex.org/W2152563826","https://openalex.org/W2194530502","https://openalex.org/W2344696827","https://openalex.org/W2406651635","https://openalex.org/W2483678764","https://openalex.org/W2599951165","https://openalex.org/W2624984019","https://openalex.org/W2734905521","https://openalex.org/W2738693741","https://openalex.org/W2765411998","https://openalex.org/W2792391458","https://openalex.org/W2800112896","https://openalex.org/W2802367398","https://openalex.org/W2809462211","https://openalex.org/W2809566189","https://openalex.org/W2887053799","https://openalex.org/W2900482489","https://openalex.org/W2904868358","https://openalex.org/W2907239922","https://openalex.org/W2911887157","https://openalex.org/W2946477357","https://openalex.org/W2962864721","https://openalex.org/W2964008208","https://openalex.org/W2964305055","https://openalex.org/W2969276152","https://openalex.org/W2970865965","https://openalex.org/W2980616093","https://openalex.org/W2981080244","https://openalex.org/W3013443218","https://openalex.org/W3015332421","https://openalex.org/W3104230113","https://openalex.org/W4301712264","https://openalex.org/W6751290694","https://openalex.org/W6845259194"],"related_works":["https://openalex.org/W4200370596","https://openalex.org/W2390496616","https://openalex.org/W2586190617","https://openalex.org/W1932496242","https://openalex.org/W1986353868","https://openalex.org/W2383799310","https://openalex.org/W2020806897","https://openalex.org/W2158790942","https://openalex.org/W2127651372","https://openalex.org/W2633963589"],"abstract_inverted_index":{"Observability":[0],"is":[1,53,72],"a":[2,35,49,61,84],"fundamental":[3],"concept":[4],"for":[5,24,55,91],"the":[6,20,41,56,76,81,92,101,107,112],"synthesis":[7],"of":[8,22,44,47,58,65,70,78,86,94,111],"both":[9],"linear":[10],"systems":[11],"and":[12,33,80],"nonlinear":[13],"systems.":[14],"This":[15],"article":[16],"devotes":[17],"to":[18,30,97,106],"discussing":[19],"robustness":[21,93],"observability":[23,57,95,109],"multivalued":[25],"logical":[26],"networks":[27],"(MVLNs)":[28],"subject":[29,96],"function":[31,98],"perturbation":[32],"establishing":[34],"graph-based":[36,51,82],"framework.":[37],"First,":[38],"based":[39,74],"on":[40,75],"transition":[42],"graph":[43],"undistinguishable":[45,68],"pairs":[46,69],"states,":[48],"new":[50],"criterion":[52],"presented":[54],"MVLNs.":[59],"Second,":[60],"candidate":[62],"set":[63],"consisting":[64],"all":[66],"suspicious":[67],"states":[71],"defined,":[73],"cardinality":[77],"which":[79],"condition,":[83],"series":[85],"effective":[87],"criteria":[88],"are":[89,104],"proposed":[90],"perturbations.":[99],"Finally,":[100],"obtained":[102],"results":[103],"applied":[105],"robust":[108],"analysis":[110],"p53-MDM2":[113],"negative":[114],"feedback":[115],"regulatory":[116],"loop.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
