{"id":"https://openalex.org/W7138273853","doi":"https://doi.org/10.1109/tmi.2026.3674458","title":"Temporal Conditioning for Longitudinal Brain MRI Registration and Aging Analysis","display_name":"Temporal Conditioning for Longitudinal Brain MRI Registration and Aging Analysis","publication_year":2026,"publication_date":"2026-03-17","ids":{"openalex":"https://openalex.org/W7138273853","doi":"https://doi.org/10.1109/tmi.2026.3674458","pmid":"https://pubmed.ncbi.nlm.nih.gov/41843526"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2026.3674458","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2026.3674458","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1109/tmi.2026.3674458","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037729712","display_name":"Bailiang Jian","orcid":"https://orcid.org/0009-0009-2419-0420"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bailiang Jian","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0009-2419-0420","affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129736691","display_name":"Jiazhen Pan","orcid":null},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jiazhen Pan","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6305-8117","affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413888","display_name":"Yitong Li","orcid":"https://orcid.org/0009-0009-3874-6055"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yitong Li","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0009-3874-6055","affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028364943","display_name":"Fabian Bongratz","orcid":"https://orcid.org/0009-0009-8879-1823"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Bongratz","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101653829","display_name":"Ruochen Li","orcid":"https://orcid.org/0009-0002-1131-5385"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruochen Li","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0007-1209-9326","affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129653100","display_name":"Daniel Rueckert","orcid":null},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Rueckert","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5683-5889","affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129645413","display_name":"Benedikt Wiestler","orcid":null},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benedikt Wiestler","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2963-7772","affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069195910","display_name":"Christian Wachinger","orcid":"https://orcid.org/0000-0002-3652-1874"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Wachinger","raw_affiliation_strings":["Technical University of Munich, TUM University Hospital, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3652-1874","affiliations":[{"raw_affiliation_string":"Technical University of Munich, TUM University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28175613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"6","first_page":"3367","last_page":"3379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.3098999857902527,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.3098999857902527,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conditioning","display_name":"Conditioning","score":0.46129998564720154},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4586000144481659},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.42419999837875366},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.399399995803833},{"id":"https://openalex.org/keywords/image-registration","display_name":"Image registration","score":0.36559998989105225},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.3441999852657318}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4717000126838684},{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.46129998564720154},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4586000144481659},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.42419999837875366},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39969998598098755},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.399399995803833},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.36559998989105225},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.3441999852657318},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3149000108242035},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3043000102043152},{"id":"https://openalex.org/C2993665655","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Brain aging","level":3,"score":0.30160000920295715},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2874000072479248},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C157787499","wikidata":"https://www.wikidata.org/wiki/Q13479657","display_name":"Real-time MRI","level":3,"score":0.2526000142097473}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2026.3674458","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2026.3674458","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41843526","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41843526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/tmi.2026.3674458","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2026.3674458","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8830792278","display_name":null,"funder_award_id":"884622","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320323803","display_name":"Bundesministerium f\u00fcr Wirtschaft und Energie","ror":"https://ror.org/02vgg2808"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F5395805803","display_name":"Munich Center for Machine Learning","ror":"https://ror.org/02nfy3535"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Longitudinal":[0,13],"brain":[1,17,48,62,103,164,200,208],"analysis":[2,198],"is":[3,106],"essential":[4],"for":[5,60,181,196],"understanding":[6],"healthy":[7],"aging":[8,165,173,201],"and":[9,38,41,92,120,129,156,184,193,202],"identifying":[10],"pathological":[11],"deviations.":[12],"registration":[14,157],"of":[15,80,151,199,206],"sequential":[16,139],"MRI":[18,63],"underpins":[19],"such":[20],"analyses.":[21],"However,":[22],"existing":[23],"methods":[24,148],"are":[25],"limited":[26],"by":[27,108,167],"reliance":[28],"on":[29],"densely":[30,137],"sampled":[31,138],"time":[32],"series,":[33],"a":[34,57,67,77],"trade-off":[35],"between":[36],"accuracy":[37],"temporal":[39,71,127],"smoothness,":[40],"an":[42,87,190],"inability":[43],"to":[44,73,100,115],"prospectively":[45],"forecast":[46],"future":[47,102,153],"states.":[49,104],"To":[50],"overcome":[51],"these":[52,124],"challenges,":[53],"we":[54],"introduce":[55],"TimeFlow,":[56],"learning-based":[58],"framework":[59,195],"longitudinal":[61,197],"registration.":[64],"TimeFlow":[65,89,145,160,188],"uses":[66],"U-Net":[68],"backbone":[69],"with":[70],"conditioning":[72],"model":[74],"neuroanatomy":[75],"as":[76],"continuous":[78],"function":[79],"age.":[81],"Given":[82],"only":[83],"two":[84],"scans":[85],"from":[86,171],"individual,":[88],"estimates":[90],"accurate":[91],"temporally":[93],"coherent":[94],"deformation":[95,118],"fields,":[96],"enabling":[97],"non-linear":[98],"extrapolation":[99],"predict":[101],"This":[105],"achieved":[107],"our":[109],"proposed":[110],"inter-/extrapolation":[111],"consistency":[112,128],"constraints":[113,125],"applied":[114],"both":[116,152],"the":[117,179,211],"fields":[119],"deformed":[121],"images.":[122],"Remarkably,":[123],"preserve":[126],"continuity":[130],"without":[131,174],"requiring":[132,175],"explicit":[133],"smoothness":[134],"regularizers":[135],"or":[136],"data.":[140],"Extensive":[141],"experiments":[142],"demonstrate":[143],"that":[144],"outperforms":[146],"state-of-the-art":[147],"in":[149],"terms":[150],"timepoint":[154],"forecasting":[155,207],"accuracy.":[158],"Moreover,":[159],"supports":[161],"novel":[162],"biological":[163],"analyses":[166],"differentiating":[168],"neurodegenerative":[169],"trajectories":[170],"normal":[172],"segmentation,":[176],"thereby":[177],"eliminating":[178],"need":[180],"labor-intensive":[182],"annotations":[183],"mitigating":[185],"segmentation":[186],"inconsistency.":[187],"offers":[189],"accurate,":[191],"data-efficient,":[192],"annotation-free":[194],"chronic":[203],"diseases,":[204],"capable":[205],"changes":[209],"beyond":[210],"observed":[212],"study":[213],"period.":[214]},"counts_by_year":[],"updated_date":"2026-06-04T06:14:18.571774","created_date":"2026-03-18T00:00:00"}