{"id":"https://openalex.org/W7131869802","doi":"https://doi.org/10.1109/tmi.2026.3668773","title":"Decouple, Reorganize, and Fuse: A Multimodal Framework for Cancer Survival Prediction","display_name":"Decouple, Reorganize, and Fuse: A Multimodal Framework for Cancer Survival Prediction","publication_year":2026,"publication_date":"2026-02-27","ids":{"openalex":"https://openalex.org/W7131869802","doi":"https://doi.org/10.1109/tmi.2026.3668773","pmid":"https://pubmed.ncbi.nlm.nih.gov/41758850"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2026.3668773","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2026.3668773","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020704186","display_name":"Huayi Wang","orcid":"https://orcid.org/0009-0003-3371-1482"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huayi Wang","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0009-0003-3371-1482","affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127411472","display_name":"Haochao Ying","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haochao Ying","raw_affiliation_strings":["State Key Laboratory of Transvascular Implantation Devices, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-7832-2518","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transvascular Implantation Devices, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059391082","display_name":"Yuyang Xu","orcid":"https://orcid.org/0000-0003-4503-4098"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyang Xu","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-4503-4098","affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055301514","display_name":"Qibo Qiu","orcid":"https://orcid.org/0000-0002-2848-6079"},"institutions":[{"id":"https://openalex.org/I180662265","display_name":"China Mobile (China)","ror":"https://ror.org/05gftfe97","country_code":"CN","type":"company","lineage":["https://openalex.org/I180662265"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qibo Qiu","raw_affiliation_strings":["China Mobile (Zhejiang) Research & Innovation Institute, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-2848-6079","affiliations":[{"raw_affiliation_string":"China Mobile (Zhejiang) Research & Innovation Institute, Hangzhou, China","institution_ids":["https://openalex.org/I180662265"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheng Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Zhang","raw_affiliation_strings":["State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, and Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, and Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127310800","display_name":"Danny Z. Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danny Z. Chen","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, USA"],"raw_orcid":"https://orcid.org/0000-0001-6565-2884","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, USA","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127116006","display_name":"Ying Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Sun","raw_affiliation_strings":["State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, and Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-5888-2929","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, and Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122317522","display_name":"Jian Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Wu","raw_affiliation_strings":["State Key Laboratory of Transvascular Implantation Devices, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-3230-6392","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Transvascular Implantation Devices, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210158318"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.1051,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.97156686,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"45","issue":"6","first_page":"3124","last_page":"3136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.13590000569820404,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.13590000569820404,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12488","display_name":"Mental Health via Writing","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modalities","display_name":"Modalities","score":0.5210999846458435},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4945000112056732},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.3846000134944916},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.37610000371932983},{"id":"https://openalex.org/keywords/fusion-mechanism","display_name":"Fusion mechanism","score":0.3637999892234802},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.36149999499320984},{"id":"https://openalex.org/keywords/sensor-fusion","display_name":"Sensor fusion","score":0.336899995803833},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.33640000224113464}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.710099995136261},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.572700023651123},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.5210999846458435},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4945000112056732},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.48559999465942383},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.3846000134944916},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3840999901294708},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C173414695","wikidata":"https://www.wikidata.org/wiki/Q5510276","display_name":"Fusion mechanism","level":4,"score":0.3637999892234802},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.36149999499320984},{"id":"https://openalex.org/C33954974","wikidata":"https://www.wikidata.org/wiki/Q486494","display_name":"Sensor fusion","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.33640000224113464},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.32350000739097595},{"id":"https://openalex.org/C205606062","wikidata":"https://www.wikidata.org/wiki/Q5249645","display_name":"Decoupling (probability)","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C38764148","wikidata":"https://www.wikidata.org/wiki/Q17098245","display_name":"Interaction information","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.25999999046325684}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2026.3668773","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2026.3668773","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41758850","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41758850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4652600884437561,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[{"id":"https://openalex.org/G3843231237","display_name":null,"funder_award_id":"62476246","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4695539221","display_name":null,"funder_award_id":"2024B01J1301","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5300913531","display_name":null,"funder_award_id":"No. 92259202","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G734432984","display_name":null,"funder_award_id":"92259202","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8134313591","display_name":null,"funder_award_id":"No. 62476246","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Cancer":[0,183,193],"survival":[1],"analysis":[2],"commonly":[3],"integrates":[4],"information":[5,83,144,152],"across":[6],"diverse":[7],"medical":[8],"modalities":[9,24,108],"to":[10,54,168],"make":[11],"survival-time":[12],"predictions.":[13],"Existing":[14],"methods":[15,39],"primarily":[16],"focus":[17],"on":[18,57,179],"extracting":[19],"different":[20],"decoupled":[21,66,79,87,154,174],"features":[22],"of":[23,65,123,132,143,173,200],"and":[25,33,50,68,110,126,137,146,185],"performing":[26],"fusion":[27,47,64,72,113],"operations":[28],"such":[29],"as":[30],"concatenation,":[31],"attention,":[32],"Mixture-of-Experts":[34],"(MoE)-based":[35],"fusion.":[36],"However,":[37],"these":[38,91],"still":[40],"face":[41],"two":[42],"key":[43],"challenges:":[44],"1)":[45,118],"fixed":[46],"schemes":[48],"(concatenation":[49],"attention)":[51],"can":[52],"lead":[53],"model":[55],"over-reliance":[56],"predefined":[58],"feature":[59,104,124],"combinations,":[60],"limiting":[61],"the":[62,86,121,129,133,141,164,170,198],"dynamic":[63,111],"features;":[67],"2)":[69,138],"in":[70],"MoE-based":[71],"methods,":[73],"each":[74],"expert":[75,135,148],"network":[76,162],"handles":[77],"separate":[78],"features,":[80],"which":[81,100],"limits":[82],"interaction":[84],"among":[85,153],"features.":[88,155,175],"To":[89],"address":[90],"challenges,":[92],"we":[93,157],"propose":[94],"a":[95,102,159],"novel":[96],"Decoupling-Reorganization-Fusion":[97],"framework":[98],"(DeReF),":[99],"devises":[101],"random":[103],"reorganization":[105],"strategy":[106],"between":[107],"decoupling":[109,166],"MoE":[112],"modules.":[114],"Its":[115],"advantages":[116],"are:":[117],"it":[119,139],"increases":[120],"diversity":[122],"combinations":[125],"granularity,":[127],"enhancing":[128],"generalization":[130],"ability":[131],"subsequent":[134],"networks;":[136],"overcomes":[140],"problem":[142],"closure":[145],"helps":[147],"networks":[149],"better":[150],"capture":[151],"Additionally,":[156],"incorporate":[158],"regional":[160],"cross-attention":[161],"within":[163],"modality":[165],"module":[167],"improve":[169],"representation":[171],"quality":[172],"Extensive":[176],"experimental":[177],"results":[178],"our":[180,201],"in-house":[181],"Liver":[182],"(LC)":[184],"three":[186],"widely":[187],"used":[188],"public":[189],"datasets":[190],"from":[191],"The":[192],"Genome":[194],"Atlas":[195],"(TCGA)":[196],"confirm":[197],"effectiveness":[199],"proposed":[202],"method.":[203],"Codes":[204],"are":[205],"available":[206],"at":[207],"https://github.com/ZJUMAI/DeReF.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-04T06:14:18.571774","created_date":"2026-02-27T00:00:00"}