{"id":"https://openalex.org/W4415338911","doi":"https://doi.org/10.1109/tmi.2025.3632555","title":"MIRROR: Multi-Modal Pathological Self-Supervised Representation Learning via Modality Alignment and Retention","display_name":"MIRROR: Multi-Modal Pathological Self-Supervised Representation Learning via Modality Alignment and Retention","publication_year":2025,"publication_date":"2025-11-13","ids":{"openalex":"https://openalex.org/W4415338911","doi":"https://doi.org/10.1109/tmi.2025.3632555","pmid":"https://pubmed.ncbi.nlm.nih.gov/41231704"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2025.3632555","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3632555","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2503.00374","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tianyi Wang","orcid":"https://orcid.org/0000-0002-5318-7361"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tianyi Wang","raw_affiliation_strings":["School of Computer Science, The University of Sydney, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0002-5318-7361","affiliations":[{"raw_affiliation_string":"School of Computer Science, The University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119272145","display_name":"Jianan Fan","orcid":"https://orcid.org/0000-0003-4424-9572"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jianan Fan","raw_affiliation_strings":["School of Computer Science, The University of Sydney, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-4424-9572","affiliations":[{"raw_affiliation_string":"School of Computer Science, The University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dingxin Zhang","orcid":"https://orcid.org/0009-0006-4444-1547"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dingxin Zhang","raw_affiliation_strings":["School of Computer Science, The University of Sydney, Sydney, Australia"],"raw_orcid":"https://orcid.org/0009-0006-4444-1547","affiliations":[{"raw_affiliation_string":"School of Computer Science, The University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027686620","display_name":"Dongnan Liu","orcid":"https://orcid.org/0000-0001-8102-3949"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dongnan Liu","raw_affiliation_strings":["School of Computer Science, The University of Sydney, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8102-3949","affiliations":[{"raw_affiliation_string":"School of Computer Science, The University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670074","display_name":"Yong Xia","orcid":"https://orcid.org/0000-0001-9273-2847"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Xia","raw_affiliation_strings":["National Engineering Laboratory for Integrated Aero-Space-Ground-Ocean Big Data Application Technology, School of Computer Science and Engineering, Northwestern Polytechnical University, Xi’an, China"],"raw_orcid":"https://orcid.org/0000-0001-9273-2847","affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Integrated Aero-Space-Ground-Ocean Big Data Application Technology, School of Computer Science and Engineering, Northwestern Polytechnical University, Xi’an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060016795","display_name":"Heng Huang","orcid":"https://orcid.org/0000-0002-3483-8333"},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng Huang","raw_affiliation_strings":["Department of Computer Science, University of Maryland, College Park, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Maryland, College Park, MD, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076697411","display_name":"Weidong Cai","orcid":"https://orcid.org/0000-0003-3706-8896"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Weidong Cai","raw_affiliation_strings":["School of Computer Science, The University of Sydney, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3706-8896","affiliations":[{"raw_affiliation_string":"School of Computer Science, The University of Sydney, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21351013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"4","first_page":"1620","last_page":"1637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9248999953269958,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9248999953269958,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.6090999841690063},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5235000252723694},{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.5116999745368958},{"id":"https://openalex.org/keywords/feature-learning","display_name":"Feature learning","score":0.4885999858379364},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.45339998602867126},{"id":"https://openalex.org/keywords/subtyping","display_name":"Subtyping","score":0.40799999237060547},{"id":"https://openalex.org/keywords/encoding","display_name":"Encoding (memory)","score":0.39660000801086426},{"id":"https://openalex.org/keywords/feature-vector","display_name":"Feature vector","score":0.38449999690055847},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3801000118255615}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7131999731063843},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.6090999841690063},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5906000137329102},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5235000252723694},{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.5116999745368958},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.4885999858379364},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.45339998602867126},{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.40799999237060547},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C83665646","wikidata":"https://www.wikidata.org/wiki/Q42139305","display_name":"Feature vector","level":2,"score":0.38449999690055847},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3801000118255615},{"id":"https://openalex.org/C94124525","wikidata":"https://www.wikidata.org/wiki/Q912550","display_name":"Categorization","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3619000017642975},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.3386000096797943},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3100999891757965},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.3041999936103821},{"id":"https://openalex.org/C159620131","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial analysis","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C138958017","wikidata":"https://www.wikidata.org/wiki/Q190087","display_name":"Data type","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C116409475","wikidata":"https://www.wikidata.org/wiki/Q1385056","display_name":"External Data Representation","level":2,"score":0.2554999887943268}],"mesh":[{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tmi.2025.3632555","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3632555","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41231704","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41231704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:arXiv.org:2503.00374","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2503.00374","pdf_url":"https://arxiv.org/pdf/2503.00374","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2503.00374","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2503.00374","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2503.00374","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2503.00374","pdf_url":"https://arxiv.org/pdf/2503.00374","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Histopathology":[0,75],"and":[1,12,65,79,85,133,163,184,190,211,227],"transcriptomics":[2,66,89],"are":[3],"fundamental":[4],"modalities":[5,109],"in":[6,25,106,221],"cancer":[7,209,230],"diagnostics,":[8],"encapsulating":[9],"the":[10,16,48,229],"morphological":[11,78],"molecular":[13,92,164],"characteristics":[14],"of":[15],"disease.":[17],"Multi-modal":[18],"self-supervised":[19],"learning":[20,26,125],"has":[21],"demonstrated":[22],"remarkable":[23],"potential":[24],"pathological":[27,193],"representations":[28,143,226],"by":[29,151,188],"integrating":[30],"diverse":[31],"data":[32,76,90],"sources.":[33],"Conventional":[34],"multi-modal":[35,57,123],"integration":[36,159],"methods":[37],"primarily":[38],"emphasize":[39],"modality":[40,131,153,168],"alignment,":[41],"while":[42,110,177],"paying":[43],"insufficient":[44],"attention":[45],"to":[46,128,139,156],"retaining":[47],"modality-specific":[49,112],"intrinsic":[50],"structures.":[51],"However,":[52],"unlike":[53],"conventional":[54],"scenarios":[55],"where":[56],"inputs":[58],"often":[59],"share":[60],"highly":[61],"overlapping":[62],"features,":[63],"histopathology":[64],"exhibit":[67],"pronounced":[68],"heterogeneity,":[69],"offering":[70],"orthogonal":[71],"yet":[72],"complementary":[73],"insights.":[74],"provides":[77],"spatial":[80],"context,":[81],"elucidating":[82],"tissue":[83],"architecture":[84],"cellular":[86],"topology,":[87],"whereas":[88],"delineates":[91],"signatures":[93,194],"through":[94],"quantifying":[95],"gene":[96],"expression":[97],"patterns.":[98],"This":[99],"inherent":[100],"disparity":[101],"introduces":[102],"a":[103,121,152,167,178,196],"major":[104],"challenge":[105],"aligning":[107,191],"these":[108,116],"maintaining":[111],"fidelity.":[113],"To":[114],"address":[115],"challenges,":[117],"we":[118],"present":[119],"MIRROR,":[120],"novel":[122],"representation":[124],"framework":[126],"designed":[127],"foster":[129],"both":[130],"alignment":[132,154],"retention.":[134],"MIRROR":[135],"employs":[136],"dedicated":[137],"encoders":[138],"extract":[140],"comprehensive":[141,223],"feature":[142,225],"for":[144,208],"each":[145,175],"modality,":[146,176],"which":[147],"is":[148,233],"further":[149],"complemented":[150],"module":[155,170,181],"achieve":[157],"seamless":[158],"between":[160],"phenotype":[161],"patterns":[162],"profiles.":[165],"Furthermore,":[166],"retention":[169],"safeguards":[171],"unique":[172],"attributes":[173],"from":[174],"style":[179],"clustering":[180,197],"mitigates":[182],"redundancy":[183],"enhances":[185],"disease-relevant":[186],"information":[187],"modeling":[189],"consistent":[192],"within":[195],"space.":[198],"Extensive":[199],"evaluations":[200],"on":[201],"The":[202],"Cancer":[203],"Genome":[204],"Atlas":[205],"(TCGA)":[206],"cohorts":[207],"subtyping":[210],"survival":[212],"analysis":[213],"highlight":[214],"MIRROR's":[215],"superior":[216],"performance,":[217],"demonstrating":[218],"its":[219],"effectiveness":[220],"constructing":[222],"oncological":[224],"benefiting":[228],"diagnosis.":[231],"Code":[232],"available":[234],"at":[235],"https://github.com/TianyiFranklinWang/MIRROR.":[236]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2025-10-19T00:00:00"}