{"id":"https://openalex.org/W4415821215","doi":"https://doi.org/10.1109/tmi.2025.3628174","title":"MCS-Stain: Boosting FFPE-to-HE Virtual Staining With Multiple Cell Semantics","display_name":"MCS-Stain: Boosting FFPE-to-HE Virtual Staining With Multiple Cell Semantics","publication_year":2025,"publication_date":"2025-11-03","ids":{"openalex":"https://openalex.org/W4415821215","doi":"https://doi.org/10.1109/tmi.2025.3628174","pmid":"https://pubmed.ncbi.nlm.nih.gov/41182920"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2025.3628174","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3628174","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016971316","display_name":"Yihuang Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yihuang Hu","raw_affiliation_strings":["Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049357307","display_name":"Zhicheng Du","orcid":"https://orcid.org/0009-0002-5318-6809"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhicheng Du","raw_affiliation_strings":["Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China","School of Medicine, Xiang’an Hospital of Xiamen University, Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer, Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210087327"]},{"raw_affiliation_string":"School of Medicine, Xiang’an Hospital of Xiamen University, Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer, Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518837","display_name":"Weiping Lin","orcid":"https://orcid.org/0009-0000-0938-5486"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiping Lin","raw_affiliation_strings":["Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100297175","display_name":"Shurong Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shurong Yang","raw_affiliation_strings":["Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012581106","display_name":"Lequan Yu","orcid":"https://orcid.org/0000-0002-9315-6527"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Lequan Yu","raw_affiliation_strings":["Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, SAR, China"],"raw_orcid":"https://orcid.org/0000-0002-9315-6527","affiliations":[{"raw_affiliation_string":"Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374268","display_name":"Guo\u2010Jun Zhang","orcid":"https://orcid.org/0000-0001-5182-5887"},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guojun Zhang","raw_affiliation_strings":["Breast Center and the Cancer Institute, International Joint Laboratory on Cancer Molecular Imaging of Yunnan, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, China","The Breast Center and the Cancer Institute, Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Peking University Cancer Hospital Yunnan, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center and the Cancer Institute, International Joint Laboratory on Cancer Molecular Imaging of Yunnan, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, China","institution_ids":["https://openalex.org/I26080491"]},{"raw_affiliation_string":"The Breast Center and the Cancer Institute, Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Peking University Cancer Hospital Yunnan, Kunming, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100613491","display_name":"Liansheng Wang","orcid":"https://orcid.org/0000-0002-2096-454X"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liansheng Wang","raw_affiliation_strings":["Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China"],"raw_orcid":"https://orcid.org/0000-0002-2096-454X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Informatics, Xiamen University, Xiamen, China","institution_ids":["https://openalex.org/I191208505"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20732326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"4","first_page":"1475","last_page":"1487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.41940000653266907,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.41940000653266907,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.12160000205039978,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/discriminator","display_name":"Discriminator","score":0.5042999982833862},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"Digital pathology","score":0.46880000829696655},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.4586000144481659},{"id":"https://openalex.org/keywords/semantics","display_name":"Semantics (computer science)","score":0.4221999943256378},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.39590001106262207},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3736000061035156},{"id":"https://openalex.org/keywords/generator","display_name":"Generator (circuit theory)","score":0.3573000133037567},{"id":"https://openalex.org/keywords/boosting","display_name":"Boosting (machine learning)","score":0.35589998960494995}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8073999881744385},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6520000100135803},{"id":"https://openalex.org/C2779803651","wikidata":"https://www.wikidata.org/wiki/Q5282088","display_name":"Discriminator","level":3,"score":0.5042999982833862},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.46880000829696655},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4586000144481659},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.44350001215934753},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.4221999943256378},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.39590001106262207},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3736000061035156},{"id":"https://openalex.org/C2780992000","wikidata":"https://www.wikidata.org/wiki/Q17016113","display_name":"Generator (circuit theory)","level":3,"score":0.3573000133037567},{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.30550000071525574},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C2780029942","wikidata":"https://www.wikidata.org/wiki/Q7935138","display_name":"Virtual microscopy","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C146044194","wikidata":"https://www.wikidata.org/wiki/Q5157334","display_name":"Computational photography","level":4,"score":0.2572000026702881}],"mesh":[{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2025.3628174","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3628174","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41182920","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41182920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1367788501","display_name":null,"funder_award_id":"32171363","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2807093373","display_name":null,"funder_award_id":"62371409","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8778972353","display_name":null,"funder_award_id":"202403AC100014","funder_id":"https://openalex.org/F4320317323","funder_display_name":"Key Research and Development Program of Heilongjiang"}],"funders":[{"id":"https://openalex.org/F4320317323","display_name":"Key Research and Development Program of Heilongjiang","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"The":[0,163],"diagnosis":[1],"of":[2,38,100,113,138],"cancer":[3],"primarily":[4],"relies":[5],"on":[6,166],"pathological":[7],"slides":[8,16],"stained":[9],"with":[10,42,177],"hematoxylin":[11],"and":[12,29,46,58,115,180,187,194],"eosin":[13],"(HE).":[14],"These":[15],"are":[17],"typically":[18],"prepared":[19],"from":[20,213],"tissue":[21],"samples":[22,41],"that":[23,170],"have":[24],"been":[25],"fixed":[26],"in":[27,31,50,69,119,158],"formalin":[28],"embedded":[30,118,157],"paraffin":[32],"(FFPE).":[33],"However,":[34,65],"the":[35,66,97,109,120,139,142,153,159,197],"traditional":[36],"process":[37],"staining":[39,52,212,230],"FFPE":[40,70],"HE":[43,214],"is":[44,233],"time-consuming":[45],"resource-intensive.":[47],"Recent":[48],"advances":[49],"virtual":[51,79,116,206,211,229],"technologies,":[53],"driven":[54],"by":[55,210],"digital":[56],"pathology":[57],"generative":[59,92],"models,":[60],"offer":[61],"a":[62,86,224],"promising":[63,225],"alternative.":[64],"blurred":[67],"structures":[68],"images":[71,215],"pose":[72],"unique":[73],"challenges":[74],"to":[75,141,216,227],"achieving":[76],"high-quality":[77],"FFPE-to-HE":[78,167,205],"staining.":[80],"In":[81,220],"this":[82],"context,":[83],"we":[84],"developed":[85],"novel":[87],"Multiple":[88],"Cell":[89],"Semantics-guided":[90],"supervised":[91],"adversarial":[93],"model,":[94],"MCS-Stain.":[95],"Specifically,":[96],"guidance":[98],"consists":[99],"three":[101],"components:":[102],"1)":[103],"pretrained":[104,121],"cell":[105,122,127,132,149,199],"semantic":[106,150,200],"guidance,":[107,129,151],"aligning":[108,152],"powerful":[110],"intermediate":[111,155],"features":[112,156],"real":[114],"images,":[117],"segmentation":[123],"model":[124],"(PCSM);":[125],"2)":[126],"mask":[128],"introducing":[130],"comprehensible":[131],"information":[133],"which":[134],"serves":[135],"as":[136],"part":[137],"input":[140],"discriminator":[143],"through":[144],"channel":[145],"concatenation;":[146],"3)":[147],"dynamic":[148,154,198],"generator":[160],"during":[161],"training.":[162],"comparative":[164],"results":[165],"datasets":[168],"demonstrated":[169,209],"MCS-Stain":[171,222],"outperforms":[172],"existing":[173],"state-of-the-art":[174],"(SOTA)":[175],"methods":[176],"substantial":[178],"qualitative":[179],"quantitative":[181],"improvements.":[182],"Results":[183],"across":[184],"various":[185],"PCSMs":[186],"data":[188],"sources":[189],"further":[190,208],"confirmed":[191],"its":[192],"effectiveness":[193],"robustness.":[195],"Notably,":[196],"exhibits":[201],"strong":[202],"potential":[203],"beyond":[204],"staining,":[207],"immunohistochemical":[217],"(IHC)":[218],"images.":[219],"general,":[221],"presents":[223],"avenue":[226],"advance":[228],"techniques.":[231],"Code":[232],"available":[234],"at":[235],"https://github.com/huyihuang/MCS-Stain.":[236]},"counts_by_year":[],"updated_date":"2026-04-04T06:10:10.580331","created_date":"2025-11-03T00:00:00"}