{"id":"https://openalex.org/W4411996608","doi":"https://doi.org/10.1109/tmi.2025.3585765","title":"A Chain of Diagnosis Framework for Accurate and Explainable Radiology Report Generation","display_name":"A Chain of Diagnosis Framework for Accurate and Explainable Radiology Report Generation","publication_year":2025,"publication_date":"2025-07-03","ids":{"openalex":"https://openalex.org/W4411996608","doi":"https://doi.org/10.1109/tmi.2025.3585765","pmid":"https://pubmed.ncbi.nlm.nih.gov/40608887"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2025.3585765","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3585765","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Haibo Jin","orcid":"https://orcid.org/0000-0001-7512-3599"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Haibo Jin","raw_affiliation_strings":["Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong, China","Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0001-7512-3599","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084761959","display_name":"Haoxuan Che","orcid":"https://orcid.org/0000-0002-5844-1285"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Haoxuan Che","raw_affiliation_strings":["Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong, China","Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000592129","display_name":"Sunan He","orcid":"https://orcid.org/0000-0002-9734-6352"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Sunan He","raw_affiliation_strings":["Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong, China","Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-9734-6352","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100353596","display_name":"Hao Chen","orcid":"https://orcid.org/0000-0002-8400-3780"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hao Chen","raw_affiliation_strings":["Department of Computer Science and Engineering, the Department of Chemical and Biological Engineering, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China","Department of Chemical and Biological Engineering and Division of Life Science, Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-8400-3780","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, the Department of Chemical and Biological Engineering, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering and Division of Life Science, Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079","https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200769079"],"apc_list":null,"apc_paid":null,"fwci":4.3465,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.94221698,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"44","issue":"12","first_page":"4986","last_page":"4997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.9728999733924866,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.9728999733924866,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9126999974250793,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5466781258583069},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.4634091556072235},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3923402428627014},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.3713178336620331},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35458630323410034},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3282673954963684},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29405975341796875}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5466781258583069},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4634091556072235},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3923402428627014},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3713178336620331},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35458630323410034},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3282673954963684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29405975341796875}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011873","descriptor_name":"Radiology Information Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011873","descriptor_name":"Radiology Information Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011873","descriptor_name":"Radiology Information Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2025.3585765","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3585765","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:40608887","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40608887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-160539","is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-160539","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4378917369","display_name":null,"funder_award_id":"MHP/002/22","funder_id":"https://openalex.org/F4320321920","funder_display_name":"Innovation and Technology Commission"},{"id":"https://openalex.org/G4614357796","display_name":null,"funder_award_id":"ITCPD/17-9","funder_id":"https://openalex.org/F4320321920","funder_display_name":"Innovation and Technology Commission"},{"id":"https://openalex.org/G6182813345","display_name":null,"funder_award_id":"2023YFE0204000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321920","display_name":"Innovation and Technology Commission","ror":"https://ror.org/04vf9tr09"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2772917594","https://openalex.org/W2036807459","https://openalex.org/W2058170566","https://openalex.org/W2755342338","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398"],"abstract_inverted_index":{"Despite":[0],"the":[1,27,39,43,134,151,155,203,218],"progress":[2],"of":[3,58,64,76,83,158,177,205,220],"radiology":[4],"report":[5],"generation":[6],"(RRG),":[7],"existing":[8],"works":[9],"face":[10],"two":[11,232],"challenges:":[12],"1)":[13,186],"The":[14],"performances":[15],"in":[16,150,207],"clinical":[17,171],"efficacy":[18],"are":[19],"unsatisfactory,":[20],"especially":[21],"for":[22,35,86,114,201],"lesion":[23,142,195,209],"attributes":[24],"description;":[25],"2)":[26,197],"generated":[28,131,242],"text":[29],"lacks":[30],"explainability,":[31,119],"making":[32],"it":[33,223],"difficult":[34],"radiologists":[36],"to":[37,101,126,147,173,185,216,244],"trust":[38],"results.":[40],"To":[41,67,117,160],"address":[42],"challenges,":[44],"we":[45,70,164],"focus":[46],"on":[47,231],"a":[48,72,81,107,120,138,141,198],"trustworthy":[49],"RRG":[50,189,233],"model,":[51],"which":[52,79],"not":[53],"only":[54],"generates":[55,94],"accurate":[56,88,115],"descriptions":[57],"abnormalities,":[59],"but":[60],"also":[61],"provides":[62],"basis":[63],"its":[65],"predictions.":[66],"this":[68],"end,":[69],"propose":[71,165],"framework":[73],"named":[74],"chain":[75,82],"diagnosis":[77,121],"(CoD),":[78],"maintains":[80],"diagnostic":[84,99],"process":[85],"clinically":[87],"and":[89,130,194,211,227,235,247],"explainable":[90],"RRG.":[91],"It":[92],"first":[93],"question-answer":[95],"(QA)":[96],"pairs":[97,193],"via":[98],"conversation":[100],"extract":[102],"key":[103],"findings,":[104],"then":[105],"prompts":[106],"large":[108],"language":[109],"model":[110],"with":[111,170,191],"QA":[112,128,192,245],"diagnoses":[113,129,135,246],"generation.":[116],"enhance":[118],"grounding":[122,143,241],"module":[123,144],"is":[124,145],"designed":[125,146],"match":[127],"sentences,":[132],"where":[133,222],"act":[136],"as":[137],"reference.":[139],"Moreover,":[140],"locate":[148],"abnormalities":[149],"image,":[152],"further":[153],"improving":[154],"working":[156],"efficiency":[157],"radiologists.":[159],"facilitate":[161],"label-efficient":[162],"training,":[163],"an":[166,187],"omni-supervised":[167],"learning":[168],"strategy":[169],"consistency":[172],"leverage":[174],"various":[175],"types":[176],"annotations":[178],"from":[179],"different":[180],"datasets.":[181],"Our":[182],"efforts":[183],"lead":[184],"omni-labeled":[188],"dataset":[190],"boxes;":[196],"evaluation":[199],"tool":[200],"assessing":[202],"accuracy":[204],"reports":[206],"describing":[208],"location":[210],"severity;":[212],"3)":[213],"extensive":[214],"experiments":[215],"demonstrate":[217],"effectiveness":[219],"CoD,":[221],"outperforms":[224],"both":[225],"specialist":[226],"generalist":[228],"models":[229],"consistently":[230],"benchmarks":[234],"shows":[236],"promising":[237],"explainability":[238],"by":[239],"accurately":[240],"sentences":[243],"images.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2025-12-06T23:10:59.065948","created_date":"2025-10-10T00:00:00"}