{"id":"https://openalex.org/W4411640153","doi":"https://doi.org/10.1109/tmi.2025.3583014","title":"Instance-Aware Multi-Task Learning for Nuclei Segmentation","display_name":"Instance-Aware Multi-Task Learning for Nuclei Segmentation","publication_year":2025,"publication_date":"2025-06-25","ids":{"openalex":"https://openalex.org/W4411640153","doi":"https://doi.org/10.1109/tmi.2025.3583014","pmid":"https://pubmed.ncbi.nlm.nih.gov/40560715"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2025.3583014","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3583014","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024492432","display_name":"Wei Lou","orcid":"https://orcid.org/0000-0002-2071-4081"},"institutions":[{"id":"https://openalex.org/I4210099586","display_name":"Shenzhen Research Institute of Big Data","ror":"https://ror.org/00z1gwf89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210099586"]},{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Lou","raw_affiliation_strings":["Shenzhen Research Institute of Big Data, School of Science and Engineering, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China","School of Science and Engineering, Shenzhen Research Institute of Big Data, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Research Institute of Big Data, School of Science and Engineering, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210116924"]},{"raw_affiliation_string":"School of Science and Engineering, Shenzhen Research Institute of Big Data, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210116924","https://openalex.org/I4210099586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077081913","display_name":"Haofeng Li","orcid":"https://orcid.org/0000-0001-9120-9843"},"institutions":[{"id":"https://openalex.org/I4210099586","display_name":"Shenzhen Research Institute of Big Data","ror":"https://ror.org/00z1gwf89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210099586"]},{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haofeng Li","raw_affiliation_strings":["Shenzhen Research Institute of Big Data, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Research Institute of Big Data, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210116924","https://openalex.org/I4210099586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042965510","display_name":"Guanbin Li","orcid":"https://orcid.org/0000-0002-4805-0926"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanbin Li","raw_affiliation_strings":["School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102982020","display_name":"Xiaoying Lou","orcid":"https://orcid.org/0009-0007-0427-5449"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Lou","raw_affiliation_strings":["Department of Pathology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210093460","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102997283","display_name":"Yuanhuan Xiong","orcid":"https://orcid.org/0000-0002-9258-6402"},"institutions":[{"id":"https://openalex.org/I4210108133","display_name":"Jiangxi Maternal and Child Health Hospital","ror":"https://ror.org/01hbm5940","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108133"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanhuan Xiong","raw_affiliation_strings":["Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, China"],"affiliations":[{"raw_affiliation_string":"Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, China","institution_ids":["https://openalex.org/I4210108133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030367905","display_name":"Xiang Wan","orcid":"https://orcid.org/0000-0002-2324-6527"},"institutions":[{"id":"https://openalex.org/I4210099586","display_name":"Shenzhen Research Institute of Big Data","ror":"https://ror.org/00z1gwf89","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210099586"]},{"id":"https://openalex.org/I4210116924","display_name":"Chinese University of Hong Kong, Shenzhen","ror":"https://ror.org/02d5ks197","country_code":"CN","type":"education","lineage":["https://openalex.org/I177725633","https://openalex.org/I180726961","https://openalex.org/I4210116924"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Wan","raw_affiliation_strings":["Shenzhen Research Institute of Big Data, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Research Institute of Big Data, The Chinese University of Hong Kong at Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210116924","https://openalex.org/I4210099586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5117823122","display_name":"Xusheng Wu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xusheng Wu","raw_affiliation_strings":["Shenzhen Health Development Research and Data Management Center, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Health Development Research and Data Management Center, Shenzhen, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5024492432"],"corresponding_institution_ids":["https://openalex.org/I4210099586","https://openalex.org/I4210116924"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21967006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"12","first_page":"4854","last_page":"4864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.963100016117096,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.963100016117096,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11183","display_name":"Advanced X-ray Imaging Techniques","score":0.946399986743927,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6953174471855164},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6018513441085815},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5751336812973022},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5649884343147278},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5587328672409058},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.46543803811073303},{"id":"https://openalex.org/keywords/multi-task-learning","display_name":"Multi-task learning","score":0.45185625553131104},{"id":"https://openalex.org/keywords/scale-space-segmentation","display_name":"Scale-space segmentation","score":0.4191967248916626},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3241102695465088},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09098172187805176}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6953174471855164},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6018513441085815},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5751336812973022},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5649884343147278},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5587328672409058},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.46543803811073303},{"id":"https://openalex.org/C28006648","wikidata":"https://www.wikidata.org/wiki/Q6934509","display_name":"Multi-task learning","level":3,"score":0.45185625553131104},{"id":"https://openalex.org/C65885262","wikidata":"https://www.wikidata.org/wiki/Q7429708","display_name":"Scale-space segmentation","level":4,"score":0.4191967248916626},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3241102695465088},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09098172187805176},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2025.3583014","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3583014","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:40560715","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40560715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5102275978","display_name":null,"funder_award_id":"2023A1515011464","funder_id":"https://openalex.org/F4320317781","funder_display_name":"Guangdong Provincial Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320317781","display_name":"Guangdong Provincial Postdoctoral Science Foundation","ror":null},{"id":"https://openalex.org/F4320329841","display_name":"Guangdong Provincial Key Laboratory of Construction Foundation","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W2030616761","https://openalex.org/W2117804827","https://openalex.org/W2124260943","https://openalex.org/W2134111100","https://openalex.org/W2158485828","https://openalex.org/W2592905743","https://openalex.org/W2798405286","https://openalex.org/W2798643036","https://openalex.org/W2806530968","https://openalex.org/W2885343725","https://openalex.org/W2921092847","https://openalex.org/W2962804068","https://openalex.org/W2963446712","https://openalex.org/W2963803174","https://openalex.org/W2974825848","https://openalex.org/W2980112230","https://openalex.org/W2980199518","https://openalex.org/W2981994674","https://openalex.org/W2999219213","https://openalex.org/W3043365685","https://openalex.org/W3093046161","https://openalex.org/W3096609285","https://openalex.org/W3098085362","https://openalex.org/W3105072416","https://openalex.org/W3111521801","https://openalex.org/W3120787319","https://openalex.org/W3132111858","https://openalex.org/W3138516171","https://openalex.org/W3154595990","https://openalex.org/W3165215947","https://openalex.org/W3168341999","https://openalex.org/W3208051929","https://openalex.org/W3211240094","https://openalex.org/W4210874399","https://openalex.org/W4214654781","https://openalex.org/W4226237098","https://openalex.org/W4288740616","https://openalex.org/W4293652318","https://openalex.org/W4308770382","https://openalex.org/W4311061640","https://openalex.org/W4312815172","https://openalex.org/W4386071535","https://openalex.org/W4386083086","https://openalex.org/W4387210952","https://openalex.org/W4387210975","https://openalex.org/W4390189790","https://openalex.org/W4390872804","https://openalex.org/W4390873352","https://openalex.org/W4390874575","https://openalex.org/W4390874596","https://openalex.org/W4392883923","https://openalex.org/W4393149442","https://openalex.org/W4393159246","https://openalex.org/W4393200219","https://openalex.org/W4394744747"],"related_works":["https://openalex.org/W1986655823","https://openalex.org/W2185902295","https://openalex.org/W2103507220","https://openalex.org/W3144569342","https://openalex.org/W3011384228","https://openalex.org/W2124969951","https://openalex.org/W2945274617","https://openalex.org/W4313052709","https://openalex.org/W4298131179","https://openalex.org/W2375430703"],"abstract_inverted_index":{"Nuclei":[0],"segmentation":[1,120,137],"is":[2],"critical":[3],"for":[4,16,72,116],"computational":[5],"pathology":[6],"analysis.":[7],"Most":[8],"previous":[9],"methods":[10],"employ":[11],"pixel-wise":[12,46,93],"classification":[13],"or":[14],"regression":[15],"automatic":[17],"nuclei":[18,136],"segmentation,":[19],"without":[20],"describing":[21],"nucleus":[22],"instances":[23],"as":[24],"individual":[25,73],"entities":[26],"at":[27],"the":[28,33,63,86,89,97,110,118],"feature":[29,80],"level.":[30],"To":[31],"address":[32],"above":[34],"limitation,":[35],"we":[36,76,101],"propose":[37],"an":[38,50,78],"instance-aware":[39],"multi-task":[40],"learning":[41,81],"framework":[42,127],"that":[43,83,108,125],"strengthens":[44],"a":[45,103,132],"prediction":[47,52,56],"branch":[48,57],"with":[49,92],"instance-wise":[51,55],"branch.":[53,99],"The":[54,139],"leverages":[58],"learnable":[59],"cell-level":[60],"queries,":[61],"enabling":[62],"model":[64,142],"to":[65],"capture":[66],"positional":[67],"information":[68],"and":[69,141],"visual":[70],"representations":[71],"nuclei.":[74],"Concretely,":[75],"introduce":[77],"instance-disentangling":[79],"module":[82],"effectively":[84],"aligns":[85],"embeddings":[87],"of":[88,113,135],"object-level":[90],"queries":[91],"decoder":[94],"features":[95],"from":[96],"first":[98],"Further,":[100],"design":[102],"dual-branch":[104],"unified":[105],"post-processing":[106],"algorithm":[107],"aggregates":[109],"complementary":[111],"outputs":[112],"both":[114],"branches":[115],"computing":[117],"instance":[119],"results.":[121],"Experimental":[122],"results":[123],"demonstrate":[124],"our":[126],"achieves":[128],"competitive":[129],"performance":[130],"on":[131],"wide":[133],"range":[134],"benchmarks.":[138],"code":[140],"weights":[143],"are":[144],"released":[145],"in":[146],"https://github.com/lhaof/IML.":[147]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}