{"id":"https://openalex.org/W4408182377","doi":"https://doi.org/10.1109/tmi.2025.3548872","title":"ToPoFM: Topology-Guided Pathology Foundation Model for High-Resolution Pathology Image Synthesis With Cellular-Level Control","display_name":"ToPoFM: Topology-Guided Pathology Foundation Model for High-Resolution Pathology Image Synthesis With Cellular-Level Control","publication_year":2025,"publication_date":"2025-03-06","ids":{"openalex":"https://openalex.org/W4408182377","doi":"https://doi.org/10.1109/tmi.2025.3548872","pmid":"https://pubmed.ncbi.nlm.nih.gov/40048327"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2025.3548872","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3548872","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064942574","display_name":"Jingxiong Li","orcid":"https://orcid.org/0000-0002-6519-5043"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingxiong Li","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044307829","display_name":"Chenglu Zhu","orcid":"https://orcid.org/0000-0001-5705-3718"},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenglu Zhu","raw_affiliation_strings":["Artificial Intelligence and Biomedical Image Analysis Laboratory, School of Engineering, Westlake University, Hangzhou, China","Artificial Intelligence and Biomedical Image Analysis Lab, School of Engineering, Westlake University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Biomedical Image Analysis Laboratory, School of Engineering, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Artificial Intelligence and Biomedical Image Analysis Lab, School of Engineering, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090182097","display_name":"Sunyi Zheng","orcid":"https://orcid.org/0000-0002-9005-4875"},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sunyi Zheng","raw_affiliation_strings":["Department of Radiology, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, the State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, the Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China","Department of Radiology, National Clinical Research Center for Cancer, Tianjin&#x2019;s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, the State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, the Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Radiology, National Clinical Research Center for Cancer, Tianjin&#x2019;s Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036911172","display_name":"Pingyi Chen","orcid":"https://orcid.org/0000-0001-5569-5725"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingyi Chen","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103108299","display_name":"Yuxuan Sun","orcid":"https://orcid.org/0000-0002-1277-4316"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxuan Sun","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Honglin Li","orcid":"https://orcid.org/0009-0006-8328-7132"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Honglin Li","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101725246","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0002-1778-2059"},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":["Artificial Intelligence and Biomedical Image Analysis Laboratory, School of Engineering, Westlake University, Hangzhou, China","Artificial Intelligence and Biomedical Image Analysis Lab, School of Engineering, Westlake University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Biomedical Image Analysis Laboratory, School of Engineering, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Artificial Intelligence and Biomedical Image Analysis Lab, School of Engineering, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5064942574"],"corresponding_institution_ids":["https://openalex.org/I168879160"],"apc_list":null,"apc_paid":null,"fwci":4.6684,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.93652588,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"44","issue":"10","first_page":"4116","last_page":"4127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9728999733924866,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4965055584907532},{"id":"https://openalex.org/keywords/foundation","display_name":"Foundation (evidence)","score":0.494081050157547},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.43995365500450134},{"id":"https://openalex.org/keywords/cellular-pathology","display_name":"Cellular pathology","score":0.4270774722099304},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.40004029870033264},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.39845559000968933},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3251287043094635},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22859612107276917},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15783190727233887}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4965055584907532},{"id":"https://openalex.org/C2780966255","wikidata":"https://www.wikidata.org/wiki/Q5474306","display_name":"Foundation (evidence)","level":2,"score":0.494081050157547},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.43995365500450134},{"id":"https://openalex.org/C2994092119","wikidata":"https://www.wikidata.org/wiki/Q1881849","display_name":"Cellular pathology","level":2,"score":0.4270774722099304},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40004029870033264},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.39845559000968933},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3251287043094635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22859612107276917},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15783190727233887},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2025.3548872","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3548872","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:40048327","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40048327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/13","display_name":"Climate action","score":0.4399999976158142}],"awards":[{"id":"https://openalex.org/G10950723","display_name":null,"funder_award_id":"92270108","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6415211155","display_name":null,"funder_award_id":"XHD23F0201","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G8319601231","display_name":null,"funder_award_id":"XHD23F0201","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320308613","display_name":"RSNA Research and Education Foundation","ror":"https://ror.org/00rj4x019"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W1961684045","https://openalex.org/W2127391932","https://openalex.org/W2885824038","https://openalex.org/W2917728795","https://openalex.org/W2922239620","https://openalex.org/W2946901414","https://openalex.org/W2979568061","https://openalex.org/W2979686823","https://openalex.org/W2999025237","https://openalex.org/W3008693315","https://openalex.org/W3016836174","https://openalex.org/W3035574324","https://openalex.org/W3044753181","https://openalex.org/W3090043060","https://openalex.org/W3093256930","https://openalex.org/W3109144862","https://openalex.org/W3159481202","https://openalex.org/W3166254754","https://openalex.org/W3180355996","https://openalex.org/W3185341429","https://openalex.org/W3200923647","https://openalex.org/W3203189213","https://openalex.org/W3212516020","https://openalex.org/W3214733388","https://openalex.org/W4312220150","https://openalex.org/W4312933868","https://openalex.org/W4365143687","https://openalex.org/W4377695098","https://openalex.org/W4378674294","https://openalex.org/W4384071683","https://openalex.org/W4384561707","https://openalex.org/W4386065771","https://openalex.org/W4386076222","https://openalex.org/W4386076598","https://openalex.org/W4386076607","https://openalex.org/W4386973901","https://openalex.org/W4387026748","https://openalex.org/W4387210975","https://openalex.org/W4387211458","https://openalex.org/W4387211951","https://openalex.org/W4390874168","https://openalex.org/W4390874575","https://openalex.org/W4391944408","https://openalex.org/W4391945515","https://openalex.org/W4394593144","https://openalex.org/W4394597784","https://openalex.org/W4402727123","https://openalex.org/W4406602253","https://openalex.org/W4410202262"],"related_works":["https://openalex.org/W2381393187","https://openalex.org/W2332779545","https://openalex.org/W2358060160","https://openalex.org/W2035483685","https://openalex.org/W1969764885","https://openalex.org/W596947562","https://openalex.org/W2793937822","https://openalex.org/W2790817834","https://openalex.org/W2777605427","https://openalex.org/W2801705870"],"abstract_inverted_index":{"Synthetic":[0],"data":[1,9,177],"generation":[2],"emerges":[3],"as":[4,188],"a":[5,91,109,139],"strategy":[6],"to":[7,114],"mitigate":[8],"scarcity":[10,38],"in":[11,61],"digital":[12],"pathology,":[13],"where":[14],"complicated":[15],"tissue":[16],"and":[17,37,56,66,202],"cellular":[18,40],"features":[19],"are":[20],"correlated":[21],"with":[22,45,103,129],"cancer":[23,199],"diagnosis.":[24,78],"The":[25,160],"synthesis":[26,98],"of":[27,39,50,77,99,162,184,195],"such":[28],"visuals,":[29],"however,":[30],"suffers":[31],"from":[32],"limited":[33],"inter":[34],"class":[35],"diversity":[36],"annotations.":[41],"Current":[42],"methodologies":[43],"struggle":[44],"capturing":[46],"the":[47,71,75,97,182,193],"broad":[48],"spectrum":[49],"pathology":[51,101,133],"features,":[52],"causing":[53],"unpredictable":[54],"objects":[55],"defected":[57],"fidelity.":[58],"Moreover,":[59],"discrepancies":[60],"image":[62],"resolution":[63],"across":[64],"developmental":[65],"operational":[67],"phases":[68],"can":[69],"amplify":[70],"distribution":[72],"shifts,":[73],"undermining":[74],"precision":[76],"To":[79],"address":[80],"these":[81],"challenges,":[82],"we":[83,180],"introduce":[84],"TOpology":[85],"guided":[86],"PathOlogy":[87],"Foundation":[88],"Model":[89],"(ToPoFM),":[90],"visual":[92],"foundation":[93],"model":[94,131,153],"designed":[95],"for":[96,119,132,158],"high-resolution":[100,150],"images":[102],"cellular-level":[104],"control.":[105],"Our":[106,152],"approach":[107],"integrates":[108],"topology-informed":[110],"cell":[111,122,126],"arrangement":[112,127],"generator":[113],"steer":[115],"large":[116],"language":[117],"models":[118],"crafting":[120],"synthetic":[121],"arrangements.":[123],"We":[124],"correlate":[125],"guidance":[128],"diffusion":[130],"content":[134],"generation,":[135],"then":[136],"further":[137],"implement":[138],"random":[140],"sliding":[141],"inference":[142],"strategy,":[143],"merging":[144],"discrete":[145],"low-resolution":[146],"samplings":[147],"into":[148],"single":[149],"representation.":[151],"requires":[154],"only":[155],"small":[156],"patches":[157],"training.":[159],"efficacy":[161],"ToPoFM":[163],"is":[164],"demonstrated":[165],"through":[166],"extensive":[167],"experiments,":[168],"complemented":[169],"by":[170],"expert":[171],"validations,":[172],"showing":[173],"high":[174],"fidelity":[175],"on":[176],"synthesis.":[178],"Additionally,":[179],"underscore":[181],"utility":[183],"our":[185],"generated":[186],"imagery":[187],"an":[189],"augmentation":[190],"tool,":[191],"enhancing":[192],"performance":[194],"downstream":[196],"tasks,":[197],"including":[198],"subtype":[200],"classification":[201],"segmentation.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}
