{"id":"https://openalex.org/W4407566516","doi":"https://doi.org/10.1109/tmi.2025.3541830","title":"Cross- and Intra-Image Prototypical Learning for Multi-Label Disease Diagnosis and Interpretation","display_name":"Cross- and Intra-Image Prototypical Learning for Multi-Label Disease Diagnosis and Interpretation","publication_year":2025,"publication_date":"2025-02-14","ids":{"openalex":"https://openalex.org/W4407566516","doi":"https://doi.org/10.1109/tmi.2025.3541830","pmid":"https://pubmed.ncbi.nlm.nih.gov/40036430"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2025.3541830","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3541830","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100329463","display_name":"Chong Wang","orcid":"https://orcid.org/0000-0003-0022-0217"},"institutions":[{"id":"https://openalex.org/I4210127558","display_name":"Australian Centre for Robotic Vision","ror":"https://ror.org/02zv9xv82","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210127558"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chong Wang","raw_affiliation_strings":["Australian Institute for Machine Learning (AIML), The University of Adelaide, Adelaide, SA, Australia","Australian Institute for Machine Learning (AIML), University of Adelaide, SA, Australia"],"raw_orcid":"https://orcid.org/0000-0003-0022-0217","affiliations":[{"raw_affiliation_string":"Australian Institute for Machine Learning (AIML), The University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210127558","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Australian Institute for Machine Learning (AIML), University of Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210127558","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049297116","display_name":"Fengbei Liu","orcid":"https://orcid.org/0000-0003-0355-2006"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4405261073","display_name":"Cornell Tech","ror":"https://ror.org/04qscbg47","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4405261073"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fengbei Liu","raw_affiliation_strings":["School of Electrical and Computer Engineering, Cornell University and Cornell Tech, New York City, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-0355-2006","affiliations":[{"raw_affiliation_string":"School of Electrical and Computer Engineering, Cornell University and Cornell Tech, New York City, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4405261073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079553960","display_name":"Yuanhong Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127558","display_name":"Australian Centre for Robotic Vision","ror":"https://ror.org/02zv9xv82","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210127558"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yuanhong Chen","raw_affiliation_strings":["Australian Institute for Machine Learning (AIML), The University of Adelaide, Adelaide, SA, Australia","Australian Institute for Machine Learning (AIML), University of Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Institute for Machine Learning (AIML), The University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210127558","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Australian Institute for Machine Learning (AIML), University of Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210127558","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074736025","display_name":"Helen Frazer","orcid":"https://orcid.org/0000-0001-9399-8102"},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Helen Frazer","raw_affiliation_strings":["St Vincent&#x2019;s Hospital Melbourne, Melbourne, VIC, Australia","St Vincent&#x2019;s Hospital Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Vincent&#x2019;s Hospital Melbourne, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210087110"]},{"raw_affiliation_string":"St Vincent&#x2019;s Hospital Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029215323","display_name":"Gustavo Carneiro","orcid":"https://orcid.org/0000-0002-5571-6220"},"institutions":[{"id":"https://openalex.org/I4210127558","display_name":"Australian Centre for Robotic Vision","ror":"https://ror.org/02zv9xv82","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210127558"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gustavo Carneiro","raw_affiliation_strings":["Australian Institute for Machine Learning (AIML), The University of Adelaide, Adelaide, SA, Australia","Australian Institute for Machine Learning (AIML), University of Adelaide, SA, Australia"],"raw_orcid":"https://orcid.org/0000-0002-5571-6220","affiliations":[{"raw_affiliation_string":"Australian Institute for Machine Learning (AIML), The University of Adelaide, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210127558","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Australian Institute for Machine Learning (AIML), University of Adelaide, SA, Australia","institution_ids":["https://openalex.org/I4210127558","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8055,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.9554,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"44","issue":"6","first_page":"2568","last_page":"2580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9625999927520752,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9625999927520752,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6650522351264954},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6128286123275757},{"id":"https://openalex.org/keywords/interpretation","display_name":"Interpretation (philosophy)","score":0.5241498947143555},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.5233209133148193},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.4581621289253235},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4385574162006378},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.42699697613716125},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.42549076676368713},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.41057324409484863}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6650522351264954},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6128286123275757},{"id":"https://openalex.org/C527412718","wikidata":"https://www.wikidata.org/wiki/Q855395","display_name":"Interpretation (philosophy)","level":2,"score":0.5241498947143555},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.5233209133148193},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4581621289253235},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4385574162006378},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.42699697613716125},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.42549076676368713},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.41057324409484863},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2025.3541830","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2025.3541830","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:40036430","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40036430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1406129521","display_name":"People-centered Mammogram Analysis","funder_award_id":"EP/Y018036/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3737619623","display_name":null,"funder_award_id":"MRFAI000090","funder_id":"https://openalex.org/F4320315885","funder_display_name":"Australian Government"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W2126385963","https://openalex.org/W2194775991","https://openalex.org/W2608854843","https://openalex.org/W2611650229","https://openalex.org/W2765813195","https://openalex.org/W2788633781","https://openalex.org/W2810230071","https://openalex.org/W2897806204","https://openalex.org/W2914016683","https://openalex.org/W2919115771","https://openalex.org/W2945976633","https://openalex.org/W2955084925","https://openalex.org/W2962858109","https://openalex.org/W2963446712","https://openalex.org/W2979418973","https://openalex.org/W2993044507","https://openalex.org/W3014064863","https://openalex.org/W3023371261","https://openalex.org/W3035524453","https://openalex.org/W3038247542","https://openalex.org/W3095707208","https://openalex.org/W3096139539","https://openalex.org/W3106641651","https://openalex.org/W3113367126","https://openalex.org/W3118287301","https://openalex.org/W3143747286","https://openalex.org/W3167456680","https://openalex.org/W3173957243","https://openalex.org/W3175314453","https://openalex.org/W3177822916","https://openalex.org/W3183198896","https://openalex.org/W3192871594","https://openalex.org/W3201914259","https://openalex.org/W3202424564","https://openalex.org/W3211407538","https://openalex.org/W3215828051","https://openalex.org/W3215928733","https://openalex.org/W4205474609","https://openalex.org/W4226428874","https://openalex.org/W4283813277","https://openalex.org/W4286436505","https://openalex.org/W4295915981","https://openalex.org/W4295934537","https://openalex.org/W4295934990","https://openalex.org/W4296121063","https://openalex.org/W4309730097","https://openalex.org/W4310461141","https://openalex.org/W4311253153","https://openalex.org/W4313023122","https://openalex.org/W4313156423","https://openalex.org/W4319300579","https://openalex.org/W4319300958","https://openalex.org/W4321071737","https://openalex.org/W4361856627","https://openalex.org/W4379767401","https://openalex.org/W4383746549","https://openalex.org/W4385347692","https://openalex.org/W4385376384","https://openalex.org/W4386025632","https://openalex.org/W4386065251","https://openalex.org/W4387055640","https://openalex.org/W4387225948","https://openalex.org/W4390096867","https://openalex.org/W4390272961","https://openalex.org/W4390872699","https://openalex.org/W4390873224","https://openalex.org/W4390874420","https://openalex.org/W4393145123","https://openalex.org/W4394597976","https://openalex.org/W4396791405","https://openalex.org/W4402062516","https://openalex.org/W4402896336","https://openalex.org/W4403067601","https://openalex.org/W4403089510","https://openalex.org/W6746693533","https://openalex.org/W6748557511","https://openalex.org/W6753001334","https://openalex.org/W6784185929","https://openalex.org/W6843355076","https://openalex.org/W6846081844","https://openalex.org/W6864221351","https://openalex.org/W6879202184"],"related_works":["https://openalex.org/W4313320911","https://openalex.org/W4327743144","https://openalex.org/W4245077728","https://openalex.org/W2607424049","https://openalex.org/W4390922876","https://openalex.org/W3183204001","https://openalex.org/W4206302830","https://openalex.org/W2185941092","https://openalex.org/W4386782890","https://openalex.org/W3210948575"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,155,177],"prototypical":[3,24,52],"learning":[4,25,53,110],"have":[5],"shown":[6],"remarkable":[7],"potential":[8],"to":[9,56,66,104,136],"provide":[10],"useful":[11],"decision":[12],"interpretations":[13],"associating":[14],"activation":[15,59],"maps":[16,60],"and":[17,37,61,81,92,140,165,186],"predictions":[18],"with":[19],"class-specific":[20],"training":[21],"prototypes.":[22],"Such":[23],"has":[26,175],"been":[27],"well-studied":[28],"for":[29,34,87],"various":[30],"single-label":[31],"diseases,":[32],"but":[33],"quite":[35],"relevant":[36],"more":[38],"challenging":[39],"multi-label":[40,89,158],"diagnosis,":[41],"where":[42],"multiple":[43,71,107],"diseases":[44,108],"are":[45],"often":[46],"concurrent":[47],"within":[48],"an":[49],"image,":[50],"existing":[51],"models":[54],"struggle":[55],"obtain":[57],"meaningful":[58],"effective":[62],"class":[63],"prototypes":[64],"due":[65],"the":[67,70,106,111,150],"entanglement":[68],"of":[69,100,117,160],"diseases.":[72],"In":[73],"this":[74],"paper,":[75],"we":[76,122],"present":[77],"a":[78,114,124],"novel":[79],"Cross-":[80],"Intra-image":[82],"Prototypical":[83],"Learning":[84],"(CIPL)":[85],"framework,":[86],"accurate":[88],"disease":[90,161,180],"diagnosis":[91],"interpretation":[93,138],"from":[94],"medical":[95],"images.":[96,167],"CIPL":[97,148,173],"takes":[98],"advantage":[99],"common":[101],"cross-image":[102],"semantics":[103],"disentangle":[105],"when":[109],"prototypes,":[112],"allowing":[113],"comprehensive":[115],"understanding":[116],"complicated":[118],"pathological":[119],"lesions.":[120],"Furthermore,":[121],"propose":[123],"new":[125],"two-level":[126],"alignment-based":[127],"regularisation":[128],"strategy":[129],"that":[130,146,172],"effectively":[131],"leverages":[132],"consistent":[133],"intra-image":[134],"information":[135],"enhance":[137],"robustness":[139],"predictive":[141],"performance.":[142],"Extensive":[143],"experiments":[144],"show":[145,171],"our":[147],"attains":[149],"state-of-the-art":[151],"(SOTA)":[152],"classification":[153],"accuracy":[154],"two":[156],"public":[157],"benchmarks":[159],"diagnosis:":[162],"thoracic":[163,179],"radiography":[164],"fundus":[166],"Quantitative":[168],"interpretability":[169],"results":[170],"also":[174],"superiority":[176],"weakly-supervised":[178],"localisation":[181],"over":[182],"other":[183],"leading":[184],"saliency-":[185],"prototype-based":[187],"explanation":[188],"methods.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7}],"updated_date":"2026-08-05T07:39:15.569665","created_date":"2025-10-10T00:00:00"}
