{"id":"https://openalex.org/W4400351025","doi":"https://doi.org/10.1109/tmi.2024.3420228","title":"Joint Regional Uptake Quantification of Thorium-227 and Radium-223 Using a Multiple-Energy-Window Projection-Domain Quantitative SPECT Method","display_name":"Joint Regional Uptake Quantification of Thorium-227 and Radium-223 Using a Multiple-Energy-Window Projection-Domain Quantitative SPECT Method","publication_year":2024,"publication_date":"2024-07-05","ids":{"openalex":"https://openalex.org/W4400351025","doi":"https://doi.org/10.1109/tmi.2024.3420228","pmid":"https://pubmed.ncbi.nlm.nih.gov/38968009"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2024.3420228","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2024.3420228","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1109/tmi.2024.3420228","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100607167","display_name":"Zekun Li","orcid":"https://orcid.org/0000-0003-1179-9834"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zekun Li","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0003-1179-9834","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041734701","display_name":"Nadia Benabdallah","orcid":"https://orcid.org/0000-0002-1511-6693"},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadia Benabdallah","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048679648","display_name":"Richard Laforest","orcid":"https://orcid.org/0000-0002-0238-1439"},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Laforest","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024722162","display_name":"Richard L. Wahl","orcid":"https://orcid.org/0000-0002-7306-2590"},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L. Wahl","raw_affiliation_strings":["Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-7306-2590","affiliations":[{"raw_affiliation_string":"Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067808348","display_name":"Daniel L.J. Thorek","orcid":"https://orcid.org/0000-0003-2437-1239"},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L. J. Thorek","raw_affiliation_strings":["Department of Biomedical Engineering, the Mallinckrodt Institute of Radiology, and the Program in Quantitative Molecular Therapeutics, Washington University, St. Louis, MO, USA","Department of Biomedical Engineering, Mallinckrodt Institute of Radiology, and Program in Quantitative Molecular Therapeutics, Washington University, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0003-2437-1239","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, the Mallinckrodt Institute of Radiology, and the Program in Quantitative Molecular Therapeutics, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Mallinckrodt Institute of Radiology, and Program in Quantitative Molecular Therapeutics, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081456414","display_name":"Abhinav K. Jha","orcid":"https://orcid.org/0000-0002-4795-4878"},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhinav K. Jha","raw_affiliation_strings":["Department of Biomedical Engineering and the Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA","Department of Biomedical Engineering and Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-4795-4878","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]},{"raw_affiliation_string":"Department of Biomedical Engineering and Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I4210102181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100607167"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":1.3062,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77723198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"43","issue":"12","first_page":"4281","last_page":"4293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10973","display_name":"Radioactive element chemistry and processing","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10973","display_name":"Radioactive element chemistry and processing","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11733","display_name":"X-ray Spectroscopy and Fluorescence Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11949","display_name":"Nuclear Physics and Applications","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thorium","display_name":"Thorium","score":0.7203457355499268},{"id":"https://openalex.org/keywords/radium","display_name":"Radium","score":0.6652661561965942},{"id":"https://openalex.org/keywords/joint","display_name":"Joint (building)","score":0.662997841835022},{"id":"https://openalex.org/keywords/projection","display_name":"Projection (relational algebra)","score":0.6452144384384155},{"id":"https://openalex.org/keywords/window","display_name":"Window (computing)","score":0.6004581451416016},{"id":"https://openalex.org/keywords/energy","display_name":"Energy (signal processing)","score":0.4690100848674774},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.46333634853363037},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.424299955368042},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.41020911931991577},{"id":"https://openalex.org/keywords/radiochemistry","display_name":"Radiochemistry","score":0.22353973984718323},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22325876355171204},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2077237069606781},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.203889399766922},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17346790432929993},{"id":"https://openalex.org/keywords/uranium","display_name":"Uranium","score":0.14580726623535156},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.14324858784675598},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.14003393054008484},{"id":"https://openalex.org/keywords/nuclear-physics","display_name":"Nuclear physics","score":0.10214260220527649},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09683564305305481}],"concepts":[{"id":"https://openalex.org/C527038400","wikidata":"https://www.wikidata.org/wiki/Q1115","display_name":"Thorium","level":3,"score":0.7203457355499268},{"id":"https://openalex.org/C550196577","wikidata":"https://www.wikidata.org/wiki/Q1128","display_name":"Radium","level":2,"score":0.6652661561965942},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.662997841835022},{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.6452144384384155},{"id":"https://openalex.org/C2778751112","wikidata":"https://www.wikidata.org/wiki/Q835016","display_name":"Window (computing)","level":2,"score":0.6004581451416016},{"id":"https://openalex.org/C186370098","wikidata":"https://www.wikidata.org/wiki/Q442787","display_name":"Energy (signal processing)","level":2,"score":0.4690100848674774},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.46333634853363037},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.424299955368042},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.41020911931991577},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.22353973984718323},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22325876355171204},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2077237069606781},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.203889399766922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17346790432929993},{"id":"https://openalex.org/C555451288","wikidata":"https://www.wikidata.org/wiki/Q1098","display_name":"Uranium","level":2,"score":0.14580726623535156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14324858784675598},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.14003393054008484},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.10214260220527649},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09683564305305481},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C170154142","wikidata":"https://www.wikidata.org/wiki/Q150737","display_name":"Architectural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011883","descriptor_name":"Radium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013910","descriptor_name":"Thorium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013910","descriptor_name":"Thorium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013910","descriptor_name":"Thorium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013910","descriptor_name":"Thorium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013910","descriptor_name":"Thorium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013910","descriptor_name":"Thorium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013910","descriptor_name":"Thorium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2024.3420228","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2024.3420228","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:38968009","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38968009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11807287","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11807287","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11807287/pdf/nihms-2039606.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/tmi.2024.3420228","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2024.3420228","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G1443778297","display_name":null,"funder_award_id":"R56-EB028287","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4112147197","display_name":null,"funder_award_id":"R01- EB031051","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4229546589","display_name":null,"funder_award_id":"R01-EB031051","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G996291107","display_name":null,"funder_award_id":"R01-EB031962","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1532568685","https://openalex.org/W1890365994","https://openalex.org/W1906922409","https://openalex.org/W1912212332","https://openalex.org/W1920946300","https://openalex.org/W1964595460","https://openalex.org/W1967111081","https://openalex.org/W1974192061","https://openalex.org/W1987349811","https://openalex.org/W2014024561","https://openalex.org/W2020943428","https://openalex.org/W2044813020","https://openalex.org/W2052291201","https://openalex.org/W2053958583","https://openalex.org/W2057219789","https://openalex.org/W2074197980","https://openalex.org/W2086784799","https://openalex.org/W2088453512","https://openalex.org/W2090564682","https://openalex.org/W2095272243","https://openalex.org/W2100977695","https://openalex.org/W2111816433","https://openalex.org/W2121839801","https://openalex.org/W2136807239","https://openalex.org/W2145720374","https://openalex.org/W2157883193","https://openalex.org/W2167199561","https://openalex.org/W2178111742","https://openalex.org/W2465520455","https://openalex.org/W2626822213","https://openalex.org/W2938724659","https://openalex.org/W2950306824","https://openalex.org/W2981871569","https://openalex.org/W2990493095","https://openalex.org/W3002452194","https://openalex.org/W3007239529","https://openalex.org/W3008344257","https://openalex.org/W3008435850","https://openalex.org/W3015002607","https://openalex.org/W3015379061","https://openalex.org/W3027922080","https://openalex.org/W3030140406","https://openalex.org/W3037289254","https://openalex.org/W3096906134","https://openalex.org/W3131399739","https://openalex.org/W3159736416","https://openalex.org/W3170605121","https://openalex.org/W3215050530","https://openalex.org/W4285258313","https://openalex.org/W4379966316","https://openalex.org/W4393377494","https://openalex.org/W4393930964","https://openalex.org/W6639579923","https://openalex.org/W6640090867","https://openalex.org/W6640278215"],"related_works":["https://openalex.org/W2037510867","https://openalex.org/W2035841045","https://openalex.org/W1579642654","https://openalex.org/W2352530174","https://openalex.org/W1986652023","https://openalex.org/W2317284648","https://openalex.org/W1567109904","https://openalex.org/W2108712865","https://openalex.org/W4240418090","https://openalex.org/W40783277"],"abstract_inverted_index":{"Thorium-227":[0],"(":[1,6],")-based":[2],"-particle":[3],"radiopharmaceutical":[4],"therapies":[5],"-RPTs)":[7],"are":[8],"currently":[9],"being":[10],"investigated":[11],"in":[12,72,87,98,150,195,221,261,270],"several":[13,61],"clinical":[14],"and":[15,36,40,52,94,121,174,182,190,240],"pre-clinical":[16],"studies.":[17],"After":[18],"administration,":[19],"decays":[20],"to":[21,68],",":[22],"another":[23],"-particle-emitting":[24],"isotope,":[25],"which":[26],"redistributes":[27],"within":[28],"the":[29,63,80,88,95,115,124,134,151,196,222,225,233,241,244,248,252],"patient.":[30],"Reliable":[31],"dose":[32],"quantification":[33,45,57,109,269],"of":[34,77,82,91,119,153,159,179,209,224,227,235,243,263],"both":[35,120,180],"is":[37,58],"clinically":[38],"important,":[39],"SPECT":[41,125],"may":[42],"perform":[43],"this":[44,264],"as":[46,192,194,213,215],"these":[47,92,102],"isotopes":[48,181],"also":[49,204],"emit":[50],"X-":[51],"-ray":[53],"photons.":[54],"However,":[55],"reliable":[56,172,201,267],"challenging":[59],"for":[60,266],"reasons:":[62],"orders-of-magnitude":[64],"lower":[65],"activity":[66,117],"compared":[67],"conventional":[69],"SPECT,":[70],"resulting":[71],"a":[73,106,146],"very":[74],"low":[75],"number":[76],"detected":[78],"counts,":[79],"presence":[81],"multiple":[83,129,237],"photopeaks,":[84],"substantial":[85],"overlap":[86],"emission":[89],"spectra":[90],"isotopes,":[93],"image-degrading":[96],"effects":[97],"SPECT.":[99],"To":[100],"address":[101],"issues,":[103],"we":[104,231],"propose":[105],"multiple-energy-window":[107],"projection-domain":[108],"(MEW-PDQ)":[110],"method":[111,135,170,250,265],"that":[112],"jointly":[113],"estimates":[114,178],"regional":[116,176],"uptake":[118,177,212,246,268],"directly":[122],"using":[123,236,247],"projection":[126],"data":[127],"from":[128],"energy":[130,238],"windows.":[131],"We":[132],"evaluated":[133],"with":[136,141,156,165,206],"realistic":[137],"simulation":[138],"studies":[139],"conducted":[140],"anthropomorphic":[142],"digital":[143],"phantoms,":[144],"including":[145],"virtual":[147,197],"imaging":[148,154,198],"trial,":[149],"context":[152],"patients":[155],"bone":[157],"metastases":[158],"prostate":[160],"cancer":[161],"who":[162],"were":[163,218],"treated":[164],"-based":[166,271],"-RPTs.":[167,272],"The":[168],"proposed":[169,249],"yielded":[171],"(accurate":[173],"precise)":[175],"outperformed":[183],"state-of-the-art":[184],"methods":[185],"across":[186],"different":[187],"lesion":[188],"sizes":[189],"contrasts,":[191],"well":[193,214],"trial.":[199],"This":[200],"performance":[202],"was":[203],"observed":[205],"moderate":[207,219],"levels":[208],"intra-regional":[210],"heterogeneous":[211],"when":[216],"there":[217],"inaccuracies":[220],"definitions":[223],"support":[226,262],"various":[228],"regions.":[229],"Additionally,":[230],"demonstrated":[232],"effectiveness":[234],"windows":[239],"variance":[242],"estimated":[245],"approached":[251],"Cram\u00e9r-Rao-lower-bound-defined":[253],"theoretical":[254],"limit.":[255],"These":[256],"results":[257],"provide":[258],"strong":[259],"evidence":[260]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}
