{"id":"https://openalex.org/W4391661541","doi":"https://doi.org/10.1109/tmi.2024.3364076","title":"Decorrelation Time Mapping as an Analysis Tool for Nanobubble-Based Contrast Enhanced Ultrasound Imaging","display_name":"Decorrelation Time Mapping as an Analysis Tool for Nanobubble-Based Contrast Enhanced Ultrasound Imaging","publication_year":2024,"publication_date":"2024-02-08","ids":{"openalex":"https://openalex.org/W4391661541","doi":"https://doi.org/10.1109/tmi.2024.3364076","pmid":"https://pubmed.ncbi.nlm.nih.gov/38329864"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2024.3364076","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2024.3364076","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11234354/pdf/nihms-1999442.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091705120","display_name":"Dana Wegierak","orcid":"https://orcid.org/0000-0003-1758-2417"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dana Wegierak","raw_affiliation_strings":["Biomedical Engineering Department, Case Western Reserve University (CWRU), Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-1758-2417","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Case Western Reserve University (CWRU), Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034574618","display_name":"Michaela B. Cooley","orcid":"https://orcid.org/0000-0002-7955-3745"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michaela B. Cooley","raw_affiliation_strings":["Biomedical Engineering Department, Case Western Reserve University (CWRU), Cleveland, OH, USA","Biomedical Engineering Department, CWRU, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-7955-3745","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Case Western Reserve University (CWRU), Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Biomedical Engineering Department, CWRU, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010456201","display_name":"Reshani Perera","orcid":"https://orcid.org/0000-0002-7856-0484"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reshani Perera","raw_affiliation_strings":["Radiology Department, CWRU, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-7856-0484","affiliations":[{"raw_affiliation_string":"Radiology Department, CWRU, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070779297","display_name":"William J. Wulftange","orcid":"https://orcid.org/0000-0003-0708-3876"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Wulftange","raw_affiliation_strings":["Biomedical Engineering Department, Case Western Reserve University (CWRU), Cleveland, OH, USA","Biomedical Engineering Department, CWRU, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-0708-3876","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Case Western Reserve University (CWRU), Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Biomedical Engineering Department, CWRU, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019537430","display_name":"Umut A. G\u00fcrkan","orcid":"https://orcid.org/0000-0002-0331-9960"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umut A. Gurkan","raw_affiliation_strings":["Mechanical and Aerospace Engineering Department, CWRU, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-0331-9960","affiliations":[{"raw_affiliation_string":"Mechanical and Aerospace Engineering Department, CWRU, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027024186","display_name":"Michael C. Kolios","orcid":"https://orcid.org/0000-0002-9994-8293"},"institutions":[{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael C. Kolios","raw_affiliation_strings":["Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9994-8293","affiliations":[{"raw_affiliation_string":"Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada","institution_ids":["https://openalex.org/I530967"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066766358","display_name":"Agata A. Exner","orcid":"https://orcid.org/0000-0003-3913-7066"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agata A. Exner","raw_affiliation_strings":["Department of Biomedical Engineering and the Department of Radiology, CWRU, Cleveland, OH, USA","Departments of Biomedical Engineering and Radiology, CWRU, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-3913-7066","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and the Department of Radiology, CWRU, Cleveland, OH, USA","institution_ids":[]},{"raw_affiliation_string":"Departments of Biomedical Engineering and Radiology, CWRU, Cleveland, OH, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5091705120"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":2.2976,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.87445955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"43","issue":"6","first_page":"2370","last_page":"2380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbubbles","display_name":"Microbubbles","score":0.6468820571899414},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.60834139585495},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.5570286512374878},{"id":"https://openalex.org/keywords/decorrelation","display_name":"Decorrelation","score":0.5263363718986511},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5189359188079834},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"Molecular imaging","score":0.5132815837860107},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4836317300796509},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.46017777919769287},{"id":"https://openalex.org/keywords/preclinical-imaging","display_name":"Preclinical imaging","score":0.4225456118583679},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.33847057819366455},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2335335612297058},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.19504323601722717},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.12639501690864563},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09247460961341858}],"concepts":[{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.6468820571899414},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.60834139585495},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5570286512374878},{"id":"https://openalex.org/C177860922","wikidata":"https://www.wikidata.org/wiki/Q788608","display_name":"Decorrelation","level":2,"score":0.5263363718986511},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5189359188079834},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.5132815837860107},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4836317300796509},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46017777919769287},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.4225456118583679},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33847057819366455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2335335612297058},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19504323601722717},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12639501690864563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09247460961341858},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2024.3364076","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2024.3364076","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:38329864","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38329864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11234354","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11234354","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11234354/pdf/nihms-1999442.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11234354","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11234354","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11234354/pdf/nihms-1999442.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1436032867","display_name":null,"funder_award_id":"T32GM007250","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1989196334","display_name":null,"funder_award_id":"TL1 TR000441","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G2374516328","display_name":null,"funder_award_id":"R21CA253108","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2514603173","display_name":null,"funder_award_id":"F30HL160111","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G269954282","display_name":null,"funder_award_id":"R42HL160384","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2719371337","display_name":null,"funder_award_id":"T32GM007250","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4083186971","display_name":null,"funder_award_id":"R01EB025741","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5366632481","display_name":null,"funder_award_id":"T32GM007250","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5809602105","display_name":null,"funder_award_id":"F30HL160111","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6290380169","display_name":null,"funder_award_id":"R01HL133574","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7175067318","display_name":null,"funder_award_id":"R01EB025741","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7183632388","display_name":null,"funder_award_id":"T32GM007250","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7850011572","display_name":null,"funder_award_id":"TR000441","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8264037495","display_name":null,"funder_award_id":"T32HL134622","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8606306621","display_name":null,"funder_award_id":"R01EB028144","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8658142226","display_name":null,"funder_award_id":"T32HL134622","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8738776723","display_name":null,"funder_award_id":"1552782","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8875010403","display_name":null,"funder_award_id":"R42HL162214","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G956687540","display_name":null,"funder_award_id":"TL1 TR000441","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4391661541.pdf"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W193807217","https://openalex.org/W1654653900","https://openalex.org/W1871308790","https://openalex.org/W1985978913","https://openalex.org/W1986701835","https://openalex.org/W2003677916","https://openalex.org/W2025036947","https://openalex.org/W2047531546","https://openalex.org/W2051936121","https://openalex.org/W2061690699","https://openalex.org/W2082065600","https://openalex.org/W2085375398","https://openalex.org/W2116118767","https://openalex.org/W2126294934","https://openalex.org/W2137682223","https://openalex.org/W2142945000","https://openalex.org/W2147982258","https://openalex.org/W2151761801","https://openalex.org/W2151925888","https://openalex.org/W2157387668","https://openalex.org/W2174473997","https://openalex.org/W2201543035","https://openalex.org/W2291061766","https://openalex.org/W2476606909","https://openalex.org/W2518509288","https://openalex.org/W2573995939","https://openalex.org/W2795483813","https://openalex.org/W2796781998","https://openalex.org/W2808903935","https://openalex.org/W2902549134","https://openalex.org/W2905757330","https://openalex.org/W2909715907","https://openalex.org/W2917943584","https://openalex.org/W2925021125","https://openalex.org/W2951681746","https://openalex.org/W2964903749","https://openalex.org/W2985713929","https://openalex.org/W2999279841","https://openalex.org/W3000004257","https://openalex.org/W3006987776","https://openalex.org/W3020503202","https://openalex.org/W3037186060","https://openalex.org/W3044149195","https://openalex.org/W3081601884","https://openalex.org/W3093464908","https://openalex.org/W3159034163","https://openalex.org/W4220771639","https://openalex.org/W4230715394","https://openalex.org/W4280500878","https://openalex.org/W4283080294","https://openalex.org/W4283587275","https://openalex.org/W4294068984","https://openalex.org/W4383710008","https://openalex.org/W6639158558"],"related_works":["https://openalex.org/W2421589566","https://openalex.org/W2358663732","https://openalex.org/W2901237116","https://openalex.org/W2049009489","https://openalex.org/W2146341506","https://openalex.org/W2142945000","https://openalex.org/W2293676308","https://openalex.org/W1969043549","https://openalex.org/W2793618125","https://openalex.org/W1568724857"],"abstract_inverted_index":{"Nanobubbles":[0],"(NBs;":[1],"~100-500":[2],"nm":[3,49],"diameter)":[4],"are":[5],"preclinical":[6],"ultrasound":[7],"(US)":[8],"contrast":[9,15],"agents":[10],"that":[11,53,113],"expand":[12],"applications":[13,43],"of":[14,34,75,91,124,133,187,196,234],"enhanced":[16,81,122,239],"US":[17,217],"(CEUS).":[18],"Due":[19],"to":[20,93,107,118,147,156,160,167,181,224],"their":[21],"sub-micron":[22],"size,":[23],"high":[24,140],"particle":[25],"density,":[26],"and":[27,105,129,204,222,227,237,241],"deformable":[28],"shell,":[29],"NBs":[30,176],"in":[31,39,101,127,141,188,215,245],"pathological":[32],"states":[33],"heightened":[35],"vascular":[36,235],"permeability":[37,236,240],"(e.g.":[38],"tumors)":[40],"extravasate,":[41],"enabling":[42],"not":[44],"possible":[45],"with":[46,153,219],"microbubbles":[47],"(~1000-10,000":[48],"diameter).":[50],"A":[51],"method":[52],"can":[54,212],"separate":[55],"intravascular":[56],"versus":[57],"extravascular":[58,201],"NB":[59,119,125,165,182,190,202],"signal":[60],"is":[61,115],"needed":[62],"as":[63,231],"an":[64,232],"imaging":[65,103],"biomarker":[66,211],"for":[67,80,229],"improved":[68,220],"tumor":[69,82,135,142,157,197],"detection.":[70],"We":[71],"present":[72],"a":[73],"demonstration":[74],"decorrelation":[76],"time":[77],"(DT)":[78],"mapping":[79,162,186],"NB-CEUS":[83],"imaging.":[84],"In":[85],"vitro":[86],"models":[87,99],"validated":[88,100],"the":[89,131,134,194,238],"sensitivity":[90,106,155,180,221],"DT":[92,114,138,171,185],"agent":[94],"motion.":[95],"Prostate":[96],"cancer":[97],"mouse":[98],"vivo":[102,189],"potential":[104,228],"cancerous":[108],"tissue.":[109],"Our":[110],"findings":[111],"show":[112],"inversely":[116],"related":[117],"motion,":[120],"offering":[121],"detail":[123],"dynamics":[126,191],"tumors,":[128],"highlighting":[130],"heterogeneity":[132,195],"environment.":[136],"Average":[137],"was":[139],"regions":[143],"(~9":[144],"s)":[145,152,173],"compared":[146,159],"surrounding":[148],"normal":[149],"tissue":[150,158,198,226],"(~1":[151],"higher":[154],"other":[161],"techniques.":[163],"Molecular":[164],"targeting":[166],"tumors":[168],"further":[169],"extended":[170],"(11":[172],"over":[174],"non-targeted":[175],"(6":[177],"s),":[178],"demonstrating":[179],"adherence.":[183],"From":[184],"we":[192],"demonstrate":[193],"while":[199],"quantifying":[200],"kinetics":[203],"delineating":[205],"intra-tumoral":[206],"vasculature.":[207],"This":[208],"new":[209],"NB-CEUS-based":[210],"be":[213],"powerful":[214],"molecular":[216],"imaging,":[218],"specificity":[223],"diseased":[225],"use":[230],"estimator":[233],"retention":[242],"(EPR)":[243],"effect":[244],"tumors.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
