{"id":"https://openalex.org/W4381716619","doi":"https://doi.org/10.1109/tmi.2023.3288746","title":"Geometric Deep Learning Using Vascular Surface Meshes for Modality-Independent Unruptured Intracranial Aneurysm Detection","display_name":"Geometric Deep Learning Using Vascular Surface Meshes for Modality-Independent Unruptured Intracranial Aneurysm Detection","publication_year":2023,"publication_date":"2023-06-23","ids":{"openalex":"https://openalex.org/W4381716619","doi":"https://doi.org/10.1109/tmi.2023.3288746","pmid":"https://pubmed.ncbi.nlm.nih.gov/37347626"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2023.3288746","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2023.3288746","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049394731","display_name":"Kimberley M. Timmins","orcid":"https://orcid.org/0000-0002-8178-2694"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Kimberley M. Timmins","raw_affiliation_strings":["Image Sciences Institute, University Medical Center Utrecht, CX Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Image Sciences Institute, University Medical Center Utrecht, CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055365141","display_name":"Irene C. van der Schaaf","orcid":"https://orcid.org/0000-0002-2588-264X"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Irene C. van der Schaaf","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, CX Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004351707","display_name":"Iris N. Vos","orcid":null},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Iris N. Vos","raw_affiliation_strings":["Image Sciences Institute, University Medical Center Utrecht, CX Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Image Sciences Institute, University Medical Center Utrecht, CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049050151","display_name":"Ynte M. Ruigrok","orcid":"https://orcid.org/0000-0002-5396-2989"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ynte M. Ruigrok","raw_affiliation_strings":["Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, CX Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069986738","display_name":"Birgitta K. Velthuis","orcid":"https://orcid.org/0000-0002-2542-9474"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Birgitta K. Velthuis","raw_affiliation_strings":["Department of Radiology, University Medical Center Utrecht, CX Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, University Medical Center Utrecht, CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078692612","display_name":"Hugo J. Kuijf","orcid":"https://orcid.org/0000-0001-6997-9059"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hugo J. Kuijf","raw_affiliation_strings":["Image Sciences Institute, University Medical Center Utrecht, CX Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Image Sciences Institute, University Medical Center Utrecht, CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5049394731"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":null,"apc_paid":null,"fwci":4.4969,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.95281847,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"42","issue":"11","first_page":"3451","last_page":"3460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7389302253723145},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.6047279238700867},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5538384914398193},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5125212669372559},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5087574124336243},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.4682900309562683},{"id":"https://openalex.org/keywords/polygon-mesh","display_name":"Polygon mesh","score":0.4571497440338135},{"id":"https://openalex.org/keywords/test-set","display_name":"Test set","score":0.45540177822113037},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4402990937232971},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4140450656414032},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07609477639198303}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7389302253723145},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.6047279238700867},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5538384914398193},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5125212669372559},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5087574124336243},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.4682900309562683},{"id":"https://openalex.org/C31487907","wikidata":"https://www.wikidata.org/wiki/Q1154597","display_name":"Polygon mesh","level":2,"score":0.4571497440338135},{"id":"https://openalex.org/C169903167","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Test set","level":2,"score":0.45540177822113037},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4402990937232971},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4140450656414032},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07609477639198303},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002532","descriptor_name":"Intracranial Aneurysm","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2023.3288746","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2023.3288746","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:37347626","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37347626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:dspace.library.uu.nl:1874/449463","is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/449463","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2177436780","display_name":null,"funder_award_id":"CVON2015-08 ERASE","funder_id":"https://openalex.org/F4320321642","funder_display_name":"Hartstichting"},{"id":"https://openalex.org/G5596466404","display_name":null,"funder_award_id":"CVON2018-02 ANEURYSM@RISK","funder_id":"https://openalex.org/F4320321642","funder_display_name":"Hartstichting"},{"id":"https://openalex.org/G8552012407","display_name":null,"funder_award_id":"852173","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320321642","display_name":"Hartstichting","ror":"https://ror.org/05nxhgm70"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1207446481","https://openalex.org/W1901129140","https://openalex.org/W2003067321","https://openalex.org/W2003940193","https://openalex.org/W2028739638","https://openalex.org/W2080628940","https://openalex.org/W2088738780","https://openalex.org/W2100051000","https://openalex.org/W2117340355","https://openalex.org/W2133287637","https://openalex.org/W2163466561","https://openalex.org/W2547066587","https://openalex.org/W2560609797","https://openalex.org/W2731316848","https://openalex.org/W2737081152","https://openalex.org/W2766568284","https://openalex.org/W2774320778","https://openalex.org/W2886132392","https://openalex.org/W2891396148","https://openalex.org/W2902078856","https://openalex.org/W2963121255","https://openalex.org/W2963719584","https://openalex.org/W3009689997","https://openalex.org/W3014974815","https://openalex.org/W3035168834","https://openalex.org/W3094840362","https://openalex.org/W3096957519","https://openalex.org/W3101228253","https://openalex.org/W3111487461","https://openalex.org/W3112701542","https://openalex.org/W3112980510","https://openalex.org/W3131091815","https://openalex.org/W3132965478","https://openalex.org/W3164470852","https://openalex.org/W3179116677","https://openalex.org/W3196757234","https://openalex.org/W3202823735","https://openalex.org/W4213015097","https://openalex.org/W4288419263","https://openalex.org/W4297828554","https://openalex.org/W4321258692","https://openalex.org/W6639824700","https://openalex.org/W6739778489","https://openalex.org/W6760045743","https://openalex.org/W6798168159"],"related_works":["https://openalex.org/W1557607869","https://openalex.org/W2366350639","https://openalex.org/W2028455732","https://openalex.org/W4313703117","https://openalex.org/W2087496541","https://openalex.org/W2108615321","https://openalex.org/W1984758362","https://openalex.org/W2085564391","https://openalex.org/W2042049060","https://openalex.org/W2992936613"],"abstract_inverted_index":{"Early":[0],"detection":[1,37,55,83,159,173],"of":[2,68,143,150],"unruptured":[3],"intracranial":[4],"aneurysms":[5],"(UIAs)":[6],"enables":[7],"better":[8],"rupture":[9],"risk":[10],"and":[11,90,94,102,111,135,145,147,152],"preventative":[12],"treatment":[13],"assessment.":[14],"UIAs":[15,126],"are":[16,44],"usually":[17],"diagnosed":[18],"on":[19],"Time-of-Flight":[20],"Magnetic":[21],"Resonance":[22],"Angiographs":[23,29],"(TOF-MRA)":[24],"or":[25],"contrast-enhanced":[26],"Computed":[27],"Tomography":[28],"(CTA).":[30],"Various":[31],"automatic":[32],"voxel-based":[33],"deep":[34,60],"learning":[35,61],"UIA":[36,54,82,158,172],"methods":[38],"have":[39],"been":[40],"developed,":[41],"but":[42],"these":[43],"limited":[45],"to":[46,170],"a":[47,52,58,105,136,161],"single":[48],"modality.":[49],"We":[50,155],"propose":[51],"modality-independent":[53,157],"method":[56],"using":[57,160],"geometric":[59],"model":[62,166],"with":[63,76,87,140,167],"high":[64],"resolution":[65,107],"surface":[66,164],"meshes":[67],"brain":[69],"vessels.":[70],"A":[71],"mesh":[72,92,108,165],"convolutional":[73],"neural":[74],"network":[75],"ResU-Net":[77],"style":[78],"architecture":[79],"was":[80,85],"used.":[81],"performance":[84,117,169],"investigated":[86],"different":[88],"input":[89,98],"pooling":[91],"resolutions,":[93],"including":[95],"additional":[96,112],"edge":[97,114],"features":[99,115],"(shape":[100],"index":[101],"curvedness).":[103],"Both":[104],"higher":[106],"(15,000":[109],"edges)":[110],"curvature":[113],"improved":[116],"(average":[118],"sensitivity:":[119],"65.6%,":[120],"false":[121],"positive":[122],"count/image":[123],"(FPC/image):":[124],"1.61).":[125],"were":[127],"detected":[128],"in":[129],"an":[130],"independent":[131],"TOF-MRA":[132],"test":[133,138],"set":[134,139],"CTA":[137],"average":[141,148],"sensitivity":[142],"52.0%":[144],"48.3%":[146],"FPC/image":[149],"1.04":[151],"1.05":[153],"respectively.":[154],"provide":[156],"deep-learning":[162],"vascular":[163],"comparable":[168],"state-of-the-art":[171],"methods.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}