{"id":"https://openalex.org/W4309094718","doi":"https://doi.org/10.1109/tmi.2022.3222093","title":"Graph Transformer Geometric Learning of Brain Networks Using Multimodal MR Images for Brain Age Estimation","display_name":"Graph Transformer Geometric Learning of Brain Networks Using Multimodal MR Images for Brain Age Estimation","publication_year":2022,"publication_date":"2022-11-14","ids":{"openalex":"https://openalex.org/W4309094718","doi":"https://doi.org/10.1109/tmi.2022.3222093","pmid":"https://pubmed.ncbi.nlm.nih.gov/36374874"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2022.3222093","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2022.3222093","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047903552","display_name":"Hongjie Cai","orcid":"https://orcid.org/0000-0001-8428-7245"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjie Cai","raw_affiliation_strings":["School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-8428-7245","affiliations":[{"raw_affiliation_string":"School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001956754","display_name":"Yue Gao","orcid":"https://orcid.org/0000-0002-8901-9335"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Gao","raw_affiliation_strings":["MoE Laboratory of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-8901-9335","affiliations":[{"raw_affiliation_string":"MoE Laboratory of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079985761","display_name":"Manhua Liu","orcid":"https://orcid.org/0000-0001-6496-670X"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manhua Liu","raw_affiliation_strings":["MoE Laboratory of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-6496-670X","affiliations":[{"raw_affiliation_string":"MoE Laboratory of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":null,"apc_paid":null,"fwci":8.7572,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.98661005,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"42","issue":"2","first_page":"456","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6205798387527466},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5891116857528687},{"id":"https://openalex.org/keywords/transformer","display_name":"Transformer","score":0.4769957363605499},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.47457244992256165},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.42395615577697754},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.38965699076652527},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.11701619625091553},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08611783385276794}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6205798387527466},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5891116857528687},{"id":"https://openalex.org/C66322947","wikidata":"https://www.wikidata.org/wiki/Q11658","display_name":"Transformer","level":3,"score":0.4769957363605499},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.47457244992256165},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.42395615577697754},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.38965699076652527},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.11701619625091553},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08611783385276794},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2022.3222093","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2022.3222093","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:36374874","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36374874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1131972899","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1978429096","display_name":null,"funder_award_id":"U19B2035","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2449871971","display_name":null,"funder_award_id":"20ZR1426300","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G2987871298","display_name":null,"funder_award_id":"62171283","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5850737185","display_name":null,"funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6117814565","display_name":null,"funder_award_id":"2019QYB02","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W2005821483","https://openalex.org/W2017022537","https://openalex.org/W2058046532","https://openalex.org/W2071881327","https://openalex.org/W2078524519","https://openalex.org/W2082704080","https://openalex.org/W2092098886","https://openalex.org/W2108103428","https://openalex.org/W2112796928","https://openalex.org/W2157035009","https://openalex.org/W2157848968","https://openalex.org/W2162615325","https://openalex.org/W2230702687","https://openalex.org/W2338124004","https://openalex.org/W2344104784","https://openalex.org/W2552208519","https://openalex.org/W2607804943","https://openalex.org/W2806974828","https://openalex.org/W2899379687","https://openalex.org/W2977883299","https://openalex.org/W2999319035","https://openalex.org/W3007486523","https://openalex.org/W3010138595","https://openalex.org/W3016088911","https://openalex.org/W3037286432","https://openalex.org/W3089258874","https://openalex.org/W3092783643","https://openalex.org/W3113177135","https://openalex.org/W3157644970","https://openalex.org/W3164341367","https://openalex.org/W3180473167","https://openalex.org/W3198401109","https://openalex.org/W4210858825","https://openalex.org/W4297733535","https://openalex.org/W6638667902","https://openalex.org/W6682889407","https://openalex.org/W6738964360","https://openalex.org/W6739901393","https://openalex.org/W6745537798","https://openalex.org/W6756192570","https://openalex.org/W6761665040","https://openalex.org/W6804049574"],"related_works":["https://openalex.org/W2772917594","https://openalex.org/W2036807459","https://openalex.org/W2058170566","https://openalex.org/W2755342338","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398"],"abstract_inverted_index":{"Brain":[0],"age":[1,31,80,156,164,168,209],"is":[2,104,124,142,169,180],"considered":[3],"as":[4,13,171],"an":[5,172],"important":[6,173],"biomarker":[7,174],"for":[8,29,78,94,154,175,207],"detecting":[9],"aging-related":[10],"diseases":[11],"such":[12],"Alzheimer's":[14,192],"Disease":[15,193],"(AD).":[16],"Magnetic":[17],"resonance":[18],"imaging":[19,76,96],"(MRI)":[20],"have":[21],"been":[22],"widely":[23],"investigated":[24],"with":[25,101,182],"deep":[26],"neural":[27],"networks":[28],"brain":[30,66,79,99,122,155,208],"estimation.":[32,81,157],"However,":[33],"most":[34],"existing":[35],"methods":[36],"cannot":[37],"make":[38],"full":[39],"use":[40],"of":[41,113,120],"multimodal":[42,65],"MRIs":[43],"due":[44],"to":[45,62,89,106,126,144],"the":[46,64,91,108,111,121,128,146,159,162,166,183],"difference":[47,160],"in":[48,132],"data":[49,187],"structure.":[50],"In":[51],"this":[52],"paper,":[53],"we":[54,83],"propose":[55],"a":[56,85,117,138],"graph":[57,139],"transformer":[58,140],"geometric":[59,152],"learning":[60,153],"framework":[61],"model":[63,145],"network":[67,123,141],"constructed":[68],"by":[69,151],"structural":[70],"MRI":[71],"(sMRI)":[72],"and":[73,135,149,165,185,191,211],"diffusion":[74],"tensor":[75],"(DTI)":[77],"First,":[82],"build":[84],"two-stream":[86],"convolutional":[87],"autoencoder":[88],"learn":[90],"latent":[92],"representations":[93],"each":[95],"modality.":[97,136],"The":[98],"template":[100],"prior":[102],"knowledge":[103],"utilized":[105],"calculate":[107],"features":[109],"from":[110,188],"regions":[112],"interest":[114],"(ROIs).":[115],"Then,":[116],"multi-level":[118],"construction":[119],"proposed":[125,143],"establish":[127],"hybrid":[129],"ROI":[130],"connections":[131],"space,":[133],"feature":[134],"Next,":[137],"cross-modal":[147],"interaction":[148],"fusion":[150],"Finally,":[158],"between":[161],"estimated":[163],"chronological":[167],"used":[170],"AD":[176,212],"diagnosis.":[177,213],"Our":[178],"method":[179,202],"evaluated":[181],"sMRI":[184],"DTI":[186],"UK":[189],"Biobank":[190],"Neuroimaging":[194],"Initiative":[195],"database.":[196],"Experimental":[197],"results":[198],"demonstrate":[199],"that":[200],"our":[201],"has":[203],"achieved":[204],"promising":[205],"performances":[206],"estimation":[210]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":12}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}