{"id":"https://openalex.org/W4283828691","doi":"https://doi.org/10.1109/tmi.2022.3188739","title":"Deep Learning-Powered Bessel-Beam Multiparametric Photoacoustic Microscopy","display_name":"Deep Learning-Powered Bessel-Beam Multiparametric Photoacoustic Microscopy","publication_year":2022,"publication_date":"2022-07-05","ids":{"openalex":"https://openalex.org/W4283828691","doi":"https://doi.org/10.1109/tmi.2022.3188739","pmid":"https://pubmed.ncbi.nlm.nih.gov/35788453"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2022.3188739","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2022.3188739","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9767649","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101783761","display_name":"Yifeng Zhou","orcid":"https://orcid.org/0000-0002-3986-1380"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yifeng Zhou","raw_affiliation_strings":["Department of Biomedical Engineering, McKelvey School of Engineering, Washington University, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-3986-1380","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, McKelvey School of Engineering, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022772474","display_name":"Naidi Sun","orcid":"https://orcid.org/0000-0002-2054-0392"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naidi Sun","raw_affiliation_strings":["Department of Biomedical Engineering, McKelvey School of Engineering, Washington University, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, McKelvey School of Engineering, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021143013","display_name":"Song Hu","orcid":"https://orcid.org/0000-0002-5760-8012"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Song Hu","raw_affiliation_strings":["Department of Biomedical Engineering, McKelvey School of Engineering, Washington University, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-5760-8012","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, McKelvey School of Engineering, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":1.7457,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83323891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"41","issue":"12","first_page":"3544","last_page":"3551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11856","display_name":"Thermography and Photoacoustic Techniques","score":0.9850999712944031,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.982200026512146,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5968008041381836},{"id":"https://openalex.org/keywords/bessel-beam","display_name":"Bessel beam","score":0.5863223075866699},{"id":"https://openalex.org/keywords/gaussian-beam","display_name":"Gaussian beam","score":0.5489927530288696},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.5352388620376587},{"id":"https://openalex.org/keywords/beam","display_name":"Beam (structure)","score":0.47590717673301697},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4561748504638672},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.44801539182662964},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.42077529430389404},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41783347725868225},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4107198119163513},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3575940430164337},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23022392392158508}],"concepts":[{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5968008041381836},{"id":"https://openalex.org/C2781389838","wikidata":"https://www.wikidata.org/wiki/Q830111","display_name":"Bessel beam","level":3,"score":0.5863223075866699},{"id":"https://openalex.org/C2778315978","wikidata":"https://www.wikidata.org/wiki/Q944873","display_name":"Gaussian beam","level":3,"score":0.5489927530288696},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5352388620376587},{"id":"https://openalex.org/C168834538","wikidata":"https://www.wikidata.org/wiki/Q3705329","display_name":"Beam (structure)","level":2,"score":0.47590717673301697},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4561748504638672},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.44801539182662964},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42077529430389404},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41783347725868225},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4107198119163513},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3575940430164337},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23022392392158508},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2022.3188739","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2022.3188739","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:35788453","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35788453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9767649","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9767649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9767649","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9767649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1137903433","display_name":null,"funder_award_id":"R01 NS120481","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3487786980","display_name":null,"funder_award_id":"NS099261","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4297786851","display_name":"CAREER: Transforming Multi-parametric Photoacoustic Microscopy","funder_award_id":"2023988","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5826685360","display_name":null,"funder_award_id":"NS120481","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G646934740","display_name":null,"funder_award_id":"R01 NS099261","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1940166613","https://openalex.org/W2010789899","https://openalex.org/W2012278812","https://openalex.org/W2019524855","https://openalex.org/W2031282806","https://openalex.org/W2069927919","https://openalex.org/W2075097705","https://openalex.org/W2148651005","https://openalex.org/W2168283408","https://openalex.org/W2204209596","https://openalex.org/W2277083020","https://openalex.org/W2515313463","https://openalex.org/W2577529438","https://openalex.org/W2594487894","https://openalex.org/W2766448598","https://openalex.org/W2795013122","https://openalex.org/W2883628966","https://openalex.org/W2886833870","https://openalex.org/W2892318814","https://openalex.org/W2902132573","https://openalex.org/W2957911792","https://openalex.org/W2963073614","https://openalex.org/W2975046440","https://openalex.org/W2981067258","https://openalex.org/W2982084551","https://openalex.org/W2982622951","https://openalex.org/W2989433233","https://openalex.org/W3010287532","https://openalex.org/W3014974815","https://openalex.org/W3093434218","https://openalex.org/W3093657850","https://openalex.org/W3094118223","https://openalex.org/W3099844944","https://openalex.org/W3112701542","https://openalex.org/W3137540208","https://openalex.org/W3156358587","https://openalex.org/W3157555184","https://openalex.org/W3190872721","https://openalex.org/W3195625084","https://openalex.org/W3208997990","https://openalex.org/W4226313370","https://openalex.org/W6631190155"],"related_works":["https://openalex.org/W2281658786","https://openalex.org/W2071247519","https://openalex.org/W3131195770","https://openalex.org/W3134812336","https://openalex.org/W2515313463","https://openalex.org/W2396122647","https://openalex.org/W4211107619","https://openalex.org/W2163888863","https://openalex.org/W2059981233","https://openalex.org/W4205471490"],"abstract_inverted_index":{"Enabling":[0],"simultaneous":[1],"and":[2,20,37,86,123,179],"high-resolution":[3],"quantification":[4],"of":[5,9,17,40,51,69,96,118,129,145,154],"the":[6,41,48,55,58,64,97,104,111,134,146,151,161,175],"total":[7],"concentration":[8],"hemoglobin":[10,18],"(":[11],"[Formula:":[12,119,130],"see":[13,120,131],"text]),":[14],"oxygen":[15],"saturation":[16],"(sO2),":[19],"cerebral":[21],"blood":[22],"flow":[23],"(CBF),":[24],"multi-parametric":[25,101,107,165],"photoacoustic":[26],"microscopy":[27],"(PAM)":[28],"has":[29],"emerged":[30],"as":[31],"a":[32,78,126],"promising":[33],"tool":[34],"for":[35,157],"functional":[36,172],"metabolic":[38],"imaging":[39,65,117],"live":[42,135],"mouse":[43,136],"brain.":[44],"However,":[45],"due":[46],"to":[47],"limited":[49],"depth":[50,127],"focus":[52],"imposed":[53],"by":[54,82],"Gaussian-beam":[56,106],"excitation,":[57],"quantitative":[59,116],"measurements":[60],"become":[61],"inaccurate":[62],"when":[63],"object":[66],"is":[67],"out":[68],"focus.":[70],"To":[71],"address":[72],"this":[73],"problem,":[74],"we":[75],"have":[76],"developed":[77],"hardware-software":[79],"combined":[80],"approach":[81],"integrating":[83],"Bessel-beam":[84,100,164],"excitation":[85],"conditional":[87],"generative":[88],"adversarial":[89],"network":[90],"(cGAN)-based":[91],"deep":[92,162],"learning.":[93],"Side-by-side":[94],"comparison":[95],"new":[98,112],"cGAN-powered":[99],"PAM":[102,108,166],"against":[103],"conventional":[105,147],"shows":[109],"that":[110],"system":[113],"enables":[114],"high-resolution,":[115],"text],":[121],"sO2,":[122],"CBF":[124],"over":[125],"range":[128],"text]":[132],"in":[133,170],"brain,":[137],"with":[138],"errors":[139],"13-58":[140],"times":[141],"lower":[142],"than":[143],"those":[144],"system.":[148],"Better":[149],"fulfilling":[150],"rigid":[152],"requirement":[153],"light":[155],"focusing":[156],"accurate":[158],"hemodynamic":[159],"measurements,":[160],"learning-powered":[163],"may":[167],"find":[168],"applications":[169],"large-field":[171],"recording":[173],"across":[174],"uneven":[176],"brain":[177],"surface":[178],"beyond":[180],"(e.g.,":[181],"tumor":[182],"imaging).":[183]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
