{"id":"https://openalex.org/W3190872721","doi":"https://doi.org/10.1109/tmi.2021.3104521","title":"Recovery of Blood Flow From Undersampled Photoacoustic Microscopy Data Using Sparse Modeling","display_name":"Recovery of Blood Flow From Undersampled Photoacoustic Microscopy Data Using Sparse Modeling","publication_year":2021,"publication_date":"2021-08-13","ids":{"openalex":"https://openalex.org/W3190872721","doi":"https://doi.org/10.1109/tmi.2021.3104521","mag":"3190872721","pmid":"https://pubmed.ncbi.nlm.nih.gov/34388091"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2021.3104521","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2021.3104521","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075684705","display_name":"Sushanth G. Sathyanarayana","orcid":"https://orcid.org/0000-0002-9281-9843"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sushanth G. Sathyanarayana","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010954671","display_name":"Zhuoying Wang","orcid":"https://orcid.org/0000-0001-7521-1468"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuoying Wang","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022772474","display_name":"Naidi Sun","orcid":"https://orcid.org/0000-0002-2054-0392"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naidi Sun","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065616079","display_name":"Bo Ning","orcid":"https://orcid.org/0000-0002-6006-5696"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo Ning","raw_affiliation_strings":["Children\u2019s National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC, USA","Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC, USA"],"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC, USA","institution_ids":[]},{"raw_affiliation_string":"Children's National Hospital, Sheikh Zayed Institute for Pediatric Surgical Innovation, Washington, DC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021143013","display_name":"Song Hu","orcid":"https://orcid.org/0000-0002-5760-8012"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Song Hu","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026554640","display_name":"John A. Hossack","orcid":"https://orcid.org/0000-0003-1299-0745"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Hossack","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5075684705"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":0.93,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.71494534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"41","issue":"1","first_page":"103","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.6067089438438416},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.5898028612136841},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5379595756530762},{"id":"https://openalex.org/keywords/interpolation","display_name":"Interpolation (computer graphics)","score":0.49748495221138},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47093144059181213},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4338320195674896},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.355988472700119},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.18563023209571838},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10685226321220398},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.10169172286987305}],"concepts":[{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6067089438438416},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5898028612136841},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5379595756530762},{"id":"https://openalex.org/C137800194","wikidata":"https://www.wikidata.org/wiki/Q11713455","display_name":"Interpolation (computer graphics)","level":3,"score":0.49748495221138},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47093144059181213},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4338320195674896},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.355988472700119},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.18563023209571838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10685226321220398},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10169172286987305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2021.3104521","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2021.3104521","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:34388091","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34388091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1149291733","https://openalex.org/W1602160603","https://openalex.org/W1791560514","https://openalex.org/W1951629768","https://openalex.org/W1982367678","https://openalex.org/W1985593321","https://openalex.org/W1996287810","https://openalex.org/W2003860031","https://openalex.org/W2005089986","https://openalex.org/W2012723987","https://openalex.org/W2017850302","https://openalex.org/W2018507306","https://openalex.org/W2022896050","https://openalex.org/W2024849456","https://openalex.org/W2029929731","https://openalex.org/W2030964111","https://openalex.org/W2047017131","https://openalex.org/W2054871318","https://openalex.org/W2068926508","https://openalex.org/W2075097705","https://openalex.org/W2090457307","https://openalex.org/W2093140498","https://openalex.org/W2100592466","https://openalex.org/W2103559027","https://openalex.org/W2104783034","https://openalex.org/W2109329707","https://openalex.org/W2109357213","https://openalex.org/W2114122776","https://openalex.org/W2117191993","https://openalex.org/W2121058967","https://openalex.org/W2127271355","https://openalex.org/W2127939378","https://openalex.org/W2131369545","https://openalex.org/W2141928727","https://openalex.org/W2145096794","https://openalex.org/W2157036858","https://openalex.org/W2157774728","https://openalex.org/W2160547390","https://openalex.org/W2160556808","https://openalex.org/W2170962921","https://openalex.org/W2204209596","https://openalex.org/W2333144807","https://openalex.org/W2345472227","https://openalex.org/W2558090171","https://openalex.org/W2577529438","https://openalex.org/W2783147662","https://openalex.org/W2896556344","https://openalex.org/W2903147509","https://openalex.org/W2905382931","https://openalex.org/W2920004930","https://openalex.org/W2946838482","https://openalex.org/W2949925497","https://openalex.org/W2970175100","https://openalex.org/W2982452885","https://openalex.org/W3011600112","https://openalex.org/W3025806813","https://openalex.org/W3093434218","https://openalex.org/W3105222728","https://openalex.org/W3114272149","https://openalex.org/W4235713725","https://openalex.org/W6707621779"],"related_works":["https://openalex.org/W2157355069","https://openalex.org/W2021792849","https://openalex.org/W1968701816","https://openalex.org/W2418264232","https://openalex.org/W2345263070","https://openalex.org/W303802408","https://openalex.org/W2350538445","https://openalex.org/W1968770722","https://openalex.org/W2541045029","https://openalex.org/W2061676111"],"abstract_inverted_index":{"Photoacoustic":[0],"microscopy":[1],"(PAM)":[2],"leverages":[3],"the":[4,16,23,94,135],"optical":[5,53],"absorption":[6],"contrast":[7],"of":[8,15,37,39,76,111,150,178],"blood":[9,24,34,67,104],"hemoglobin":[10],"for":[11,66,102,128,164,192],"high-resolution,":[12],"multi-parametric":[13],"imaging":[14],"microvasculature":[17],"in":[18,45,80,83,119,126,155,162,183,190],"vivo.":[19],"However,":[20],"to":[21,32,99],"quantify":[22],"flow":[25,68,105],"speed,":[26],"dense":[27],"spatial":[28],"sampling":[29],"is":[30,138],"required":[31],"assess":[33],"flow-induced":[35],"loss":[36],"correlation":[38],"sequentially":[40],"acquired":[41],"A-line":[42],"signals,":[43],"resulting":[44],"increased":[46],"laser":[47],"pulse":[48],"repetition":[49],"rate":[50],"and":[51,82,121,157,185],"consequently":[52],"fluence.":[54],"To":[55],"address":[56],"this":[57,87],"issue,":[58],"we":[59],"have":[60],"developed":[61],"a":[62,108],"sparse":[63,88],"modeling":[64,89],"approach":[65],"quantification":[69],"based":[70],"on":[71,139],"downsampled":[72,96,130,166,194],"PAM":[73],"data.":[74],"Evaluation":[75],"its":[77],"performance":[78],"both":[79],"vitro":[81,120,156,184],"vivo":[84,127,163,191],"shows":[85,175],"that":[86],"method":[90,137],"can":[91],"accurately":[92],"recover":[93],"substantially":[95],"data":[97,129,165,193],"(up":[98],"8":[100,131,167,195],"times)":[101],"correlation-based":[103],"analysis,":[106],"with":[107,134,141],"relative":[109],"error":[110,149,177],"12.7":[112,122],"\u00b1":[113,123,152,159,180,187],"6.1":[114],"%":[115,125,154,161,182,189],"across":[116],"10":[117],"datasets":[118],"12.1":[124],"times.":[132,168,196],"Reconstruction":[133],"proposed":[136],"par":[140],"recovery":[142],"using":[143],"compressive":[144],"sensing,":[145],"which":[146,174],"exhibits":[147],"an":[148,176],"12.0":[151],"7.9":[153],"33.86":[158],"26.18":[160],"Both":[169],"methods":[170],"outperform":[171],"bicubic":[172],"interpolation,":[173],"15.95":[179],"9.85":[181],"110.7":[186],"87.1":[188]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-12T08:34:05.389933","created_date":"2025-10-10T00:00:00"}
