{"id":"https://openalex.org/W3165207548","doi":"https://doi.org/10.1109/tmi.2021.3085828","title":"Perfusion Imaging: An Advection Diffusion Approach","display_name":"Perfusion Imaging: An Advection Diffusion Approach","publication_year":2021,"publication_date":"2021-06-04","ids":{"openalex":"https://openalex.org/W3165207548","doi":"https://doi.org/10.1109/tmi.2021.3085828","mag":"3165207548","pmid":"https://pubmed.ncbi.nlm.nih.gov/34086563"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2021.3085828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2021.3085828","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8686530","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Peirong Liu","orcid":"https://orcid.org/0000-0001-7645-009X"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peirong Liu","raw_affiliation_strings":["Department of Computer Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0001-7645-009X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yueh Z. Lee","orcid":"https://orcid.org/0000-0003-1846-7680"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yueh Z. Lee","raw_affiliation_strings":["Department of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0003-1846-7680","affiliations":[{"raw_affiliation_string":"Department of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephen R. Aylward","orcid":"https://orcid.org/0000-0002-7862-8856"},"institutions":[{"id":"https://openalex.org/I74786994","display_name":"Kitware (United States)","ror":"https://ror.org/02s2acn37","country_code":"US","type":"company","lineage":["https://openalex.org/I74786994"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Aylward","raw_affiliation_strings":["Kitware, Inc., Carrboro, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-7862-8856","affiliations":[{"raw_affiliation_string":"Kitware, Inc., Carrboro, NC, USA","institution_ids":["https://openalex.org/I74786994"]}]},{"author_position":"last","author":{"id":null,"display_name":"Marc Niethammer","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Niethammer","raw_affiliation_strings":["Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Computer Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Imaging Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Computer Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7609,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.69694102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"40","issue":"12","first_page":"3424","last_page":"3435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.5676000118255615,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.5676000118255615,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.24379999935626984,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5792999863624573},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.4684999883174896},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.4287000000476837},{"id":"https://openalex.org/keywords/perfusion-scanning","display_name":"Perfusion scanning","score":0.4117000102996826},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.3698999881744385},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.35839998722076416},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.34150001406669617}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5792999863624573},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5482000112533569},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4684999883174896},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4287000000476837},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.4117000102996826},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3698999881744385},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.362199991941452},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.35839998722076416},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C5072599","wikidata":"https://www.wikidata.org/wiki/Q379788","display_name":"Advection","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C157286648","wikidata":"https://www.wikidata.org/wiki/Q846780","display_name":"Kalman filter","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3257000148296356},{"id":"https://openalex.org/C82641631","wikidata":"https://www.wikidata.org/wiki/Q5975472","display_name":"Intravoxel incoherent motion","level":4,"score":0.3133000135421753},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.26820001006126404},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.26019999384880066},{"id":"https://openalex.org/C68710425","wikidata":"https://www.wikidata.org/wiki/Q5275442","display_name":"Diffusion process","level":3,"score":0.25200000405311584}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055420","descriptor_name":"Perfusion Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2021.3085828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2021.3085828","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:34086563","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34086563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8686530","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8686530","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8686530","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8686530","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2311699224","display_name":null,"funder_award_id":"R21 NS125369","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2367659792","display_name":"Automated Assessment of Leptomeningeal Collaterals on CT Angiograms","funder_award_id":"2r42ns086295-02a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2739190678","display_name":null,"funder_award_id":"R01 EB028283","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G4418478850","display_name":null,"funder_award_id":"R42 NS086295","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1507765817","https://openalex.org/W1555627060","https://openalex.org/W1964973909","https://openalex.org/W1980045703","https://openalex.org/W1995046979","https://openalex.org/W2000052576","https://openalex.org/W2000269560","https://openalex.org/W2015008359","https://openalex.org/W2039823156","https://openalex.org/W2047959632","https://openalex.org/W2049152314","https://openalex.org/W2065438814","https://openalex.org/W2078350258","https://openalex.org/W2082065600","https://openalex.org/W2101531313","https://openalex.org/W2123742075","https://openalex.org/W2150134853","https://openalex.org/W2155246606","https://openalex.org/W2484736472","https://openalex.org/W2537481264","https://openalex.org/W2929923580","https://openalex.org/W2954774909","https://openalex.org/W3006349194","https://openalex.org/W4244244128"],"related_works":[],"abstract_inverted_index":{"Perfusion":[0],"imaging":[1],"is":[2,8,103],"of":[3,15,29,38,81,138,177,196,221,245,252],"great":[4],"clinical":[5],"importance":[6],"and":[7,19,46,59,135,156,185,194,206,225,233,237],"used":[9,23,71],"to":[10,87,110,202,249],"assess":[11],"a":[12,39,165,174,181,213],"wide":[13],"range":[14],"diseases":[16],"including":[17],"strokes":[18],"brain":[20,215],"tumors.":[21],"Commonly":[22],"approaches":[24,93],"for":[25,52,153,242],"the":[26,36,79,82,101,128,133,144,160,178,192,243],"quantitative":[27],"analysis":[28],"perfusion":[30,112,129,219],"images":[31],"are":[32,66],"based":[33,54],"on":[34,55,78,164,212],"measuring":[35],"effect":[37],"contrast":[40,145,167],"agent":[41,168],"moving":[42],"through":[43],"blood":[44],"vessels":[45],"into":[47,127],"tissue.":[48],"Contrast-agent":[49],"free":[50],"approaches,":[51],"example,":[53],"intravoxel":[56],"incoherent":[57],"motion":[58],"arterial":[60,83],"spin":[61],"labeling,":[62],"also":[63],"exist,":[64],"but":[65],"so":[67],"far":[68],"not":[69],"routinely":[70],"clinically.":[72],"Existing":[73],"contrast-agent-dependent":[74],"methods":[75],"typically":[76],"rely":[77],"estimation":[80,179,183],"input":[84],"function":[85],"(AIF)":[86],"approximately":[88],"model":[89,141],"tissue":[90],"perfusion.":[91,253],"These":[92],"neglect":[94],"spatial":[95,154],"dependencies.":[96],"Further,":[97],"as":[98],"reliably":[99],"estimating":[100,159],"AIF":[102,106,161],"non-trivial,":[104],"different":[105,111],"estimates":[107,132],"may":[108],"lead":[109],"measures.":[113],"In":[114],"this":[115],"work":[116],"we":[117,172],"therefore":[118],"propose":[119,173],"PIANO,":[120,197],"an":[121,139,149],"approach":[122],"that":[123,227],"provides":[124],"additional":[125],"insights":[126],"process.":[130],"PIANO":[131,151,211,228],"velocity":[134,232],"diffusion":[136,234],"fields":[137],"advection-diffusion":[140],"best":[142],"explaining":[143],"dynamics":[146],"without":[147],"using":[148],"AIF.":[150],"accounts":[152],"dependencies":[155],"neither":[157],"requires":[158],"nor":[162],"relies":[163],"particular":[166],"bolus":[169],"shape.":[170],"Specifically,":[171],"convenient":[175],"parameterization":[176],"problem,":[180],"numerical":[182],"approach,":[184],"extensively":[186],"evaluate":[187],"PIANO.":[188],"Simulation":[189],"experiments":[190],"show":[191],"robustness":[193],"effectiveness":[195],"along":[198],"with":[199],"its":[200],"ability":[201],"distinguish":[203],"between":[204],"advection":[205],"diffusion.":[207],"We":[208],"further":[209],"apply":[210],"public":[214],"magnetic":[216],"resonance":[217],"(MR)":[218],"dataset":[220],"acute":[222],"stroke":[223],"patients,":[224],"demonstrate":[226],"can":[229],"successfully":[230],"resolve":[231],"field":[235],"ambiguities":[236],"results":[238],"in":[239],"sensitive":[240],"measures":[241,251],"assessment":[244],"stroke,":[246],"comparing":[247],"favorably":[248],"conventional":[250]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2021-06-07T00:00:00"}