{"id":"https://openalex.org/W3138558404","doi":"https://doi.org/10.1109/tmi.2021.3067169","title":"A Linearized Fit Model for Robust Shape Parameterization of FET-PET TACs","display_name":"A Linearized Fit Model for Robust Shape Parameterization of FET-PET TACs","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3138558404","doi":"https://doi.org/10.1109/tmi.2021.3067169","mag":"3138558404","pmid":"https://pubmed.ncbi.nlm.nih.gov/33735076"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2021.3067169","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2021.3067169","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054258988","display_name":"Christoph Lerche","orcid":"https://orcid.org/0000-0003-2749-2108"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christoph W. Lerche","raw_affiliation_strings":["Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0003-2749-2108","affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066627858","display_name":"Timon Radomski","orcid":"https://orcid.org/0000-0002-2367-9154"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timon Radomski","raw_affiliation_strings":["Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0002-2367-9154","affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091809961","display_name":"Philipp Lohmann","orcid":"https://orcid.org/0000-0002-5360-046X"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Lohmann","raw_affiliation_strings":["Department of Stereotaxy and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0002-5360-046X","affiliations":[{"raw_affiliation_string":"Department of Stereotaxy and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210153755","https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106225453","display_name":"Liliana Caldeira","orcid":"https://orcid.org/0000-0002-9530-5899"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Liliana Caldeira","raw_affiliation_strings":["Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany","Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039331246","display_name":"Cl\u00e1udia R\u00e9gio Brambilla","orcid":"https://orcid.org/0000-0002-3735-8511"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Regio Brambilla","raw_affiliation_strings":["Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0002-3735-8511","affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075538338","display_name":"Lutz Tellmann","orcid":"https://orcid.org/0000-0002-1154-2847"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lutz Tellmann","raw_affiliation_strings":["Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0002-1154-2847","affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001366515","display_name":"J. Scheins","orcid":"https://orcid.org/0000-0003-3474-430X"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jurgen Scheins","raw_affiliation_strings":["Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061107147","display_name":"Elena Rota Kops","orcid":"https://orcid.org/0000-0002-0959-9457"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena Rota Kops","raw_affiliation_strings":["Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0002-0959-9457","affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048404962","display_name":"Norbert Galldiks","orcid":"https://orcid.org/0000-0002-2485-1796"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210094797","display_name":"Integrated Oncology (United States)","ror":"https://ror.org/00w8byr45","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094797"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Norbert Galldiks","raw_affiliation_strings":["Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany","Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","Institute of Neuroscience and Medicine 3, Forschungszentrum J\u00fclich, J\u00fclich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2485-1796","affiliations":[{"raw_affiliation_string":"Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210094797"]},{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210153755","https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine 3, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062516261","display_name":"Karl\u2010Josef Langen","orcid":"https://orcid.org/0000-0003-1101-5075"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210094797","display_name":"Integrated Oncology (United States)","ror":"https://ror.org/00w8byr45","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094797"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Karl-Josef Langen","raw_affiliation_strings":["Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany","Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0003-1101-5075","affiliations":[{"raw_affiliation_string":"Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210094797"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006033207","display_name":"Hans Herzog","orcid":"https://orcid.org/0000-0002-6751-7165"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Herzog","raw_affiliation_strings":["Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]"],"raw_orcid":"https://orcid.org/0000-0002-6751-7165","affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"[Institute of Neuroscience and Medicine 4, Forschungszentrum J\u00fclich, J\u00fclich, Germany]","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071643772","display_name":"N. Jon Shah","orcid":"https://orcid.org/0000-0002-8151-6169"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I4210133912","display_name":"J\u00fclich Aachen Research Alliance","ror":"https://ror.org/02r0e4r58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I4210133912"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Jon Shah","raw_affiliation_strings":["Department of Neurology, RWTH Aachen University, Aachen, Germany","Institutes of Neuroscience and Medicine 4 and 11, Forschungszentrum J\u00fclich, J\u00fclich, Germany","JARA\u2013BRAIN\u2013Translational Medicine, Aachen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8151-6169","affiliations":[{"raw_affiliation_string":"Department of Neurology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institutes of Neuroscience and Medicine 4 and 11, Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"JARA\u2013BRAIN\u2013Translational Medicine, Aachen, Germany","institution_ids":["https://openalex.org/I4210133912"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5054258988"],"corresponding_institution_ids":["https://openalex.org/I171892758"],"apc_list":null,"apc_paid":null,"fwci":0.5277,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65526107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"40","issue":"7","first_page":"1852","last_page":"1862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.601745069026947},{"id":"https://openalex.org/keywords/isocitrate-dehydrogenase","display_name":"Isocitrate dehydrogenase","score":0.5720140933990479},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5461339950561523},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.49965906143188477},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.46153342723846436},{"id":"https://openalex.org/keywords/homogeneity","display_name":"Homogeneity (statistics)","score":0.42562156915664673},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4147261679172516},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.39405977725982666},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36547571420669556},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3580978512763977},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3386160135269165},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.2780059576034546},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.20382484793663025},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.18361735343933105},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14687788486480713}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.601745069026947},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.5720140933990479},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5461339950561523},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.49965906143188477},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.46153342723846436},{"id":"https://openalex.org/C142259097","wikidata":"https://www.wikidata.org/wiki/Q5891314","display_name":"Homogeneity (statistics)","level":2,"score":0.42562156915664673},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4147261679172516},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.39405977725982666},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36547571420669556},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3580978512763977},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3386160135269165},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.2780059576034546},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.20382484793663025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18361735343933105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14687788486480713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tmi.2021.3067169","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2021.3067169","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:33735076","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33735076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:58523","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:publications.rwth-aachen.de:851307","is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/851307","pdf_url":null,"source":{"id":"https://openalex.org/S4306401033","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE transactions on medical imaging 40(7), 1852-1862 (2021). doi:10.1109/TMI.2021.3067169","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.6399999856948853,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1513180487","https://openalex.org/W1895931341","https://openalex.org/W1908383608","https://openalex.org/W1966729003","https://openalex.org/W1976643892","https://openalex.org/W1980185649","https://openalex.org/W1993002126","https://openalex.org/W2013457550","https://openalex.org/W2026160939","https://openalex.org/W2053701690","https://openalex.org/W2053882060","https://openalex.org/W2073695582","https://openalex.org/W2079141522","https://openalex.org/W2101498866","https://openalex.org/W2103674995","https://openalex.org/W2123870530","https://openalex.org/W2160382843","https://openalex.org/W2165434507","https://openalex.org/W2166619576","https://openalex.org/W2166847050","https://openalex.org/W2200739180","https://openalex.org/W2264709743","https://openalex.org/W2321998191","https://openalex.org/W2366536035","https://openalex.org/W2488748284","https://openalex.org/W2558811751","https://openalex.org/W2605167804","https://openalex.org/W2765212633","https://openalex.org/W2767326874","https://openalex.org/W2770581584","https://openalex.org/W2794165115","https://openalex.org/W2800009827","https://openalex.org/W2810033003","https://openalex.org/W2887445161","https://openalex.org/W2892337247","https://openalex.org/W2893195505","https://openalex.org/W2902487187","https://openalex.org/W2962396195","https://openalex.org/W2968808440","https://openalex.org/W2973984026","https://openalex.org/W6678330116","https://openalex.org/W6684231558"],"related_works":["https://openalex.org/W3032557428","https://openalex.org/W3163784693","https://openalex.org/W3094614985","https://openalex.org/W1986186581","https://openalex.org/W2892337247","https://openalex.org/W2998853147","https://openalex.org/W2887130720","https://openalex.org/W2015606986","https://openalex.org/W2143548977","https://openalex.org/W3199544822"],"abstract_inverted_index":{"The":[0,18,92,146,235],"kinetic":[1],"analysis":[2,19,86],"of":[3,63,77,87,95,121,237,246],"[Formula:":[4,64],"see":[5,65],"text]-FET":[6,66],"time-activity":[7],"curves":[8],"(TAC)":[9],"can":[10],"provide":[11],"valuable":[12],"diagnostic":[13,93],"information":[14],"in":[15,67,118,171,203],"glioma":[16,112,124],"patients.":[17,125],"is":[20,34],"most":[21],"often":[22],"limited":[23],"to":[24,161,183,197],"the":[25,43,49,75,78,96,101,130,157,162,172,180,230],"average":[26],"TAC":[27,88,164],"over":[28],"a":[29,58,119,212],"large":[30],"tissue":[31],"volume":[32],"and":[33,45,56,81,109,133,139,151,194,244],"normally":[35],"assessed":[36,114],"by":[37,41,115],"visual":[38],"inspection":[39],"or":[40],"evaluating":[42],"time-to-peak":[44],"linear":[46,201],"slope":[47],"during":[48],"late":[50],"uptake":[51],"phase.":[52],"Here,":[53],"we":[54],"derived":[55],"validated":[57],"linearized":[59,158,231],"model":[60,132,159,232],"for":[61,100,226],"TACs":[62,135,248],"dynamic":[68,167],"PET":[69,169],"scans.":[70],"Emphasis":[71],"was":[72,90,113,154,189,195,209,249],"put":[73],"on":[74,200],"robustness":[76],"numerical":[79],"parameters":[80,99,239],"how":[82],"reliably":[83],"automatic":[84],"voxel-wise":[85,242],"kinetics":[89],"possible.":[91],"performance":[94],"extracted":[97],"shape":[98],"discrimination":[102],"between":[103,129,149],"isocitrate":[104],"dehydrogenase":[105],"(IDH)":[106],"wildtype":[107],"(wt)":[108],"IDH-mutant":[110],"(mut)":[111],"receiver-operating":[116],"characteristic":[117],"group":[120],"33":[122],"adult":[123],"A":[126],"high":[127,251],"agreement":[128,236],"adjusted":[131],"measured":[134],"could":[136],"be":[137],"obtained":[138],"relative,":[140],"estimated":[141],"parameter":[142],"uncertainties":[143,222],"were":[144,233],"small.":[145],"best":[147],"differentiation":[148],"IDH-wt":[150],"IDH-mut":[152],"gliomas":[153],"achieved":[155],"with":[156,229],"fitted":[160],"averaged":[163,247],"values":[165],"from":[166],"FET":[168],"data":[170],"time":[173,182,205,214],"interval":[174],"4-50":[175],"min":[176,185,217],"p.i..":[177],"When":[178],"limiting":[179],"acquisition":[181],"20-40":[184],"p.i.,":[186],"classification":[187,198],"accuracy":[188],"only":[190],"slightly":[191],"lower":[192],"(-3%)":[193],"comparable":[196],"based":[199],"fits":[202,228,243,245],"this":[204],"interval.":[206],"Voxel-wise":[207],"fitting":[208],"possible":[210],"within":[211],"computation":[213],"\u2248":[215],"1":[216],"per":[218],"image":[219],"slice.":[220],"Parameter":[221],"smaller":[223],"than":[224],"80%":[225],"all":[227],"achieved.":[234],"best-fit":[238],"when":[240],"comparing":[241],"very":[250],"(p":[252],"<":[253],"0.001).":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}