{"id":"https://openalex.org/W2981626968","doi":"https://doi.org/10.1109/tmi.2019.2945219","title":"A Spatio-Temporal Ageing Atlas of the Proximal Femur","display_name":"A Spatio-Temporal Ageing Atlas of the Proximal Femur","publication_year":2019,"publication_date":"2019-10-23","ids":{"openalex":"https://openalex.org/W2981626968","doi":"https://doi.org/10.1109/tmi.2019.2945219","mag":"2981626968","pmid":"https://pubmed.ncbi.nlm.nih.gov/31647421"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2019.2945219","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2019.2945219","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/9084068/08880676.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/42/9084068/08880676.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020846083","display_name":"Mohsen Farzi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210125693","display_name":"Simulation Technologies (United States)","ror":"https://ror.org/02ypd5h61","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125693"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Mohsen Farzi","raw_affiliation_strings":["Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), The University of Leeds, Leeds, U.K","Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K"],"raw_orcid":"https://orcid.org/0000-0003-4663-2110","affiliations":[{"raw_affiliation_string":"Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), The University of Leeds, Leeds, U.K","institution_ids":["https://openalex.org/I4210125693"]},{"raw_affiliation_string":"Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078441502","display_name":"Jos\u00e9 M. Pozo","orcid":"https://orcid.org/0000-0002-0759-3510"},"institutions":[{"id":"https://openalex.org/I4210125693","display_name":"Simulation Technologies (United States)","ror":"https://ror.org/02ypd5h61","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose M. Pozo","raw_affiliation_strings":["Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), The University of Leeds, Leeds, U.K"],"raw_orcid":"https://orcid.org/0000-0002-0759-3510","affiliations":[{"raw_affiliation_string":"Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), The University of Leeds, Leeds, U.K","institution_ids":["https://openalex.org/I4210125693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037004738","display_name":"Eug\u00e8ne McCloskey","orcid":"https://orcid.org/0000-0003-0177-8140"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eugene McCloskey","raw_affiliation_strings":["Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K","MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), The University of Sheffield, Sheffield, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), The University of Sheffield, Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064307236","display_name":"Richard Eastell","orcid":"https://orcid.org/0000-0002-0323-3366"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Eastell","raw_affiliation_strings":["Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K","MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), The University of Sheffield, Sheffield, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), The University of Sheffield, Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047582694","display_name":"Nicholas C. Harvey","orcid":"https://orcid.org/0000-0002-8194-2512"},"institutions":[{"id":"https://openalex.org/I4210148293","display_name":"MRC Lifecourse Epidemiology Unit","ror":"https://ror.org/04j4a6x59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210148293","https://openalex.org/I43439940","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Harvey","raw_affiliation_strings":["MRC Lifecourse Epidemiology Unit, The University of Southampton, Southampton, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Lifecourse Epidemiology Unit, The University of Southampton, Southampton, U.K","institution_ids":["https://openalex.org/I4210148293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005962865","display_name":"J. Mark Wilkinson","orcid":"https://orcid.org/0000-0001-5577-3674"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Mark Wilkinson","raw_affiliation_strings":["Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K","MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), The University of Sheffield, Sheffield, U.K"],"raw_orcid":"https://orcid.org/0000-0001-5577-3674","affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, The University of Sheffield, Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), The University of Sheffield, Sheffield, U.K","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049192404","display_name":"Alejandro F. Frangi","orcid":"https://orcid.org/0000-0002-2675-528X"},"institutions":[{"id":"https://openalex.org/I4210125693","display_name":"Simulation Technologies (United States)","ror":"https://ror.org/02ypd5h61","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125693"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro F. Frangi","raw_affiliation_strings":["Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), The University of Leeds, Leeds, U.K"],"raw_orcid":"https://orcid.org/0000-0002-2675-528X","affiliations":[{"raw_affiliation_string":"Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), The University of Leeds, Leeds, U.K","institution_ids":["https://openalex.org/I4210125693"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5020846083"],"corresponding_institution_ids":["https://openalex.org/I4210125693","https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":0.5841,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67494297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"39","issue":"5","first_page":"1359","last_page":"1368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.9700000286102295,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantile","display_name":"Quantile","score":0.7003384828567505},{"id":"https://openalex.org/keywords/bone-mineral","display_name":"Bone mineral","score":0.6765756607055664},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"Osteoporosis","score":0.6496825814247131},{"id":"https://openalex.org/keywords/femur","display_name":"Femur","score":0.5152797698974609},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.4876514673233032},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4513671398162842},{"id":"https://openalex.org/keywords/ageing","display_name":"Ageing","score":0.4203207492828369},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40584927797317505},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35189419984817505},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16644158959388733},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.11007162928581238},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11001917719841003},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09533506631851196},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.09097832441329956}],"concepts":[{"id":"https://openalex.org/C118671147","wikidata":"https://www.wikidata.org/wiki/Q578714","display_name":"Quantile","level":2,"score":0.7003384828567505},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.6765756607055664},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6496825814247131},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.5152797698974609},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.4876514673233032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4513671398162842},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4203207492828369},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40584927797317505},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35189419984817505},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16644158959388733},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.11007162928581238},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11001917719841003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09533506631851196},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09097832441329956}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015502","descriptor_name":"Absorptiometry, Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1109/tmi.2019.2945219","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2019.2945219","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/9084068/08880676.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:31647421","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31647421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/a22012bb-6771-49ed-b597-1cb3cf858b84","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/a22012bb-6771-49ed-b597-1cb3cf858b84","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Farzi, M, Pozo, J M, McCloskey, E, Eastell, R, Harvey, N, Wilkinson, J M & Frangi, A F 2020, 'A Spatio-Temporal Ageing Atlas of the Proximal Femur', IEEE Transactions on Medical Imaging, vol. 39, no. 5, pp. 1359-1368. https://doi.org/10.1109/TMI.2019.2945219","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:eprints.soton.ac.uk:438347","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/651219","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/bitstream/123456789/651219/2/153113%5b1%5d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1109/tmi.2019.2945219","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2019.2945219","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/9084068/08880676.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2298345532","display_name":null,"funder_award_id":"H2020-SC1-PM-17-2017-777090","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2988294562","display_name":null,"funder_award_id":"MR/P020941/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3366015303","display_name":"Centre for Integrated research into Musculoskeletal Ageing (CIMA) Renewal","funder_award_id":"MR/P020941/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4711322557","display_name":"EPSRC-NIHR HTC Partnership Award 'Plus': Medical Image Analysis Network (MedIAN)","funder_award_id":"EP/N026993/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4937468798","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5045220161","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6049260834","display_name":null,"funder_award_id":"H2020-SC1","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G6297194692","display_name":null,"funder_award_id":"H2020-SC1","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6333133484","display_name":null,"funder_award_id":"EP/N026993/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7216901621","display_name":null,"funder_award_id":"777090","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7829004498","display_name":null,"funder_award_id":"EP/N026993/1","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8495397954","display_name":null,"funder_award_id":"777090","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2981626968.pdf","grobid_xml":"https://content.openalex.org/works/W2981626968.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W33507944","https://openalex.org/W1966741541","https://openalex.org/W1978406597","https://openalex.org/W1989171659","https://openalex.org/W1999010575","https://openalex.org/W1999888995","https://openalex.org/W2010167745","https://openalex.org/W2016459086","https://openalex.org/W2025136046","https://openalex.org/W2029117812","https://openalex.org/W2061081924","https://openalex.org/W2064082484","https://openalex.org/W2068613829","https://openalex.org/W2073327859","https://openalex.org/W2077512165","https://openalex.org/W2080756176","https://openalex.org/W2082704080","https://openalex.org/W2095569436","https://openalex.org/W2115660903","https://openalex.org/W2121688201","https://openalex.org/W2128409098","https://openalex.org/W2134620313","https://openalex.org/W2135931458","https://openalex.org/W2136326182","https://openalex.org/W2142162824","https://openalex.org/W2149520406","https://openalex.org/W2152826766","https://openalex.org/W2153088288","https://openalex.org/W2155982020","https://openalex.org/W2163998463","https://openalex.org/W2169552569","https://openalex.org/W2315671897","https://openalex.org/W2328036229","https://openalex.org/W2586745850","https://openalex.org/W2686556072","https://openalex.org/W2771193347","https://openalex.org/W2890735335","https://openalex.org/W4213265195","https://openalex.org/W4243825606"],"related_works":["https://openalex.org/W1488761988","https://openalex.org/W2044551864","https://openalex.org/W1572557500","https://openalex.org/W3124946120","https://openalex.org/W4390690393","https://openalex.org/W2047938026","https://openalex.org/W2359070681","https://openalex.org/W2740921033","https://openalex.org/W2991782731","https://openalex.org/W2355994828"],"abstract_inverted_index":{"Osteoporosis":[0],"is":[1,109,159],"an":[2],"age-associated":[3],"disease":[4],"characterised":[5],"by":[6,118],"low":[7],"bone":[8,53,78,94,206,221,230],"mineral":[9],"density":[10],"(BMD)":[11],"and":[12,71,223,239],"micro-architectural":[13],"deterioration":[14],"leading":[15],"to":[16,56,87,111,161,235],"enhanced":[17,236],"fracture":[18],"risk.":[19],"Conventional":[20],"dual-energy":[21],"X-ray":[22],"absorptiometry":[23],"(DXA)":[24],"analysis":[25,106],"has":[26],"facilitated":[27],"our":[28],"understanding":[29,227],"of":[30,36,60,76,92,183,205,228],"BMD":[31,46,62,169,185],"reduction":[32],"in":[33,52,95,142,146],"specific":[34],"regions":[35,210],"interest":[37],"(ROIs)":[38],"within":[39,211],"the":[40,96,128,212,216,229,243],"femur,":[41],"but":[42],"cannot":[43],"resolve":[44],"spatial":[45],"patterns":[47,187],"nor":[48],"reflect":[49],"age-related":[50],"changes":[51],"microarchitecture":[54],"due":[55],"its":[57],"inherent":[58],"averaging":[59],"pixel":[61,199],"values":[63],"into":[64,122],"large":[65],"ROIs.":[66],"To":[67,126],"address":[68],"these":[69],"limitations":[70],"develop":[72],"a":[73,83,89,123],"comprehensive":[74],"model":[75],"involutional":[77],"loss,":[79],"this":[80],"paper":[81],"presents":[82],"fully":[84],"automatic":[85],"pipeline":[86],"build":[88],"spatio-temporal":[90,220],"atlas":[91],"ageing":[93,172,231],"proximal":[97],"femur.":[98],"A":[99,151],"new":[100],"technique,":[101],"termed":[102,155],"DXA":[103,116,133,166],"region":[104],"free":[105],"(DXA":[107],"RFA),":[108],"proposed":[110,160],"eliminate":[112],"morphological":[113],"variation":[114],"between":[115,219],"scans":[117],"warping":[119],"each":[120],"image":[121],"reference":[124],"template.":[125],"construct":[127],"atlas,":[129],"we":[130],"use":[131],"unprocessed":[132],"data":[134,163],"from":[135,164],"Caucasian":[136],"women":[137],"aged":[138],"20-97":[139],"years":[140],"participating":[141],"three":[143],"cohort":[144],"studies":[145],"Western":[147],"Europe":[148],"(":[149],",000).":[150],"novel":[152],"calibration":[153],"procedure,":[154],"quantile":[156,177,194],"matching":[157],"regression,":[158],"integrate":[162],"different":[165,198,203,209],"manufacturers.":[167],"Pixel-wise":[168],"evolution":[170],"with":[171,188],"was":[173],"modelled":[174],"using":[175,191],"smooth":[176],"curves.":[178],"This":[179],"technique":[180],"enables":[181],"characterisation":[182],"spatially-complex":[184],"change":[186],"ageing,":[189],"visualised":[190],"heat-maps.":[192],"Furthermore,":[193],"curves":[195],"plotted":[196],"at":[197,208],"coordinates":[200],"showed":[201],"consistently":[202],"rates":[204],"loss":[207,222],"femoral":[213],"neck.":[214],"Given":[215],"close":[217],"relationship":[218],"osteoporotic":[224],"fracture,":[225],"improved":[226],"process":[232],"could":[233],"lead":[234],"prognostic,":[237],"preventive":[238],"therapeutic":[240],"strategies":[241],"for":[242],"disease.":[244]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}