{"id":"https://openalex.org/W2774685105","doi":"https://doi.org/10.1109/tmi.2017.2779811","title":"A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth","display_name":"A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth","publication_year":2017,"publication_date":"2017-12-04","ids":{"openalex":"https://openalex.org/W2774685105","doi":"https://doi.org/10.1109/tmi.2017.2779811","mag":"2774685105","pmid":"https://pubmed.ncbi.nlm.nih.gov/29533893"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2017.2779811","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2017.2779811","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ora.ox.ac.uk/objects/uuid:b5ac631d-56ba-4d86-be8b-387a7a7785cc","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081713433","display_name":"Tha\u00eds Roque","orcid":"https://orcid.org/0000-0003-2589-0874"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210119896","display_name":"King's College School","ror":"https://ror.org/02bbqcn27","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210119896"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Thais Roque","raw_affiliation_strings":["Division of Imaging Sciences and Biomedical Engineering, King\u2019s College London, London, U.K","Institute of Biomedical Engineering, University of Oxford, Oxford, U.K","Division of Imaging Sciences and Biomedical Engineering, King's College London, London, U.K"],"affiliations":[{"raw_affiliation_string":"Division of Imaging Sciences and Biomedical Engineering, King\u2019s College London, London, U.K","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210119896"]},{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Division of Imaging Sciences and Biomedical Engineering, King's College London, London, U.K","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I4210119896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082554847","display_name":"Laurent Risser","orcid":"https://orcid.org/0000-0003-2207-6615"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I84500057","display_name":"Institut de Math\u00e9matiques de Toulouse","ror":"https://ror.org/014vp6c30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210141950","https://openalex.org/I4210152422","https://openalex.org/I4405258862","https://openalex.org/I4405258862","https://openalex.org/I4405258862","https://openalex.org/I4405259414","https://openalex.org/I84500057"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Risser","raw_affiliation_strings":["Institut de Math\u00e9matiques de Toulouse, Toulouse, CNRS, France"],"affiliations":[{"raw_affiliation_string":"Institut de Math\u00e9matiques de Toulouse, Toulouse, CNRS, France","institution_ids":["https://openalex.org/I84500057","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059449850","display_name":"Veerle Kersemans","orcid":"https://orcid.org/0000-0002-4669-236X"},"institutions":[{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Veerle Kersemans","raw_affiliation_strings":["Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I4210106471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017932546","display_name":"Sean Smart","orcid":"https://orcid.org/0000-0002-0919-4505"},"institutions":[{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sean Smart","raw_affiliation_strings":["Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I4210106471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079428721","display_name":"Philip D. Allen","orcid":"https://orcid.org/0000-0002-6200-0925"},"institutions":[{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Danny Allen","raw_affiliation_strings":["Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I4210106471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055691162","display_name":"Paul Kinchesh","orcid":null},"institutions":[{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Kinchesh","raw_affiliation_strings":["Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I4210106471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103284962","display_name":"Stuart Gilchrist","orcid":"https://orcid.org/0000-0002-7368-3733"},"institutions":[{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stuart Gilchrist","raw_affiliation_strings":["Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I4210106471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005540802","display_name":"Ana L. Gomes","orcid":"https://orcid.org/0000-0002-4796-6537"},"institutions":[{"id":"https://openalex.org/I4210106471","display_name":"CRUK/MRC Oxford Institute for Radiation Oncology","ror":"https://ror.org/011hz4254","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4210106471","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana L. Gomes","raw_affiliation_strings":["Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I4210106471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019012882","display_name":"Julia A. Schnabel","orcid":"https://orcid.org/0000-0001-6107-3009"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia A. Schnabel","raw_affiliation_strings":["Institute of Biomedical Engineering, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001596439","display_name":"Michael A. Chappell","orcid":"https://orcid.org/0000-0003-1802-4214"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael A. Chappell","raw_affiliation_strings":["Institute of Biomedical Engineering, University of Oxford, Oxford, U.K"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, University of Oxford, Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5081713433"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I40120149","https://openalex.org/I4210119896"],"apc_list":null,"apc_paid":null,"fwci":2.7934,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.90587412,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"37","issue":"3","first_page":"724","last_page":"732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/time-point","display_name":"Time point","score":0.6091936230659485},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48514971137046814},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4488985538482666},{"id":"https://openalex.org/keywords/growth-model","display_name":"Growth model","score":0.4338303804397583},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23669832944869995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17239326238632202},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11413121223449707}],"concepts":[{"id":"https://openalex.org/C2779466056","wikidata":"https://www.wikidata.org/wiki/Q107630651","display_name":"Time point","level":2,"score":0.6091936230659485},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48514971137046814},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4488985538482666},{"id":"https://openalex.org/C2983335520","wikidata":"https://www.wikidata.org/wiki/Q47537570","display_name":"Growth model","level":2,"score":0.4338303804397583},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23669832944869995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17239326238632202},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11413121223449707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1109/tmi.2017.2779811","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2017.2779811","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:29533893","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29533893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/b0700e70-2586-4c6e-aa9a-c34dd04dc46d","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/b0700e70-2586-4c6e-aa9a-c34dd04dc46d","pdf_url":"https://ora.ox.ac.uk/objects/uuid:b5ac631d-56ba-4d86-be8b-387a7a7785cc","source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Roque, T, Risser, L, Kersemans, V, Smart, S, Allen, D, Kinchesh, P, Gilchrist, S, Gomes, A L, Schnabel, J A & Chappell, M A 2018, 'A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth', IEEE transactions on medical imaging, vol. 37, no. 3, pp. 724-732. https://doi.org/10.1109/TMI.2017.2779811","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:HAL:hal-01702015v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01702015","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Transactions on Medical Imaging, 2017, pp.1 - 1. &#x27E8;10.1109/TMI.2017.2779811&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:nottingham-repository.worktribe.com:4930808","is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/4930808","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/b0700e70-2586-4c6e-aa9a-c34dd04dc46d","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/b0700e70-2586-4c6e-aa9a-c34dd04dc46d","pdf_url":"https://ora.ox.ac.uk/objects/uuid:b5ac631d-56ba-4d86-be8b-387a7a7785cc","source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Roque, T, Risser, L, Kersemans, V, Smart, S, Allen, D, Kinchesh, P, Gilchrist, S, Gomes, A L, Schnabel, J A & Chappell, M A 2018, 'A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth', IEEE transactions on medical imaging, vol. 37, no. 3, pp. 724-732. https://doi.org/10.1109/TMI.2017.2779811","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1093520412","display_name":null,"funder_award_id":"Scholarship","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3460797570","display_name":null,"funder_award_id":"1870061","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6333133484","display_name":null,"funder_award_id":"EP/N026993/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7491718243","display_name":null,"funder_award_id":"EP/M000133/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320335173","display_name":"Oxford Cancer Imaging Centre","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2774685105.pdf","grobid_xml":"https://content.openalex.org/works/W2774685105.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W251810509","https://openalex.org/W610135995","https://openalex.org/W1587345366","https://openalex.org/W1965640838","https://openalex.org/W1975068889","https://openalex.org/W1980242505","https://openalex.org/W1982425190","https://openalex.org/W1989403505","https://openalex.org/W1997611659","https://openalex.org/W2010769464","https://openalex.org/W2018577646","https://openalex.org/W2024060531","https://openalex.org/W2024080420","https://openalex.org/W2025538125","https://openalex.org/W2042098439","https://openalex.org/W2045527031","https://openalex.org/W2047232697","https://openalex.org/W2055272161","https://openalex.org/W2061366065","https://openalex.org/W2080098019","https://openalex.org/W2088003984","https://openalex.org/W2101482993","https://openalex.org/W2104644297","https://openalex.org/W2111967308","https://openalex.org/W2116926422","https://openalex.org/W2130257210","https://openalex.org/W2133127239","https://openalex.org/W2135558784","https://openalex.org/W2141226754","https://openalex.org/W2147938585","https://openalex.org/W2152803686","https://openalex.org/W2161543607","https://openalex.org/W2171707507","https://openalex.org/W2539246379","https://openalex.org/W4234794606"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122"],"abstract_inverted_index":{"Predicting":[0],"tumor":[1,19,37,48,87,139],"growth":[2,20],"and":[3,15,28,45,50,55,78,89,120,133,175],"its":[4],"response":[5],"to":[6,80,135,149,159,180],"therapy":[7],"remains":[8],"a":[9,30],"major":[10],"challenge":[11],"in":[12,111,115],"cancer":[13],"research":[14],"strongly":[16],"relies":[17],"on":[18,103],"models.":[21],"In":[22],"this":[23],"paper,":[24],"we":[25,145],"introduce,":[26],"calibrate,":[27],"verify":[29],"novel":[31],"image-driven":[32],"reaction-diffusion":[33],"model":[34,40,127,148],"of":[35,47,64,85,153],"avascular":[36],"growth.":[38,140],"The":[39],"allows":[41],"for":[42,52,165,168,184],"proliferation,":[43],"death":[44],"spread":[46],"cells,":[49],"accounts":[51],"nutrient":[53],"distribution":[54],"hypoxia.":[56],"It":[57],"is":[58],"constrained":[59],"by":[60,142],"longitudinal":[61],"time":[62,76,94,170,186],"series":[63],"dynamic":[65],"contrast-enhancement-MRI":[66],"images.":[67],"Tumor":[68],"specific":[69],"parameters":[70,128],"are":[71,157],"estimated":[72],"from":[73,106],"two":[74],"early":[75,169],"points":[77],"used":[79,134],"predict":[81,137],"the":[82,86,138,166],"spatio-temporal":[83],"evolution":[84],"volume":[88,117],"cell":[90],"densities":[91],"at":[92],"later":[93,185],"points.":[95,171,187],"We":[96,156],"first":[97],"test":[98],"our":[99,147],"parameter":[100],"estimation":[101,167],"approach":[102],"synthetic":[104],"data":[105],"15":[107],"generated":[108],"tumors.":[109],"Our":[110],"silico":[112],"study":[113],"resulted":[114],"small":[116],"errors":[118],"(<5%)":[119],"high":[121],"Dice":[122],"overlaps":[123],"(>97%),":[124],"showing":[125],"that":[126],"can":[129],"be":[130,178],"successfully":[131],"recovered":[132],"accurately":[136],"Encouraged":[141],"these":[143],"results,":[144,163],"apply":[146],"seven":[150],"pre-clinical":[151],"cases":[152],"breast":[154],"carcinoma.":[155],"able":[158],"show":[160],"promising":[161],"preliminary":[162],"especially":[164],"Processes":[172],"like":[173],"angiogenesis":[174],"apoptosis":[176],"should":[177],"included":[179],"further":[181],"improve":[182],"predictions":[183]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}