{"id":"https://openalex.org/W2602876440","doi":"https://doi.org/10.1109/tmi.2017.2686006","title":"Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography","display_name":"Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography","publication_year":2017,"publication_date":"2017-03-23","ids":{"openalex":"https://openalex.org/W2602876440","doi":"https://doi.org/10.1109/tmi.2017.2686006","mag":"2602876440","pmid":"https://pubmed.ncbi.nlm.nih.gov/28333622"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2017.2686006","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2017.2686006","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":null,"any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101654841","display_name":"Lu Ding","orcid":"https://orcid.org/0000-0002-6316-8527"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lu Ding","raw_affiliation_strings":["Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany","Faculty of Medicine and the Faculty of Electrical Engineering, Technical University of Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Faculty of Medicine and the Faculty of Electrical Engineering, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072211195","display_name":"Xos\u00e9 Lu\u00eds De\u00e1n\u2010Ben","orcid":"https://orcid.org/0000-0002-8557-7778"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xos\u00e9 Lu\u00eds De\u00e1n-Ben","raw_affiliation_strings":["Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Neal C. Burton","orcid":null},"institutions":[{"id":"https://openalex.org/I4210150004","display_name":"iThera Medical (Germany)","ror":"https://ror.org/04f3qs775","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210150004"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Neal C. Burton","raw_affiliation_strings":["iThera Medical GmbH, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"iThera Medical GmbH, Munich, Germany","institution_ids":["https://openalex.org/I4210150004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027876809","display_name":"Robert W. Sobol","orcid":"https://orcid.org/0000-0001-7385-3563"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210089171","display_name":"USA Mitchell Cancer Institute","ror":"https://ror.org/009wx7055","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210089171"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Sobol","raw_affiliation_strings":["Departments of Pharmacology & Chemical Biology and Human Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Departments of Pharmacology & Chemical Biology and Human Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA"],"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology & Chemical Biology and Human Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Departments of Pharmacology & Chemical Biology and Human Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA","institution_ids":["https://openalex.org/I4210089171","https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059881887","display_name":"Vasilis Ntziachristos","orcid":"https://orcid.org/0000-0002-9988-0233"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vasilis Ntziachristos","raw_affiliation_strings":["Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany","Faculty of Medicine and the Faculty of Electrical Engineering, Technical University of Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Faculty of Medicine and the Faculty of Electrical Engineering, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082319905","display_name":"Daniel Razansky","orcid":"https://orcid.org/0000-0001-8676-0964"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Razansky","raw_affiliation_strings":["Faculty of Medicine and the Faculty of Electrical Engineering, Technical University of Munich, Munich, Germany","Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and the Faculty of Electrical Engineering, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Helmholtz Center Munich, Institute for Biological and Medical Imaging, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101654841"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":1.4445,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.80149549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"36","issue":"8","first_page":"1676","last_page":"1685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11856","display_name":"Thermography and Photoacoustic Techniques","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multispectral-image","display_name":"Multispectral image","score":0.812787652015686},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.6815189719200134},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6724724173545837},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.6701758503913879},{"id":"https://openalex.org/keywords/inverse-problem","display_name":"Inverse problem","score":0.6143757104873657},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5299549698829651},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5241273045539856},{"id":"https://openalex.org/keywords/optical-tomography","display_name":"Optical tomography","score":0.5080256462097168},{"id":"https://openalex.org/keywords/tomographic-reconstruction","display_name":"Tomographic reconstruction","score":0.4561057686805725},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.36893022060394287},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3515814542770386},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3427552282810211},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2369777262210846},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20701709389686584}],"concepts":[{"id":"https://openalex.org/C173163844","wikidata":"https://www.wikidata.org/wiki/Q1761440","display_name":"Multispectral image","level":2,"score":0.812787652015686},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.6815189719200134},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6724724173545837},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.6701758503913879},{"id":"https://openalex.org/C135252773","wikidata":"https://www.wikidata.org/wiki/Q1567213","display_name":"Inverse problem","level":2,"score":0.6143757104873657},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5299549698829651},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5241273045539856},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.5080256462097168},{"id":"https://openalex.org/C97742081","wikidata":"https://www.wikidata.org/wiki/Q7820109","display_name":"Tomographic reconstruction","level":3,"score":0.4561057686805725},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.36893022060394287},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3515814542770386},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3427552282810211},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2369777262210846},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20701709389686584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014054","descriptor_name":"Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014054","descriptor_name":"Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014054","descriptor_name":"Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014054","descriptor_name":"Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1109/tmi.2017.2686006","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2017.2686006","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:28333622","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28333622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:www.zora.uzh.ch:172712","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ding, Lu; Dean-Ben, Xose Luis; Burton, Neal C; Sobol, Robert W; Ntziachristos, Vasilis; Razansky, Daniel  (2017). Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography.  IEEE Transactions on Medical Imaging, 36(8):1676-1685.","raw_type":"info:eu-repo/semantics/acceptedVersion"},{"id":"pmh:oai:europepmc.org:5019349","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5585740","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1440034","is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1440034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:50975","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50975","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans. Med. Imaging 36, 1676-1685 (2017)","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5585740","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5585740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:50975","is_oa":false,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=50975","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans. Med. Imaging 36, 1676-1685 (2017)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5167/uzh-172712","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-172712","pdf_url":null,"source":{"id":"https://openalex.org/S7407051291","display_name":"Universit\u00e4t Z\u00fcrich, ZORA","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:www.zora.uzh.ch:172712","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ding, Lu; Dean-Ben, Xose Luis; Burton, Neal C; Sobol, Robert W; Ntziachristos, Vasilis; Razansky, Daniel  (2017). Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography.  IEEE Transactions on Medical Imaging, 36(8):1676-1685.","raw_type":"info:eu-repo/semantics/acceptedVersion"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2851048061","display_name":null,"funder_award_id":"RGY0070/2016","funder_id":"https://openalex.org/F4320320338","funder_display_name":"Human Frontier Science Program"},{"id":"https://openalex.org/G4113966179","display_name":null,"funder_award_id":"R01CA148629","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5348430179","display_name":null,"funder_award_id":"ERC-2015-CoG-682379","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320338","display_name":"Human Frontier Science Program","ror":"https://ror.org/02ebx7v45"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1625682459","https://openalex.org/W1751143965","https://openalex.org/W1917042571","https://openalex.org/W1939890979","https://openalex.org/W1969455435","https://openalex.org/W1972892876","https://openalex.org/W1976701003","https://openalex.org/W1979515779","https://openalex.org/W1992009035","https://openalex.org/W1994616770","https://openalex.org/W1995131110","https://openalex.org/W1997692791","https://openalex.org/W1999502333","https://openalex.org/W2009283961","https://openalex.org/W2011758100","https://openalex.org/W2019493368","https://openalex.org/W2025680292","https://openalex.org/W2031338189","https://openalex.org/W2040035390","https://openalex.org/W2049966245","https://openalex.org/W2050261554","https://openalex.org/W2050366771","https://openalex.org/W2051225792","https://openalex.org/W2062662849","https://openalex.org/W2068358021","https://openalex.org/W2070796256","https://openalex.org/W2072096031","https://openalex.org/W2075421578","https://openalex.org/W2076700051","https://openalex.org/W2077720339","https://openalex.org/W2080632732","https://openalex.org/W2083454481","https://openalex.org/W2092513871","https://openalex.org/W2097683070","https://openalex.org/W2097897435","https://openalex.org/W2098098075","https://openalex.org/W2114702171","https://openalex.org/W2115843483","https://openalex.org/W2116040950","https://openalex.org/W2118270453","https://openalex.org/W2122545253","https://openalex.org/W2122742194","https://openalex.org/W2123924700","https://openalex.org/W2126025526","https://openalex.org/W2133863204","https://openalex.org/W2148309086","https://openalex.org/W2150017534","https://openalex.org/W2156463417","https://openalex.org/W2162418751","https://openalex.org/W2170361231","https://openalex.org/W2173934646","https://openalex.org/W2183266787","https://openalex.org/W2272061938","https://openalex.org/W2339398025","https://openalex.org/W2414183551","https://openalex.org/W3103029346","https://openalex.org/W4237234927"],"related_works":["https://openalex.org/W1994496918","https://openalex.org/W1928301487","https://openalex.org/W2151220638","https://openalex.org/W2725829804","https://openalex.org/W3013621226","https://openalex.org/W2982317495","https://openalex.org/W2295596929","https://openalex.org/W2088308468","https://openalex.org/W170151271","https://openalex.org/W2017732498"],"abstract_inverted_index":{"Accurate":[0],"extraction":[1],"of":[2,17,92,100,111,135,194,197],"physical":[3,48],"and":[4,39,84,127,158,206],"biochemical":[5],"parameters":[6],"from":[7,124],"optoacoustic":[8,69,121],"images":[9,70],"is":[10,116,142,166,171],"often":[11],"impeded":[12],"due":[13],"to":[14,53,201],"the":[15,36,47,59,66,90,108,112,175,186,191,195,203],"use":[16],"unrigorous":[18],"inversion":[19,83],"schemes,":[20],"incomplete":[21],"tomographic":[22],"detection":[23],"coverage,":[24],"or":[25],"other":[26],"experimental":[27],"factors":[28],"that":[29,168],"cannot":[30],"be":[31,72],"readily":[32],"accounted":[33],"for":[34,173],"during":[35],"image":[37,177],"acquisition":[38],"reconstruction":[40,79,113,170,208],"process.":[41,114],"For":[42],"instance,":[43],"inaccurate":[44,181],"assumptions":[45],"in":[46,58,65,81,118,128,139,210],"forward":[49],"model":[50],"may":[51],"lead":[52],"negative":[54],"optical":[55,162],"absorption":[56],"values":[57],"reconstructed":[60],"images.":[61],"Any":[62],"artifacts":[63,178],"present":[64],"single":[67],"wavelength":[68],"can":[71],"significantly":[73],"aggravated":[74],"when":[75],"performing":[76],"a":[77,98],"two-step":[78],"consisting":[80],"acoustic":[82],"spectral":[85],"unmixing":[86],"aimed":[87],"at":[88,107],"rendering":[89],"distributions":[91],"spectrally":[93],"distinct":[94],"absorbers.":[95],"We":[96],"investigate":[97],"number":[99],"algorithmic":[101],"strategies":[102],"with":[103,132,145,153,180],"non-negativity":[104,187],"constraints":[105],"imposed":[106],"different":[109],"phases":[110],"Performance":[115],"evaluated":[117],"cross-sectional":[119],"multispectral":[120],"tomography":[122],"recordings":[123],"tissue-mimicking":[125],"phantoms":[126],"vivo":[129,140],"mice":[130],"embedded":[131],"varying":[133],"concentrations":[134],"contrast":[136,163],"agents.":[137,164],"Additional":[138],"validation":[141],"subsequently":[143],"performed":[144],"molecular":[146],"imaging":[147],"data":[148],"involving":[149],"subcutaneous":[150],"tumors":[151],"labeled":[152],"genetically":[154],"expressed":[155],"iRFP":[156],"proteins":[157],"organ":[159],"perfusion":[160],"by":[161],"It":[165],"shown":[167],"constrained":[169],"essential":[172],"reducing":[174],"critical":[176],"associated":[179],"modeling":[182],"assumptions.":[183],"Furthermore,":[184],"imposing":[185],"constraint":[188],"directly":[189],"on":[190],"unmixed":[192],"distribution":[193],"probe":[196],"interest":[198],"was":[199],"found":[200],"maintain":[202],"most":[204],"robust":[205],"accurate":[207],"performance":[209],"all":[211],"experiments.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2}],"updated_date":"2026-04-02T15:55:50.835912","created_date":"2025-10-10T00:00:00"}