{"id":"https://openalex.org/W2589710688","doi":"https://doi.org/10.1109/tmi.2017.2673022","title":"Visualizing Epithelial Expression in Vertical and Horizontal Planes With Dual Axes Confocal Endomicroscope Using Compact Distal Scanner","display_name":"Visualizing Epithelial Expression in Vertical and Horizontal Planes With Dual Axes Confocal Endomicroscope Using Compact Distal Scanner","publication_year":2017,"publication_date":"2017-02-23","ids":{"openalex":"https://openalex.org/W2589710688","doi":"https://doi.org/10.1109/tmi.2017.2673022","mag":"2589710688","pmid":"https://pubmed.ncbi.nlm.nih.gov/28252391"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2017.2673022","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2017.2673022","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042954646","display_name":"Gaoming Li","orcid":"https://orcid.org/0000-0003-2092-8191"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaoming Li","raw_affiliation_strings":["Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317783","display_name":"Haijun Li","orcid":"https://orcid.org/0000-0001-9887-7342"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haijun Li","raw_affiliation_strings":["Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041762048","display_name":"Xiyu Duan","orcid":"https://orcid.org/0000-0003-1251-7026"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiyu Duan","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051170836","display_name":"Quan Zhou","orcid":"https://orcid.org/0000-0002-9351-5614"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quan Zhou","raw_affiliation_strings":["Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100737052","display_name":"Juan Zhou","orcid":"https://orcid.org/0000-0003-2500-6110"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Zhou","raw_affiliation_strings":["Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032749727","display_name":"Kenn R. Oldham","orcid":"https://orcid.org/0000-0002-5962-3056"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenn R. Oldham","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078504833","display_name":"Thomas D. Wang","orcid":"https://orcid.org/0000-0001-9182-9620"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Wang","raw_affiliation_strings":["Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":"https://orcid.org/0000-0001-9182-9620","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.9388,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.76071034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"36","issue":"7","first_page":"1482","last_page":"1490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scanner","display_name":"Scanner","score":0.7140008211135864},{"id":"https://openalex.org/keywords/confocal","display_name":"Confocal","score":0.6777392029762268},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.6096269488334656},{"id":"https://openalex.org/keywords/microelectromechanical-systems","display_name":"Microelectromechanical systems","score":0.5101068615913391},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5037304759025574},{"id":"https://openalex.org/keywords/confocal-microscopy","display_name":"Confocal microscopy","score":0.49288272857666016},{"id":"https://openalex.org/keywords/cardinal-point","display_name":"Cardinal point","score":0.41003191471099854},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.34276896715164185},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.23134583234786987}],"concepts":[{"id":"https://openalex.org/C2779751349","wikidata":"https://www.wikidata.org/wiki/Q1474480","display_name":"Scanner","level":2,"score":0.7140008211135864},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.6777392029762268},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.6096269488334656},{"id":"https://openalex.org/C37977207","wikidata":"https://www.wikidata.org/wiki/Q175561","display_name":"Microelectromechanical systems","level":2,"score":0.5101068615913391},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5037304759025574},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.49288272857666016},{"id":"https://openalex.org/C138395690","wikidata":"https://www.wikidata.org/wiki/Q376733","display_name":"Cardinal point","level":2,"score":0.41003191471099854},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.34276896715164185},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.23134583234786987}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2017.2673022","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2017.2673022","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:28252391","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28252391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G334157615","display_name":null,"funder_award_id":"R01 EB020644 (KRO)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4920752153","display_name":null,"funder_award_id":"R01 CA193377","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6918355635","display_name":null,"funder_award_id":"R01 CA193377 (TDW)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8302725833","display_name":null,"funder_award_id":"R01 EB020644","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G8345562400","display_name":null,"funder_award_id":"R01 CA200007","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8385769373","display_name":null,"funder_award_id":"R01 CA200007 (TDW)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W926645070","https://openalex.org/W1201605281","https://openalex.org/W1482570919","https://openalex.org/W1601798363","https://openalex.org/W1980863117","https://openalex.org/W1987592925","https://openalex.org/W1995807984","https://openalex.org/W2003420201","https://openalex.org/W2003428092","https://openalex.org/W2004818616","https://openalex.org/W2015948644","https://openalex.org/W2017964224","https://openalex.org/W2028697059","https://openalex.org/W2034269086","https://openalex.org/W2037455416","https://openalex.org/W2038078260","https://openalex.org/W2038991110","https://openalex.org/W2053352622","https://openalex.org/W2054096250","https://openalex.org/W2058043554","https://openalex.org/W2059452572","https://openalex.org/W2067386697","https://openalex.org/W2068632504","https://openalex.org/W2075496756","https://openalex.org/W2078799040","https://openalex.org/W2080292607","https://openalex.org/W2090562908","https://openalex.org/W2091290859","https://openalex.org/W2095201384","https://openalex.org/W2096989406","https://openalex.org/W2106519300","https://openalex.org/W2110576662","https://openalex.org/W2112579958","https://openalex.org/W2121873271","https://openalex.org/W2155083296","https://openalex.org/W2161545940","https://openalex.org/W2163478207","https://openalex.org/W2185893808","https://openalex.org/W2315598956","https://openalex.org/W2323230607","https://openalex.org/W2917837889","https://openalex.org/W6654499089","https://openalex.org/W6686792761"],"related_works":["https://openalex.org/W2726111829","https://openalex.org/W4250585504","https://openalex.org/W2008049857","https://openalex.org/W1978803831","https://openalex.org/W2105513520","https://openalex.org/W2580002495","https://openalex.org/W2056668469","https://openalex.org/W82035557","https://openalex.org/W4285171187","https://openalex.org/W1972388159"],"abstract_inverted_index":{"The":[0,41,109,139],"epithelium":[1,215],"is":[2,23,200],"a":[3,97,143,196,228,233],"thin":[4],"layer":[5],"of":[6,70,106,162,221,242],"tissue":[7,39,50],"that":[8,30,153,199,238],"lines":[9],"hollow":[10],"organs,":[11],"such":[12],"as":[13,90,92],"colon.":[14],"Visualizing":[15],"in":[16,33,49,87,158,169,232,245,255],"vertical":[17,89,172,247],"cross":[18],"sections":[19,48,241],"with":[20,121,176],"sub-cellular":[21],"resolution":[22],"essential":[24],"to":[25,37,58,67,84,123,216,251],"understanding":[26],"early":[27],"disease":[28],"mechanisms":[29],"progress":[31],"naturally":[32],"the":[34,38,59,88,104,159,171,218,256],"plane":[35],"perpendicular":[36],"surface.":[40],"dual":[42,234],"axes":[43,235],"confocal":[44,236],"architecture":[45],"collects":[46,239],"optical":[47,240],"by":[51],"directing":[52],"light":[53],"at":[54,190],"an":[55,163],"angle":[56],"incident":[57],"surface":[60],"using":[61,113],"separate":[62],"illumination":[63],"and":[64,75,118,134,204],"collection":[65],"beams":[66],"reduce":[68],"effects":[69],"scattering,":[71],"enhance":[72],"dynamic":[73],"range,":[74],"increase":[76],"imaging":[77],"depth.":[78],"This":[79],"configuration":[80],"allows":[81,154],"for":[82,155,202],"images":[83,208],"be":[85,167],"collected":[86,205],"well":[91],"horizontal":[93,174,249],"planes.":[94],"We":[95,127,193],"designed":[96],"fast,":[98],"compact":[99],"monolithic":[100],"scanner":[101],"based":[102],"on":[103],"principle":[105],"parametric":[107],"resonance.":[108],"mirrors":[110],"were":[111,119],"fabricated":[112],"microelectromechanical":[114],"systems":[115],"(MEMS)":[116],"technology":[117],"coated":[120],"aluminum":[122],"maximize":[124],"near-infrared":[125,206,243],"reflectivity.":[126],"achieved":[128],"large":[129],"axial":[130],"displacements":[131],">400":[132],"\u03bcm":[133,178],"wide":[135],"lateral":[136],"deflections":[137],">20\u00b0.":[138],"MEMS":[140],"chip":[141],"has":[142],"3.2":[144],"\u00d7":[145,182],"2.9":[146],"mm":[147,184],"<sup":[148,185],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[149,186],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[150,187],"form":[151],"factor":[152],"efficient":[156],"packaging":[157],"distal":[160],"end":[161],"endomicroscope.":[164],"Imaging":[165],"can":[166],"performed":[168],"either":[170,246],"or":[173,180,248],"planes":[175,250],"430":[177],"depth":[179],"1":[181,183],"area,":[188],"respectively,":[189],"5":[191],"frames/s.":[192],"systemically":[194],"administered":[195],"Cy5.5-labeled":[197],"peptide":[198],"specific":[201],"EGFR,":[203],"fluorescence":[207,244],"ex":[209],"vivo":[210],"from":[211],"pre-malignant":[212],"mouse":[213],"colonic":[214],"reveal":[217],"spatial":[219],"distribution":[220],"this":[222],"molecular":[223,253],"target.":[224],"Here,":[225],"we":[226],"demonstrate":[227],"novel":[229],"scanning":[230],"mechanism":[231],"endomicroscope":[237],"visualize":[252],"expression":[254],"epithelium.":[257]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
