{"id":"https://openalex.org/W2091753181","doi":"https://doi.org/10.1109/tmi.2015.2419072","title":"Bayesian Model Selection for Pathological Neuroimaging Data Applied to White Matter Lesion Segmentation","display_name":"Bayesian Model Selection for Pathological Neuroimaging Data Applied to White Matter Lesion Segmentation","publication_year":2015,"publication_date":"2015-04-03","ids":{"openalex":"https://openalex.org/W2091753181","doi":"https://doi.org/10.1109/tmi.2015.2419072","mag":"2091753181","pmid":"https://pubmed.ncbi.nlm.nih.gov/25850086"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2015.2419072","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2015.2419072","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/7283692/07078891.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/42/7283692/07078891.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044422433","display_name":"Carole H. Sudre","orcid":"https://orcid.org/0000-0001-5753-428X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Carole H. Sudre","raw_affiliation_strings":["University College, Dementia Research Centre (DRC), London, UK","Centre for Medical Image Computing (CMIC), University College London, UK#TAB#"],"affiliations":[{"raw_affiliation_string":"University College, Dementia Research Centre (DRC), London, UK","institution_ids":["https://openalex.org/I4210126463"]},{"raw_affiliation_string":"Centre for Medical Image Computing (CMIC), University College London, UK#TAB#","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077080413","display_name":"M. Jorge Cardoso","orcid":"https://orcid.org/0000-0003-1284-2558"},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Jorge Cardoso","raw_affiliation_strings":["University College, Dementia Research Centre (DRC), London, UK","Centre for Medical Image Computing (CMIC), University College London, UK#TAB#"],"affiliations":[{"raw_affiliation_string":"University College, Dementia Research Centre (DRC), London, UK","institution_ids":["https://openalex.org/I4210126463"]},{"raw_affiliation_string":"Centre for Medical Image Computing (CMIC), University College London, UK#TAB#","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020682397","display_name":"Willem H. Bouvy","orcid":null},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Willem H. Bouvy","raw_affiliation_strings":["UMC, Department of Neurology and Neurosurgery, Utrecht, Netherlands","Department of Neurology and Neurosurgery, UMC, Utrecht, Netherlands"],"affiliations":[{"raw_affiliation_string":"UMC, Department of Neurology and Neurosurgery, Utrecht, Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Department of Neurology and Neurosurgery, UMC, Utrecht, Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028587177","display_name":"Geert Jan Biessels","orcid":"https://orcid.org/0000-0001-6862-2496"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert Jan Biessels","raw_affiliation_strings":["UMC, Department of Neurology and Neurosurgery, Utrecht, Netherlands","Department of Neurology and Neurosurgery, UMC, Utrecht, Netherlands"],"affiliations":[{"raw_affiliation_string":"UMC, Department of Neurology and Neurosurgery, Utrecht, Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Department of Neurology and Neurosurgery, UMC, Utrecht, Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007836718","display_name":"Josephine Barnes","orcid":"https://orcid.org/0000-0003-3178-025X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Josephine Barnes","raw_affiliation_strings":["University College, Dementia Research Centre (DRC), London, UK","Dementia Research Centre (DRC), University College London, UK#TAB#"],"affiliations":[{"raw_affiliation_string":"University College, Dementia Research Centre (DRC), London, UK","institution_ids":["https://openalex.org/I4210126463"]},{"raw_affiliation_string":"Dementia Research Centre (DRC), University College London, UK#TAB#","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082106258","display_name":"S\u00e9bastien Ourselin","orcid":"https://orcid.org/0000-0002-5694-5340"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sebastien Ourselin","raw_affiliation_strings":["University College, Dementia Research Centre (DRC), London, UK","Centre for Medical Image Computing (CMIC), University College London, UK#TAB#"],"affiliations":[{"raw_affiliation_string":"University College, Dementia Research Centre (DRC), London, UK","institution_ids":["https://openalex.org/I4210126463"]},{"raw_affiliation_string":"Centre for Medical Image Computing (CMIC), University College London, UK#TAB#","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044422433"],"corresponding_institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":5.2415,"has_fulltext":true,"cited_by_count":181,"citation_normalized_percentile":{"value":0.97031784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"34","issue":"10","first_page":"2079","last_page":"2102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.819930911064148},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6885310411453247},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6801740527153015},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5833778977394104},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5457446575164795},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.45911306142807007},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.43937402963638306},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3470038175582886},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.21900993585586548},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2000921666622162},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.19085270166397095},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.16836822032928467},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1619797646999359}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.819930911064148},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6885310411453247},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6801740527153015},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5833778977394104},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5457446575164795},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.45911306142807007},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.43937402963638306},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3470038175582886},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.21900993585586548},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2000921666622162},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19085270166397095},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16836822032928467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1619797646999359}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056784","descriptor_name":"Leukoencephalopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D056784","descriptor_name":"Leukoencephalopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D056784","descriptor_name":"Leukoencephalopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D056784","descriptor_name":"Leukoencephalopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1109/tmi.2015.2419072","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2015.2419072","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/7283692/07078891.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:25850086","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25850086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/44c7039b-a3a0-4742-8082-83845e7fb902","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/44c7039b-a3a0-4742-8082-83845e7fb902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sudre, C H, Cardoso, M J, Bouvy, W H, Biessels, G J, Barnes, J & Ourselin, S 2015, 'Bayesian Model Selection for Pathological Neuroimaging Data Applied to White Matter Lesion Segmentation', IEEE Transactions on Medical Imaging, vol. 34, no. 10, 7078891, pp. 2079-2102. https://doi.org/10.1109/TMI.2015.2419072","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1466255","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1466255/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   IEEE Transactions on Medical Imaging , 34  (10)   pp. 2079-2102.   (2015)      ","raw_type":"Article"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/335847","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/335847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Transactions on Medical Imaging, 34(10), 2079. Institute of Electrical and Electronics Engineers Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/335847","is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/335847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Transactions on Medical Imaging, 34(10), 2079","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1109/tmi.2015.2419072","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2015.2419072","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/7283692/07078891.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1074010309","display_name":null,"funder_award_id":"EP/H046410/1, EP/J020990/1, EP/K005278","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G150562299","display_name":null,"funder_award_id":"EP/H046410","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1737639950","display_name":null,"funder_award_id":"EP/K005278","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1775974636","display_name":null,"funder_award_id":"H046410","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1852290088","display_name":null,"funder_award_id":"MR/J01107X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2073424641","display_name":null,"funder_award_id":"EP/W046410/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2145614116","display_name":null,"funder_award_id":"EP/J020990/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2216861611","display_name":null,"funder_award_id":"(EP/H046410/1, EP/J020990/1, EP/K005278),","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3959461325","display_name":"Intelligent Imaging: Motion, Form and Function Across Scale","funder_award_id":"EP/H046410/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4065409414","display_name":null,"funder_award_id":"MR/J01107X/","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4171234563","display_name":"Computational models of neurodegenerative disease progression","funder_award_id":"EP/J020990/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4831256949","display_name":null,"funder_award_id":"(MR/J01107X/1)","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5814724622","display_name":null,"funder_award_id":"FP7-ICT-2011-9-601055","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6137862389","display_name":null,"funder_award_id":"FP7-ICT-2011-9-601055","funder_id":"https://openalex.org/F4320338370","funder_display_name":"FP7 Information and Communication Technologies"},{"id":"https://openalex.org/G6399526341","display_name":null,"funder_award_id":"UCLH/UCL","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6468513278","display_name":null,"funder_award_id":"Queen Square Dementia Biomedical Research UK","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6496510108","display_name":null,"funder_award_id":"J020990","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6800468499","display_name":null,"funder_award_id":"MR/J01107X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7486377412","display_name":null,"funder_award_id":"EP/H046410/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8266812316","display_name":null,"funder_award_id":"UCLH/UCL Biomedical Research Centre","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8866806938","display_name":"EPICure@19 - the extremely preterm young adult","funder_award_id":"MR/J01107X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320319841","display_name":"Alzheimer's Research Trust","ror":"https://ror.org/02ymzm013"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320072","display_name":"Brain Research Trust","ror":"https://ror.org/04q4ck618"},{"id":"https://openalex.org/F4320320670","display_name":"Wolfson Foundation","ror":"https://ror.org/0333xzh65"},{"id":"https://openalex.org/F4320322140","display_name":"Universitair Medisch Centrum Utrecht","ror":"https://ror.org/0575yy874"},{"id":"https://openalex.org/F4320325311","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320335827","display_name":"UCLH Biomedical Research Centre","ror":"https://ror.org/03r9qc142"},{"id":"https://openalex.org/F4320338370","display_name":"FP7 Information and Communication Technologies","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091753181.pdf","grobid_xml":"https://content.openalex.org/works/W2091753181.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W143626721","https://openalex.org/W1512438306","https://openalex.org/W1549669396","https://openalex.org/W1569698437","https://openalex.org/W1919821049","https://openalex.org/W1964580878","https://openalex.org/W1970939577","https://openalex.org/W1973457617","https://openalex.org/W1980183712","https://openalex.org/W1981964326","https://openalex.org/W1982623426","https://openalex.org/W1987030261","https://openalex.org/W1989102171","https://openalex.org/W1993391176","https://openalex.org/W1993999110","https://openalex.org/W1994947322","https://openalex.org/W1995768871","https://openalex.org/W1998070036","https://openalex.org/W2002514626","https://openalex.org/W2005714056","https://openalex.org/W2008101963","https://openalex.org/W2009017316","https://openalex.org/W2011832962","https://openalex.org/W2018017287","https://openalex.org/W2020208806","https://openalex.org/W2020456061","https://openalex.org/W2021204548","https://openalex.org/W2024782313","https://openalex.org/W2026752633","https://openalex.org/W2031405180","https://openalex.org/W2035053340","https://openalex.org/W2037972318","https://openalex.org/W2038885294","https://openalex.org/W2045673120","https://openalex.org/W2046985712","https://openalex.org/W2047027336","https://openalex.org/W2047354468","https://openalex.org/W2047440597","https://openalex.org/W2048074616","https://openalex.org/W2049633694","https://openalex.org/W2053983047","https://openalex.org/W2053984362","https://openalex.org/W2059784307","https://openalex.org/W2060529732","https://openalex.org/W2066526204","https://openalex.org/W2066579873","https://openalex.org/W2066766733","https://openalex.org/W2078604986","https://openalex.org/W2079623157","https://openalex.org/W2082616494","https://openalex.org/W2084392880","https://openalex.org/W2096878708","https://openalex.org/W2102290518","https://openalex.org/W2102848905","https://openalex.org/W2105202736","https://openalex.org/W2107956652","https://openalex.org/W2113884510","https://openalex.org/W2114759290","https://openalex.org/W2117735874","https://openalex.org/W2120994224","https://openalex.org/W2122894564","https://openalex.org/W2123782121","https://openalex.org/W2124526114","https://openalex.org/W2124915460","https://openalex.org/W2132106992","https://openalex.org/W2135361930","https://openalex.org/W2140804420","https://openalex.org/W2143895814","https://openalex.org/W2144816454","https://openalex.org/W2147945386","https://openalex.org/W2150529596","https://openalex.org/W2153236418","https://openalex.org/W2153441116","https://openalex.org/W2155085197","https://openalex.org/W2158742097","https://openalex.org/W2160804681","https://openalex.org/W2161591846","https://openalex.org/W2166916666","https://openalex.org/W2168066653","https://openalex.org/W2168399612","https://openalex.org/W2338681188","https://openalex.org/W4205923499","https://openalex.org/W4230920194","https://openalex.org/W6632808620","https://openalex.org/W6651837868","https://openalex.org/W6682544013"],"related_works":["https://openalex.org/W2327340211","https://openalex.org/W2027542625","https://openalex.org/W4292199793","https://openalex.org/W2282195379","https://openalex.org/W2089784006","https://openalex.org/W2295388821","https://openalex.org/W2102312026","https://openalex.org/W2071433170","https://openalex.org/W2885663991","https://openalex.org/W1016623679"],"abstract_inverted_index":{"In":[0],"neuroimaging":[1,89],"studies,":[2],"pathologies":[3],"can":[4],"present":[5],"themselves":[6],"as":[7],"abnormal":[8,15,99,119],"intensity":[9,120],"patterns.":[10],"Thus,":[11],"solutions":[12],"for":[13,54,88],"detecting":[14],"intensities":[16],"are":[17],"currently":[18],"under":[19],"investigation.":[20],"As":[21],"each":[22],"patient":[23],"is":[24],"unique,":[25],"an":[26],"unbiased":[27],"and":[28,63,111],"biologically":[29],"plausible":[30],"model":[31,49,85],"of":[32,58,98],"pathological":[33,103],"data":[34,90,113],"would":[35,50],"have":[36],"to":[37,40,42,67,117,126,136],"be":[38],"able":[39],"adapt":[41],"the":[43,52,59,93,115],"subject's":[44],"individual":[45],"presentation.":[46],"Such":[47],"a":[48,55,81,104,124],"provide":[51],"means":[53],"better":[56],"understanding":[57],"underlying":[60],"biological":[61],"processes":[62],"improve":[64],"one's":[65],"ability":[66,116],"define":[68],"pathologically":[69],"meaningful":[70],"imaging":[71],"biomarkers.":[72],"With":[73],"this":[74,78],"aim":[75],"in":[76,123,129],"mind,":[77],"work":[79],"proposes":[80],"hierarchical":[82],"fully":[83],"unsupervised":[84],"selection":[86],"framework":[87],"which":[91],"enables":[92],"distinction":[94],"between":[95],"different":[96],"types":[97],"image":[100],"patterns":[101],"without":[102],"priori":[105],"knowledge.":[106],"Its":[107],"application":[108],"on":[109],"simulated":[110],"clinical":[112],"demonstrated":[114],"detect":[118],"clusters,":[121],"resulting":[122],"competitive":[125],"improved":[127],"behavior":[128],"white":[130],"matter":[131],"lesion":[132],"segmentation":[133],"when":[134],"compared":[135],"three":[137],"other":[138],"freely-available":[139],"automated":[140],"methods.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":43},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}