{"id":"https://openalex.org/W1990889412","doi":"https://doi.org/10.1109/tmi.2015.2408632","title":"Stratified Sampling Voxel Classification for Segmentation of Intraretinal and Subretinal Fluid in Longitudinal Clinical OCT Data","display_name":"Stratified Sampling Voxel Classification for Segmentation of Intraretinal and Subretinal Fluid in Longitudinal Clinical OCT Data","publication_year":2015,"publication_date":"2015-03-06","ids":{"openalex":"https://openalex.org/W1990889412","doi":"https://doi.org/10.1109/tmi.2015.2408632","mag":"1990889412","pmid":"https://pubmed.ncbi.nlm.nih.gov/25769146"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2015.2408632","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2015.2408632","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033831630","display_name":"Xiayu Xu","orcid":"https://orcid.org/0000-0002-5286-0454"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiayu Xu","raw_affiliation_strings":["University of Iowa, Iowa City, IA, US","Department of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA, US","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002093193","display_name":"Kyungmoo Lee","orcid":"https://orcid.org/0000-0003-2608-6095"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyungmoo Lee","raw_affiliation_strings":["University of Iowa, Iowa City, IA, US","Department of Electrical and Computer Engineering, University of Iowa Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA, US","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Iowa Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425443","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0001-7700-0357"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["University of Iowa, Iowa City, IA, US","Department of Electrical and Computer Engineering, University of Iowa Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA, US","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Iowa Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836634","display_name":"Milan Sonka","orcid":"https://orcid.org/0000-0002-9613-9968"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milan Sonka","raw_affiliation_strings":["University of Iowa, Iowa City, IA, US","Department of Electrical and Computer Engineering, the Department of Ophthalmology and Visual Sciences, and the Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA, US","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, the Department of Ophthalmology and Visual Sciences, and the Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036660665","display_name":"Michael D. Abr\u00e0moff","orcid":"https://orcid.org/0000-0002-3490-0037"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Abramoff","raw_affiliation_strings":["University of Iowa, Iowa City, IA, US","Department of Ophthalmology and Visual Sciences, the Department of Electrical and Computer Engineering, the Department of Biomedical Engineering, University of Iowa, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA, US","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, the Department of Electrical and Computer Engineering, the Department of Biomedical Engineering, University of Iowa, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.3238,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.97993578,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"34","issue":"7","first_page":"1616","last_page":"1623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.703543484210968},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6801891922950745},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.6525613069534302},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5968416929244995},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.5564313530921936},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4692663550376892},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4276163578033447},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.41956180334091187},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.416775107383728},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3194911777973175},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.27532529830932617}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.703543484210968},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6801891922950745},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.6525613069534302},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5968416929244995},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5564313530921936},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4692663550376892},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4276163578033447},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.41956180334091187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.416775107383728},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3194911777973175},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.27532529830932617},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2015.2408632","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2015.2408632","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:25769146","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25769146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:europepmc.org:4665997","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5750134","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.800000011920929,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G3688174913","display_name":null,"funder_award_id":"81401480","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W137705853","https://openalex.org/W142804191","https://openalex.org/W1500728559","https://openalex.org/W1834839393","https://openalex.org/W1968069998","https://openalex.org/W1974420926","https://openalex.org/W1979102712","https://openalex.org/W1983723060","https://openalex.org/W1986515506","https://openalex.org/W2001900885","https://openalex.org/W2057842522","https://openalex.org/W2062786827","https://openalex.org/W2072474479","https://openalex.org/W2077389784","https://openalex.org/W2085232786","https://openalex.org/W2086339711","https://openalex.org/W2089351839","https://openalex.org/W2100756624","https://openalex.org/W2101131351","https://openalex.org/W2101211008","https://openalex.org/W2115527343","https://openalex.org/W2122333898","https://openalex.org/W2130094715","https://openalex.org/W2134357733","https://openalex.org/W2134542952","https://openalex.org/W2319127413","https://openalex.org/W2418802570","https://openalex.org/W2427881153","https://openalex.org/W4234612763","https://openalex.org/W6638613586","https://openalex.org/W6679784325"],"related_works":["https://openalex.org/W3027020613","https://openalex.org/W2016533837","https://openalex.org/W3167885074","https://openalex.org/W2892386716","https://openalex.org/W4306164210","https://openalex.org/W1998563493","https://openalex.org/W4313316311","https://openalex.org/W4362608745","https://openalex.org/W2082728368","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Automated":[0],"three-dimensional":[1],"retinal":[2,102],"fluid":[3],"(named":[4],"symptomatic":[5],"exudate-associated":[6],"derangements,":[7],"SEAD)":[8],"segmentation":[9,30,43],"in":[10,18,35,78,114],"3D":[11,91],"OCT":[12,92],"volumes":[13],"is":[14,44],"of":[15,22,38,47,51,88,123,136],"high":[16],"interest":[17],"the":[19,36,48,74],"improved":[20],"management":[21],"neovascular":[23,39,137],"Age":[24],"Related":[25],"Macular":[26],"Degeneration":[27],"(AMD).":[28],"SEAD":[29,52,79],"plays":[31],"an":[32],"important":[33],"role":[34],"treatment":[37],"AMD,":[40],"but":[41],"accurate":[42],"challenging":[45],"because":[46],"large":[49],"diversity":[50],"size,":[53],"location,":[54],"and":[55,108,119,125],"shape.":[56],"Here":[57],"a":[58,65,86,115],"novel":[59],"voxel":[60],"classification":[61],"based":[62],"approach":[63],"using":[64],"layer-dependent":[66],"stratified":[67],"sampling":[68],"strategy":[69],"was":[70,83],"developed":[71],"to":[72],"address":[73],"class":[75],"imbalance":[76],"problem":[77],"detection.":[80],"The":[81],"method":[82,129],"validated":[84],"on":[85],"set":[87],"30":[89],"longitudinal":[90],"scans":[93],"from":[94],"10":[95],"patients":[96],"who":[97],"underwent":[98],"anti-VEGF":[99],"treatment.":[100,139],"Two":[101],"specialists":[103],"manually":[104],"delineated":[105],"all":[106],"intraretinal":[107],"subretinal":[109],"fluid.":[110],"Leave-one-patient-out":[111],"evaluation":[112],"resulted":[113],"true":[116,120],"positive":[117],"rate":[118,122],"negative":[121],"96%":[124],"0.16%":[126],"respectively.":[127],"This":[128],"showed":[130],"promise":[131],"for":[132],"image":[133],"guided":[134],"therapy":[135],"AMD":[138]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
