{"id":"https://openalex.org/W2166467219","doi":"https://doi.org/10.1109/tmi.2014.2305113","title":"An Analysis of Whole Body Tracer Kinetics in Dynamic PET Studies With Application to Image-Based Blood Input Function Extraction","display_name":"An Analysis of Whole Body Tracer Kinetics in Dynamic PET Studies With Application to Image-Based Blood Input Function Extraction","publication_year":2014,"publication_date":"2014-02-07","ids":{"openalex":"https://openalex.org/W2166467219","doi":"https://doi.org/10.1109/tmi.2014.2305113","mag":"2166467219","pmid":"https://pubmed.ncbi.nlm.nih.gov/24770914"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2014.2305113","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2014.2305113","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/6803900/06734713.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ieeexplore.ieee.org/ielx7/42/6803900/06734713.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057792771","display_name":"Jian Huang","orcid":"https://orcid.org/0000-0002-0862-1384"},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Jian Huang","raw_affiliation_strings":["Department of Statistics, University College Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University College Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055780546","display_name":"Finbarr O\u2019Sullivan","orcid":"https://orcid.org/0000-0002-7938-4697"},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Finbarr O'Sullivan","raw_affiliation_strings":["Department of Statistics, University College Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University College Cork, Ireland","institution_ids":["https://openalex.org/I27577105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057792771"],"corresponding_institution_ids":["https://openalex.org/I27577105"],"apc_list":null,"apc_paid":null,"fwci":2.4803,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88771983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"33","issue":"5","first_page":"1093","last_page":"1108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.7064394950866699},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5625618696212769},{"id":"https://openalex.org/keywords/tracer","display_name":"TRACER","score":0.5110596418380737},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4925402104854584},{"id":"https://openalex.org/keywords/arterial-blood","display_name":"Arterial blood","score":0.4556295573711395},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4261434078216553},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19725605845451355},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17874523997306824},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.095887690782547}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.7064394950866699},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5625618696212769},{"id":"https://openalex.org/C2778863792","wikidata":"https://www.wikidata.org/wiki/Q16909918","display_name":"TRACER","level":2,"score":0.5110596418380737},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4925402104854584},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.4556295573711395},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4261434078216553},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19725605845451355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17874523997306824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.095887690782547},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2014.2305113","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2014.2305113","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/6803900/06734713.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:24770914","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24770914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4130476","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4130476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1109/tmi.2014.2305113","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmi.2014.2305113","pdf_url":"https://ieeexplore.ieee.org/ielx7/42/6803900/06734713.pdf","source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1200550227","display_name":null,"funder_award_id":"AG031485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1945467027","display_name":null,"funder_award_id":"11/PI/1027","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166467219.pdf","grobid_xml":"https://content.openalex.org/works/W2166467219.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W50135966","https://openalex.org/W172803389","https://openalex.org/W239577987","https://openalex.org/W1486452837","https://openalex.org/W1796663898","https://openalex.org/W1825690985","https://openalex.org/W1896879352","https://openalex.org/W1944705852","https://openalex.org/W1974393218","https://openalex.org/W1982276155","https://openalex.org/W1984875208","https://openalex.org/W1996542647","https://openalex.org/W2002477254","https://openalex.org/W2007346130","https://openalex.org/W2024424774","https://openalex.org/W2031560849","https://openalex.org/W2034416686","https://openalex.org/W2039534486","https://openalex.org/W2047423950","https://openalex.org/W2062259223","https://openalex.org/W2067347526","https://openalex.org/W2068484625","https://openalex.org/W2080399872","https://openalex.org/W2081540648","https://openalex.org/W2083793124","https://openalex.org/W2086278062","https://openalex.org/W2094847554","https://openalex.org/W2096084239","https://openalex.org/W2099585390","https://openalex.org/W2121144107","https://openalex.org/W2122450421","https://openalex.org/W2122759946","https://openalex.org/W2122770995","https://openalex.org/W2122984078","https://openalex.org/W2128903014","https://openalex.org/W2130904218","https://openalex.org/W2134823797","https://openalex.org/W2141468529","https://openalex.org/W2149771854","https://openalex.org/W2163794208","https://openalex.org/W2168239564","https://openalex.org/W2244155566","https://openalex.org/W2321741636","https://openalex.org/W2334958735","https://openalex.org/W2582743722","https://openalex.org/W2795536332","https://openalex.org/W3016133651","https://openalex.org/W3146425672","https://openalex.org/W4213201159","https://openalex.org/W4243249476","https://openalex.org/W6602072410","https://openalex.org/W6638205471","https://openalex.org/W6638457792","https://openalex.org/W6680605406","https://openalex.org/W6684497302","https://openalex.org/W6690366090"],"related_works":["https://openalex.org/W2001254114","https://openalex.org/W2045362891","https://openalex.org/W1987137663","https://openalex.org/W2090152913","https://openalex.org/W2018752697","https://openalex.org/W1966069390","https://openalex.org/W1998782558","https://openalex.org/W2054546918","https://openalex.org/W1970746087","https://openalex.org/W2278340220"],"abstract_inverted_index":{"In":[0],"a":[1,97,106,125,136,182,191],"positron":[2],"emission":[3],"tomography":[4],"(PET)":[5],"study,":[6],"the":[7,11,23,35,40,49,116,133,140,166,169,205,208,237,246,253,256],"local":[8],"uptake":[9,25],"of":[10,34,37,63,67,79,85,99,109,132,135,155,168,207,215,222,245,252,258,260],"tracer":[12,38,137,156],"is":[13,42,45,70,74,90,112,163,181,195,200,233,267],"dependent":[14],"on":[15,212],"vascular":[16],"delivery":[17],"and":[18,57,102,147,160,231,270,276,282],"retention.":[19],"For":[20],"dynamic":[21],"studies":[22,69,228,279],"measured":[24,217],"time-course":[26,36,81,149],"information":[27],"can":[28],"be":[29],"best":[30],"interpreted":[31],"when":[32],"knowledge":[33],"in":[39,77,139,158],"blood":[41,64,80,87,162,218,262],"available.":[43],"This":[44],"certainly":[46],"true":[47],"for":[48,130,177,274],"most":[50],"established":[51],"tracers":[52],"such":[53],"as":[54,65],"18F-Fluorodeoxyglucose":[55],"(FDG)":[56],"15O-Water":[58],"(H2O).":[59],"Since":[60],"direct":[61],"sampling":[62],"part":[66],"PET":[68,170,227],"increasingly":[71],"impractical,":[72],"there":[73],"ongoing":[75],"interest":[76],"image-extraction":[78],"information.":[82,104],"But":[83],"analysis":[84,199],"PET-measured":[86],"pool":[88],"signals":[89,263],"complicated":[91],"because":[92],"they":[93],"will":[94],"typically":[95],"involve":[96],"combination":[98],"arterial,":[100],"venous":[101,148,161],"tissue":[103],"Thus,":[105],"careful":[107],"appreciation":[108],"these":[110],"components":[111],"needed":[113],"to":[114,202,235,255],"interpret":[115],"available":[117],"data.":[118,219],"To":[119],"facilitate":[120],"this":[121],"process,":[122,189],"we":[123],"propose":[124],"novel":[126],"Markov":[127,178],"chain":[128],"model":[129,143,179,254],"representation":[131],"circulation":[134],"atom":[138],"body.":[141],"The":[142],"represents":[144],"both":[145],"arterial":[146,159,261],"patterns.":[150],"Under":[151],"reasonable":[152],"conditions":[153],"equilibration":[154],"activity":[157],"achieved":[164],"by":[165],"end":[167],"study-consistent":[171],"with":[172,229,280],"empirical":[173],"measurement.":[174],"Statistical":[175],"inference":[176],"parameters":[180],"challenge.":[183],"A":[184,220],"penalized":[185],"nonlinear":[186],"least":[187],"squares":[188],"incorporating":[190],"generalized":[192],"cross-validation":[193],"score,":[194],"proposed.":[196],"Random":[197],"effects":[198],"used":[201,234],"adaptively":[203],"specify":[204],"structure":[206],"penalty":[209],"function":[210],"based":[211],"historical":[213],"samples":[214],"directly":[216],"collection":[221],"arterially":[223],"sampled":[224],"data":[225,240,266],"from":[226,264],"FDG":[230,281],"H2O":[232,283],"illustrate":[236],"methodology.":[238],"These":[239],"analyses":[241],"are":[242,284],"highly":[243],"supportive":[244],"overall":[247],"modeling":[248],"approach.":[249],"An":[250],"adaptation":[251],"problem":[257],"extraction":[259],"imaging":[265,278],"also":[268],"developed":[269],"promising":[271],"preliminary":[272],"results":[273],"cerebral":[275],"thoracic":[277],"obtained.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}