{"id":"https://openalex.org/W2080382703","doi":"https://doi.org/10.1109/tmi.2012.2213828","title":"4-D Reconstruction for Dynamic Fluorescence Diffuse Optical Tomography","display_name":"4-D Reconstruction for Dynamic Fluorescence Diffuse Optical Tomography","publication_year":2012,"publication_date":"2012-08-17","ids":{"openalex":"https://openalex.org/W2080382703","doi":"https://doi.org/10.1109/tmi.2012.2213828","mag":"2080382703","pmid":"https://pubmed.ncbi.nlm.nih.gov/22910097"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2012.2213828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2012.2213828","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100352350","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0003-4627-3058"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Department of Biomedical Engineering, Tsinghua University, Beijing, China","Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101522167","display_name":"Bin Zhang","orcid":"https://orcid.org/0000-0002-9532-1274"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, Tsinghua University, Beijing, China","Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084231233","display_name":"Jianwen Luo","orcid":"https://orcid.org/0000-0001-9215-5568"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwen Luo","raw_affiliation_strings":["Center for Biomedical Imaging Research, Tsinghua University, Beijing, China","Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Center for Biomedical Imaging Research, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100746164","display_name":"Jing Bai","orcid":"https://orcid.org/0000-0001-5412-7793"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Bai","raw_affiliation_strings":["Department of Biomedical Engineering, Tsinghua University, Beijing, China","Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100352350"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":2.1832,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.8692288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"11","first_page":"2120","last_page":"2132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.8161543607711792},{"id":"https://openalex.org/keywords/decorrelation","display_name":"Decorrelation","score":0.7236462235450745},{"id":"https://openalex.org/keywords/imaging-phantom","display_name":"Imaging phantom","score":0.6256639361381531},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.6168212890625},{"id":"https://openalex.org/keywords/tomographic-reconstruction","display_name":"Tomographic reconstruction","score":0.6143996715545654},{"id":"https://openalex.org/keywords/optical-tomography","display_name":"Optical tomography","score":0.6090466976165771},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5541486144065857},{"id":"https://openalex.org/keywords/reconstruction-algorithm","display_name":"Reconstruction algorithm","score":0.5217481851577759},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.520747184753418},{"id":"https://openalex.org/keywords/diffuse-optical-imaging","display_name":"Diffuse optical imaging","score":0.5123618841171265},{"id":"https://openalex.org/keywords/transformation","display_name":"Transformation (genetics)","score":0.49865269660949707},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.485635906457901},{"id":"https://openalex.org/keywords/algebraic-reconstruction-technique","display_name":"Algebraic Reconstruction Technique","score":0.45811596512794495},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.35465896129608154},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.34960994124412537},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3474867343902588},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2664433717727661}],"concepts":[{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.8161543607711792},{"id":"https://openalex.org/C177860922","wikidata":"https://www.wikidata.org/wiki/Q788608","display_name":"Decorrelation","level":2,"score":0.7236462235450745},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.6256639361381531},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.6168212890625},{"id":"https://openalex.org/C97742081","wikidata":"https://www.wikidata.org/wiki/Q7820109","display_name":"Tomographic reconstruction","level":3,"score":0.6143996715545654},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.6090466976165771},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5541486144065857},{"id":"https://openalex.org/C2779898584","wikidata":"https://www.wikidata.org/wiki/Q7820109","display_name":"Reconstruction algorithm","level":3,"score":0.5217481851577759},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.520747184753418},{"id":"https://openalex.org/C145417883","wikidata":"https://www.wikidata.org/wiki/Q5275421","display_name":"Diffuse optical imaging","level":3,"score":0.5123618841171265},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.49865269660949707},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.485635906457901},{"id":"https://openalex.org/C206654267","wikidata":"https://www.wikidata.org/wiki/Q4723986","display_name":"Algebraic Reconstruction Technique","level":3,"score":0.45811596512794495},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35465896129608154},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.34960994124412537},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3474867343902588},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2664433717727661},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/tmi.2012.2213828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2012.2213828","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:22910097","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22910097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309978","display_name":"Florida Department of Transportation","ror":"https://ror.org/01v2vzt58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1488435683","https://openalex.org/W1976646682","https://openalex.org/W1977512896","https://openalex.org/W1978377658","https://openalex.org/W1979521077","https://openalex.org/W1979734853","https://openalex.org/W2003635675","https://openalex.org/W2014359315","https://openalex.org/W2017054309","https://openalex.org/W2017096549","https://openalex.org/W2019641859","https://openalex.org/W2031782274","https://openalex.org/W2032838670","https://openalex.org/W2037521346","https://openalex.org/W2040532000","https://openalex.org/W2040703019","https://openalex.org/W2044202315","https://openalex.org/W2045304572","https://openalex.org/W2046758959","https://openalex.org/W2059651047","https://openalex.org/W2062779374","https://openalex.org/W2063589313","https://openalex.org/W2071552927","https://openalex.org/W2075498685","https://openalex.org/W2080823347","https://openalex.org/W2081098120","https://openalex.org/W2081204668","https://openalex.org/W2085873825","https://openalex.org/W2086018477","https://openalex.org/W2100073770","https://openalex.org/W2106773456","https://openalex.org/W2112101570","https://openalex.org/W2112513512","https://openalex.org/W2112663205","https://openalex.org/W2123847381","https://openalex.org/W2124355659","https://openalex.org/W2132074652","https://openalex.org/W2133097426","https://openalex.org/W2134951181","https://openalex.org/W2135054999","https://openalex.org/W2140041425","https://openalex.org/W2144534840","https://openalex.org/W2144636090","https://openalex.org/W2144933051","https://openalex.org/W2148588305","https://openalex.org/W2151904753","https://openalex.org/W2156992898","https://openalex.org/W2162058791","https://openalex.org/W2164668388","https://openalex.org/W2165830279","https://openalex.org/W2170624487","https://openalex.org/W2171965255","https://openalex.org/W2397546497","https://openalex.org/W2593119388","https://openalex.org/W4212783130","https://openalex.org/W4292023222"],"related_works":["https://openalex.org/W2037916999","https://openalex.org/W2073776015","https://openalex.org/W2318737792","https://openalex.org/W4385335355","https://openalex.org/W3010250986","https://openalex.org/W4253832138","https://openalex.org/W2056209239","https://openalex.org/W4242834832","https://openalex.org/W2090799487","https://openalex.org/W2148431801"],"abstract_inverted_index":{"Dynamic":[0],"fluorescence":[1],"diffuse":[2],"optical":[3,110],"tomography":[4,137],"(FDOT)":[5],"is":[6,64,81,113],"important":[7],"for":[8,33,77],"the":[9,34,41,60,91,98,104,107,118,121,145,150,163,178],"research":[10],"of":[11,97,103,120],"drug":[12],"delivery,":[13],"medical":[14],"diagnosis":[15],"and":[16,51,100,125],"treatment.":[17],"Conventionally,":[18],"dynamic":[19,78],"tomographic":[20],"images":[21,147],"are":[22,130],"reconstructed":[23],"frame":[24],"by":[25,83,149,158],"frame,":[26],"independently.":[27],"This":[28],"approach":[29,76],"fails":[30],"to":[31,90,177],"account":[32],"temporal":[35,86],"correlations":[36],"in":[37,126,175],"measurement":[38],"data.":[39],"Ideally,":[40],"entire":[42],"image":[43],"sequence":[44],"should":[45,56],"be":[46,57,172],"considered":[47],"as":[48],"a":[49,52,72,85,133],"whole":[50],"four-dimensional":[53],"(4-D)":[54],"reconstruction":[55,63,75,111,146,155,170],"performed.":[58],"However,":[59],"fully":[61,168],"4-D":[62,74,109,169],"computationally":[65],"intensive.":[66],"In":[67],"this":[68],"paper,":[69],"we":[70],"propose":[71],"new":[73],"FDOT,":[79],"which":[80],"achieved":[82],"applying":[84],"Karhunen-Lo\u00e8ve":[87],"(KL)":[88],"transformation":[89],"imaging":[92,138],"equation.":[93],"By":[94],"taking":[95],"advantage":[96],"decorrelation":[99],"compression":[101],"properties":[102],"KL":[105,151,161],"transformation,":[106],"complex":[108],"problem":[112],"greatly":[114,173],"simplified.":[115],"To":[116],"evaluate":[117],"performance":[119],"method,":[122],"simulation,":[123],"phantom,":[124],"vivo":[127],"experiments":[128],"(N=7)":[129],"performed":[131],"on":[132],"hybrid":[134],"FDOT/x-ray":[135],"computed":[136],"system.":[139],"The":[140],"experimental":[141],"results":[142],"indicate":[143],"that":[144],"obtained":[148],"method":[152],"provide":[153],"good":[154],"quality.":[156],"Additionally,":[157],"discarding":[159],"high-order":[160],"components,":[162],"computation":[164],"time":[165],"involved":[166],"with":[167],"can":[171],"reduced":[174],"contrast":[176],"conventional":[179],"frame-by-frame":[180],"reconstruction.":[181]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}