{"id":"https://openalex.org/W2113792310","doi":"https://doi.org/10.1109/tmi.2011.2147327","title":"Topology-Based Kernels With Application to Inference Problems in Alzheimer's Disease","display_name":"Topology-Based Kernels With Application to Inference Problems in Alzheimer's Disease","publication_year":2011,"publication_date":"2011-05-03","ids":{"openalex":"https://openalex.org/W2113792310","doi":"https://doi.org/10.1109/tmi.2011.2147327","mag":"2113792310","pmid":"https://pubmed.ncbi.nlm.nih.gov/21536520"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2011.2147327","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2011.2147327","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245735","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109219797","display_name":"Deepti Pachauri","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210105618","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepti Pachauri","raw_affiliation_strings":["Alzheimer\u2019s Disease Neuroimaging Initiative and Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. pachauri@cs.wisc.edu","[Department of Computer Science, University of Wisconsin\u2013Madison, Madison, WI, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Neuroimaging Initiative and Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA. pachauri@cs.wisc.edu","institution_ids":["https://openalex.org/I4210105618"]},{"raw_affiliation_string":"[Department of Computer Science, University of Wisconsin\u2013Madison, Madison, WI, USA]","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041266976","display_name":"Chris Hinrichs","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210105618","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Hinrichs","raw_affiliation_strings":["Alzheimer's Disease Neuroimaging Initiative and with the Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI, USA","[Department of Computer Science, University of Wisconsin\u2013Madison, Madison, WI, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Neuroimaging Initiative and with the Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210105618"]},{"raw_affiliation_string":"[Department of Computer Science, University of Wisconsin\u2013Madison, Madison, WI, USA]","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029674397","display_name":"Moo K. Chung","orcid":"https://orcid.org/0000-0003-2852-9670"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210105618","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moo K. Chung","raw_affiliation_strings":["Alzheimer's Disease Neuroimaging Initiative, and with the Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA","Dept. of Biostat. & Med. Inf., Univ. of Wisconsin-Madison, Madison, WI, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Neuroimaging Initiative, and with the Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210105618"]},{"raw_affiliation_string":"Dept. of Biostat. & Med. Inf., Univ. of Wisconsin-Madison, Madison, WI, USA#TAB#","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108148269","display_name":"Sterling C. Johnson","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sterling C. Johnson","raw_affiliation_strings":["Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA","Dept of Medicine, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Dept of Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100779003","display_name":"Vikas Singh","orcid":"https://orcid.org/0000-0002-8355-6519"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210141342","display_name":"William S. Middleton Memorial Veterans Hospital","ror":"https://ror.org/037xafn82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210141342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Singh","raw_affiliation_strings":["William S. Middleton VA Hospital, Madison, WI, USA","Dept. of Biostat. & Med. Inf., Univ. of Wisconsin-Madison, Madison, WI, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William S. Middleton VA Hospital, Madison, WI, USA","institution_ids":["https://openalex.org/I4210141342"]},{"raw_affiliation_string":"Dept. of Biostat. & Med. Inf., Univ. of Wisconsin-Madison, Madison, WI, USA#TAB#","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3411,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.96286001,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"30","issue":"10","first_page":"1760","last_page":"1770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5704227089881897},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5682237148284912},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.528346598148346},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.4306827783584595},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3502004146575928},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35005441308021545},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3274076581001282},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2453005611896515},{"id":"https://openalex.org/keywords/discrete-mathematics","display_name":"Discrete mathematics","score":0.17765086889266968}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5704227089881897},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5682237148284912},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.528346598148346},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.4306827783584595},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3502004146575928},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35005441308021545},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3274076581001282},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2453005611896515},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.17765086889266968}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/tmi.2011.2147327","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2011.2147327","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:21536520","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21536520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.310.5247","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.310.5247","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.stat.wisc.edu/~mchung/papers/pachauri.2011.TMI.pdf","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3245735","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245735","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3245735","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3245735","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Med Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1131972899","display_name":null,"funder_award_id":"U01 AG024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1557667123","display_name":null,"funder_award_id":"U19 AG010483","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2249541592","display_name":null,"funder_award_id":"R01 AG021155","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2785991020","display_name":null,"funder_award_id":"R01-AG021155","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3630838104","display_name":null,"funder_award_id":"TL1 RR025013","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3748651787","display_name":null,"funder_award_id":"P50 AG033514","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3888188522","display_name":null,"funder_award_id":"P30 HD003352","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3985224559","display_name":null,"funder_award_id":"1UL 1RR025011","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5426709320","display_name":null,"funder_award_id":"R01 AG040396","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5583689053","display_name":null,"funder_award_id":"R21-AG034315","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6013441","display_name":null,"funder_award_id":"UL1 RR025011","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6382328078","display_name":null,"funder_award_id":"T15 LM007359","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G7947190857","display_name":null,"funder_award_id":"R21 AG034315","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1505479281","https://openalex.org/W1519178192","https://openalex.org/W1523441917","https://openalex.org/W1836357517","https://openalex.org/W1965775572","https://openalex.org/W1983537704","https://openalex.org/W1987011701","https://openalex.org/W2006261891","https://openalex.org/W2011286803","https://openalex.org/W2012059337","https://openalex.org/W2017794330","https://openalex.org/W2022266599","https://openalex.org/W2023121717","https://openalex.org/W2037613900","https://openalex.org/W2059192589","https://openalex.org/W2079484785","https://openalex.org/W2087925678","https://openalex.org/W2087964262","https://openalex.org/W2101282194","https://openalex.org/W2103145898","https://openalex.org/W2110208125","https://openalex.org/W2117856505","https://openalex.org/W2119848633","https://openalex.org/W2120111102","https://openalex.org/W2128251808","https://openalex.org/W2128480875","https://openalex.org/W2132458496","https://openalex.org/W2133015986","https://openalex.org/W2140082297","https://openalex.org/W2143017382","https://openalex.org/W2146089088","https://openalex.org/W2149906774","https://openalex.org/W2154462399","https://openalex.org/W2158063156","https://openalex.org/W2159362218","https://openalex.org/W2164417323","https://openalex.org/W2165122923","https://openalex.org/W2165840723","https://openalex.org/W2167840686","https://openalex.org/W2171380313","https://openalex.org/W2171831801","https://openalex.org/W2185010281","https://openalex.org/W3013843370","https://openalex.org/W4251391716","https://openalex.org/W4300640952","https://openalex.org/W6683181193"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4224009465","https://openalex.org/W2357241418","https://openalex.org/W4286629047","https://openalex.org/W4306321456","https://openalex.org/W4285260836","https://openalex.org/W3046775127","https://openalex.org/W3170094116","https://openalex.org/W4205958290"],"abstract_inverted_index":{"Alzheimer's":[0,236],"disease":[1],"(AD)":[2],"research":[3],"has":[4],"recently":[5],"witnessed":[6],"a":[7,49,54,72,111,153,215,224,229],"great":[8],"deal":[9],"of":[10,29,45,53,114,119,209,220,226,231],"activity":[11],"focused":[12],"on":[13,128,228,245],"developing":[14],"new":[15],"statistical":[16,247],"learning":[17],"tools":[18],"for":[19,27,140,172,189,217],"automated":[20],"inference":[21,149,248],"using":[22],"imaging":[23],"data.":[24,193],"The":[25,63],"workhorse":[26],"many":[28],"these":[30,46,178],"techniques":[31,184],"is":[32,85,106,135,156],"the":[33,207,235],"support":[34],"vector":[35],"machine":[36],"(SVM)":[37],"framework":[38],"(or":[39],"more":[40],"generally":[41,76],"kernel-based":[42],"methods).":[43],"Most":[44],"require,":[47],"as":[48,90,124],"first":[50],"step,":[51],"specification":[52],"kernel":[55,221],"matrix":[56],"K":[57,89],"between":[58,66,116],"input":[59],"examples":[60],"(i.e.,":[61],"images).":[62],"inner":[64],"product":[65],"images":[67],"I(i)":[68],"and":[69,82],"I(j)":[70],"in":[71,79,93,147],"feature":[73,252],"space":[74],"can":[75],"be":[77,138],"written":[78],"closed":[80],"form":[81],"so":[83,143],"it":[84,105],"convenient":[86],"to":[87,109,137,185,199,214],"treat":[88],"\"given.\"":[91],"However,":[92],"certain":[94],"neuroimaging":[95],"applications":[96],"such":[97,123,145,190],"an":[98,103,148],"assumption":[99],"becomes":[100],"problematic.":[101],"As":[102,223],"example,":[104],"rather":[107],"challenging":[108],"provide":[110],"scalar":[112],"measure":[113,171],"similarity":[115,187],"two":[117],"instances":[118],"highly":[120],"attributed":[121,192],"data":[122],"cortical":[125,129,133,203],"thickness":[126,134],"measures":[127],"surfaces.":[130],"Note":[131],"that":[132],"known":[136],"discriminative":[139],"neurological":[141],"disorders,":[142],"leveraging":[144],"information":[146],"framework,":[150],"especially":[151],"within":[152],"multi-modal":[154],"method,":[155],"potentially":[157],"advantageous.":[158],"But":[159],"despite":[160],"being":[161],"clinically":[162],"meaningful,":[163],"relatively":[164],"few":[165],"works":[166],"have":[167],"successfully":[168],"exploited":[169],"this":[170],"classification":[173],"or":[174,256],"regression.":[175],"Motivated":[176],"by":[177,206],"applications,":[179],"our":[180],"paper":[181],"presents":[182],"novel":[183],"compute":[186],"matrices":[188],"topologically-based":[191],"Our":[194],"ideas":[195],"leverage":[196],"recent":[197],"developments":[198],"characterize":[200],"signals":[201],"(e.g.,":[202],"thickness)":[204],"motivated":[205],"persistence":[208],"their":[210],"topological":[211],"features,":[212],"leading":[213],"scheme":[216],"simple":[218],"constructions":[219],"matrices.":[222],"proof":[225],"principle,":[227],"dataset":[230],"356":[232],"subjects":[233],"from":[234],"Disease":[237],"Neuroimaging":[238],"Initiative":[239],"study,":[240],"we":[241],"report":[242],"good":[243],"performance":[244],"several":[246],"tasks":[249],"without":[250],"any":[251],"selection,":[253],"dimensionality":[254],"reduction,":[255],"parameter":[257],"tuning.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}