{"id":"https://openalex.org/W2098410722","doi":"https://doi.org/10.1109/tmi.2010.2042814","title":"An Efficient Numerical Method for General $L_{p}$ Regularization in Fluorescence Molecular Tomography","display_name":"An Efficient Numerical Method for General $L_{p}$ Regularization in Fluorescence Molecular Tomography","publication_year":2010,"publication_date":"2010-03-16","ids":{"openalex":"https://openalex.org/W2098410722","doi":"https://doi.org/10.1109/tmi.2010.2042814","mag":"2098410722","pmid":"https://pubmed.ncbi.nlm.nih.gov/20236875"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2010.2042814","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2010.2042814","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/163623","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091260150","display_name":"Jean-Charles Baritaux","orcid":"https://orcid.org/0000-0003-0825-6265"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J.-C. Baritaux","raw_affiliation_strings":["Swiss Federal Institute of Technology, Lausanne, Switzerland. jean-charles.baritaux@epfl.ch","Swiss Fed. Inst. of Technol., Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Federal Institute of Technology, Lausanne, Switzerland. jean-charles.baritaux@epfl.ch","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Fed. Inst. of Technol., Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020229146","display_name":"Ka\u00ef Hassler","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145677","display_name":"Scanco Medical (Switzerland)","ror":"https://ror.org/047n5wn91","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210145677"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"K. Hassler","raw_affiliation_strings":["SCANCO Medical AG, Bruttisellen, Switzerland","SCANCO Med. AG, Briittisellen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SCANCO Medical AG, Bruttisellen, Switzerland","institution_ids":["https://openalex.org/I4210145677"]},{"raw_affiliation_string":"SCANCO Med. AG, Briittisellen, Switzerland","institution_ids":["https://openalex.org/I4210145677"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027830035","display_name":"Micha\u00ebl Unser","orcid":"https://orcid.org/0000-0003-1248-2513"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M. Unser","raw_affiliation_strings":["Swiss Federal Institute of Technology, Lausanne, Switzerland","Swiss Fed. Inst. of Technol., Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Federal Institute of Technology, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Fed. Inst. of Technol., Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6169,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.92362345,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":"4","first_page":"1075","last_page":"1087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11778","display_name":"Electrical and Bioimpedance Tomography","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.8199689388275146},{"id":"https://openalex.org/keywords/iterative-reconstruction","display_name":"Iterative reconstruction","score":0.7193807363510132},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.6083564162254333},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5413787364959717},{"id":"https://openalex.org/keywords/imaging-phantom","display_name":"Imaging phantom","score":0.5231695771217346},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.5221731662750244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5156804323196411},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"Computed tomography","score":0.42847371101379395},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3503198027610779},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22391057014465332},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10381954908370972},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.07572194933891296}],"concepts":[{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.8199689388275146},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.7193807363510132},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.6083564162254333},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5413787364959717},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.5231695771217346},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.5221731662750244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5156804323196411},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.42847371101379395},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3503198027610779},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22391057014465332},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10381954908370972},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.07572194933891296},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015336","descriptor_name":"Molecular Probe Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015336","descriptor_name":"Molecular Probe Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015336","descriptor_name":"Molecular Probe Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D041622","descriptor_name":"Tomography, Optical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/tmi.2010.2042814","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2010.2042814","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:20236875","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20236875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:infoscience.epfl.ch:163623","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/163623","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:163623","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/163623","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1568539694","https://openalex.org/W1573293896","https://openalex.org/W1602659231","https://openalex.org/W1966078249","https://openalex.org/W1966130810","https://openalex.org/W1968889446","https://openalex.org/W1971516240","https://openalex.org/W1976709621","https://openalex.org/W1982458486","https://openalex.org/W1996085026","https://openalex.org/W2017054309","https://openalex.org/W2017062848","https://openalex.org/W2020955650","https://openalex.org/W2023915497","https://openalex.org/W2033106066","https://openalex.org/W2033172414","https://openalex.org/W2039832787","https://openalex.org/W2053358046","https://openalex.org/W2059568694","https://openalex.org/W2063286545","https://openalex.org/W2065390928","https://openalex.org/W2070882610","https://openalex.org/W2071544995","https://openalex.org/W2074639335","https://openalex.org/W2078937780","https://openalex.org/W2105091837","https://openalex.org/W2116792347","https://openalex.org/W2122426644","https://openalex.org/W2123873515","https://openalex.org/W2124355659","https://openalex.org/W2126167415","https://openalex.org/W2136003379","https://openalex.org/W2146775659","https://openalex.org/W2148062277","https://openalex.org/W2148944632","https://openalex.org/W2153175851","https://openalex.org/W2156059855","https://openalex.org/W2157210186","https://openalex.org/W2161005732","https://openalex.org/W2162884502","https://openalex.org/W2163108870","https://openalex.org/W2167834340","https://openalex.org/W4206925688"],"related_works":["https://openalex.org/W2417440389","https://openalex.org/W4385556839","https://openalex.org/W4378746257","https://openalex.org/W2734382758","https://openalex.org/W2109481748","https://openalex.org/W2381719890","https://openalex.org/W4206096448","https://openalex.org/W275168305","https://openalex.org/W2144778520","https://openalex.org/W2971758066"],"abstract_inverted_index":{"Reconstruction":[0],"algorithms":[1],"for":[2,116],"fluorescence":[3,64],"tomography":[4],"have":[5],"to":[6,63,76,99],"address":[7],"two":[8],"crucial":[9],"issues:":[10],"1)":[11],"the":[12,15,19,34,57,74,89,94,97,100,110,117],"ill-posedness":[13],"of":[14,22,28,38,52,59,96,102,112,119],"reconstruction":[16,40,80],"problem,":[17],"2)":[18],"large":[20,79],"scale":[21],"numerical":[23],"problems":[24,81],"arising":[25],"from":[26],"imaging":[27],"3-D":[29],"samples.":[30],"Our":[31],"contribution":[32],"is":[33],"design":[35],"and":[36,85],"implementation":[37],"a":[39,126],"algorithm":[41,75,98],"that":[42,72,121],"incorporates":[43],"general":[44,60],"Lp":[45,61],"regularization":[46,115],"(p":[47],"\u00bf":[48],"1).":[49],"The":[50],"originality":[51],"this":[53],"work":[54],"lies":[55],"in":[56],"application":[58,95],"constraints":[62,105],"tomography,":[65],"combined":[66],"with":[67,78],"an":[68],"efficient":[69],"matrix-free":[70],"strategy":[71],"enables":[73],"deal":[77],"at":[82],"reduced":[83],"memory":[84],"computational":[86],"costs.":[87],"In":[88],"experimental":[90],"part,":[91],"we":[92],"specialize":[93],"case":[101],"sparsity":[103],"promoting":[104],"(L":[106],"(1)).":[107],"We":[108],"validate":[109],"adequacy":[111],"L":[113],"(1)":[114],"investigation":[118],"phenomena":[120],"are":[122],"well":[123],"described":[124],"by":[125],"sparse":[127],"model,":[128],"using":[129],"data":[130],"acquired":[131],"during":[132],"phantom":[133],"experiments.":[134]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}