{"id":"https://openalex.org/W2168237413","doi":"https://doi.org/10.1109/tmi.2009.2025127","title":"Quantitative Comparison of Spot Detection Methods in Fluorescence Microscopy","display_name":"Quantitative Comparison of Spot Detection Methods in Fluorescence Microscopy","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W2168237413","doi":"https://doi.org/10.1109/tmi.2009.2025127","mag":"2168237413","pmid":"https://pubmed.ncbi.nlm.nih.gov/19556194"},"language":"en","primary_location":{"id":"doi:10.1109/tmi.2009.2025127","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2009.2025127","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026507016","display_name":"Ihor Smal","orcid":"https://orcid.org/0000-0001-7576-7028"},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"I. Smal","raw_affiliation_strings":["Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands. i.smal@erasmusmc.nl","Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands"],"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands. i.smal@erasmusmc.nl","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086060106","display_name":"Marco Loog","orcid":"https://orcid.org/0000-0002-1298-8461"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. Loog","raw_affiliation_strings":["Pattern Recognition Group, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technnology, Delft, Netherlands"],"affiliations":[{"raw_affiliation_string":"Pattern Recognition Group, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technnology, Delft, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038384386","display_name":"Wiro J. Niessen","orcid":"https://orcid.org/0000-0002-5822-1995"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. Niessen","raw_affiliation_strings":["Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands","Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technnology, Delft, Netherlands"],"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technnology, Delft, Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023548565","display_name":"Erik Meijering","orcid":"https://orcid.org/0000-0001-8015-8358"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E. Meijering","raw_affiliation_strings":["Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands"],"affiliations":[{"raw_affiliation_string":"Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026507016"],"corresponding_institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I913958620"],"apc_list":null,"apc_paid":null,"fwci":13.4278,"has_fulltext":false,"cited_by_count":261,"citation_normalized_percentile":{"value":0.98576447,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"29","issue":"2","first_page":"282","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7769829034805298},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7625325322151184},{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.6555694937705994},{"id":"https://openalex.org/keywords/detector","display_name":"Detector","score":0.6341603994369507},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5963165163993835},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4408698081970215},{"id":"https://openalex.org/keywords/supervised-learning","display_name":"Supervised learning","score":0.4268583655357361},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4094444513320923},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.3626418113708496},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3310014605522156},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.09382793307304382}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7769829034805298},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7625325322151184},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.6555694937705994},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.6341603994369507},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5963165163993835},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4408698081970215},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.4268583655357361},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4094444513320923},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.3626418113708496},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3310014605522156},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.09382793307304382},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016011","descriptor_name":"Normal Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/tmi.2009.2025127","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmi.2009.2025127","pdf_url":null,"source":{"id":"https://openalex.org/S58069681","display_name":"IEEE Transactions on Medical Imaging","issn_l":"0278-0062","issn":["0278-0062","1558-254X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Medical Imaging","raw_type":"journal-article"},{"id":"pmid:19556194","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19556194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on medical imaging","raw_type":null},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/967285d1-f2fe-4d30-a19b-133ddcbbc052","is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/967285d1-f2fe-4d30-a19b-133ddcbbc052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Smal, I, Loog, M, Niessen, W & Meijering, E 2010, 'Quantitative Comparison of Spot Detection Methods in Fluorescence Microscopy', IEEE Transactions on Medical Imaging, vol. 29, no. 2, pp. 282-301. https://doi.org/10.1109/TMI.2009.2025127","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pure.eur.nl:publications/967285d1-f2fe-4d30-a19b-133ddcbbc052","is_oa":false,"landing_page_url":"http://hdl.handle.net/1765/62882","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Smal , I , Loog , M , Niessen , W &amp; Meijering , E 2010 , ' Quantitative Comparison of Spot Detection Methods in Fluorescence Microscopy ' , IEEE Transactions on Medical Imaging , vol. 29 , no. 2 , pp. 282-301 . https://doi.org/10.1109/TMI.2009.2025127","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W36489998","https://openalex.org/W85002878","https://openalex.org/W148837820","https://openalex.org/W175458883","https://openalex.org/W214577476","https://openalex.org/W271775295","https://openalex.org/W1501344851","https://openalex.org/W1518891633","https://openalex.org/W1560910787","https://openalex.org/W1561442812","https://openalex.org/W1574347237","https://openalex.org/W1995355073","https://openalex.org/W1995583822","https://openalex.org/W2001560639","https://openalex.org/W2003013680","https://openalex.org/W2008953669","https://openalex.org/W2019285240","https://openalex.org/W2021262032","https://openalex.org/W2025406593","https://openalex.org/W2027339406","https://openalex.org/W2031257497","https://openalex.org/W2035737465","https://openalex.org/W2040516748","https://openalex.org/W2046385387","https://openalex.org/W2064931480","https://openalex.org/W2067191022","https://openalex.org/W2069496952","https://openalex.org/W2072184377","https://openalex.org/W2073783182","https://openalex.org/W2075275335","https://openalex.org/W2084656440","https://openalex.org/W2091205354","https://openalex.org/W2093680414","https://openalex.org/W2095485540","https://openalex.org/W2097084589","https://openalex.org/W2099244020","https://openalex.org/W2101916976","https://openalex.org/W2105916176","https://openalex.org/W2106950091","https://openalex.org/W2107422873","https://openalex.org/W2107634464","https://openalex.org/W2109200236","https://openalex.org/W2109365020","https://openalex.org/W2110213173","https://openalex.org/W2111202632","https://openalex.org/W2111896212","https://openalex.org/W2112076978","https://openalex.org/W2113127660","https://openalex.org/W2113144687","https://openalex.org/W2114336941","https://openalex.org/W2115755118","https://openalex.org/W2115763357","https://openalex.org/W2116928225","https://openalex.org/W2127510560","https://openalex.org/W2129140439","https://openalex.org/W2129476886","https://openalex.org/W2130954007","https://openalex.org/W2132355119","https://openalex.org/W2133701212","https://openalex.org/W2136043254","https://openalex.org/W2138825607","https://openalex.org/W2143623375","https://openalex.org/W2146404768","https://openalex.org/W2147093685","https://openalex.org/W2150134853","https://openalex.org/W2151842905","https://openalex.org/W2156706175","https://openalex.org/W2157840858","https://openalex.org/W2158706178","https://openalex.org/W2160337655","https://openalex.org/W2164598857","https://openalex.org/W2164741953","https://openalex.org/W2167885378","https://openalex.org/W2168469752","https://openalex.org/W2169066090","https://openalex.org/W2170350338","https://openalex.org/W2413430215","https://openalex.org/W2498299656","https://openalex.org/W2911709767","https://openalex.org/W2977554044","https://openalex.org/W2980988205","https://openalex.org/W3216100919","https://openalex.org/W4230339119","https://openalex.org/W4375802365","https://openalex.org/W6606037716","https://openalex.org/W6676769703","https://openalex.org/W6715468428"],"related_works":["https://openalex.org/W2047973478","https://openalex.org/W4295532600","https://openalex.org/W2063823869","https://openalex.org/W2366906938","https://openalex.org/W2067569035","https://openalex.org/W2090985514","https://openalex.org/W2349391998","https://openalex.org/W4386076228","https://openalex.org/W4310825149","https://openalex.org/W2798269247"],"abstract_inverted_index":{"Quantitative":[0],"analysis":[1],"of":[2,10,61,76,100,140,205],"biological":[3,123],"image":[4,116],"data":[5,117],"generally":[6],"involves":[7],"the":[8,26,43,67,74,77,106,151,160,163,167,176,184,201],"detection":[9,37,81],"many":[11,45],"subresolution":[12],"spots.":[13],"Especially":[14],"in":[15,66,203],"live":[16],"cell":[17],"imaging,":[18],"for":[19,83,104,120,125,144],"which":[20,105,126],"fluorescence":[21],"microscopy":[22],"is":[23,64],"often":[24],"used,":[25],"signal-to-noise":[27],"ratio":[28],"(SNR)":[29],"can":[30],"be":[31],"extremely":[32],"low,":[33],"making":[34],"automated":[35],"spot":[36],"a":[38,55,191],"very":[39,145],"challenging":[40],"task.":[41],"In":[42,69],"past,":[44],"methods":[46,63,82,155],"have":[47,183],"been":[48],"proposed":[49],"to":[50,132],"perform":[51,95,156,180],"this":[52,70,84],"task,":[53],"but":[54],"thorough":[56],"quantitative":[57],"evaluation":[58],"and":[59,90,182],"comparison":[60],"these":[62],"lacking":[65],"literature.":[68],"paper,":[71],"we":[72,127],"evaluate":[73],"performance":[75,204],"most":[78],"frequently":[79],"used":[80],"purpose.":[85],"These":[86],"include":[87],"seven":[88],"unsupervised":[89,161],"two":[91,121],"supervised":[92,152],"methods.":[93],"We":[94],"experiments":[96,141],"on":[97,114,166],"synthetic":[98],"images":[99],"three":[101],"different":[102,122],"types,":[103],"ground":[107],"truth":[108],"was":[109],"available,":[110],"as":[111,113],"well":[112],"real":[115],"sets":[118],"acquired":[119],"studies,":[124],"obtained":[128],"expert":[129],"manual":[130],"annotations":[131],"compare":[133],"with.":[134],"The":[135],"results":[136],"from":[137,172],"both":[138],"types":[139],"suggest":[142],"that":[143,186],"low":[146],"SNRs":[147,197],"(":[148,198],"approximately":[149],"2),":[150],"(machine":[153],"learning)":[154],"best":[157],"overall.":[158],"Of":[159],"methods,":[162],"detectors":[164,208],"based":[165],"so-called":[168],"h":[169],"-dome":[170],"transform":[171,179],"mathematical":[173],"morphology":[174],"or":[175],"multiscale":[177],"variance-stabilizing":[178],"comparably,":[181],"advantage":[185],"they":[187],"do":[188],"not":[189],"require":[190],"cumbersome":[192],"learning":[193],"stage.":[194],"At":[195],"high":[196],">":[199],"5),":[200],"difference":[202],"all":[206],"considered":[207],"becomes":[209],"negligible.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":16}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
