{"id":"https://openalex.org/W4389076453","doi":"https://doi.org/10.1109/tmbmc.2023.3336322","title":"Intercellular Chemical Communication Through EV Exchange: Evaluation of the EV Fusion Process Parameters at the Receiving Cell","display_name":"Intercellular Chemical Communication Through EV Exchange: Evaluation of the EV Fusion Process Parameters at the Receiving Cell","publication_year":2023,"publication_date":"2023-11-28","ids":{"openalex":"https://openalex.org/W4389076453","doi":"https://doi.org/10.1109/tmbmc.2023.3336322"},"language":"en","primary_location":{"id":"doi:10.1109/tmbmc.2023.3336322","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmbmc.2023.3336322","pdf_url":"https://ieeexplore.ieee.org/ielx7/6687308/7181695/10330635.pdf","source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/6687308/7181695/10330635.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013490800","display_name":"Alfio Lombardo","orcid":"https://orcid.org/0000-0003-3617-7732"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfio Lombardo","raw_affiliation_strings":["Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3617-7732","affiliations":[{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050880787","display_name":"Giacomo Morabito","orcid":"https://orcid.org/0000-0002-8714-4001"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Morabito","raw_affiliation_strings":["Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8714-4001","affiliations":[{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085373032","display_name":"Carla Panarello","orcid":"https://orcid.org/0000-0003-1888-2374"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Panarello","raw_affiliation_strings":["Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1888-2374","affiliations":[{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005303957","display_name":"Fabrizio Pappalardo","orcid":"https://orcid.org/0000-0001-5671-2064"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Pappalardo","raw_affiliation_strings":["Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5671-2064","affiliations":[{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Electrical, Electronics and Informatics Engineering (DIEEI), University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39063666"],"apc_list":null,"apc_paid":null,"fwci":0.1345,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58635295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"10","issue":"1","first_page":"21","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.7094637751579285},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"Extracellular vesicles","score":0.6467156410217285},{"id":"https://openalex.org/keywords/lipid-bilayer-fusion","display_name":"Lipid bilayer fusion","score":0.5954769253730774},{"id":"https://openalex.org/keywords/internalization","display_name":"Internalization","score":0.5901588797569275},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.535438597202301},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.5310851335525513},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"Drug delivery","score":0.4946896731853485},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4867870509624481},{"id":"https://openalex.org/keywords/cytosol","display_name":"Cytosol","score":0.4369467496871948},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4132694900035858},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3066675662994385},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3054983913898468},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.24934208393096924},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2481217086315155},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.23159927129745483},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18710744380950928},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16604676842689514}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.7094637751579285},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.6467156410217285},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.5954769253730774},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.5901588797569275},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.535438597202301},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5310851335525513},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4946896731853485},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4867870509624481},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4369467496871948},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4132694900035858},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3066675662994385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3054983913898468},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24934208393096924},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2481217086315155},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.23159927129745483},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18710744380950928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16604676842689514},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tmbmc.2023.3336322","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmbmc.2023.3336322","pdf_url":"https://ieeexplore.ieee.org/ielx7/6687308/7181695/10330635.pdf","source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1109/tmbmc.2023.3336322","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmbmc.2023.3336322","pdf_url":"https://ieeexplore.ieee.org/ielx7/6687308/7181695/10330635.pdf","source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389076453.pdf","grobid_xml":"https://content.openalex.org/works/W4389076453.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1970870994","https://openalex.org/W1983127525","https://openalex.org/W1999426076","https://openalex.org/W2003343932","https://openalex.org/W2014656661","https://openalex.org/W2014666851","https://openalex.org/W2068823337","https://openalex.org/W2080418767","https://openalex.org/W2081158331","https://openalex.org/W2088536371","https://openalex.org/W2088553879","https://openalex.org/W2094001022","https://openalex.org/W2098693272","https://openalex.org/W2111011993","https://openalex.org/W2154652221","https://openalex.org/W2165477861","https://openalex.org/W2169061810","https://openalex.org/W2464940383","https://openalex.org/W2476697612","https://openalex.org/W2755806464","https://openalex.org/W2979511940","https://openalex.org/W2989402686","https://openalex.org/W3023322703","https://openalex.org/W3038440044","https://openalex.org/W3080804488","https://openalex.org/W3084567698","https://openalex.org/W3151708782","https://openalex.org/W3158874935","https://openalex.org/W3175628958","https://openalex.org/W3194257905","https://openalex.org/W4214933741","https://openalex.org/W4239503984","https://openalex.org/W4300818461","https://openalex.org/W4380303533"],"related_works":["https://openalex.org/W4366318089","https://openalex.org/W2068721292","https://openalex.org/W4225584766","https://openalex.org/W2145545797","https://openalex.org/W2764950946","https://openalex.org/W2952148578","https://openalex.org/W2014118959","https://openalex.org/W1585685362","https://openalex.org/W1807798123","https://openalex.org/W2078432352"],"abstract_inverted_index":{"Cells":[0],"communicate":[1],"with":[2,194],"each":[3],"other":[4],"exploiting":[5],"a":[6,42,66,180],"variety":[7],"of":[8,35,61,74,101,120,139,148,151,159,186],"chemical":[9],"signals.":[10],"Among":[11],"them,":[12],"Extracellular":[13],"Vesicles":[14],"(EVs)":[15],"have":[16],"attracted":[17],"large":[18],"interest":[19],"by":[20],"the":[21,28,33,54,59,72,99,106,112,117,121,125,131,137,149,152,157,160,164,177],"scientific":[22],"community.":[23],"In":[24,90,133],"fact,":[25],"thanks":[26],"to":[27,77,85,135,169,182],"advances":[29],"in":[30,172],"bio-nano-technology":[31],"and":[32,80,124],"possibility":[34],"engineering":[36],"EVs,":[37],"they":[38],"are":[39,192],"envisioned":[40],"as":[41,179],"perfect":[43],"means":[44],"for":[45],"distributing":[46],"biological":[47,161],"information":[48,94],"among":[49],"receiving":[50],"cells.":[51],"However,":[52],"deciphering":[53],"molecular":[55],"mechanisms":[56],"that":[57,191],"regulate":[58],"delivery":[60,88],"EV":[62,75,102,107,113,126],"cargo":[63],"is,":[64],"today,":[65],"necessary,":[67],"yet":[68],"challenging,":[69],"step":[70],"toward":[71],"exploitation":[73],"signaling":[76],"support":[78],"innovative":[79],"efficient":[81],"therapeutic":[82],"protocols,":[83],"alternative":[84],"current":[86,195],"drug":[87],"technologies.":[89],"particular,":[91],"very":[92],"little":[93],"is":[95,105,128,167],"currently":[96],"available":[97],"on":[98],"processes":[100],"fusion,":[103],"which":[104],"internalization":[108],"process":[109,166],"occurring":[110],"when":[111],"membrane":[114,119],"dissolves":[115],"into":[116,130],"plasma":[118],"target":[122],"cell,":[123],"content":[127],"released":[129],"cytosol.":[132],"order":[134],"understand":[136],"dynamics":[138],"this":[140,142,173],"process,":[141],"paper":[143,174],"introduces":[144],"an":[145],"analytical":[146],"model":[147,178],"evolution":[150],"fusion":[153,165],"process.":[154],"Moreover,":[155],"since":[156],"measurement":[158],"parameters":[162,188,190],"driving":[163],"far":[168],"be":[170],"achieved,":[171],"we":[175],"use":[176],"tool":[181],"infer":[183],"likely":[184],"values":[185],"such":[187],"from":[189],"measurable":[193],"technology.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}