{"id":"https://openalex.org/W4387951985","doi":"https://doi.org/10.1109/tmbmc.2023.3327869","title":"Channel Characterization of Molecular Communications for Cytokine Storm in COVID-19 Patients","display_name":"Channel Characterization of Molecular Communications for Cytokine Storm in COVID-19 Patients","publication_year":2023,"publication_date":"2023-10-26","ids":{"openalex":"https://openalex.org/W4387951985","doi":"https://doi.org/10.1109/tmbmc.2023.3327869"},"language":"en","primary_location":{"id":"doi:10.1109/tmbmc.2023.3327869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmbmc.2023.3327869","pdf_url":null,"source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082450502","display_name":"Saswati Pal","orcid":"https://orcid.org/0000-0003-1218-4022"},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saswati Pal","raw_affiliation_strings":["School of Nano-Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India"],"raw_orcid":"https://orcid.org/0000-0003-1218-4022","affiliations":[{"raw_affiliation_string":"School of Nano-Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032787307","display_name":"Sudip Misra","orcid":"https://orcid.org/0000-0002-2467-6414"},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudip Misra","raw_affiliation_strings":["Department of Computer Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur, India"],"raw_orcid":"https://orcid.org/0000-0002-2467-6414","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur, India","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083116915","display_name":"Nabiul Islam","orcid":"https://orcid.org/0000-0001-5435-0397"},"institutions":[{"id":"https://openalex.org/I4210095504","display_name":"Shannon Applied Biotechnology Centre","ror":"https://ror.org/00rve9x39","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210095504"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Nabiul Islam","raw_affiliation_strings":["Vehicle Engineering, Jaguar Land Rover, Shannon, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vehicle Engineering, Jaguar Land Rover, Shannon, Ireland","institution_ids":["https://openalex.org/I4210095504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077005247","display_name":"Sasitharan Balasubramaniam","orcid":"https://orcid.org/0000-0003-4022-3615"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasitharan Balasubramaniam","raw_affiliation_strings":["School of Computing, University of Nebraska-Lincoln, Lincoln, NE, USA"],"raw_orcid":"https://orcid.org/0000-0003-4022-3615","affiliations":[{"raw_affiliation_string":"School of Computing, University of Nebraska-Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2345,"currency":"USD","value_usd":2345},"apc_paid":null,"fwci":0.0804,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33879066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"9","issue":"4","first_page":"425","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"Cytokine storm","score":0.7948912382125854},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.7181880474090576},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.6250486373901367},{"id":"https://openalex.org/keywords/storm","display_name":"Storm","score":0.6093872785568237},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.5517515540122986},{"id":"https://openalex.org/keywords/characterization","display_name":"Characterization (materials science)","score":0.5118104815483093},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.5000977516174316},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.4539406895637512},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.421598345041275},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3974143862724304},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.31529706716537476},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.28897416591644287},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.28163301944732666},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27508068084716797},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2684227228164673},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.26194387674331665},{"id":"https://openalex.org/keywords/meteorology","display_name":"Meteorology","score":0.15976482629776},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.15421348810195923},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.12450012564659119},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09968364238739014},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.07500821352005005}],"concepts":[{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.7948912382125854},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7181880474090576},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.6250486373901367},{"id":"https://openalex.org/C105306849","wikidata":"https://www.wikidata.org/wiki/Q81054","display_name":"Storm","level":2,"score":0.6093872785568237},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5517515540122986},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5118104815483093},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5000977516174316},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4539406895637512},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.421598345041275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3974143862724304},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.31529706716537476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28897416591644287},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.28163301944732666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27508068084716797},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2684227228164673},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.26194387674331665},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.15976482629776},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.15421348810195923},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12450012564659119},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09968364238739014},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.07500821352005005},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tmbmc.2023.3327869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmbmc.2023.3327869","pdf_url":null,"source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1966722005","https://openalex.org/W2023243224","https://openalex.org/W2084621368","https://openalex.org/W2090114724","https://openalex.org/W2140732194","https://openalex.org/W2154061066","https://openalex.org/W2155091152","https://openalex.org/W2478353508","https://openalex.org/W2498910350","https://openalex.org/W2554414794","https://openalex.org/W2893435380","https://openalex.org/W2962929666","https://openalex.org/W2963911599","https://openalex.org/W2979439451","https://openalex.org/W3010668517","https://openalex.org/W3014384904","https://openalex.org/W3015292413","https://openalex.org/W3019663170","https://openalex.org/W3021577619","https://openalex.org/W3025317961","https://openalex.org/W3031365196","https://openalex.org/W3033255658","https://openalex.org/W3036613347","https://openalex.org/W3039870524","https://openalex.org/W3041846146","https://openalex.org/W3080981445","https://openalex.org/W3084418970","https://openalex.org/W3093770074","https://openalex.org/W3095024243","https://openalex.org/W3096875040","https://openalex.org/W3111812920","https://openalex.org/W3152749975","https://openalex.org/W3153771247","https://openalex.org/W3156637493","https://openalex.org/W3164174624","https://openalex.org/W3182774911","https://openalex.org/W3184570862"],"related_works":["https://openalex.org/W3119991010","https://openalex.org/W4226410771","https://openalex.org/W3112349872","https://openalex.org/W3127156785","https://openalex.org/W3216071038","https://openalex.org/W3009669391","https://openalex.org/W4200329650","https://openalex.org/W4372272125","https://openalex.org/W3196326822","https://openalex.org/W4205215807"],"abstract_inverted_index":{"In":[0,38],"the":[1,7,12,48,53,55,58,62,65,71,86,101,107,120,131,143,151,162,166,172,181,185,198],"most":[2],"severe":[3],"COVID-19":[4],"cases,":[5],"often":[6],"cytokine":[8,78,89,108,182,195],"molecules":[9],"produced":[10],"by":[11],"immune":[13],"system":[14,44],"to":[15,24,99,165,193],"fight":[16],"off":[17],"coronavirus":[18],"infection":[19],"become":[20],"hyperactive.":[21],"This":[22],"leads":[23,192],"\u201ccytokine":[25],"storm\u201d,":[26],"which":[27,116],"is":[28,117],"a":[29,43],"serious":[30],"adverse":[31],"medical":[32,93],"condition":[33],"causing":[34],"multiple":[35],"organ":[36],"failures.":[37],"this":[39],"work,":[40],"we":[41],"propose":[42],"model":[45,83,105],"that":[46,130,189],"captures":[47],"transmission":[49],"of":[50,73,88,112,169],"cytokines":[51,173],"from":[52,119,126],"alveoli,":[54],"propagation":[56],"via":[57],"vascular":[59],"channel,":[60],"and":[61,114,174,187],"reception":[63],"in":[64,91,110,142],"blood":[66],"vessel":[67],"wall.":[68],"We":[69,95,128,160,179],"analyze":[70,100,161],"impact":[72],"different":[74,92,167],"diseases":[75],"on":[76],"induced":[77],"storm.":[79],"The":[80],"proposed":[81,102],"analytical":[82],"helps":[84],"observe":[85,129,188],"behavior":[87],"storm":[90,109],"conditions.":[94],"perform":[96],"particle-based":[97],"simulations":[98],"end-to-end":[103],"channel":[104,124,132,144,163],"describing":[106],"terms":[111],"gain":[113,133,152],"delay,":[115],"inspired":[118],"existing":[121],"molecular":[122],"communication":[123],"models":[125],"literature.":[127],"mostly":[134],"remains":[135],"unaffected":[136],"for":[137],"upto":[138,154],"three":[139],"times":[140,149],"increase":[141],"length,":[145],"while,":[146],"with":[147],"four":[148],"increase,":[150],"increases":[153],"16%":[155],"at":[156,184,197],"1000":[157],"rad/s":[158],"frequency.":[159],"response":[164],"stimuli":[168],"interactions":[170],"between":[171],"their":[175],"varying":[176],"release":[177],"rates.":[178],"evaluate":[180],"signal":[183],"receiver":[186],"lesser":[190],"diffusion":[191],"higher":[194],"concentration":[196],"receiver.":[199]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}