{"id":"https://openalex.org/W4384786450","doi":"https://doi.org/10.1109/tmbmc.2023.3296430","title":"m-MSC: Molecular Communication-Based Analysis for Controlled MSC Treatment of Cytokine Storm","display_name":"m-MSC: Molecular Communication-Based Analysis for Controlled MSC Treatment of Cytokine Storm","publication_year":2023,"publication_date":"2023-07-18","ids":{"openalex":"https://openalex.org/W4384786450","doi":"https://doi.org/10.1109/tmbmc.2023.3296430"},"language":"en","primary_location":{"id":"doi:10.1109/tmbmc.2023.3296430","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmbmc.2023.3296430","pdf_url":null,"source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082450502","display_name":"Saswati Pal","orcid":"https://orcid.org/0000-0003-1218-4022"},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saswati Pal","raw_affiliation_strings":["School of Nano Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India"],"raw_orcid":"https://orcid.org/0000-0003-1218-4022","affiliations":[{"raw_affiliation_string":"School of Nano Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032787307","display_name":"Sudip Misra","orcid":"https://orcid.org/0000-0002-2467-6414"},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudip Misra","raw_affiliation_strings":["Department of Computer Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur, India"],"raw_orcid":"https://orcid.org/0000-0002-2467-6414","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur, India","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083116915","display_name":"Nabiul Islam","orcid":"https://orcid.org/0000-0001-5435-0397"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nabiul Islam","raw_affiliation_strings":["Department of Vehicle Engineering, Jaguar Land Rover, Shanon, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vehicle Engineering, Jaguar Land Rover, Shanon, Ireland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2345,"currency":"USD","value_usd":2345},"apc_paid":null,"fwci":0.1607,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.38225344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"3","first_page":"286","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"Cytokine storm","score":0.8371449708938599},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.7571227550506592},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell","display_name":"Mesenchymal stem cell","score":0.6613771915435791},{"id":"https://openalex.org/keywords/storm","display_name":"Storm","score":0.5199976563453674},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5099669694900513},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.4240248501300812},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4210777282714844},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.41112035512924194},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.33418595790863037},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3274819850921631},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2926894724369049},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19298410415649414},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1285267174243927},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.1250409483909607},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.12500309944152832},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.0886196494102478}],"concepts":[{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.8371449708938599},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.7571227550506592},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6613771915435791},{"id":"https://openalex.org/C105306849","wikidata":"https://www.wikidata.org/wiki/Q81054","display_name":"Storm","level":2,"score":0.5199976563453674},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5099669694900513},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4240248501300812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4210777282714844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41112035512924194},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33418595790863037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3274819850921631},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2926894724369049},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19298410415649414},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1285267174243927},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1250409483909607},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12500309944152832},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0886196494102478},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tmbmc.2023.3296430","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmbmc.2023.3296430","pdf_url":null,"source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1980529152","https://openalex.org/W1991671533","https://openalex.org/W2059218683","https://openalex.org/W2082165523","https://openalex.org/W2184131220","https://openalex.org/W2262262336","https://openalex.org/W2802631485","https://openalex.org/W2962929666","https://openalex.org/W2965698862","https://openalex.org/W2979439451","https://openalex.org/W2991025251","https://openalex.org/W2995224835","https://openalex.org/W3010994778","https://openalex.org/W3025317961","https://openalex.org/W3031365196","https://openalex.org/W3048443418","https://openalex.org/W3080162541","https://openalex.org/W3087385265","https://openalex.org/W3089234362","https://openalex.org/W3091944910","https://openalex.org/W3099078921","https://openalex.org/W3108922873","https://openalex.org/W3110777641","https://openalex.org/W3111812920","https://openalex.org/W3112902030","https://openalex.org/W3119940003","https://openalex.org/W3120418504","https://openalex.org/W3129435793","https://openalex.org/W3134737120","https://openalex.org/W3152749975","https://openalex.org/W3155547463","https://openalex.org/W3156637493","https://openalex.org/W3174694600","https://openalex.org/W3178306758","https://openalex.org/W3184570862","https://openalex.org/W3196776352","https://openalex.org/W4206381257","https://openalex.org/W4214572254","https://openalex.org/W4214641444","https://openalex.org/W4287281956","https://openalex.org/W6791893181"],"related_works":["https://openalex.org/W3119991010","https://openalex.org/W4226410771","https://openalex.org/W3112349872","https://openalex.org/W3216071038","https://openalex.org/W4372272125","https://openalex.org/W3196326822","https://openalex.org/W2617620062","https://openalex.org/W2159140922","https://openalex.org/W3118803821","https://openalex.org/W4389500665"],"abstract_inverted_index":{"COVID-19-induced":[0],"cytokine":[1,12,39,90,198],"storm,":[2],"which":[3],"is":[4,56,188],"formed":[5],"due":[6,58],"to":[7,33,38,48,59,78,88,116,190],"the":[8,19,35,43,60,80,89,100,103,118,125,131,135,138,143,158,164,174,177,182,197],"excessive":[9],"secretion":[10],"of":[11,21,46,86,102,121,130,137],"molecules,":[13],"causes":[14],"multi-organ":[15],"damage":[16],"and":[17,64,83,105,128],"subsequently,":[18],"death":[20],"COVID-19":[22],"patients.":[23],"Mesenchymal":[24],"Stem":[25],"Cells":[26],"(MSCs)":[27],"are":[28],"regarded":[29],"as":[30,109],"cellular":[31],"vaccines":[32],"combat":[34],"hyper-inflammatory":[36],"response":[37,85],"storms.":[40],"However,":[41],"determining":[42],"required":[44,119,189],"dose":[45,120],"MSCs":[47,87],"be":[49,107],"infused":[50],"within":[51],"a":[52,74,110,192],"certain":[53],"time":[54],"period":[55],"challenging":[57],"complex":[61],"vascular":[62,132],"networks":[63],"varying":[65,126],"individual":[66],"immune":[67],"responses.":[68],"In":[69],"this":[70],"work,":[71],"we":[72],"propose":[73],"molecular":[75],"communication-based":[76],"system":[77,104],"model":[79,95],"transmission,":[81],"propagation,":[82,150],"immuno-modulatory":[84],"storm.":[91,199],"The":[92],"proposed":[93],"analytical":[94],"provides":[96],"valuable":[97],"insights":[98],"into":[99],"behavior":[101],"can":[106],"used":[108],"framework":[111],"for":[112],"further":[113],"experimental-based":[114],"studies":[115],"estimate":[117],"MSCs.":[122,139,175],"We":[123,140],"analyze":[124],"shapes":[127],"geometries":[129],"channel":[133],"on":[134,185,196],"propagation":[136,156],"observe":[141],"that":[142,163,180],"higher":[144],"shear":[145,153],"stress":[146,154],"hinders":[147],"MSC":[148,165,183],"signal":[149,166],"while":[151],"lower":[152],"induces":[155],"along":[157],"channel.":[159],"Simulation":[160],"results":[161,178],"show":[162],"peaks":[167],"in":[168],"four":[169],"simulation":[170],"days":[171,187],"upon":[172],"administering":[173],"Further,":[176],"reveal":[179],"repeating":[181],"infusion":[184],"alternate":[186],"maintain":[191],"prolonged":[193],"immuno-modulating":[194],"effect":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}
