{"id":"https://openalex.org/W3126023996","doi":"https://doi.org/10.1109/tmbmc.2021.3054890","title":"Larger Connection Radius Increases Hub Astrocyte Number in a 3-D Neuron\u2013Astrocyte Network Model","display_name":"Larger Connection Radius Increases Hub Astrocyte Number in a 3-D Neuron\u2013Astrocyte Network Model","publication_year":2021,"publication_date":"2021-01-27","ids":{"openalex":"https://openalex.org/W3126023996","doi":"https://doi.org/10.1109/tmbmc.2021.3054890","mag":"3126023996"},"language":"en","primary_location":{"id":"doi:10.1109/tmbmc.2021.3054890","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmbmc.2021.3054890","pdf_url":"https://ieeexplore.ieee.org/ielx7/6687308/9467383/09336670.pdf","source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological and Multi-Scale Communications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/6687308/9467383/09336670.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039161334","display_name":"Kerstin Lenk","orcid":"https://orcid.org/0000-0002-8329-1127"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kerstin Lenk","raw_affiliation_strings":["BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"],"raw_orcid":"https://orcid.org/0000-0002-8329-1127","affiliations":[{"raw_affiliation_string":"BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065456836","display_name":"Barbara Genocchi","orcid":"https://orcid.org/0000-0002-7574-4835"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Barbara Genocchi","raw_affiliation_strings":["BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"],"raw_orcid":"https://orcid.org/0000-0002-7574-4835","affiliations":[{"raw_affiliation_string":"BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084092008","display_name":"Michael Taynnan Barros","orcid":"https://orcid.org/0000-0002-9765-7660"},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Michael Taynnan Barros","raw_affiliation_strings":["BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","School of Computer Science and Electronic Engineering, University of Essex, Colchester, U.K"],"raw_orcid":"https://orcid.org/0000-0002-9765-7660","affiliations":[{"raw_affiliation_string":"BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]},{"raw_affiliation_string":"School of Computer Science and Electronic Engineering, University of Essex, Colchester, U.K","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050747402","display_name":"Jari Hyttinen","orcid":"https://orcid.org/0000-0003-1850-3055"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jari A. K. Hyttinen","raw_affiliation_strings":["BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":{"value":1733,"currency":"EUR","value_usd":1869},"fwci":1.2642,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76687493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"2","first_page":"83","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocyte","display_name":"Astrocyte","score":0.8951438665390015},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6588716506958008},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.5810303092002869},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.5680316090583801},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.508405864238739},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4944572448730469},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4355945885181427},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3775407075881958},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3231821060180664},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.2502528429031372},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19724610447883606},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.11033934354782104},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.10841268301010132}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8951438665390015},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6588716506958008},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5810303092002869},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5680316090583801},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.508405864238739},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4944572448730469},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4355945885181427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3775407075881958},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3231821060180664},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.2502528429031372},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19724610447883606},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.11033934354782104},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.10841268301010132}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tmbmc.2021.3054890","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmbmc.2021.3054890","pdf_url":"https://ieeexplore.ieee.org/ielx7/6687308/9467383/09336670.pdf","source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological and Multi-Scale Communications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1109/tmbmc.2021.3054890","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tmbmc.2021.3054890","pdf_url":"https://ieeexplore.ieee.org/ielx7/6687308/9467383/09336670.pdf","source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological and Multi-Scale Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1726306447","display_name":"Stochastic Communication Inside Cortical Microcolumns","funder_award_id":"839553","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G1950272051","display_name":"Stochastic Communication Inside Cortical Microcolumns","funder_award_id":"839553","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G384915824","display_name":"Biomedical Engineering and Medical Physics","funder_award_id":"713645","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G5462850158","display_name":null,"funder_award_id":"314647","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G7158739914","display_name":"Biomedical Engineering and Medical Physics","funder_award_id":"713645","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8330689397","display_name":null,"funder_award_id":"326452","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3126023996.pdf","grobid_xml":"https://content.openalex.org/works/W3126023996.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1969326379","https://openalex.org/W2004497217","https://openalex.org/W2018648013","https://openalex.org/W2029592532","https://openalex.org/W2044730840","https://openalex.org/W2108301529","https://openalex.org/W2170938030","https://openalex.org/W2177918269","https://openalex.org/W2482686371","https://openalex.org/W2587305225","https://openalex.org/W2618097454","https://openalex.org/W2777525962","https://openalex.org/W2787893134","https://openalex.org/W2804479495","https://openalex.org/W2896861622","https://openalex.org/W2898107034","https://openalex.org/W2975749752","https://openalex.org/W2976033851","https://openalex.org/W3002370256","https://openalex.org/W3002950002","https://openalex.org/W3037085755","https://openalex.org/W3082401852","https://openalex.org/W4255557256"],"related_works":["https://openalex.org/W2026577098","https://openalex.org/W4390116023","https://openalex.org/W1984689716","https://openalex.org/W4223495245","https://openalex.org/W2090970493","https://openalex.org/W2284538027","https://openalex.org/W2896971219","https://openalex.org/W4224793487","https://openalex.org/W2037133501","https://openalex.org/W4226111235"],"abstract_inverted_index":{"Astrocytes":[0],"-":[1,10],"a":[2,76,106],"prominent":[3],"glial":[4],"cell":[5],"type":[6],"in":[7,48],"the":[8,17,27,45,52,66,91,96,100,112,120,123,130,137,148,155],"brain":[9,151],"form":[11],"networks":[12,85],"that":[13,110,144],"tightly":[14],"interact":[15],"with":[16,86],"brain's":[18],"neuronal":[19,59,71],"circuits.":[20],"Thus,":[21],"it":[22],"is":[23,62,133],"essential":[24],"to":[25,35,51,79,136],"study":[26],"modes":[28],"of":[29,93,122,150,157],"such":[30],"interaction":[31],"if":[32],"we":[33,74,104],"aim":[34],"understand":[36],"how":[37,65],"neural":[38],"circuits":[39],"process":[40],"information.":[41],"Thereby,":[42],"calcium":[43],"elevations,":[44],"primary":[46],"signal":[47],"astrocytes,":[49,129],"propagate":[50],"adjacent":[53],"neighboring":[54],"cells":[55],"and":[56,82,99,147],"directly":[57],"regulate":[58],"communication.":[60],"It":[61],"mostly":[63],"unknown":[64],"astrocyte":[67,158],"network":[68,113,117],"topology":[69,149],"influences":[70],"activity.":[72],"Here,":[73],"used":[75],"computational":[77],"model":[78],"simulate":[80],"planar":[81],"3D":[83],"neuron-astrocyte":[84],"varying":[87],"topologies.":[88],"We":[89],"investigated":[90],"number":[92],"active":[94],"nodes,":[95],"shortest":[97],"path,":[98],"mean":[101],"degree.":[102],"Furthermore,":[103],"applied":[105],"graph":[107],"coloring":[108],"analysis":[109],"highlights":[111],"organization":[114],"between":[115,126],"different":[116],"structures.":[118],"With":[119],"increase":[121],"maximum":[124],"distance":[125],"two":[127],"connected":[128,139],"information":[131],"flow":[132],"more":[134],"centralized":[135],"most":[138],"cells.":[140],"Our":[141],"results":[142],"suggest":[143],"activity-dependent":[145],"plasticity":[146],"areas":[152],"might":[153],"alter":[154],"amount":[156],"controlled":[159],"synapses.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-07-09T07:52:08.696243","created_date":"2025-10-10T00:00:00"}