{"id":"https://openalex.org/W2966172427","doi":"https://doi.org/10.1109/tmbmc.2019.2933391","title":"Inferring Genome-Wide Interaction Networks Using the Phi-Mixing Coefficient, and Applications to Lung and Breast Cancer","display_name":"Inferring Genome-Wide Interaction Networks Using the Phi-Mixing Coefficient, and Applications to Lung and Breast Cancer","publication_year":2018,"publication_date":"2018-09-01","ids":{"openalex":"https://openalex.org/W2966172427","doi":"https://doi.org/10.1109/tmbmc.2019.2933391","mag":"2966172427","pmid":"https://pubmed.ncbi.nlm.nih.gov/33313341"},"language":"en","primary_location":{"id":"doi:10.1109/tmbmc.2019.2933391","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmbmc.2019.2933391","pdf_url":null,"source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological and Multi-Scale Communications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7731978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004469409","display_name":"Nitin K. Singh","orcid":"https://orcid.org/0000-0001-5344-1190"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I87573096","display_name":"University of North Texas at Dallas","ror":"https://ror.org/01n51v443","country_code":"US","type":"education","lineage":["https://openalex.org/I87573096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Singh","raw_affiliation_strings":["Department the Department of Bioengineering at the University of Texas at Dallas","Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department the Department of Bioengineering at the University of Texas at Dallas","institution_ids":["https://openalex.org/I87573096","https://openalex.org/I162577319"]},{"raw_affiliation_string":"Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030913634","display_name":"Mehmet Eren Ahsen","orcid":"https://orcid.org/0000-0002-4907-0427"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet Eren Ahsen","raw_affiliation_strings":["Gies College of Business, Champaign, IL","Business Administration, Gies College of Business, Champaign, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gies College of Business, Champaign, IL","institution_ids":[]},{"raw_affiliation_string":"Business Administration, Gies College of Business, Champaign, IL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059437865","display_name":"Niharika Challapalli","orcid":null},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niharika Challapalli","raw_affiliation_strings":["Electrical Engineering Department at the University of Texas at Dallas, Richardson, TX","Electrical Engineering Department, University of Texas at Dallas, Richardson, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Department at the University of Texas at Dallas, Richardson, TX","institution_ids":["https://openalex.org/I162577319"]},{"raw_affiliation_string":"Electrical Engineering Department, University of Texas at Dallas, Richardson, TX, USA","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326518","display_name":"Hyunseok Kim","orcid":"https://orcid.org/0000-0002-4907-214X"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Seok Kim","raw_affiliation_strings":["Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea","Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088421747","display_name":"Michael A. White","orcid":"https://orcid.org/0000-0001-6772-1388"},"institutions":[{"id":"https://openalex.org/I4210096815","display_name":"Southwestern Medical Center","ror":"https://ror.org/00t9vx427","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096815"]},{"id":"https://openalex.org/I4388891891","display_name":"Southwestern Medical Center","ror":"https://ror.org/05d80e146","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891891"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. White","raw_affiliation_strings":["Pfizer, La Jolla, CA, on leave from the UT Southwestern Medical Center, Dallas","Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, La Jolla, CA, on leave from the UT Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210096815"]},{"raw_affiliation_string":"Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210096815","https://openalex.org/I4388891891"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089027398","display_name":"M. Vidyasagar","orcid":"https://orcid.org/0000-0003-1057-1942"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I65181880","display_name":"Indian Institute of Technology Hyderabad","ror":"https://ror.org/01j4v3x97","country_code":"IN","type":"education","lineage":["https://openalex.org/I65181880"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Mathukumalli Vidyasagar","raw_affiliation_strings":["Systems Engineering Department at the University of Texas at Dallas, Richardson, TX. He is now with the Indian Institute of Technology, Hyderabad","Electrical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, India"],"raw_orcid":"https://orcid.org/0000-0003-1057-1942","affiliations":[{"raw_affiliation_string":"Systems Engineering Department at the University of Texas at Dallas, Richardson, TX. He is now with the Indian Institute of Technology, Hyderabad","institution_ids":["https://openalex.org/I65181880","https://openalex.org/I162577319"]},{"raw_affiliation_string":"Electrical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, India","institution_ids":["https://openalex.org/I65181880"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2707,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.57711044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"3","first_page":"123","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6291893720626831},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5443986058235168},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5430921316146851},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5405415892601013},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5204575061798096},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5101985931396484},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.496509850025177},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.46843037009239197},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45468899607658386},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4125209152698517},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3470924496650696},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3441508710384369},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3286060094833374},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.10325652360916138},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10129818320274353}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6291893720626831},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5443986058235168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5430921316146851},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5405415892601013},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5204575061798096},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5101985931396484},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.496509850025177},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.46843037009239197},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45468899607658386},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4125209152698517},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3470924496650696},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3441508710384369},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3286060094833374},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.10325652360916138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10129818320274353}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/tmbmc.2019.2933391","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmbmc.2019.2933391","pdf_url":null,"source":{"id":"https://openalex.org/S2490853239","display_name":"IEEE Transactions on Molecular Biological and Multi-Scale Communications","issn_l":"2332-7804","issn":["2332-7804","2372-2061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Molecular, Biological and Multi-Scale Communications","raw_type":"journal-article"},{"id":"pmid:33313341","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33313341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on molecular, biological, and multi-scale communications","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7731978","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7731978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Mol Biol Multiscale Commun","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7731978","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7731978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Trans Mol Biol Multiscale Commun","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1033701244","display_name":"Optimal Biomarkers for Personalized Cancer Therapy: A Network-Based Approach","funder_award_id":"RP140517","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G1074039261","display_name":null,"funder_award_id":"I-1414","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G2166602338","display_name":null,"funder_award_id":"1306630","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G3077828257","display_name":null,"funder_award_id":"ECCS-1300660","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3906073295","display_name":null,"funder_award_id":"U01 CA176284","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4191296743","display_name":null,"funder_award_id":"R35 CA197717","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G717078306","display_name":null,"funder_award_id":"RP110595","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1482196458","https://openalex.org/W1511986666","https://openalex.org/W1563736811","https://openalex.org/W1583825963","https://openalex.org/W1979594866","https://openalex.org/W1980362252","https://openalex.org/W1995945562","https://openalex.org/W2008620264","https://openalex.org/W2018518196","https://openalex.org/W2037544231","https://openalex.org/W2044525257","https://openalex.org/W2054416990","https://openalex.org/W2076513103","https://openalex.org/W2078149659","https://openalex.org/W2081172240","https://openalex.org/W2086426115","https://openalex.org/W2095475448","https://openalex.org/W2097413644","https://openalex.org/W2112947018","https://openalex.org/W2120190778","https://openalex.org/W2125631472","https://openalex.org/W2128562611","https://openalex.org/W2136479434","https://openalex.org/W2140911775","https://openalex.org/W2143310531","https://openalex.org/W2143996748","https://openalex.org/W2145557819","https://openalex.org/W2149268774","https://openalex.org/W2154147842","https://openalex.org/W2154454113","https://openalex.org/W2158217645","https://openalex.org/W2161409973","https://openalex.org/W2161511352","https://openalex.org/W2163296115","https://openalex.org/W2327972292","https://openalex.org/W2478708596","https://openalex.org/W2479575276","https://openalex.org/W2611370172","https://openalex.org/W2964335458","https://openalex.org/W3099289621","https://openalex.org/W3125904337","https://openalex.org/W4285719527","https://openalex.org/W6635125930","https://openalex.org/W6670026339","https://openalex.org/W6681130209"],"related_works":["https://openalex.org/W2086525401","https://openalex.org/W2949927938","https://openalex.org/W2029387041","https://openalex.org/W2135896045","https://openalex.org/W1973268559","https://openalex.org/W2117395648","https://openalex.org/W2884256268","https://openalex.org/W2131025197","https://openalex.org/W2031892952","https://openalex.org/W2171763327"],"abstract_inverted_index":{"Constructing":[0],"gene":[1,7,128],"interaction":[2,182],"networks":[3,22,67,83,183],"(GINs)":[4],"from":[5,57,148],"high-throughput":[6],"expression":[8],"data":[9,147],"is":[10,137],"an":[11],"important":[12],"and":[13,27,72,74,93,119,193],"challenging":[14],"problem":[15],"in":[16,129,174],"systems":[17],"biology.":[18],"Existing":[19],"algorithms":[20],"produce":[21],"that":[23,65,121],"either":[24],"have":[25],"undirected":[26],"unweighted":[28],"edges,":[29],"or":[30],"else":[31],"are":[32,41,70,75],"constrained":[33],"to":[34,77,138,152],"contain":[35,78],"no":[36],"cycles,":[37],"both":[38],"of":[39,87,108,111,126,141,157,167,188],"which":[40],"biologically":[42],"unrealistic.":[43],"In":[44],"the":[45,62,106,122,124,130,133,139,175],"present":[46],"paper,":[47],"we":[48,81,104],"propose":[49],"a":[50,55,127,142,149],"new":[51],"algorithm,":[52],"based":[53],"on":[54,114],"concept":[56],"probability":[58],"theory":[59],"known":[60,196],"as":[61,97,99,197],"\u03c6-mixing":[63],"coefficient,":[64],"produces":[66],"whose":[68],"edges":[69],"weighted":[71],"directed,":[73],"permitted":[76],"cycles.":[79],"Specifically,":[80],"inferred":[82,131],"for":[84,164,184],"two":[85,185],"subtypes":[86,187],"lung":[88,101],"cancer":[89],"small":[90],"cell":[91,95,117],"(SCLC)":[92],"non-small":[94],"(NSCLC)":[96],"well":[98],"normal":[100],"tissue.":[102],"Then,":[103],"compared":[105],"outcomes":[107],"siRNA":[109],"screening":[110],"19,000+":[112],"genes":[113],"11":[115],"NSCLC":[116,176],"lines,":[118],"found":[120],"higher":[123],"degree":[125],"network,":[132],"more":[134],"essential":[135],"it":[136],"survival":[140],"cell.":[143],"We":[144,178],"also":[145,179],"analyzed":[146],"ChIP-Seq":[150],"experiment":[151],"determine":[153],"putative":[154],"downstream":[155],"targets":[156],"ASCL1.":[158],"The":[159],"SCLC":[160],"network":[161],"was":[162],"enriched":[163],"ChIP-seq":[165],"neighbors":[166],"this":[168],"oncogenic":[169],"transcription":[170],"factor,":[171],"but":[172],"not":[173],"network.":[177],"reverse-engineered":[180],"whole-genome":[181],"distinct":[186],"breast":[189],"cancer,":[190],"namely":[191],"Luminal-A":[192],"Basal":[194],"(also":[195],"triple":[198],"negative).":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2019-08-13T00:00:00"}