{"id":"https://openalex.org/W2790446188","doi":"https://doi.org/10.1109/tkde.2018.2816029","title":"Identifying Genetic Risk Factors for Alzheimer's Disease via Shared Tree-guided Feature Learning across Multiple Tasks","display_name":"Identifying Genetic Risk Factors for Alzheimer's Disease via Shared Tree-guided Feature Learning across Multiple Tasks","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2790446188","doi":"https://doi.org/10.1109/tkde.2018.2816029","mag":"2790446188"},"language":"en","primary_location":{"id":"doi:10.1109/tkde.2018.2816029","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tkde.2018.2816029","pdf_url":null,"source":{"id":"https://openalex.org/S30698027","display_name":"IEEE Transactions on Knowledge and Data Engineering","issn_l":"1041-4347","issn":["1041-4347","1558-2191","2326-3865"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Knowledge and Data Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100693727","display_name":"Weizhong Zhang","orcid":"https://orcid.org/0000-0001-7311-0698"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weizhong Zhang","raw_affiliation_strings":["State Key Lab of CAD&CG, Zhejiang University, 388 Yuhang Tang Road, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"State Key Lab of CAD&CG, Zhejiang University, 388 Yuhang Tang Road, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074096377","display_name":"Tingjin Luo","orcid":"https://orcid.org/0000-0002-8171-3971"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingjin Luo","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI"],"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103213699","display_name":"Shuang Qiu","orcid":"https://orcid.org/0000-0002-9651-1061"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuang Qiu","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI"],"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010419481","display_name":"Jieping Ye","orcid":"https://orcid.org/0000-0001-8662-5818"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jieping Ye","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI"],"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037942269","display_name":"Deng Cai","orcid":"https://orcid.org/0000-0001-9817-4065"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deng Cai","raw_affiliation_strings":["State Key Lab of CAD&CG, Zhejiang University, 388 Yuhang Tang Road, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"State Key Lab of CAD&CG, Zhejiang University, 388 Yuhang Tang Road, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102013345","display_name":"Xiaofei He","orcid":"https://orcid.org/0009-0001-9107-2354"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei He","raw_affiliation_strings":["State Key Lab of CAD&CG, Zhejiang University, 388 Yuhang Tang Road, Hangzhou, Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"State Key Lab of CAD&CG, Zhejiang University, 388 Yuhang Tang Road, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100440184","display_name":"Jie Wang","orcid":"https://orcid.org/0000-0003-3278-2708"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Wang","raw_affiliation_strings":["Department of Electronic Engineering and Information Science, University of Science and Technology of China, 96 JinZhai Road, Baohe District, Hefei, Anhui, China"],"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering and Information Science, University of Science and Technology of China, 96 JinZhai Road, Baohe District, Hefei, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100693727"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":2.8675,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.9101264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8309541344642639},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6713824272155762},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6537866592407227},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.568723201751709},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.5586656332015991},{"id":"https://openalex.org/keywords/feature-learning","display_name":"Feature learning","score":0.5493443012237549},{"id":"https://openalex.org/keywords/tree-structure","display_name":"Tree structure","score":0.5420220494270325},{"id":"https://openalex.org/keywords/speedup","display_name":"Speedup","score":0.47717157006263733},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.4731111228466034},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.4472004771232605},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3919283449649811},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34848880767822266},{"id":"https://openalex.org/keywords/data-structure","display_name":"Data structure","score":0.20874321460723877}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8309541344642639},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6713824272155762},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6537866592407227},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.568723201751709},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.5586656332015991},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.5493443012237549},{"id":"https://openalex.org/C163797641","wikidata":"https://www.wikidata.org/wiki/Q2067937","display_name":"Tree structure","level":3,"score":0.5420220494270325},{"id":"https://openalex.org/C68339613","wikidata":"https://www.wikidata.org/wiki/Q1549489","display_name":"Speedup","level":2,"score":0.47717157006263733},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4731111228466034},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4472004771232605},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3919283449649811},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34848880767822266},{"id":"https://openalex.org/C162319229","wikidata":"https://www.wikidata.org/wiki/Q175263","display_name":"Data structure","level":2,"score":0.20874321460723877},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/tkde.2018.2816029","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tkde.2018.2816029","pdf_url":null,"source":{"id":"https://openalex.org/S30698027","display_name":"IEEE Transactions on Knowledge and Data Engineering","issn_l":"1041-4347","issn":["1041-4347","1558-2191","2326-3865"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Knowledge and Data Engineering","raw_type":"journal-article"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-103708","is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-103708","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:repository.ust.hk:1783.1-103708","is_oa":false,"landing_page_url":"http://www.scopus.com/record/display.url?eid=2-s2.0-85043762803&origin=inward","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1488505114","https://openalex.org/W1497745584","https://openalex.org/W1595210656","https://openalex.org/W1618978521","https://openalex.org/W1885499468","https://openalex.org/W1979229570","https://openalex.org/W1983534832","https://openalex.org/W1986144956","https://openalex.org/W1986744686","https://openalex.org/W2005935256","https://openalex.org/W2008569137","https://openalex.org/W2017079501","https://openalex.org/W2017581860","https://openalex.org/W2025143098","https://openalex.org/W2036097053","https://openalex.org/W2038003677","https://openalex.org/W2071536472","https://openalex.org/W2097620183","https://openalex.org/W2104048700","https://openalex.org/W2108292688","https://openalex.org/W2109907994","https://openalex.org/W2117078302","https://openalex.org/W2120491838","https://openalex.org/W2127072914","https://openalex.org/W2132484969","https://openalex.org/W2135046866","https://openalex.org/W2139886607","https://openalex.org/W2141459724","https://openalex.org/W2144752499","https://openalex.org/W2154560360","https://openalex.org/W2158830336","https://openalex.org/W2161633633","https://openalex.org/W2165644552","https://openalex.org/W2166348468","https://openalex.org/W2166501262","https://openalex.org/W2188123378","https://openalex.org/W2291446607","https://openalex.org/W2389178838","https://openalex.org/W2405159765","https://openalex.org/W2562162676","https://openalex.org/W2595455544","https://openalex.org/W2740984310","https://openalex.org/W2916408032","https://openalex.org/W4240204556","https://openalex.org/W6629275658","https://openalex.org/W6629935912","https://openalex.org/W6635631671","https://openalex.org/W6636669962","https://openalex.org/W6639180537","https://openalex.org/W6674848032","https://openalex.org/W6676181923","https://openalex.org/W6681414149","https://openalex.org/W6684671274","https://openalex.org/W6687205678","https://openalex.org/W6713619996","https://openalex.org/W6759535392"],"related_works":["https://openalex.org/W2058965144","https://openalex.org/W2164382479","https://openalex.org/W2146343568","https://openalex.org/W98480971","https://openalex.org/W2150291671","https://openalex.org/W2013643406","https://openalex.org/W2027972911","https://openalex.org/W2157978810","https://openalex.org/W2597809628","https://openalex.org/W3046370962"],"abstract_inverted_index":{"The":[0],"genome-wide":[1],"association":[2],"study":[3],"(GWAS)":[4],"is":[5],"a":[6,46,151],"popular":[7],"approach":[8,172],"to":[9,89,115,122,156],"identify":[10,38,158],"disease-associated":[11],"genetic":[12,39,179],"factors":[13,41,181],"for":[14,42],"Alzhemer's":[15],"Disease":[16],"(AD).":[17],"However,":[18,120],"it":[19],"remains":[20],"challenging":[21],"because":[22],"of":[23,27,54,96,107,182,196],"the":[24,55,59,62,73,81,91,105,109,117,123,129,133,138,161,170,175,185,189],"small":[25],"number":[26],"samples,":[28],"very":[29],"high":[30,135],"feature":[31,86,136],"dimensionality":[32],"and":[33,61,71,113,132,159,184],"complex":[34,125],"structures.":[35],"To":[36,145],"accurately":[37],"risk":[40,180],"AD,":[43],"we":[44,68,79,102,148],"propose":[45],"novel":[47,152],"method":[48],"based":[49],"on":[50],"an":[51],"in-depth":[52],"exploration":[53],"hierarchical":[56],"structure":[57,111,131],"among":[58,76],"features":[60,163],"commonality":[63],"across":[64],"related":[65,98],"tasks.":[66],"Specifically,":[67],"first":[69],"extract":[70],"encode":[72],"tree":[74,82,130],"hierarchy":[75],"features;":[77],"then,":[78],"integrate":[80],"structures":[83],"with":[84],"multi-task":[85],"learning":[87,139],"(MTFL)":[88],"learn":[90],"shared":[92],"features-that":[93],"are":[94],"predictive":[95],"AD-among":[97],"tasks":[99],"simultaneously.":[100],"Thus,":[101],"can":[103,141,192],"unify":[104],"strength":[106],"both":[108],"prior":[110],"information":[112],"MTFL":[114],"boost":[116],"prediction":[118],"performance.":[119],"due":[121],"highly":[124],"regularizer":[126],"that":[127,169],"encodes":[128],"extremely":[134],"dimensionality,":[137],"process":[140],"be":[142,193],"computationally":[143],"prohibitive.":[144],"address":[146],"this,":[147],"further":[149],"develop":[150],"safe":[153],"screening":[154,191],"rule":[155],"quickly":[157],"remove":[160],"irrelevant":[162],"before":[164],"training.":[165],"Experiment":[166],"results":[167],"demonstrate":[168],"proposed":[171,190],"significantly":[173],"outperforms":[174],"state-of-the-art":[176],"in":[177],"detecting":[178],"AD":[183],"speedup":[186],"gained":[187],"by":[188],"several":[194],"orders":[195],"magnitude.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}