{"id":"https://openalex.org/W2164515781","doi":"https://doi.org/10.1109/titb.2011.2130531","title":"Investigating the Minimum Required Number of Genes for the Classification of Neuromuscular Disease Microarray Data","display_name":"Investigating the Minimum Required Number of Genes for the Classification of Neuromuscular Disease Microarray Data","publication_year":2011,"publication_date":"2011-03-22","ids":{"openalex":"https://openalex.org/W2164515781","doi":"https://doi.org/10.1109/titb.2011.2130531","mag":"2164515781","pmid":"https://pubmed.ncbi.nlm.nih.gov/21427026"},"language":"en","primary_location":{"id":"doi:10.1109/titb.2011.2130531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/titb.2011.2130531","pdf_url":null,"source":{"id":"https://openalex.org/S68937846","display_name":"IEEE Transactions on Information Technology in Biomedicine","issn_l":"1089-7771","issn":["1089-7771","1558-0032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Technology in Biomedicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034830997","display_name":"\u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u03a3\u03b1\u03ba\u03b5\u03bb\u03bb\u03b1\u03c1\u03af\u03bf\u03c5","orcid":"https://orcid.org/0000-0002-5427-933X"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I206127235","display_name":"Academy of Athens","ror":"https://ror.org/00qsdn986","country_code":"GR","type":"education","lineage":["https://openalex.org/I206127235"]},{"id":"https://openalex.org/I4210093138","display_name":"Biomedical Research Foundation of the Academy of Athens","ror":"https://ror.org/00gban551","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210093138"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"A Sakellariou","raw_affiliation_strings":["Biomedical Research Foundation, Academy of Athens, and the Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, Athens 115 27, Greece. asake@bioacademy.gr","Biomedical Research Foundation, Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, Athens, Greece"],"affiliations":[{"raw_affiliation_string":"Biomedical Research Foundation, Academy of Athens, and the Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, Athens 115 27, Greece. asake@bioacademy.gr","institution_ids":["https://openalex.org/I206127235"]},{"raw_affiliation_string":"Biomedical Research Foundation, Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I4210093138","https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039759348","display_name":"Despina Sanoudou","orcid":"https://orcid.org/0000-0003-3704-1941"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D Sanoudou","raw_affiliation_strings":["Pharmacology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece"],"affiliations":[{"raw_affiliation_string":"Pharmacology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058322678","display_name":"George M. Spyrou","orcid":"https://orcid.org/0000-0002-2470-3363"},"institutions":[{"id":"https://openalex.org/I206127235","display_name":"Academy of Athens","ror":"https://ror.org/00qsdn986","country_code":"GR","type":"education","lineage":["https://openalex.org/I206127235"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G Spyrou","raw_affiliation_strings":["Biomedical Research Foundation, Academy of Athens, Athens, Greece"],"affiliations":[{"raw_affiliation_string":"Biomedical Research Foundation, Academy of Athens, Athens, Greece","institution_ids":["https://openalex.org/I206127235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034830997"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I206127235","https://openalex.org/I4210093138"],"apc_list":null,"apc_paid":null,"fwci":0.2606,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59032444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"3","first_page":"349","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.6893223524093628},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5966566801071167},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5903922319412231},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5219730138778687},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.4710911214351654},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.46810293197631836},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.46666377782821655},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.43734025955200195},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3916865587234497},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38024911284446716},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3759147524833679},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35428908467292786},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34750404953956604},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32605305314064026},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.31308600306510925},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3128401041030884},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1761203110218048},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13572287559509277},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09317886829376221},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.07824826240539551}],"concepts":[{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.6893223524093628},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5966566801071167},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5903922319412231},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5219730138778687},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4710911214351654},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.46810293197631836},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.46666377782821655},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43734025955200195},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3916865587234497},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38024911284446716},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3759147524833679},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35428908467292786},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34750404953956604},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32605305314064026},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31308600306510925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3128401041030884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1761203110218048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13572287559509277},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09317886829376221},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07824826240539551},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009468","descriptor_name":"Neuromuscular Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009468","descriptor_name":"Neuromuscular Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009468","descriptor_name":"Neuromuscular Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009468","descriptor_name":"Neuromuscular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009468","descriptor_name":"Neuromuscular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009468","descriptor_name":"Neuromuscular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/titb.2011.2130531","is_oa":false,"landing_page_url":"https://doi.org/10.1109/titb.2011.2130531","pdf_url":null,"source":{"id":"https://openalex.org/S68937846","display_name":"IEEE Transactions on Information Technology in Biomedicine","issn_l":"1089-7771","issn":["1089-7771","1558-0032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Technology in Biomedicine","raw_type":"journal-article"},{"id":"pmid:21427026","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21427026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.75,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1509612648","https://openalex.org/W1524141331","https://openalex.org/W1912123407","https://openalex.org/W1999370812","https://openalex.org/W2013444425","https://openalex.org/W2021129827","https://openalex.org/W2035421116","https://openalex.org/W2072184218","https://openalex.org/W2072328028","https://openalex.org/W2081098333","https://openalex.org/W2107598685","https://openalex.org/W2118782378","https://openalex.org/W2119387367","https://openalex.org/W2120824812","https://openalex.org/W2128985829","https://openalex.org/W2133990480","https://openalex.org/W2143840439","https://openalex.org/W2145126338","https://openalex.org/W2147169507","https://openalex.org/W2149697028","https://openalex.org/W2157795344","https://openalex.org/W2158698691","https://openalex.org/W2164893149","https://openalex.org/W2181762526","https://openalex.org/W2911964244","https://openalex.org/W3120421331","https://openalex.org/W4244238212","https://openalex.org/W4294107304","https://openalex.org/W6640114639"],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2015700328","https://openalex.org/W2364565895","https://openalex.org/W2767847608","https://openalex.org/W2911678823","https://openalex.org/W2152648570","https://openalex.org/W2037892364","https://openalex.org/W2319154570","https://openalex.org/W3152114242","https://openalex.org/W3028764459"],"abstract_inverted_index":{"The":[0,138],"discovery":[1],"of":[2,24,36,63,83,91,111,115,136,145],"potential":[3],"microarray":[4,38],"markers,":[5],"which":[6,30,65,117],"will":[7],"expedite":[8,142],"molecular":[9],"diagnosis/prognosis":[10],"and":[11,18,88,164],"provide":[12],"reliable":[13],"results":[14,129],"to":[15],"clinical":[16],"decision-making":[17],"treatment":[19],"selection":[20,28,86,96],"for":[21,161],"patients,":[22],"is":[23],"paramount":[25],"importance.":[26],"Feature":[27],"techniques,":[29],"aim":[31],"at":[32],"minimizing":[33],"the":[34,37,42,59,81,143,158],"dimensionality":[35],"data":[39,92],"by":[40],"keeping":[41],"most":[43],"statistically":[44],"significant":[45],"genes,":[46,64,116],"are":[47],"a":[48,76],"powerful":[49],"approach":[50],"toward":[51],"this":[52,55,72],"goal.":[53],"In":[54],"paper,":[56],"we":[57,74,124],"investigate":[58],"minimum":[60],"required":[61],"subsets":[62,110,135,148],"best":[66],"classify":[67,120],"neuromuscular":[68,103],"disease":[69],"data.":[70],"For":[71],"purpose,":[73],"implemented":[75],"methodology":[77,140],"pipeline":[78],"that":[79,126,152],"facilitated":[80],"use":[82],"multiple":[84],"feature":[85,95],"methods":[87,97],"subsequent":[89],"performance":[90],"classification.":[93],"Five":[94],"on":[98],"datasets":[99],"from":[100,133],"ten":[101],"different":[102,134],"diseases":[104],"were":[105],"utilized.":[106],"Our":[107],"findings":[108],"reveal":[109],"very":[112],"small":[113,146],"number":[114],"can":[118,141],"successfully":[119],"normal/disease":[121],"samples.":[122],"Interestingly,":[123],"observe":[125],"similar":[127],"classification":[128],"may":[130],"be":[131,155],"obtained":[132],"genes.":[137],"proposed":[139],"identification":[144],"gene":[147],"with":[149],"high-classification":[150],"accuracy":[151],"could":[153],"ultimately":[154],"used":[156],"in":[157],"genetics":[159],"clinics":[160],"diagnostic,":[162],"prognostic,":[163],"pharmacogenomic":[165],"purposes.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}