{"id":"https://openalex.org/W2149948323","doi":"https://doi.org/10.1109/titb.2011.2116797","title":"Development of Red Blood Cell\u2013Photon Simulator for Optical Propagation Analysis in Blood using Monte Carlo Method","display_name":"Development of Red Blood Cell\u2013Photon Simulator for Optical Propagation Analysis in Blood using Monte Carlo Method","publication_year":2011,"publication_date":"2011-02-22","ids":{"openalex":"https://openalex.org/W2149948323","doi":"https://doi.org/10.1109/titb.2011.2116797","mag":"2149948323","pmid":"https://pubmed.ncbi.nlm.nih.gov/21342854"},"language":"en","primary_location":{"id":"doi:10.1109/titb.2011.2116797","is_oa":false,"landing_page_url":"https://doi.org/10.1109/titb.2011.2116797","pdf_url":null,"source":{"id":"https://openalex.org/S68937846","display_name":"IEEE Transactions on Information Technology in Biomedicine","issn_l":"1089-7771","issn":["1089-7771","1558-0032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Technology in Biomedicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112927777","display_name":"Shiori Oshima","orcid":null},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Oshima","raw_affiliation_strings":["Cybernics Laboratory, System and Information Engineering, University of Tsukuba, Ibaraki 305-8573, Japan. oshima@golem.kz.tsukuba.ac.jp","Cybernics Laboratory, System and Information Engineering, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernics Laboratory, System and Information Engineering, University of Tsukuba, Ibaraki 305-8573, Japan. oshima@golem.kz.tsukuba.ac.jp","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Cybernics Laboratory, System and Information Engineering, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039658736","display_name":"Yoshiyuki Sankai","orcid":"https://orcid.org/0000-0002-6345-1541"},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Sankai","raw_affiliation_strings":["Cybernics Laboratory, System and Information Engineering, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernics Laboratory, System and Information Engineering, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":null,"apc_paid":null,"fwci":0.5241,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71441197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"3","first_page":"356","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.7584317922592163},{"id":"https://openalex.org/keywords/hematocrit","display_name":"Hematocrit","score":0.5723953247070312},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.550815224647522},{"id":"https://openalex.org/keywords/red-blood-cell","display_name":"Red blood cell","score":0.4793061316013336},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33655333518981934},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17107173800468445},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.14250332117080688},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1217305064201355},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11085978150367737}],"concepts":[{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.7584317922592163},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5723953247070312},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.550815224647522},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.4793061316013336},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33655333518981934},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17107173800468445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14250332117080688},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1217305064201355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11085978150367737},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004903","descriptor_name":"Erythrocyte Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004903","descriptor_name":"Erythrocyte Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004903","descriptor_name":"Erythrocyte Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/titb.2011.2116797","is_oa":false,"landing_page_url":"https://doi.org/10.1109/titb.2011.2116797","pdf_url":null,"source":{"id":"https://openalex.org/S68937846","display_name":"IEEE Transactions on Information Technology in Biomedicine","issn_l":"1089-7771","issn":["1089-7771","1558-0032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Technology in Biomedicine","raw_type":"journal-article"},{"id":"pmid:21342854","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21342854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W92664137","https://openalex.org/W1973887650","https://openalex.org/W1997276919","https://openalex.org/W1999182952","https://openalex.org/W2011550515","https://openalex.org/W2013492930","https://openalex.org/W2014240639","https://openalex.org/W2021837301","https://openalex.org/W2026593736","https://openalex.org/W2029141895","https://openalex.org/W2034180226","https://openalex.org/W2056512002","https://openalex.org/W2074948889","https://openalex.org/W2090382325","https://openalex.org/W2095595785","https://openalex.org/W2106991982","https://openalex.org/W2121493978","https://openalex.org/W2150628260","https://openalex.org/W2156474828","https://openalex.org/W2162102056","https://openalex.org/W2169523701","https://openalex.org/W2332223821","https://openalex.org/W6603822254"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W297056630","https://openalex.org/W2994410525","https://openalex.org/W2054060818","https://openalex.org/W84640643","https://openalex.org/W2395601063","https://openalex.org/W1634909898","https://openalex.org/W2211344098","https://openalex.org/W2036165889","https://openalex.org/W3126276609"],"abstract_inverted_index":{"We":[0,148],"have":[1,113],"developed":[2],"a":[3],"\"red":[4],"blood":[5,15,32,139,163,189],"cell":[6],"(RBC)-photon":[7],"simulator\"":[8],"to":[9,37,55,70,92,144,170],"reveal":[10],"optical":[11,27,118,185],"propagation":[12,28,119,186],"in":[13,29,44,124,132,133],"prethrombus":[14,31,188,195],"for":[16,41,187,193],"various":[17,106],"levels":[18,107],"of":[19,59,78,86,108,120],"RBC":[20,109,150,158],"density":[21,110,151],"and":[22,33,84,111,157,190],"aggregation.":[23],"The":[24,126,166],"simulator":[25,80,172,181],"investigates":[26],"the":[30,57,64,94,101,117,146,153,171,183,194],"will":[34],"be":[35,89],"applied":[36,69],"detect":[38],"it":[39],"noninvasively":[40],"thrombosis":[42],"prevention":[43],"an":[45],"earlier":[46],"stage.":[47],"In":[48],"our":[49,79,180],"simulator,":[50,102],"Lambert-Beer's":[51],"law":[52],"is":[53,68,81,191],"employed":[54],"simulate":[56,71],"absorption":[58],"RBCs":[60,87],"with":[61,136],"hemoglobin,":[62],"while":[63,96],"Monte":[65],"Carlo":[66],"method":[67],"scattering":[72],"through":[73],"iterative":[74],"calculations.":[75],"One":[76],"advantage":[77],"that":[82,105,179],"concentrations":[83],"distributions":[85],"can":[88],"arbitrarily":[90],"chosen":[91],"exhibit":[93],"prethrombus,":[95],"conventional":[97],"models":[98],"cannot.":[99],"Using":[100],"we":[103,176],"found":[104],"aggregation":[112,159],"different":[114,128],"effects":[115,129],"on":[116],"near-infrared":[121],"response":[122],"light":[123],"blood.":[125],"same":[127],"were":[130,142],"acquired":[131],"vitro":[134],"experiments":[135],"12":[137],"bovine":[138],"samples,":[140],"which":[141],"performed":[143],"evaluate":[145],"simulator.":[147],"measured":[149],"using":[152,160,197],"clinical":[154],"hematocrit":[155],"index":[156],"activated":[161],"whole":[162],"clotting":[164],"time.":[165],"experimental":[167],"results":[168,173],"correspond":[169],"well.":[174],"Therefore,":[175],"could":[177],"show":[178],"exhibits":[182],"correct":[184],"applicable":[192],"detection":[196],"multiple":[198],"detectors.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}