{"id":"https://openalex.org/W2132150166","doi":"https://doi.org/10.1109/titb.2010.2072964","title":"Complementary Gene Signature Integration in Multiplatform Microarray Experiments","display_name":"Complementary Gene Signature Integration in Multiplatform Microarray Experiments","publication_year":2010,"publication_date":"2010-09-07","ids":{"openalex":"https://openalex.org/W2132150166","doi":"https://doi.org/10.1109/titb.2010.2072964","mag":"2132150166","pmid":"https://pubmed.ncbi.nlm.nih.gov/20813648"},"language":"en","primary_location":{"id":"doi:10.1109/titb.2010.2072964","is_oa":false,"landing_page_url":"https://doi.org/10.1109/titb.2010.2072964","pdf_url":null,"source":{"id":"https://openalex.org/S68937846","display_name":"IEEE Transactions on Information Technology in Biomedicine","issn_l":"1089-7771","issn":["1089-7771","1558-0032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Technology in Biomedicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081022123","display_name":"Michalis E. Blazadonakis","orcid":null},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I55741626","display_name":"Technical University of Crete","ror":"https://ror.org/03f8bz564","country_code":"GR","type":"education","lineage":["https://openalex.org/I55741626"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M E Blazadonakis","raw_affiliation_strings":["Department of Electronic and Computer Engineering, Technical University of Crete, Chania 73100, Greece. mblazad@gmail.com","Dept. of Electron. & Comput. Eng., Tech. Univ. of Crete, Chania, Greece#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic and Computer Engineering, Technical University of Crete, Chania 73100, Greece. mblazad@gmail.com","institution_ids":["https://openalex.org/I55741626"]},{"raw_affiliation_string":"Dept. of Electron. & Comput. Eng., Tech. Univ. of Crete, Chania, Greece#TAB#","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031391584","display_name":"Michalis Zervakis","orcid":"https://orcid.org/0000-0002-0705-631X"},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I55741626","display_name":"Technical University of Crete","ror":"https://ror.org/03f8bz564","country_code":"GR","type":"education","lineage":["https://openalex.org/I55741626"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M E Zervakis","raw_affiliation_strings":["Department of Electronic and Computer Engineering, Technical University of Crete, Chania, Greece","Dept. of Electron. & Comput. Eng., Tech. Univ. of Crete, Chania, Greece#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic and Computer Engineering, Technical University of Crete, Chania, Greece","institution_ids":["https://openalex.org/I55741626"]},{"raw_affiliation_string":"Dept. of Electron. & Comput. Eng., Tech. Univ. of Crete, Chania, Greece#TAB#","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024607981","display_name":"Dimitrios Kafetzopoulos","orcid":"https://orcid.org/0000-0002-0081-9409"},"institutions":[{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D Kafetzopoulos","raw_affiliation_strings":["Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece","Inst. of Mol. Biol. & Biotechnol., Found. for Res. & Technol.-Hellas, Heraklion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]},{"raw_affiliation_string":"Inst. of Mol. Biol. & Biotechnol., Found. for Res. & Technol.-Hellas, Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.537,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66730517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"155","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.7650861740112305},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6801823377609253},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6587434411048889},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5492222905158997},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.42648231983184814},{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.41446760296821594},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.35611510276794434},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3439309000968933},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3400760293006897},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.330846905708313},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32682764530181885},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2970621585845947},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2272961139678955},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18304350972175598},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10300305485725403},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10268965363502502}],"concepts":[{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.7650861740112305},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6801823377609253},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6587434411048889},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5492222905158997},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.42648231983184814},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.41446760296821594},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.35611510276794434},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3439309000968933},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3400760293006897},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.330846905708313},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32682764530181885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2970621585845947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2272961139678955},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18304350972175598},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10300305485725403},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10268965363502502},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/titb.2010.2072964","is_oa":false,"landing_page_url":"https://doi.org/10.1109/titb.2010.2072964","pdf_url":null,"source":{"id":"https://openalex.org/S68937846","display_name":"IEEE Transactions on Information Technology in Biomedicine","issn_l":"1089-7771","issn":["1089-7771","1558-0032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Technology in Biomedicine","raw_type":"journal-article"},{"id":"pmid:20813648","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20813648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W196157878","https://openalex.org/W1262485082","https://openalex.org/W1492893697","https://openalex.org/W1562190372","https://openalex.org/W1971278063","https://openalex.org/W1995880999","https://openalex.org/W2027622187","https://openalex.org/W2044758663","https://openalex.org/W2109363337","https://openalex.org/W2118413367","https://openalex.org/W2128985829","https://openalex.org/W2149154376","https://openalex.org/W2157132621","https://openalex.org/W2160450758","https://openalex.org/W2163563958","https://openalex.org/W2165776880","https://openalex.org/W2420137744"],"related_works":["https://openalex.org/W1671124163","https://openalex.org/W2168674042","https://openalex.org/W2770593030","https://openalex.org/W3154990682","https://openalex.org/W4281727072","https://openalex.org/W2560201613","https://openalex.org/W2535275505","https://openalex.org/W2171975302","https://openalex.org/W3030774134","https://openalex.org/W2022352247"],"abstract_inverted_index":{"The":[0],"concept":[1],"of":[2,13,22,39,76,114,128,149],"gene":[3,44],"signature":[4,104],"overlap":[5],"has":[6],"been":[7],"addressed":[8],"previously":[9],"in":[10,112,133,138],"a":[11,53,74,102,134,139,147,153],"number":[12],"research":[14],"papers.":[15],"A":[16],"common":[17],"conclusion":[18],"is":[19,106,123,144],"the":[20,30,37,43,48,62,85,126],"absence":[21],"significant":[23],"overlap.":[24],"In":[25,87],"this":[26,88,121],"paper,":[27],"we":[28,34,100],"verify":[29],"aforementioned":[31],"fact,":[32],"but":[33,46,136],"also":[35],"assess":[36,125],"issue":[38],"similarities":[40],"not":[41,132],"on":[42,47,84],"level,":[45],"biology":[49],"level":[50],"hidden":[51],"underneath":[52],"given":[54],"signature.":[55],"We":[56],"proceed":[57],"by":[58,90],"taking":[59],"into":[60],"account":[61],"biological":[63,92],"knowledge":[64,93,150],"that":[65,105],"exists":[66],"among":[67],"different":[68,130],"signatures,":[69],"and":[70,79,116,155],"use":[71],"it":[72],"as":[73,146],"means":[75],"integrating":[77,91],"them":[78],"refining":[80],"their":[81],"statistical":[82],"significance":[83],"datasets.":[86],"form,":[89],"with":[94],"information":[95],"stemming":[96],"from":[97],"data":[98],"distributions,":[99],"derive":[101],"unified":[103,156],"significantly":[107],"improved":[108],"over":[109],"its":[110],"predecessors":[111],"terms":[113],"performance":[115],"robustness.":[117],"Our":[118],"motive":[119],"behind":[120],"approach":[122],"to":[124,152],"problem":[127],"evaluating":[129],"signatures":[131],"competitive":[135],"rather":[137],"complementary":[140],"manner,":[141],"where":[142],"one":[143],"treated":[145],"pool":[148],"contributing":[151],"global":[154],"solution.":[157]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}