{"id":"https://openalex.org/W2511512977","doi":"https://doi.org/10.1109/tit.2016.2599178","title":"Capacity of a Simple Intercellular Signal Transduction Channel","display_name":"Capacity of a Simple Intercellular Signal Transduction Channel","publication_year":2016,"publication_date":"2016-08-10","ids":{"openalex":"https://openalex.org/W2511512977","doi":"https://doi.org/10.1109/tit.2016.2599178","mag":"2511512977"},"language":"en","primary_location":{"id":"doi:10.1109/tit.2016.2599178","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tit.2016.2599178","pdf_url":null,"source":{"id":"https://openalex.org/S4502562","display_name":"IEEE Transactions on Information Theory","issn_l":"0018-9448","issn":["0018-9448","1557-9654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Theory","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1305.2245","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083157573","display_name":"Peter J. Thomas","orcid":"https://orcid.org/0000-0001-7533-6770"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J. Thomas","raw_affiliation_strings":["Department of Mathematics, Applied Mathematics, and Statistics, the Department of Biology, the Department of Cognitive Science, and the Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Applied Mathematics, and Statistics, the Department of Biology, the Department of Cognitive Science, and the Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046532019","display_name":"Andrew W. Eckford","orcid":"https://orcid.org/0000-0002-9808-1229"},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew W. Eckford","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada","institution_ids":["https://openalex.org/I192455969"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083157573"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":4.3832,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.94608769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"62","issue":"12","first_page":"7358","last_page":"7382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.720930814743042},{"id":"https://openalex.org/keywords/channel-capacity","display_name":"Channel capacity","score":0.6609945297241211},{"id":"https://openalex.org/keywords/independent-and-identically-distributed-random-variables","display_name":"Independent and identically distributed random variables","score":0.6018929481506348},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.49202463030815125},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.4710502624511719},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4528743028640747},{"id":"https://openalex.org/keywords/limit","display_name":"Limit (mathematics)","score":0.4438720941543579},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4152677059173584},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4116889238357544},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.3428349494934082},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.22967100143432617},{"id":"https://openalex.org/keywords/random-variable","display_name":"Random variable","score":0.16964489221572876},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1065981388092041},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.10012492537498474},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.09439262747764587}],"concepts":[{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.720930814743042},{"id":"https://openalex.org/C97744766","wikidata":"https://www.wikidata.org/wiki/Q870845","display_name":"Channel capacity","level":3,"score":0.6609945297241211},{"id":"https://openalex.org/C141513077","wikidata":"https://www.wikidata.org/wiki/Q378542","display_name":"Independent and identically distributed random variables","level":3,"score":0.6018929481506348},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.49202463030815125},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.4710502624511719},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4528743028640747},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.4438720941543579},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4152677059173584},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4116889238357544},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3428349494934082},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.22967100143432617},{"id":"https://openalex.org/C122123141","wikidata":"https://www.wikidata.org/wiki/Q176623","display_name":"Random variable","level":2,"score":0.16964489221572876},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1065981388092041},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.10012492537498474},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.09439262747764587},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/tit.2016.2599178","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tit.2016.2599178","pdf_url":null,"source":{"id":"https://openalex.org/S4502562","display_name":"IEEE Transactions on Information Theory","issn_l":"0018-9448","issn":["0018-9448","1557-9654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Information Theory","raw_type":"journal-article"},{"id":"pmh:oai:arXiv.org:1305.2245","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1305.2245","pdf_url":"https://arxiv.org/pdf/1305.2245","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.762.8295","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.762.8295","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://arxiv.org/pdf/1411.1650.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1305.2245","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1305.2245","pdf_url":"https://arxiv.org/pdf/1305.2245","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G28797605","display_name":null,"funder_award_id":"EF-1038677","funder_id":"https://openalex.org/F4320332167","funder_display_name":"Directorate for Biological Sciences"},{"id":"https://openalex.org/G583627467","display_name":null,"funder_award_id":"DMS-1413770","funder_id":"https://openalex.org/F4320332167","funder_display_name":"Directorate for Biological Sciences"},{"id":"https://openalex.org/G8607284145","display_name":null,"funder_award_id":"DMS-0720142","funder_id":"https://openalex.org/F4320332167","funder_display_name":"Directorate for Biological Sciences"},{"id":"https://openalex.org/G910356003","display_name":null,"funder_award_id":"259837","funder_id":"https://openalex.org/F4320306164","funder_display_name":"Simons Foundation"}],"funders":[{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320307842","display_name":"Council for International Exchange of Scholars","ror":"https://ror.org/05etjgx39"},{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W20397492","https://openalex.org/W81409850","https://openalex.org/W172803389","https://openalex.org/W206086817","https://openalex.org/W1483773410","https://openalex.org/W1560696154","https://openalex.org/W1577527822","https://openalex.org/W1592379908","https://openalex.org/W1608472120","https://openalex.org/W1965522838","https://openalex.org/W1967431161","https://openalex.org/W1968363642","https://openalex.org/W1971984407","https://openalex.org/W1973151289","https://openalex.org/W1975173993","https://openalex.org/W1980069022","https://openalex.org/W1989008275","https://openalex.org/W1990992471","https://openalex.org/W1995468345","https://openalex.org/W1996185141","https://openalex.org/W2001183673","https://openalex.org/W2001932342","https://openalex.org/W2002512051","https://openalex.org/W2008911022","https://openalex.org/W2020564163","https://openalex.org/W2021058886","https://openalex.org/W2024098183","https://openalex.org/W2024184910","https://openalex.org/W2027657888","https://openalex.org/W2034801578","https://openalex.org/W2038364742","https://openalex.org/W2041238782","https://openalex.org/W2049647155","https://openalex.org/W2050991126","https://openalex.org/W2055696143","https://openalex.org/W2056145172","https://openalex.org/W2057068800","https://openalex.org/W2060049742","https://openalex.org/W2064994654","https://openalex.org/W2065190161","https://openalex.org/W2074882928","https://openalex.org/W2086501021","https://openalex.org/W2088903986","https://openalex.org/W2090209167","https://openalex.org/W2091684412","https://openalex.org/W2093842873","https://openalex.org/W2099926568","https://openalex.org/W2106695208","https://openalex.org/W2111604404","https://openalex.org/W2111622704","https://openalex.org/W2115161063","https://openalex.org/W2117509237","https://openalex.org/W2118917401","https://openalex.org/W2122741244","https://openalex.org/W2122844515","https://openalex.org/W2125852686","https://openalex.org/W2128301658","https://openalex.org/W2128956210","https://openalex.org/W2129885443","https://openalex.org/W2131766020","https://openalex.org/W2136783219","https://openalex.org/W2137813581","https://openalex.org/W2139762024","https://openalex.org/W2139815948","https://openalex.org/W2140911775","https://openalex.org/W2142557392","https://openalex.org/W2142901448","https://openalex.org/W2146052282","https://openalex.org/W2147163807","https://openalex.org/W2147210834","https://openalex.org/W2147610677","https://openalex.org/W2150275923","https://openalex.org/W2152297274","https://openalex.org/W2155418451","https://openalex.org/W2157921009","https://openalex.org/W2163496989","https://openalex.org/W2164019639","https://openalex.org/W2168093113","https://openalex.org/W2168614460","https://openalex.org/W2478708596","https://openalex.org/W2507701479","https://openalex.org/W2571449524","https://openalex.org/W2743922224","https://openalex.org/W2947000318","https://openalex.org/W2953261230","https://openalex.org/W2963122720","https://openalex.org/W3102875255","https://openalex.org/W4210574564","https://openalex.org/W4231270807","https://openalex.org/W4231963165","https://openalex.org/W4233200385","https://openalex.org/W4238203481","https://openalex.org/W4245354300","https://openalex.org/W4255073686","https://openalex.org/W4256577106","https://openalex.org/W4285719527","https://openalex.org/W4300187847","https://openalex.org/W6600808343","https://openalex.org/W6603267330","https://openalex.org/W6680284693","https://openalex.org/W6681130209","https://openalex.org/W6683817718","https://openalex.org/W6684743173"],"related_works":["https://openalex.org/W3004218185","https://openalex.org/W4390241083","https://openalex.org/W4245457074","https://openalex.org/W2323735050","https://openalex.org/W2347733609","https://openalex.org/W2912990606","https://openalex.org/W2951342029","https://openalex.org/W1717256175","https://openalex.org/W2335738591","https://openalex.org/W2085971695"],"abstract_inverted_index":{"We":[0,26,50,75],"model":[1],"biochemical":[2],"signal":[3],"transduction,":[4],"based":[5],"on":[6],"a":[7,12],"ligand-receptor":[8],"binding":[9,21],"mechanism,":[10],"as":[11],"discrete-time":[13,82],"finite-state":[14],"Markov":[15],"channel,":[16,35,90],"which":[17],"we":[18,63],"call":[19],"the":[20,31,37,53,70,78,81,85,92],"in":[22,91],"discrete":[23],"time":[24,96],"channel.":[25,74],"show":[27,51,64,76],"how":[28,77],"to":[29],"obtain":[30],"capacity":[32,71,79,86],"of":[33,39,72,80,87,94],"this":[34,73],"for":[36],"case":[38],"binary":[40,42],"output,":[41],"channel":[43,83],"state,":[44],"and":[45,59,98],"arbitrary":[46],"finite":[47],"input":[48,55],"alphabets.":[49],"that":[52,65],"capacity-achieving":[54],"distribution":[56],"is":[57],"identically":[58],"independently":[60],"distributed.":[61],"Furthermore,":[62],"feedback":[66],"does":[67],"not":[68],"increase":[69],"approaches":[84],"Kabanov's":[88],"Poisson":[89],"limit":[93],"short":[95],"steps":[97],"rapid":[99],"ligand":[100],"release.":[101]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
