{"id":"https://openalex.org/W4407831679","doi":"https://doi.org/10.1109/tim.2025.3544294","title":"A Comprehensive Hardware Platform Leveraging Impedimetric nanoMIP Sensors for Fast Evaluation of Trypsin in Artificial Saliva","display_name":"A Comprehensive Hardware Platform Leveraging Impedimetric nanoMIP Sensors for Fast Evaluation of Trypsin in Artificial Saliva","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4407831679","doi":"https://doi.org/10.1109/tim.2025.3544294"},"language":"en","primary_location":{"id":"doi:10.1109/tim.2025.3544294","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tim.2025.3544294","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056178650","display_name":"Antonio Vincenzo Radogna","orcid":"https://orcid.org/0000-0002-7305-5614"},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonio Vincenzo Radogna","raw_affiliation_strings":["Department of Experimental Medicine, University of Salento, Lecce, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7305-5614","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Salento, Lecce, Italy","institution_ids":["https://openalex.org/I142910587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052919817","display_name":"Marco Costa","orcid":"https://orcid.org/0000-0003-3957-846X"},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Costa","raw_affiliation_strings":["Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3957-846X","affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy","institution_ids":["https://openalex.org/I142910587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089800706","display_name":"Sabrina Di Masi","orcid":"https://orcid.org/0000-0001-5206-1997"},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabrina Di Masi","raw_affiliation_strings":["Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5206-1997","affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy","institution_ids":["https://openalex.org/I142910587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050991363","display_name":"Giuseppe Egidio De Benedetto","orcid":"https://orcid.org/0000-0002-0832-5470"},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Egidio De Benedetto","raw_affiliation_strings":["Department of Cultural Heritage, University of Salento, Lecce, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0832-5470","affiliations":[{"raw_affiliation_string":"Department of Cultural Heritage, University of Salento, Lecce, Italy","institution_ids":["https://openalex.org/I142910587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028903966","display_name":"Cosimino Malitesta","orcid":"https://orcid.org/0000-0002-3547-210X"},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cosimino Malitesta","raw_affiliation_strings":["Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3547-210X","affiliations":[{"raw_affiliation_string":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy","institution_ids":["https://openalex.org/I142910587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055199720","display_name":"Giuseppe Grassi","orcid":"https://orcid.org/0000-0002-8876-3760"},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Grassi","raw_affiliation_strings":["Department of Engineering for Innovation, University of Salento, Lecce, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8876-3760","affiliations":[{"raw_affiliation_string":"Department of Engineering for Innovation, University of Salento, Lecce, Italy","institution_ids":["https://openalex.org/I142910587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5056178650"],"corresponding_institution_ids":["https://openalex.org/I142910587"],"apc_list":null,"apc_paid":null,"fwci":0.7114,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67160255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"74","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5731962323188782},{"id":"https://openalex.org/keywords/computer-hardware","display_name":"Computer hardware","score":0.5350770950317383},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.4486958980560303},{"id":"https://openalex.org/keywords/saliva","display_name":"Saliva","score":0.44847604632377625},{"id":"https://openalex.org/keywords/computer-architecture","display_name":"Computer architecture","score":0.32471513748168945},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1642366647720337},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10449212789535522}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5731962323188782},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.5350770950317383},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.4486958980560303},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.44847604632377625},{"id":"https://openalex.org/C118524514","wikidata":"https://www.wikidata.org/wiki/Q173212","display_name":"Computer architecture","level":1,"score":0.32471513748168945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1642366647720337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10449212789535522}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tim.2025.3544294","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tim.2025.3544294","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.5400000214576721,"display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W47327254","https://openalex.org/W1485114642","https://openalex.org/W1553887387","https://openalex.org/W1994796831","https://openalex.org/W2002996015","https://openalex.org/W2030282784","https://openalex.org/W2041476916","https://openalex.org/W2062758108","https://openalex.org/W2081895687","https://openalex.org/W2095513534","https://openalex.org/W2095885304","https://openalex.org/W2106330541","https://openalex.org/W2196682534","https://openalex.org/W2203475219","https://openalex.org/W2478327183","https://openalex.org/W2491348337","https://openalex.org/W2583706707","https://openalex.org/W2736006547","https://openalex.org/W2770910436","https://openalex.org/W2772169959","https://openalex.org/W2802131721","https://openalex.org/W2803126702","https://openalex.org/W2913606481","https://openalex.org/W3110041621","https://openalex.org/W3171127898","https://openalex.org/W3189278858","https://openalex.org/W3208637160","https://openalex.org/W4252463539","https://openalex.org/W4255718196","https://openalex.org/W4285230726","https://openalex.org/W4315754639","https://openalex.org/W4385543906","https://openalex.org/W4389619335","https://openalex.org/W4390381225","https://openalex.org/W6629079164","https://openalex.org/W6633131850","https://openalex.org/W6674678333","https://openalex.org/W6688621951"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3214746088","https://openalex.org/W4388337094","https://openalex.org/W3129847635","https://openalex.org/W3045507769","https://openalex.org/W2539791946","https://openalex.org/W2103600127","https://openalex.org/W1984738739"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,39,136],"is":[2,175,212],"a":[3,31,66,105,122,148,182,232],"leading":[4],"cause":[5],"of":[6,21,73,96,141,147,167,181,228],"death":[7],"worldwide,":[8],"primarily":[9],"due":[10,90],"to":[11,50,69,91,112,134,158,161,178,200,214],"late-stage":[12],"diagnoses":[13],"and":[14,58,86,94,216,220],"limited":[15],"treatment":[16],"options.":[17],"With":[18],"the":[19,51,71,97,142,145,164,179,193,226,229],"aim":[20],"introducing":[22],"new":[23],"screening":[24],"strategies,":[25],"research":[26],"has":[27],"intensified":[28],"around":[29],"trypsin,":[30],"promising":[32],"biomarker":[33],"exhibiting":[34],"altered":[35],"expression":[36],"in":[37,45,83,102,108,131,169,209],"pancreatic":[38,135],"patients.":[40],"Conventional":[41],"trypsin":[42,129,168,196,238],"detection":[43,165,174],"methods":[44],"biofluids":[46],"show":[47],"problems":[48],"related":[49],"need":[52],"for":[53,126,218,236],"trained":[54],"personnel,":[55],"bulky":[56],"instrumentation,":[57],"high":[59],"measurement":[60,88],"time.":[61],"The":[62,138,173,186,223],"latter":[63],"should":[64],"be":[65],"key":[67,139],"feature":[68],"accelerate":[70],"training":[72,219],"robust":[74],"regression":[75],"models":[76],"with":[77,195],"large":[78],"datasets,":[79],"gain":[80],"prompt":[81],"predictions":[82],"clinical":[84],"environments,":[85],"reduce":[87,163],"errors":[89],"intrinsic":[92],"variations":[93],"drift":[95],"sensors.":[98],"Moreover,":[99],"despite":[100],"advancements":[101],"sensing":[103],"technology,":[104,160],"gap":[106],"remains":[107],"deploying":[109],"high-performance":[110],"sensors":[111],"point-of-care":[113],"devices.":[114],"This":[115],"article":[116],"addresses":[117],"these":[118],"issues":[119],"by":[120,191],"presenting":[121],"comprehensive":[123],"hardware":[124],"platform":[125],"fast,":[127],"noninvasive":[128],"evaluation":[130],"saliva":[132,171],"aimed":[133],"screening.":[137],"finding":[140],"work":[143],"regards":[144],"adoption":[146,180],"fast":[149],"electrochemical":[150],"impedance":[151],"spectroscopy":[152],"(EIS)":[153],"time-based":[154],"read-out":[155],"approach,":[156],"applied":[157],"nanoMIP":[159],"drastically":[162],"time":[166],"artificial":[170,210],"samples.":[172],"possible":[176],"thanks":[177],"neural":[183],"network":[184],"(NN).":[185],"root-mean-squared":[187],"error":[188],"(RMSE),":[189],"obtained":[190],"testing":[192],"system":[194,230],"concentrations":[197],"from":[198],"0":[199],"100":[201],"ng<inline-formula":[202],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[203],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">":[204],"<tex-math":[205],"notation=\"LaTeX\">$\\cdot":[206],"$":[207],"</tex-math></inline-formula>mL\u22121":[208],"saliva,":[211],"equal":[213],"5.9":[215],"5.4":[217],"test,":[221],"respectively.":[222],"results":[224],"prove":[225],"efficacy":[227],"as":[231],"portable,":[233],"user-friendly":[234],"device":[235],"rapid":[237],"evaluation.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
