{"id":"https://openalex.org/W4402630620","doi":"https://doi.org/10.1109/tim.2024.3457970","title":"Fiber-Based SPR Sensor for Ultrahigh-Sensitivity Creatinine Sensing Based on Enzymatic Self-Assembly Structure","display_name":"Fiber-Based SPR Sensor for Ultrahigh-Sensitivity Creatinine Sensing Based on Enzymatic Self-Assembly Structure","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4402630620","doi":"https://doi.org/10.1109/tim.2024.3457970"},"language":"en","primary_location":{"id":"doi:10.1109/tim.2024.3457970","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/tim.2024.3457970","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077259153","display_name":"Pengqi Gong","orcid":"https://orcid.org/0000-0001-6258-7693"},"institutions":[{"id":"https://openalex.org/I4391767858","display_name":"State Key Laboratory of Synthetical Automation for Process Industries","ror":"https://ror.org/0380ng272","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengqi Gong","raw_affiliation_strings":["State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0001-6258-7693","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078863586","display_name":"Xuegang Li","orcid":"https://orcid.org/0000-0002-7894-6483"},"institutions":[{"id":"https://openalex.org/I4391767858","display_name":"State Key Laboratory of Synthetical Automation for Process Industries","ror":"https://ror.org/0380ng272","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuegang Li","raw_affiliation_strings":["State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0002-7894-6483","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741734","display_name":"Xue Zhou","orcid":"https://orcid.org/0000-0003-3833-3129"},"institutions":[{"id":"https://openalex.org/I4391767858","display_name":"State Key Laboratory of Synthetical Automation for Process Industries","ror":"https://ror.org/0380ng272","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Zhou","raw_affiliation_strings":["State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0003-3833-3129","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321409","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0002-3812-1866"},"institutions":[{"id":"https://openalex.org/I4391767858","display_name":"State Key Laboratory of Synthetical Automation for Process Industries","ror":"https://ror.org/0380ng272","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0002-3812-1866","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415519","display_name":"Yanan Zhang","orcid":"https://orcid.org/0000-0002-3059-9291"},"institutions":[{"id":"https://openalex.org/I4391767858","display_name":"State Key Laboratory of Synthetical Automation for Process Industries","ror":"https://ror.org/0380ng272","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Zhang","raw_affiliation_strings":["State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0002-3059-9291","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100692194","display_name":"Yong Zhao","orcid":"https://orcid.org/0000-0002-2041-4580"},"institutions":[{"id":"https://openalex.org/I4391767858","display_name":"State Key Laboratory of Synthetical Automation for Process Industries","ror":"https://ror.org/0380ng272","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhao","raw_affiliation_strings":["State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0002-2041-4580","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Synthetical Automation for Process Industries and the College of Information Science and Engineering, Northeastern University, Shenyang, China","institution_ids":["https://openalex.org/I4391767858","https://openalex.org/I9224756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4939,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62077815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"73","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.7000740170478821},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6485889554023743},{"id":"https://openalex.org/keywords/fiber","display_name":"Fiber","score":0.5123802423477173},{"id":"https://openalex.org/keywords/optical-fiber","display_name":"Optical fiber","score":0.44640374183654785},{"id":"https://openalex.org/keywords/fiber-optic-sensor","display_name":"Fiber optic sensor","score":0.4252846837043762},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.3473593592643738},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.26239970326423645},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2594456076622009},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1839638650417328},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.14366701245307922},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.13223621249198914}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.7000740170478821},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6485889554023743},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.5123802423477173},{"id":"https://openalex.org/C194232370","wikidata":"https://www.wikidata.org/wiki/Q162","display_name":"Optical fiber","level":2,"score":0.44640374183654785},{"id":"https://openalex.org/C21651689","wikidata":"https://www.wikidata.org/wiki/Q1397427","display_name":"Fiber optic sensor","level":3,"score":0.4252846837043762},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.3473593592643738},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.26239970326423645},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2594456076622009},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1839638650417328},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.14366701245307922},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.13223621249198914}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tim.2024.3457970","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/tim.2024.3457970","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1703721647","display_name":null,"funder_award_id":"CXZZBS2024182","funder_id":"https://openalex.org/F4320336591","funder_display_name":"Hebei Province Graduate Innovation Funding Project"},{"id":"https://openalex.org/G3653018197","display_name":null,"funder_award_id":"62203090","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4335460446","display_name":null,"funder_award_id":"2023JH2/101600047","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G4687570110","display_name":null,"funder_award_id":"12304355","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6259247475","display_name":null,"funder_award_id":"2022QNRC001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6442155756","display_name":null,"funder_award_id":"62373088","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7148886901","display_name":null,"funder_award_id":"N2204013","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320336591","display_name":"Hebei Province Graduate Innovation Funding Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W932250880","https://openalex.org/W1973001249","https://openalex.org/W2003735193","https://openalex.org/W2047133699","https://openalex.org/W2071616938","https://openalex.org/W2087341884","https://openalex.org/W2088996675","https://openalex.org/W2555127285","https://openalex.org/W2580939229","https://openalex.org/W2582721169","https://openalex.org/W2746472804","https://openalex.org/W2782675889","https://openalex.org/W2789167483","https://openalex.org/W2800669901","https://openalex.org/W2904913307","https://openalex.org/W2962660071","https://openalex.org/W2969545914","https://openalex.org/W2995484432","https://openalex.org/W2999101638","https://openalex.org/W3007834429","https://openalex.org/W3012925126","https://openalex.org/W3094893526","https://openalex.org/W3112210351","https://openalex.org/W3200298887","https://openalex.org/W3210753654","https://openalex.org/W4220734654","https://openalex.org/W4223938609","https://openalex.org/W4225712259","https://openalex.org/W4226238952","https://openalex.org/W4284963192","https://openalex.org/W4312854065","https://openalex.org/W4367671600","https://openalex.org/W4378696976","https://openalex.org/W4381795030","https://openalex.org/W4385194643","https://openalex.org/W4386344818","https://openalex.org/W4388595195","https://openalex.org/W4389104602"],"related_works":["https://openalex.org/W610912452","https://openalex.org/W2942569287","https://openalex.org/W2547494374","https://openalex.org/W1979506785","https://openalex.org/W3182082895","https://openalex.org/W1996601847","https://openalex.org/W3012181898","https://openalex.org/W2082444836","https://openalex.org/W2092877997","https://openalex.org/W2075841941"],"abstract_inverted_index":{"In":[0,164],"this":[1,79,184],"article,":[2],"we":[3],"presented":[4],"an":[5],"ultrahigh-sensitivity":[6],"creatinine":[7],"(CRE)":[8],"sensor":[9,40,132,146],"based":[10],"on":[11,38],"the":[12,39,52,63,67,85,101,106,116,130,135,139,144,148,156,166,170,187,193,206],"optical":[13],"fiber":[14],"surface":[15],"plasmon":[16],"resonance":[17],"(SPR)":[18],"effect":[19,54,76],"and":[20,44,60,82,87,99,115,161,177,211],"layer-by-layer":[21],"self-assembly":[22,25,102,136,149],"technology.":[23],"The":[24,74,91],"technology":[26],"is":[27],"used":[28],"to":[29,189],"immobilize":[30],"different":[31],"polymer":[32,58,72,175],"films":[33,59,176],"containing":[34],"creatininase":[35],"(CA)":[36],"molecules":[37,180],"surface.":[41],"We":[42],"found":[43],"verified":[45],"that":[46,105],"CRE":[47,92,107,160,182],"decomposition":[48],"products":[49],"can":[50,77],"induce":[51],"expansion":[53],"of":[55,66,71,89,95,109,118,143,159,169,195,208],"multilayer":[56],"self-assembled":[57,174],"further":[61],"cause":[62],"rapid":[64],"reduction":[65],"refractive":[68],"index":[69],"(RI)":[70],"films.":[73],"SPR":[75,96,110,131,145],"detect":[78],"RI":[80],"change":[81],"therefore":[83],"infer":[84],"presence":[86],"concentration":[88],"CRE.":[90],"detection":[93,119,157,194],"results":[94,158],"sensors":[97,111],"with":[98,134,147],"without":[100],"structure":[103,150],"confirmed":[104,153],"sensitivity":[108],"improved":[112],"by":[113,154],"11.6-fold":[114],"limit":[117],"(LOD)":[120],"reached":[121],"<inline-formula":[122],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[123],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">":[124],"<tex-math":[125],"notation=\"LaTeX\">$10^{-5}$":[126],"</tex-math></inline-formula>":[127],"mg/mL":[128],"when":[129],"combined":[133],"structure.":[137],"Moreover,":[138],"selective":[140],"recognition":[141],"ability":[142],"has":[151,186],"been":[152],"comparing":[155],"non-CRE":[162],"samples.":[163],"addition,":[165],"underlying":[167],"principle":[168],"sensitization":[171],"technique":[172],"using":[173],"specific":[178,212],"biorecognition":[179],"(like":[181],"in":[183],"case)":[185],"potential":[188],"be":[190],"adapted":[191],"for":[192,205],"various":[196],"other":[197],"biomolecules,":[198],"which":[199],"could":[200],"provide":[201],"a":[202],"new":[203],"way":[204],"development":[207],"highly":[209],"sensitive":[210],"biosensors.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}