{"id":"https://openalex.org/W4401163833","doi":"https://doi.org/10.1109/tim.2024.3436109","title":"A Subpixel Calibration Strategy for Micro-Raman Spectrometer in Subvisible Particles Traceable Detection","display_name":"A Subpixel Calibration Strategy for Micro-Raman Spectrometer in Subvisible Particles Traceable Detection","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4401163833","doi":"https://doi.org/10.1109/tim.2024.3436109"},"language":"en","primary_location":{"id":"doi:10.1109/tim.2024.3436109","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/tim.2024.3436109","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101689967","display_name":"Suyi Li","orcid":"https://orcid.org/0000-0003-3599-2102"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suyi Li","raw_affiliation_strings":["College of Instrumentation and Electrical Engineering, Jilin University, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0003-3599-2102","affiliations":[{"raw_affiliation_string":"College of Instrumentation and Electrical Engineering, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004776347","display_name":"X Li","orcid":"https://orcid.org/0009-0008-7444-0830"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinli Li","raw_affiliation_strings":["College of Instrumentation and Electrical Engineering, Jilin University, Changchun, China"],"raw_orcid":"https://orcid.org/0009-0008-7444-0830","affiliations":[{"raw_affiliation_string":"College of Instrumentation and Electrical Engineering, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052912697","display_name":"Mengxi Yu","orcid":"https://orcid.org/0009-0006-9775-3210"},"institutions":[{"id":"https://openalex.org/I4210096815","display_name":"Southwestern Medical Center","ror":"https://ror.org/00t9vx427","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096815"]},{"id":"https://openalex.org/I4388891891","display_name":"Southwestern Medical Center","ror":"https://ror.org/05d80e146","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4388891891"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengxi Yu","raw_affiliation_strings":["Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA"],"raw_orcid":"https://orcid.org/0009-0006-9775-3210","affiliations":[{"raw_affiliation_string":"Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210096815","https://openalex.org/I4388891891"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.582,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.78925489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"73","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14249","display_name":"Water Quality Monitoring and Analysis","score":0.9259999990463257,"subfield":{"id":"https://openalex.org/subfields/2311","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.7841570377349854},{"id":"https://openalex.org/keywords/spectrometer","display_name":"Spectrometer","score":0.7026056051254272},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5572738647460938},{"id":"https://openalex.org/keywords/raman-spectroscopy","display_name":"Raman spectroscopy","score":0.5415018796920776},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.47436055541038513},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.44909414649009705},{"id":"https://openalex.org/keywords/visible-spectrum","display_name":"Visible spectrum","score":0.4371715188026428},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.32647210359573364},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.27959948778152466}],"concepts":[{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.7841570377349854},{"id":"https://openalex.org/C33390570","wikidata":"https://www.wikidata.org/wiki/Q188463","display_name":"Spectrometer","level":2,"score":0.7026056051254272},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5572738647460938},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.5415018796920776},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.47436055541038513},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.44909414649009705},{"id":"https://openalex.org/C104663316","wikidata":"https://www.wikidata.org/wiki/Q76299","display_name":"Visible spectrum","level":2,"score":0.4371715188026428},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.32647210359573364},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.27959948778152466},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tim.2024.3436109","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/tim.2024.3436109","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5610381472","display_name":null,"funder_award_id":"2022YFC2807904","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2754763504","https://openalex.org/W2789437280","https://openalex.org/W2797987848","https://openalex.org/W2803696071","https://openalex.org/W2807742982","https://openalex.org/W2897952682","https://openalex.org/W2945914828","https://openalex.org/W2978205648","https://openalex.org/W3030137746","https://openalex.org/W3045642638","https://openalex.org/W3103284895","https://openalex.org/W3189961068","https://openalex.org/W4210318946","https://openalex.org/W4224992109","https://openalex.org/W4280558632","https://openalex.org/W4323294205","https://openalex.org/W4382934793","https://openalex.org/W4386227090"],"related_works":["https://openalex.org/W2058864804","https://openalex.org/W960385439","https://openalex.org/W2138878738","https://openalex.org/W4393417729","https://openalex.org/W3108187263","https://openalex.org/W2908284971","https://openalex.org/W1487885362","https://openalex.org/W4399445128","https://openalex.org/W1975083980","https://openalex.org/W2365262940"],"abstract_inverted_index":{"Subvisible":[0],"particles":[1],"are":[2],"a":[3,21,47,60,90,121,140,149],"major":[4],"cause":[5],"of":[6,28,39,56,77,86,103,129,213,216,224,239,249,257,262],"adverse":[7],"clinical":[8],"infusion":[9],"reactions":[10],"and":[11,67,83,154,165,170,185,254],"can":[12,119],"lead":[13],"to":[14,51,71,98,108,125,182,191,194,206],"serious":[15],"health":[16],"problems.":[17],"Raman":[18],"spectroscopy":[19],"is":[20,69,96,145,232],"rapid,":[22],"nondestructive":[23],"method":[24,95],"for":[25,270],"traceable":[26,214,268],"detection":[27,54,162,215,256,269],"subvisible":[29],"particles;":[30],"however,":[31],"the":[32,37,40,53,73,78,84,87,100,104,109,114,126,130,134,159,177,186,195,199,211,221,236,246,260],"pixel-level":[33,196],"spectral":[34,115,136],"resolution":[35,142],"limits":[36],"accuracy":[38,55,164,178,238],"existing":[41],"micro-Raman":[42,57,200,225,250],"spectrometers.":[43,58],"Consequently,":[44],"we":[45,118],"propose":[46],"subpixel":[48,122,169,227],"calibration":[49,144,175,228,248],"strategy":[50],"improve":[52,72],"First,":[59],"combined":[61],"light":[62],"source":[63],"with":[64],"higher":[65,141,234],"stability":[66,85,166,187],"uniformity":[68],"selected":[70],"standard":[74,110,160],"wavelength":[75,131],"coverage":[76],"charge-coupled":[79],"device":[80],"(CCD)":[81],"pixels":[82],"calibration.":[88,172,241],"Subsequently,":[89],"wavelet-based":[91],"automatic":[92],"peak":[93,105,127,137,155],"localization":[94],"designed":[97],"obtain":[99,120],"pixel-integer":[101],"values":[102],"points":[106],"corresponding":[107,124],"wavelengths.":[111],"Based":[112],"on":[113],"distribution":[116],"characteristics,":[117],"value":[123],"center":[128],"by":[132,147,167],"fitting":[133],"Gaussian":[135],"curve.":[138],"Then,":[139],"subpixel-level":[143,174],"achieved":[146],"establishing":[148],"mapping":[150],"function":[151],"between":[152],"wavelengths":[153],"centers.":[156],"We":[157],"compare":[158],"sample":[161],"shift":[163],"using":[168,226],"pixel":[171,240],"The":[173],"reduces":[176],"error":[179,188],"from":[180,189,203],"4.3":[181],"1.3":[183],"cm-1":[184],"4.8%":[190],"2.4%":[192],"compared":[193],"calibration,":[197],"improving":[198],"performance":[201],"indicator":[202],"Level":[204,207],"III":[205],"II.":[208],"Additionally,":[209],"comparing":[210],"results":[212,243],"eight":[217],"common":[218],"injectable":[219],"particles,":[220,258],"average":[222],"similarity":[223],"was":[229],"96.6%,":[230],"which":[231],"7.5%":[233],"than":[235],"matching":[237],"These":[242],"demonstrate":[244],"that":[245],"improved":[247],"enables":[251],"more":[252],"accurate":[253],"stable":[255],"meeting":[259],"requirements":[261],"high-accuracy":[263],"engineering":[264],"applications":[265],"in":[266],"particle":[267],"pharmaceutical":[271],"companies.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}