{"id":"https://openalex.org/W3159022280","doi":"https://doi.org/10.1109/tim.2021.3077988","title":"Joint Segmentation and Quantification of Chorioretinal Biomarkers in Optical Coherence Tomography Scans: A Deep Learning Approach","display_name":"Joint Segmentation and Quantification of Chorioretinal Biomarkers in Optical Coherence Tomography Scans: A Deep Learning Approach","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3159022280","doi":"https://doi.org/10.1109/tim.2021.3077988","mag":"3159022280"},"language":"en","primary_location":{"id":"doi:10.1109/tim.2021.3077988","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tim.2021.3077988","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001125873","display_name":"Bilal Hassan","orcid":"https://orcid.org/0000-0003-3672-8100"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bilal Hassan","raw_affiliation_strings":["School of Automation Science and Electrical Engineering, Beihang University (BUAA), Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3672-8100","affiliations":[{"raw_affiliation_string":"School of Automation Science and Electrical Engineering, Beihang University (BUAA), Beijing, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058280770","display_name":"Shiyin Qin","orcid":"https://orcid.org/0000-0002-2663-3813"},"institutions":[{"id":"https://openalex.org/I2799850029","display_name":"Dongguan University of Technology","ror":"https://ror.org/01m8p7q42","country_code":"CN","type":"education","lineage":["https://openalex.org/I2799850029"]},{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyin Qin","raw_affiliation_strings":["School of Automation Science and Electrical Engineering, Beihang University (BUAA), Beijing, China","School of Electrical Engineering and Intelligentization, Dongguan University of Technology, Dongguan, China"],"raw_orcid":"https://orcid.org/0000-0002-2663-3813","affiliations":[{"raw_affiliation_string":"School of Automation Science and Electrical Engineering, Beihang University (BUAA), Beijing, China","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"School of Electrical Engineering and Intelligentization, Dongguan University of Technology, Dongguan, China","institution_ids":["https://openalex.org/I2799850029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011636952","display_name":"Taimur Hassan","orcid":"https://orcid.org/0000-0002-5896-8677"},"institutions":[{"id":"https://openalex.org/I176601375","display_name":"Khalifa University of Science and Technology","ror":"https://ror.org/05hffr360","country_code":"AE","type":"education","lineage":["https://openalex.org/I176601375"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Taimur Hassan","raw_affiliation_strings":["Center for Cyber-Physical Systems (C2PS), Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates","KUCARS Center, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-5896-8677","affiliations":[{"raw_affiliation_string":"Center for Cyber-Physical Systems (C2PS), Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I176601375"]},{"raw_affiliation_string":"KUCARS Center, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I176601375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016211840","display_name":"Ramsha Ahmed","orcid":"https://orcid.org/0000-0002-9337-1921"},"institutions":[{"id":"https://openalex.org/I92403157","display_name":"University of Science and Technology Beijing","ror":"https://ror.org/02egmk993","country_code":"CN","type":"education","lineage":["https://openalex.org/I92403157"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ramsha Ahmed","raw_affiliation_strings":["School of Computer and Communication Engineering, University of Science and Technology Beijing (USTB), Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-9337-1921","affiliations":[{"raw_affiliation_string":"School of Computer and Communication Engineering, University of Science and Technology Beijing (USTB), Beijing, China","institution_ids":["https://openalex.org/I92403157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059512412","display_name":"Naoufel Werghi","orcid":"https://orcid.org/0000-0002-5542-448X"},"institutions":[{"id":"https://openalex.org/I176601375","display_name":"Khalifa University of Science and Technology","ror":"https://ror.org/05hffr360","country_code":"AE","type":"education","lineage":["https://openalex.org/I176601375"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Naoufel Werghi","raw_affiliation_strings":["Center for Cyber-Physical Systems (C2PS), Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates","KUCARS Center, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-5542-448X","affiliations":[{"raw_affiliation_string":"Center for Cyber-Physical Systems (C2PS), Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I176601375"]},{"raw_affiliation_string":"KUCARS Center, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I176601375"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7409,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.97447707,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"70","issue":null,"first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.8461775779724121},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7116730213165283},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6958628296852112},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6895678043365479},{"id":"https://openalex.org/keywords/contouring","display_name":"Contouring","score":0.6514278650283813},{"id":"https://openalex.org/keywords/preprocessor","display_name":"Preprocessor","score":0.6241125464439392},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5970706939697266},{"id":"https://openalex.org/keywords/pooling","display_name":"Pooling","score":0.4548736810684204},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4443351924419403},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.44345802068710327},{"id":"https://openalex.org/keywords/glaucoma","display_name":"Glaucoma","score":0.42738527059555054},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3853742182254791},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3576332628726959},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2375825047492981},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.18850204348564148},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.1505059003829956}],"concepts":[{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.8461775779724121},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7116730213165283},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6958628296852112},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6895678043365479},{"id":"https://openalex.org/C2779104521","wikidata":"https://www.wikidata.org/wiki/Q23058469","display_name":"Contouring","level":2,"score":0.6514278650283813},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.6241125464439392},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5970706939697266},{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.4548736810684204},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4443351924419403},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.44345802068710327},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.42738527059555054},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3853742182254791},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3576332628726959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2375825047492981},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18850204348564148},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.1505059003829956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tim.2021.3077988","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tim.2021.3077988","pdf_url":null,"source":{"id":"https://openalex.org/S10892749","display_name":"IEEE Transactions on Instrumentation and Measurement","issn_l":"0018-9456","issn":["0018-9456","1557-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Instrumentation and Measurement","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1593272421","https://openalex.org/W1905829557","https://openalex.org/W1964432666","https://openalex.org/W2001080026","https://openalex.org/W2001412060","https://openalex.org/W2013754472","https://openalex.org/W2027606067","https://openalex.org/W2033150785","https://openalex.org/W2048278407","https://openalex.org/W2074598933","https://openalex.org/W2097073572","https://openalex.org/W2098142346","https://openalex.org/W2106510254","https://openalex.org/W2145023731","https://openalex.org/W2152854926","https://openalex.org/W2165829366","https://openalex.org/W2288495312","https://openalex.org/W2289913085","https://openalex.org/W2520186357","https://openalex.org/W2523513766","https://openalex.org/W2532338709","https://openalex.org/W2564681053","https://openalex.org/W2773475231","https://openalex.org/W2784716645","https://openalex.org/W2788633781","https://openalex.org/W2849298850","https://openalex.org/W2892496989","https://openalex.org/W2898829509","https://openalex.org/W2907100905","https://openalex.org/W2914016683","https://openalex.org/W2919070891","https://openalex.org/W2921406441","https://openalex.org/W2943578415","https://openalex.org/W2954143083","https://openalex.org/W2964309882","https://openalex.org/W2974131077","https://openalex.org/W2979893297","https://openalex.org/W2980131041","https://openalex.org/W2992749535","https://openalex.org/W2996651271","https://openalex.org/W3010023414","https://openalex.org/W3010066814","https://openalex.org/W3011135183","https://openalex.org/W3015217229","https://openalex.org/W3017850177","https://openalex.org/W3027233270","https://openalex.org/W3035516249","https://openalex.org/W3036782889","https://openalex.org/W3036883289","https://openalex.org/W3066595230","https://openalex.org/W3080434985","https://openalex.org/W3093086118","https://openalex.org/W3116279133","https://openalex.org/W3134431802","https://openalex.org/W4211205882","https://openalex.org/W6658985058","https://openalex.org/W6748481559","https://openalex.org/W6788338583"],"related_works":["https://openalex.org/W2028761375","https://openalex.org/W2915337797","https://openalex.org/W2360204191","https://openalex.org/W2968335000","https://openalex.org/W2044363672","https://openalex.org/W2073091389","https://openalex.org/W2045558343","https://openalex.org/W4315646535","https://openalex.org/W1968493577","https://openalex.org/W2500847435"],"abstract_inverted_index":{"In":[0],"ophthalmology,":[1],"chorioretinal":[2],"biomarkers":[3],"(CRBMs)":[4],"play":[5],"a":[6,63,73,93,120,135,147,214],"significant":[7],"role":[8],"in":[9,62,85,176,185,226],"detecting,":[10],"quantifying,":[11],"and":[12,32,43,75,88,106,113,129,159,188,199,206,224,243],"ameliorating":[13],"the":[14,49,67,153,180,227,241,246],"treatment":[15],"of":[16,35,46,51,69,81,115,122,132,183,190,203,217,229,245],"chronic":[17],"eye":[18],"conditions.":[19,37,249],"Optical":[20],"coherence":[21],"tomography":[22],"(OCT)":[23],"imaging":[24],"is":[25,143,164],"primarily":[26],"used":[27,119],"for":[28,78,126,138,151],"investigating":[29],"various":[30],"CRBMs":[31,154,218],"prompt":[33],"intervention":[34],"retinal":[36,230],"However,":[38],"with":[39,192,219],"extensive":[40],"clinical":[41,86],"applications":[42],"increasing":[44],"prevalence":[45],"ocular":[47,248],"diseases,":[48],"number":[50],"OCT":[52],"scans":[53,125],"obtained":[54],"globally":[55],"exceeds":[56],"ophthalmologists'":[57],"capacity":[58],"to":[59,109,145,239],"examine":[60],"these":[61],"meaningful":[64],"manner.":[65],"Instead,":[66],"emergence":[68],"deep":[70],"learning":[71],"provides":[72],"cost-effective":[74],"reliable":[76],"alternative":[77],"automated":[79],"analysis":[80],"scans,":[82],"assisting":[83],"ophthalmologists":[84],"routines":[87],"research.":[89],"This":[90,232],"article":[91],"presents":[92],"residual":[94],"learning-based":[95],"framework":[96,163],"(RASP-Net)":[97],"that":[98],"integrates":[99],"atrous":[100],"spatial":[101],"pyramid":[102],"pooling,":[103],"coherent":[104],"preprocessing,":[105],"postprocessing":[107],"mechanisms":[108],"achieve":[110],"joint":[111],"segmentation":[112,189],"quantification":[114,225],"11":[116],"CRBMs.":[117],"We":[118],"total":[121],"7000":[123],"annotated":[124],"training,":[127],"validation,":[128],"testing":[130],"purposes":[131],"RASP-Net.":[133],"Moreover,":[134],"novel":[136],"algorithm":[137],"3-D":[139],"macular":[140],"profiles":[141],"reconstruction":[142],"presented":[144,175],"give":[146],"more":[148],"intuitive":[149],"way":[150],"characterizing":[152],"based":[155],"on":[156],"coarse":[157],"contouring":[158],"quantification.":[160],"The":[161,173,209],"proposed":[162,210,233],"evaluated":[165],"through":[166],"several":[167],"experiments":[168],"using":[169],"different":[170],"performance":[171,182],"metrics.":[172],"results":[174],"this":[177],"study":[178],"validate":[179],"optimal":[181],"RASP-Net":[184,211],"precise":[186],"detection":[187],"CRBMs,":[191],"mean":[193],"balanced":[194],"accuracy,":[195],"intersection":[196],"over":[197],"union,":[198],"dice":[200],"score":[201],"values":[202],"0.916,":[204],"0.634,":[205],"0.776":[207],"respectively.":[208],"model":[212],"characterizes":[213],"wide":[215],"range":[216],"fine-grained":[220],"pixelwise":[221],"segmentation,":[222],"extraction,":[223],"context":[228],"pathologies.":[231],"system":[234],"can":[235],"allow":[236],"retina":[237],"experts":[238],"monitor":[240],"improvement":[242],"deterioration":[244],"underlying":[247]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":8}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
