{"id":"https://openalex.org/W4400726513","doi":"https://doi.org/10.1109/tii.2024.3424266","title":"Causality Enhanced Global-Local Graph Neural Network for Bioprocess Factor Forecasting","display_name":"Causality Enhanced Global-Local Graph Neural Network for Bioprocess Factor Forecasting","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400726513","doi":"https://doi.org/10.1109/tii.2024.3424266"},"language":"en","primary_location":{"id":"doi:10.1109/tii.2024.3424266","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tii.2024.3424266","pdf_url":null,"source":{"id":"https://openalex.org/S184777250","display_name":"IEEE Transactions on Industrial Informatics","issn_l":"1551-3203","issn":["1551-3203","1941-0050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Industrial Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069064259","display_name":"Ziyue Sun","orcid":"https://orcid.org/0009-0007-5573-2902"},"institutions":[{"id":"https://openalex.org/I4391767838","display_name":"State Key Laboratory of Industrial Control Technology","ror":"https://ror.org/03a33a786","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767838","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ziyue Sun","raw_affiliation_strings":["State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0009-0007-5573-2902","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101457757","display_name":"Yinlong Li","orcid":"https://orcid.org/0009-0006-9170-9227"},"institutions":[{"id":"https://openalex.org/I4391767838","display_name":"State Key Laboratory of Industrial Control Technology","ror":"https://ror.org/03a33a786","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767838","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinlong Li","raw_affiliation_strings":["State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0009-0006-9170-9227","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012782367","display_name":"Qunshan He","orcid":"https://orcid.org/0000-0002-4630-4056"},"institutions":[{"id":"https://openalex.org/I4391767838","display_name":"State Key Laboratory of Industrial Control Technology","ror":"https://ror.org/03a33a786","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767838","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qunshan He","raw_affiliation_strings":["State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-4630-4056","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099431743","display_name":"Hu Xu","orcid":"https://orcid.org/0009-0004-3001-2472"},"institutions":[{"id":"https://openalex.org/I4391767838","display_name":"State Key Laboratory of Industrial Control Technology","ror":"https://ror.org/03a33a786","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767838","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu Xu","raw_affiliation_strings":["State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0009-0004-3001-2472","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062687402","display_name":"Wenhai Wang","orcid":"https://orcid.org/0000-0003-3707-6546"},"institutions":[{"id":"https://openalex.org/I4391767838","display_name":"State Key Laboratory of Industrial Control Technology","ror":"https://ror.org/03a33a786","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767838","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhai Wang","raw_affiliation_strings":["State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-3707-6546","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034516630","display_name":"Xinggao Liu","orcid":"https://orcid.org/0000-0002-0948-1942"},"institutions":[{"id":"https://openalex.org/I4391767838","display_name":"State Key Laboratory of Industrial Control Technology","ror":"https://ror.org/03a33a786","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767838","https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinggao Liu","raw_affiliation_strings":["State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-0948-1942","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Industrial Control Technology, College of Control Science and Engineering, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4391767838"]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5069064259"],"corresponding_institution_ids":["https://openalex.org/I4391767838"],"apc_list":null,"apc_paid":null,"fwci":1.5429,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.82429282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"20","issue":"10","first_page":"12428","last_page":"12438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9004999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9004999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.6454163789749146},{"id":"https://openalex.org/keywords/bioprocess","display_name":"Bioprocess","score":0.6342442631721497},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5945025086402893},{"id":"https://openalex.org/keywords/causality","display_name":"Causality (physics)","score":0.5645604133605957},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4543073773384094},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4395875930786133},{"id":"https://openalex.org/keywords/factor","display_name":"Factor (programming language)","score":0.4131166338920593},{"id":"https://openalex.org/keywords/graph-theory","display_name":"Graph theory","score":0.4109649658203125},{"id":"https://openalex.org/keywords/factor-graph","display_name":"Factor graph","score":0.4106637239456177},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.37091517448425293},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.21377477049827576},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2055198848247528},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18924319744110107},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.14155131578445435}],"concepts":[{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.6454163789749146},{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.6342442631721497},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5945025086402893},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.5645604133605957},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4543073773384094},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4395875930786133},{"id":"https://openalex.org/C2781039887","wikidata":"https://www.wikidata.org/wiki/Q1391724","display_name":"Factor (programming language)","level":2,"score":0.4131166338920593},{"id":"https://openalex.org/C88230418","wikidata":"https://www.wikidata.org/wiki/Q131476","display_name":"Graph theory","level":2,"score":0.4109649658203125},{"id":"https://openalex.org/C159246509","wikidata":"https://www.wikidata.org/wiki/Q5428725","display_name":"Factor graph","level":3,"score":0.4106637239456177},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37091517448425293},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.21377477049827576},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2055198848247528},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18924319744110107},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.14155131578445435},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tii.2024.3424266","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tii.2024.3424266","pdf_url":null,"source":{"id":"https://openalex.org/S184777250","display_name":"IEEE Transactions on Industrial Informatics","issn_l":"1551-3203","issn":["1551-3203","1941-0050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Industrial Informatics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Climate action","id":"https://metadata.un.org/sdg/13"}],"awards":[{"id":"https://openalex.org/G1743648890","display_name":null,"funder_award_id":"12075212","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3498820794","display_name":null,"funder_award_id":"11975207","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7285477154","display_name":null,"funder_award_id":"62073288","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7844103239","display_name":null,"funder_award_id":"12105246","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2041782669","https://openalex.org/W2078355959","https://openalex.org/W2102164505","https://openalex.org/W2116341502","https://openalex.org/W2150271534","https://openalex.org/W2519091744","https://openalex.org/W2586262377","https://openalex.org/W2802280146","https://openalex.org/W2910030584","https://openalex.org/W2962006367","https://openalex.org/W2965341826","https://openalex.org/W2982310938","https://openalex.org/W3025853597","https://openalex.org/W3033415292","https://openalex.org/W3039107035","https://openalex.org/W3044625502","https://openalex.org/W3048310814","https://openalex.org/W3080253043","https://openalex.org/W3134999273","https://openalex.org/W4200312990","https://openalex.org/W4206006040","https://openalex.org/W4283315029","https://openalex.org/W4287282757","https://openalex.org/W4291109205","https://openalex.org/W4311176980","https://openalex.org/W4311401295","https://openalex.org/W4311897818","https://openalex.org/W4313156423","https://openalex.org/W4313420829","https://openalex.org/W4321485093","https://openalex.org/W4323275667","https://openalex.org/W4361856754","https://openalex.org/W4382203079","https://openalex.org/W4385543074","https://openalex.org/W4387387521","https://openalex.org/W4389371835","https://openalex.org/W4389977645","https://openalex.org/W4391318136","https://openalex.org/W4391749636","https://openalex.org/W6729448088","https://openalex.org/W6780221082","https://openalex.org/W6780532237","https://openalex.org/W6786152982","https://openalex.org/W6840343660","https://openalex.org/W6846825190"],"related_works":["https://openalex.org/W1518145255","https://openalex.org/W2911891560","https://openalex.org/W4399593311","https://openalex.org/W1590003579","https://openalex.org/W1502859157","https://openalex.org/W3160141509","https://openalex.org/W2232791606","https://openalex.org/W1557056212","https://openalex.org/W2757251458","https://openalex.org/W4386072419"],"abstract_inverted_index":{"Forecasting":[0],"governing":[1],"key":[2],"factors":[3],"in":[4,14,47],"industrial":[5,30,140],"bioprocesses":[6],"is":[7,20,67],"crucial":[8],"for":[9,90,120],"ensuring":[10],"stability":[11],"and":[12,26,38,77,94,115,130],"efficiency":[13],"production.":[15],"However,":[16],"the":[17,23,35,41,56,92,121],"accurate":[18],"prediction":[19],"challenged":[21],"by":[22],"strong":[24],"coupling":[25],"uncertainty":[27],"characteristic":[28],"of":[29],"bioprocess":[31,79,141],"data.":[32],"To":[33],"capture":[34],"common":[36],"dynamics":[37],"comprehensively":[39],"model":[40,54],"interrelationships":[42],"among":[43,133],"multivariate":[44],"time":[45,71],"series":[46,80],"bioprocesses,":[48],"this":[49,145],"study":[50],"introduces":[51],"a":[52],"predictive":[53,149],"called":[55],"causality":[57,109],"enhanced":[58],"global-local":[59,64],"graph":[60,102,110,119,123],"neural":[61,124],"network.":[62],"A":[63],"decomposition":[65],"module":[66,104],"first":[68],"constructed":[69],"utilizing":[70],"regularization,":[72],"thereby,":[73],"explicitly":[74],"obtaining":[75],"global":[76,93],"local":[78,95],"while":[81],"preserving":[82],"temporal":[83],"structure.":[84],"Subsequently,":[85],"we":[86,98],"construct":[87],"node":[88],"embedding":[89],"both":[91],"series.":[96],"Finally,":[97],"presents":[99],"an":[100,107,116],"innovative":[101],"generation":[103],"that":[105,144],"creates":[106],"explicit":[108],"based":[111,137],"on":[112,138],"transfer":[113],"entropy":[114],"implicit":[117],"static-dynamic":[118],"downstream":[122],"network,":[125],"considering":[126],"causal":[127],"information,":[128],"static":[129],"dynamic":[131],"dependencies":[132],"variables.":[134],"Application":[135],"results":[136],"real":[139],"data":[142],"demonstrate":[143],"method":[146],"has":[147],"high":[148],"accuracy.":[150]},"counts_by_year":[{"year":2025,"cited_by_count":7}],"updated_date":"2026-05-03T08:25:01.440150","created_date":"2025-10-10T00:00:00"}