{"id":"https://openalex.org/W4401415175","doi":"https://doi.org/10.1109/tetci.2024.3436568","title":"Diffusion-Based Radiotherapy Dose Prediction Guided by Inter-Slice Aware Structure Encoding","display_name":"Diffusion-Based Radiotherapy Dose Prediction Guided by Inter-Slice Aware Structure Encoding","publication_year":2024,"publication_date":"2024-08-08","ids":{"openalex":"https://openalex.org/W4401415175","doi":"https://doi.org/10.1109/tetci.2024.3436568"},"language":"en","primary_location":{"id":"doi:10.1109/tetci.2024.3436568","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tetci.2024.3436568","pdf_url":null,"source":{"id":"https://openalex.org/S4210210251","display_name":"IEEE Transactions on Emerging Topics in Computational Intelligence","issn_l":"2471-285X","issn":["2471-285X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Emerging Topics in Computational Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109729509","display_name":"Zhenghao Feng","orcid":"https://orcid.org/0009-0007-3211-3279"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210125143","display_name":"Chengdu University","ror":"https://ror.org/034z67559","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210125143"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenghao Feng","raw_affiliation_strings":["School of Computer Science, Sichuan University, Chengdu, China"],"raw_orcid":"https://orcid.org/0009-0007-3211-3279","affiliations":[{"raw_affiliation_string":"School of Computer Science, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I4210125143","https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320313","display_name":"Lu Wen","orcid":"https://orcid.org/0000-0002-7521-9846"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210125143","display_name":"Chengdu University","ror":"https://ror.org/034z67559","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210125143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wen","raw_affiliation_strings":["School of Computer Science, Sichuan University, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0002-7521-9846","affiliations":[{"raw_affiliation_string":"School of Computer Science, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I4210125143","https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009334041","display_name":"Jianghong Xiao","orcid":"https://orcid.org/0000-0002-2514-1614"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianghong Xiao","raw_affiliation_strings":["Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103814778","display_name":"Yuanyuan Xu","orcid":"https://orcid.org/0009-0009-6614-1803"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210125143","display_name":"Chengdu University","ror":"https://ror.org/034z67559","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210125143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Xu","raw_affiliation_strings":["School of Computer Science, Sichuan University, Chengdu, China"],"raw_orcid":"https://orcid.org/0009-0009-6614-1803","affiliations":[{"raw_affiliation_string":"School of Computer Science, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I4210125143","https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101608091","display_name":"Xi Wu","orcid":"https://orcid.org/0000-0002-0689-1735"},"institutions":[{"id":"https://openalex.org/I24201400","display_name":"Chengdu University of Information Technology","ror":"https://ror.org/01yxwrh59","country_code":"CN","type":"education","lineage":["https://openalex.org/I24201400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Wu","raw_affiliation_strings":["School of Computer Science, Chengdu University of Information Technology, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0002-0689-1735","affiliations":[{"raw_affiliation_string":"School of Computer Science, Chengdu University of Information Technology, Chengdu, China","institution_ids":["https://openalex.org/I24201400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102009027","display_name":"Jiliu Zhou","orcid":"https://orcid.org/0000-0001-6864-9509"},"institutions":[{"id":"https://openalex.org/I24201400","display_name":"Chengdu University of Information Technology","ror":"https://ror.org/01yxwrh59","country_code":"CN","type":"education","lineage":["https://openalex.org/I24201400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiliu Zhou","raw_affiliation_strings":["School of Computer Science, Chengdu University of Information Technology, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0001-6864-9509","affiliations":[{"raw_affiliation_string":"School of Computer Science, Chengdu University of Information Technology, Chengdu, China","institution_ids":["https://openalex.org/I24201400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051630281","display_name":"Xingchen Peng","orcid":"https://orcid.org/0000-0001-7042-718X"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingchen Peng","raw_affiliation_strings":["Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100733310","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0002-8843-8685"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210125143","display_name":"Chengdu University","ror":"https://ror.org/034z67559","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210125143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["School of Computer Science, Sichuan University, Chengdu, China"],"raw_orcid":"https://orcid.org/0000-0002-8843-8685","affiliations":[{"raw_affiliation_string":"School of Computer Science, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I4210125143","https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5109729509"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210125143"],"apc_list":null,"apc_paid":null,"fwci":6.4098,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.97295703,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"9","issue":"2","first_page":"1119","last_page":"1129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9660000205039978,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.963100016117096,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/encoding","display_name":"Encoding (memory)","score":0.6295126080513},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5614660382270813},{"id":"https://openalex.org/keywords/radiation-dose","display_name":"Radiation dose","score":0.4879741072654724},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48584315180778503},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2767781615257263},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.24000611901283264},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23692724108695984},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07818624377250671}],"concepts":[{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.6295126080513},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5614660382270813},{"id":"https://openalex.org/C2987700449","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Radiation dose","level":2,"score":0.4879741072654724},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48584315180778503},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2767781615257263},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.24000611901283264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23692724108695984},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07818624377250671},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tetci.2024.3436568","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tetci.2024.3436568","pdf_url":null,"source":{"id":"https://openalex.org/S4210210251","display_name":"IEEE Transactions on Emerging Topics in Computational Intelligence","issn_l":"2471-285X","issn":["2471-285X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Emerging Topics in Computational Intelligence","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2182196317","display_name":null,"funder_award_id":"62071314","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6622944791","display_name":null,"funder_award_id":"62371325","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W2119298887","https://openalex.org/W2143472867","https://openalex.org/W2164718209","https://openalex.org/W2194775991","https://openalex.org/W2507943999","https://openalex.org/W2791897958","https://openalex.org/W2898757811","https://openalex.org/W2921903201","https://openalex.org/W3026792403","https://openalex.org/W3040441798","https://openalex.org/W3108244608","https://openalex.org/W3131762691","https://openalex.org/W3155072588","https://openalex.org/W3171527745","https://openalex.org/W3204506322","https://openalex.org/W3216919020","https://openalex.org/W4200048078","https://openalex.org/W4210345762","https://openalex.org/W4226014430","https://openalex.org/W4366256919","https://openalex.org/W4385245566","https://openalex.org/W4386083151","https://openalex.org/W4387225552","https://openalex.org/W6639824700","https://openalex.org/W6679045638","https://openalex.org/W6744422213","https://openalex.org/W6753426341","https://openalex.org/W6779823529","https://openalex.org/W6788990321","https://openalex.org/W6795288823","https://openalex.org/W6843184996","https://openalex.org/W6843976751","https://openalex.org/W6849273598","https://openalex.org/W6849519549"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W2382290278","https://openalex.org/W4395014643"],"abstract_inverted_index":{"Deep":[0],"learning":[1],"(DL)":[2],"has":[3],"successfully":[4],"automated":[5],"dose":[6,59,86,138,170],"distribution":[7,60,87,139,171],"prediction":[8],"for":[9,61],"radiotherapy":[10,58],"planning,":[11],"increasing":[12],"both":[13],"efficiency":[14],"and":[15,72,99,133,183],"quality.":[16],"However,":[17],"existing":[18],"methods":[19],"commonly":[20],"utilize":[21],"<inline-formula":[22,27],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[23,28],"xmlns:xlink=\"http://www.w3.org/1999/xlink\"><tex-math":[24,29],"notation=\"LaTeX\">${{\\mathbf{L}}_1}$</tex-math></inline-formula>":[25],"or":[26],"notation=\"LaTeX\">${{\\mathbf{L}}_2}$</tex-math></inline-formula>":[30],"loss":[31],"to":[32,55,85,95,106,142,155,168,201],"calculate":[33],"the":[34,41,77,108,115,121,129,136,144,157,165,180,198,218],"posterior":[35],"average,":[36],"thus":[37],"heavily":[38],"suffering":[39],"from":[40,123,160],"over-smoothing":[42],"problem.":[43],"To":[44],"address":[45],"this,":[46],"we":[47,150],"propose":[48],"a":[49,69,73,100,124,152],"diffusion":[50],"model-based":[51],"method,":[52],"named":[53],"DiffDose,":[54],"automatically":[56],"predict":[57],"cancer":[62,215],"patients.":[63],"Specifically,":[64],"our":[65,221],"DiffDose":[66,80,118],"model":[67,145],"contains":[68],"forward":[70,78],"process":[71],"reverse":[74,116],"process.":[75],"In":[76,114],"process,":[79,117],"gradually":[81],"adds":[82],"small":[83],"noise":[84,101,109,122,127,131,166],"maps":[88,172],"via":[89],"multiple":[90],"steps":[91],"until":[92],"converting":[93],"them":[94],"pure":[96,125],"Gaussian":[97,126],"noise,":[98],"predictor":[102,132,167],"is":[103,195],"simultaneously":[104],"trained":[105],"estimate":[107],"added":[110],"in":[111,197],"each":[112],"step.":[113],"iteratively":[119],"removes":[120],"leveraging":[128],"well-trained":[130],"finally":[134],"outputs":[135],"predicted":[137],"maps.":[140],"Concretely,":[141],"provide":[143],"with":[146],"essential":[147],"structure":[148,153,199],"information,":[149],"design":[151],"encoder":[154,200],"learn":[156],"anatomical":[158],"knowledge":[159],"patients\u2019":[161],"anatomy":[162,187],"images,":[163,188],"guiding":[164],"generate":[169],"that":[173],"are":[174],"aware":[175],"of":[176,220],"personalized":[177],"structures.":[178],"Considering":[179],"latent":[181],"continuity":[182],"similarity":[184],"among":[185],"sliced":[186],"an":[189,209],"inter-slice":[190],"interaction":[191],"transformer":[192],"(I2T)":[193],"block":[194],"embedded":[196],"capture":[202],"such":[203],"long-range":[204],"dependency.":[205],"Extensive":[206],"experiments":[207],"on":[208],"in-house":[210],"dataset":[211],"involving":[212],"130":[213],"rectum":[214],"cases":[216],"validate":[217],"superiority":[219],"method.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6}],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}
