{"id":"https://openalex.org/W3092905484","doi":"https://doi.org/10.1109/tetc.2020.3031024","title":"A Computing System for Discovering Causal Relationships Among Human Genes to Improve Drug Repositioning","display_name":"A Computing System for Discovering Causal Relationships Among Human Genes to Improve Drug Repositioning","publication_year":2020,"publication_date":"2020-10-14","ids":{"openalex":"https://openalex.org/W3092905484","doi":"https://doi.org/10.1109/tetc.2020.3031024","mag":"3092905484"},"language":"en","primary_location":{"id":"doi:10.1109/tetc.2020.3031024","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tetc.2020.3031024","pdf_url":"https://ieeexplore.ieee.org/ielx7/6245516/9635600/09224179.pdf","source":{"id":"https://openalex.org/S2496326734","display_name":"IEEE Transactions on Emerging Topics in Computing","issn_l":"2168-6750","issn":["2168-6750","2376-4562"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Emerging Topics in Computing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/6245516/9635600/09224179.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020235155","display_name":"Enrico Blanzieri","orcid":"https://orcid.org/0000-0001-6524-0601"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I4210096308","display_name":"Institute of Materials for Electronics and Magnetism","ror":"https://ror.org/00z8ws214","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210096308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Blanzieri","raw_affiliation_strings":["CNR-IMEM, Trento, Italy","DISI, University of Trento, Trento, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6524-0601","affiliations":[{"raw_affiliation_string":"CNR-IMEM, Trento, Italy","institution_ids":["https://openalex.org/I4210096308"]},{"raw_affiliation_string":"DISI, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002300255","display_name":"Toma Tebaldi","orcid":"https://orcid.org/0000-0002-0625-1631"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Toma Tebaldi","raw_affiliation_strings":["DISI, University of Trento, Trento, Italy","School of Medicine, New Haven, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-0625-1631","affiliations":[{"raw_affiliation_string":"DISI, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]},{"raw_affiliation_string":"School of Medicine, New Haven, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083078475","display_name":"Valter Cavecchia","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096308","display_name":"Institute of Materials for Electronics and Magnetism","ror":"https://ror.org/00z8ws214","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210096308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valter Cavecchia","raw_affiliation_strings":["CNR-IMEM, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-IMEM, Trento, Italy","institution_ids":["https://openalex.org/I4210096308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023870348","display_name":"Francesco Asnicar","orcid":"https://orcid.org/0000-0003-3732-1468"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Asnicar","raw_affiliation_strings":["CIBIO, University of Trento, Trento, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3732-1468","affiliations":[{"raw_affiliation_string":"CIBIO, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015906490","display_name":"Luca Masera","orcid":"https://orcid.org/0000-0001-9734-4202"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Masera","raw_affiliation_strings":["DISI, University of Trento, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DISI, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082739234","display_name":"Gabriele Tom\u00e8","orcid":"https://orcid.org/0000-0002-3976-6068"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Tome","raw_affiliation_strings":["DISI, University of Trento, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DISI, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010397239","display_name":"Eleonora Nigro","orcid":"https://orcid.org/0000-0002-5077-8035"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Nigro","raw_affiliation_strings":["CIBIO, University of Trento, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBIO, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065141878","display_name":"Enrica Colasurdo","orcid":null},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrica Colasurdo","raw_affiliation_strings":["CIBIO, University of Trento, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBIO, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070464616","display_name":"Matteo Ciciani","orcid":"https://orcid.org/0000-0003-2045-5435"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Ciciani","raw_affiliation_strings":["CIBIO, University of Trento, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBIO, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050152413","display_name":"Chiara Mazzoni","orcid":"https://orcid.org/0000-0002-0988-3108"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Mazzoni","raw_affiliation_strings":["CIBIO, University of Trento, Trento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBIO, University of Trento, Trento, Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023915407","display_name":"S. Pilati","orcid":"https://orcid.org/0000-0001-7103-9613"},"institutions":[{"id":"https://openalex.org/I103225651","display_name":"Fondazione Edmund Mach","ror":"https://ror.org/0381bab64","country_code":"IT","type":"other","lineage":["https://openalex.org/I103225651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Pilati","raw_affiliation_strings":["Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7103-9613","affiliations":[{"raw_affiliation_string":"Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy","institution_ids":["https://openalex.org/I103225651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4882,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62544952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"1667","last_page":"1682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.664878249168396},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4614405035972595},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.43225693702697754},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4157821238040924},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39431437849998474},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.24842020869255066},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1606214940547943},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10327678918838501}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.664878249168396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4614405035972595},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.43225693702697754},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4157821238040924},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39431437849998474},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.24842020869255066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1606214940547943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10327678918838501},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/tetc.2020.3031024","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tetc.2020.3031024","pdf_url":"https://ieeexplore.ieee.org/ielx7/6245516/9635600/09224179.pdf","source":{"id":"https://openalex.org/S2496326734","display_name":"IEEE Transactions on Emerging Topics in Computing","issn_l":"2168-6750","issn":["2168-6750","2376-4562"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Emerging Topics in Computing","raw_type":"journal-article"},{"id":"pmh:oai:iris.unitn.it:11572/279813","is_oa":true,"landing_page_url":"https://hdl.handle.net/11572/279813","pdf_url":"https://iris.unitn.it/bitstream/11572/279813/4/A_Computing_System_for_Discovering_Causal_Relationships_Among_Human_Genes_to_Improve_Drug_Repositioning.pdf","source":{"id":"https://openalex.org/S4306401913","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Trento)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193223587","host_organization_name":"University of Trento","host_organization_lineage":["https://openalex.org/I193223587"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openpub.fmach.it:10449/63130","is_oa":true,"landing_page_url":"http://hdl.handle.net/10449/63130","pdf_url":"https://openpub.fmach.it/bitstream/10449/63130/6/2021%20IEEE%20Pilati.pdf","source":{"id":"https://openalex.org/S4377196413","display_name":"CINECA IRIS Institutional Research Information System (Fondazione Edmund Mach)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I103225651","host_organization_name":"Fondazione Edmund Mach","host_organization_lineage":["https://openalex.org/I103225651"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1109/tetc.2020.3031024","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tetc.2020.3031024","pdf_url":"https://ieeexplore.ieee.org/ielx7/6245516/9635600/09224179.pdf","source":{"id":"https://openalex.org/S2496326734","display_name":"IEEE Transactions on Emerging Topics in Computing","issn_l":"2168-6750","issn":["2168-6750","2376-4562"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Emerging Topics in Computing","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092905484.pdf","grobid_xml":"https://content.openalex.org/works/W3092905484.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W49194309","https://openalex.org/W1538803922","https://openalex.org/W1573602524","https://openalex.org/W1595661905","https://openalex.org/W1966327575","https://openalex.org/W1975062332","https://openalex.org/W1990930479","https://openalex.org/W2103094466","https://openalex.org/W2103962300","https://openalex.org/W2110065044","https://openalex.org/W2124649657","https://openalex.org/W2126907894","https://openalex.org/W2143891888","https://openalex.org/W2161112598","https://openalex.org/W2163296115","https://openalex.org/W2179359265","https://openalex.org/W2187426993","https://openalex.org/W2460139914","https://openalex.org/W2514090652","https://openalex.org/W2587435215","https://openalex.org/W2600420905","https://openalex.org/W2620966921","https://openalex.org/W2746328470","https://openalex.org/W2750304043","https://openalex.org/W2767891136","https://openalex.org/W2796153844","https://openalex.org/W2808743742","https://openalex.org/W2887872729","https://openalex.org/W2890871828","https://openalex.org/W2900099657","https://openalex.org/W2900569176","https://openalex.org/W2900668971","https://openalex.org/W2923935359","https://openalex.org/W2948579453","https://openalex.org/W2950663303","https://openalex.org/W2950753203","https://openalex.org/W3006419771","https://openalex.org/W3024161231","https://openalex.org/W3117540822","https://openalex.org/W3190841117","https://openalex.org/W4256581468","https://openalex.org/W6601985403","https://openalex.org/W6683167872","https://openalex.org/W6738674058","https://openalex.org/W6743665679","https://openalex.org/W6757958943","https://openalex.org/W7009591407"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2006667691","https://openalex.org/W2886266969","https://openalex.org/W4281673370","https://openalex.org/W2903687253","https://openalex.org/W4366527864","https://openalex.org/W4206422705","https://openalex.org/W3174741986","https://openalex.org/W4389861022","https://openalex.org/W4366833264"],"abstract_inverted_index":{"The":[0,54,75,87,157],"automatic":[1],"discovery":[2,28],"of":[3,39,61,90,97,115,143,179],"causal":[4,27],"relationships":[5],"among":[6],"human":[7,65,149],"genes":[8,144,164],"can":[9],"shed":[10],"light":[11],"on":[12,31,78,83],"gene":[13,51],"regulatory":[14,52],"processes":[15],"and":[16,42,67,82,153,162],"guide":[17],"drug":[18,186],"repositioning.":[19,187],"To":[20],"this":[21,134],"end,":[22],"a":[23,32],"computationally-heavy":[24],"method":[25,158],"for":[26,48,171],"is":[29],"distributed":[30],"volunteer":[33],"computing":[34],"grid":[35],"and,":[36],"taking":[37],"advantage":[38],"variable":[40],"subsetting":[41],"stratification,":[43],"proves":[44],"to":[45,139,165,185],"be":[46,166],"useful":[47],"expanding":[49],"local":[50],"networks.":[53],"input":[55],"data":[56],"are":[57],"purely":[58],"observational":[59],"measures":[60],"transcripts":[62],"expression":[63],"in":[64,112,125,182],"tissues":[66],"cell":[68],"lines":[69],"collected":[70],"within":[71],"the":[72,79,95,98,104,109,129,141,176,180],"FANTOM":[73],"project.":[74],"system":[76],"relies":[77],"BOINC":[80],"platform":[81],"optimized":[84],"client":[85],"code.":[86],"functional":[88],"relevance":[89],"results,":[91],"measured":[92],"by":[93],"analyzing":[94],"annotations":[96],"identified":[99,159],"interactions,":[100],"increases":[101],"significantly":[102,118],"over":[103],"simple":[105],"Pearson":[106],"correlation":[107],"between":[108],"transcripts.":[110],"Additionally,":[111],"82":[113],"percent":[114],"cases":[116],"networks":[117,142],"overlap":[119],"with":[120,146],"known":[121],"protein-protein":[122],"interactions":[123],"annotated":[124],"biological":[126],"databases.":[127],"In":[128],"two":[130,147],"case":[131],"studies":[132],"presented,":[133],"approach":[135,181],"has":[136],"been":[137],"used":[138],"expand":[140],"associated":[145],"severe":[148],"pathologies:":[150],"prostate":[151],"cancer":[152],"coronary":[154],"artery":[155],"disease.":[156],"respectively":[160],"22":[161],"36":[163],"evaluated":[167],"as":[168],"novel":[169],"targets":[170],"already":[172],"approved":[173],"drugs,":[174],"demonstrating":[175],"effective":[177],"applicability":[178],"pipelines":[183],"aimed":[184]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}