{"id":"https://openalex.org/W4406321370","doi":"https://doi.org/10.1109/tcsvt.2025.3528625","title":"Focus Your Attention: Multiple Instance Learning With Attention Modification for Whole Slide Pathological Image Classification","display_name":"Focus Your Attention: Multiple Instance Learning With Attention Modification for Whole Slide Pathological Image Classification","publication_year":2025,"publication_date":"2025-01-13","ids":{"openalex":"https://openalex.org/W4406321370","doi":"https://doi.org/10.1109/tcsvt.2025.3528625"},"language":"en","primary_location":{"id":"doi:10.1109/tcsvt.2025.3528625","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcsvt.2025.3528625","pdf_url":null,"source":{"id":"https://openalex.org/S115173108","display_name":"IEEE Transactions on Circuits and Systems for Video Technology","issn_l":"1051-8215","issn":["1051-8215","1558-2205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Circuits and Systems for Video Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1109/tcsvt.2025.3528625","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hailun Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114105","display_name":"Tsinghua\u2013Berkeley Shenzhen Institute","ror":"https://ror.org/02hhwwz98","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210114105","https://openalex.org/I95457486","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hailun Cheng","raw_affiliation_strings":["Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China","Shenzhen International Graduate School, Institute of Biopharmaceutical and Health Engineering, Tsinghua University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China","institution_ids":["https://openalex.org/I4210114105","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Shenzhen International Graduate School, Institute of Biopharmaceutical and Health Engineering, Tsinghua University, Shenzhen, China","institution_ids":["https://openalex.org/I4210114105","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shenjin Huang","orcid":"https://orcid.org/0009-0000-9874-4267"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenjin Huang","raw_affiliation_strings":["Faculty of Computing, Harbin Institute of Technology, Harbin, China"],"raw_orcid":"https://orcid.org/0009-0000-9874-4267","affiliations":[{"raw_affiliation_string":"Faculty of Computing, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087479926","display_name":"Linghan Cai","orcid":"https://orcid.org/0000-0002-7931-7697"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linghan Cai","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101600198","display_name":"Yangfan Xu","orcid":"https://orcid.org/0009-0005-6986-0214"},"institutions":[{"id":"https://openalex.org/I4210114105","display_name":"Tsinghua\u2013Berkeley Shenzhen Institute","ror":"https://ror.org/02hhwwz98","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210114105","https://openalex.org/I95457486","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangfan Xu","raw_affiliation_strings":["Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China","Shenzhen International Graduate School, Institute of Biopharmaceutical and Health Engineering, Tsinghua University, Shenzhen, China"],"raw_orcid":"https://orcid.org/0009-0005-6986-0214","affiliations":[{"raw_affiliation_string":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China","institution_ids":["https://openalex.org/I4210114105","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Shenzhen International Graduate School, Institute of Biopharmaceutical and Health Engineering, Tsinghua University, Shenzhen, China","institution_ids":["https://openalex.org/I4210114105","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020865835","display_name":"Runming Wang","orcid":"https://orcid.org/0000-0001-8525-5659"},"institutions":[{"id":"https://openalex.org/I4210114105","display_name":"Tsinghua\u2013Berkeley Shenzhen Institute","ror":"https://ror.org/02hhwwz98","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210114105","https://openalex.org/I95457486","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runming Wang","raw_affiliation_strings":["Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China","Shenzhen International Graduate School, Institute of Biopharmaceutical and Health Engineering, Tsinghua University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China","institution_ids":["https://openalex.org/I4210114105","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Shenzhen International Graduate School, Institute of Biopharmaceutical and Health Engineering, Tsinghua University, Shenzhen, China","institution_ids":["https://openalex.org/I4210114105","https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101653272","display_name":"Yongbing Zhang","orcid":"https://orcid.org/0000-0003-3320-2904"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongbing Zhang","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0003-3320-2904","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114105","https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":32.2547,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.9958402,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"35","issue":"6","first_page":"5791","last_page":"5804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9121999740600586,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6685800552368164},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.6406933665275574},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6286563277244568},{"id":"https://openalex.org/keywords/contextual-image-classification","display_name":"Contextual image classification","score":0.4911498725414276},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4821740984916687},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3990466594696045},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.3961799442768097},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.33689945936203003}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6685800552368164},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.6406933665275574},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6286563277244568},{"id":"https://openalex.org/C75294576","wikidata":"https://www.wikidata.org/wiki/Q5165192","display_name":"Contextual image classification","level":3,"score":0.4911498725414276},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4821740984916687},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3990466594696045},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.3961799442768097},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.33689945936203003},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tcsvt.2025.3528625","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcsvt.2025.3528625","pdf_url":null,"source":{"id":"https://openalex.org/S115173108","display_name":"IEEE Transactions on Circuits and Systems for Video Technology","issn_l":"1051-8215","issn":["1051-8215","1558-2205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Circuits and Systems for Video Technology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1109/tcsvt.2025.3528625","is_oa":true,"landing_page_url":"https://doi.org/10.1109/tcsvt.2025.3528625","pdf_url":null,"source":{"id":"https://openalex.org/S115173108","display_name":"IEEE Transactions on Circuits and Systems for Video Technology","issn_l":"1051-8215","issn":["1051-8215","1558-2205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Circuits and Systems for Video Technology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1126116352","display_name":null,"funder_award_id":"01020200063","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2424749866","display_name":null,"funder_award_id":"20225820246","funder_id":"https://openalex.org/F4320337986","funder_display_name":"Tsinghua Shenzhen International Graduate School"},{"id":"https://openalex.org/G3057868066","display_name":null,"funder_award_id":"01020200063","funder_id":"https://openalex.org/F4320337986","funder_display_name":"Tsinghua Shenzhen International Graduate School"},{"id":"https://openalex.org/G6852716870","display_name":null,"funder_award_id":"20225820246","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8137439496","display_name":null,"funder_award_id":"62331011","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320337986","display_name":"Tsinghua Shenzhen International Graduate School","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W153185079","https://openalex.org/W2110119381","https://openalex.org/W2294868278","https://openalex.org/W2302302587","https://openalex.org/W2560886373","https://openalex.org/W2571156573","https://openalex.org/W2772723798","https://openalex.org/W2806435421","https://openalex.org/W2889232360","https://openalex.org/W2900595477","https://openalex.org/W2948475969","https://openalex.org/W2948930564","https://openalex.org/W2954996726","https://openalex.org/W2956228567","https://openalex.org/W2964275459","https://openalex.org/W2969278648","https://openalex.org/W2971376088","https://openalex.org/W2986297814","https://openalex.org/W2992308087","https://openalex.org/W2997512706","https://openalex.org/W3013975953","https://openalex.org/W3021850183","https://openalex.org/W3029598567","https://openalex.org/W3043535018","https://openalex.org/W3091730259","https://openalex.org/W3093416812","https://openalex.org/W3115662399","https://openalex.org/W3135547872","https://openalex.org/W3156423522","https://openalex.org/W3162407014","https://openalex.org/W3165804767","https://openalex.org/W3176719058","https://openalex.org/W3191409400","https://openalex.org/W4226098466","https://openalex.org/W4283801948","https://openalex.org/W4284713902","https://openalex.org/W4293861233","https://openalex.org/W4297095624","https://openalex.org/W4312765357","https://openalex.org/W4319214685","https://openalex.org/W4319299841","https://openalex.org/W4385245566","https://openalex.org/W4386076358","https://openalex.org/W4386076404","https://openalex.org/W4386857835","https://openalex.org/W4387211838","https://openalex.org/W4390706891","https://openalex.org/W4390873172","https://openalex.org/W4396910025","https://openalex.org/W4402716098","https://openalex.org/W4403365605","https://openalex.org/W4403365611","https://openalex.org/W6631190155","https://openalex.org/W6683033130","https://openalex.org/W6747701563","https://openalex.org/W6779072788","https://openalex.org/W6779447676","https://openalex.org/W6791827750","https://openalex.org/W6803426362","https://openalex.org/W6863793141"],"related_works":["https://openalex.org/W2012531322","https://openalex.org/W2402761219","https://openalex.org/W2785900585","https://openalex.org/W2353730437","https://openalex.org/W2490303674","https://openalex.org/W2609066826","https://openalex.org/W2810752900","https://openalex.org/W2365677836","https://openalex.org/W2531295127","https://openalex.org/W2546503577"],"abstract_inverted_index":{"Computer-aided":[0],"pathology":[1],"diagnosis":[2],"based":[3],"on":[4,72,140,184],"whole":[5],"slide":[6],"images,":[7],"which":[8],"is":[9],"often":[10,41],"formulated":[11],"as":[12],"a":[13,64,80],"weakly":[14,33],"supervised":[15,34],"multiple":[16],"instance":[17,39],"learning":[18],"(MIL)":[19],"paradigm.":[20],"Current":[21],"approaches":[22],"generally":[23],"employ":[24],"attention":[25,45,74],"mechanisms":[26],"to":[27,43,118,165,180],"aggregate":[28],"instance-level":[29],"features.":[30],"However,":[31],"the":[32,37,48,54,100,108,120,145,158,170,173],"signal":[35],"and":[36,50,75,83,94,129,182,186],"imbalanced":[38],"distribution":[40],"lead":[42],"inaccurate":[44,73],"localization,":[46],"compromising":[47],"performance":[49],"generalization":[51],"capability":[52],"of":[53,102,147],"MIL":[55,66,109,136],"framework.":[56],"To":[57],"address":[58],"these":[59,124],"problems,":[60],"this":[61],"paper":[62],"presents":[63],"novel":[65],"framework":[67],"called":[68],"FAMIL":[69,78],"that":[70],"focuses":[71],"refines":[76],"them.":[77],"adopts":[79],"dual-branch":[81],"structure":[82],"incorporates":[84],"two":[85,125],"innovative":[86],"online":[87],"data":[88],"augmentation":[89],"strategies:":[90],"attention-based":[91,95,135],"Mixup":[92,106],"(ABMix)":[93],"Masking":[96],"(ABMask).":[97],"ABMix":[98],"emphasizes":[99],"significance":[101],"positive":[103,116],"instances,":[104],"generalizing":[105],"in":[107],"scenarios,":[110],"while":[111],"ABMask":[112],"flexibly":[113],"identifies":[114],"challenging":[115],"instances":[117],"optimize":[119],"feature":[121],"representation.":[122],"Moreover,":[123],"methods":[126],"are":[127],"plug-and-play":[128],"can":[130,162,177],"be":[131,163,178],"easily":[132],"embedded":[133],"into":[134],"methods.":[137,153],"Extensive":[138],"experiments":[139],"three":[141],"public":[142],"benchmarks":[143],"demonstrate":[144],"superiority":[146],"our":[148],"FAMIL,":[149],"outperforming":[150],"current":[151],"state-of-the-art":[152],"The":[154],"test":[155],"AUC":[156,171],"for":[157],"binary":[159],"tumor":[160],"classification":[161,176],"up":[164,179],"92.61%":[166],"over":[167,172],"CAMELYON16.":[168],"And":[169],"cancer":[174],"subtype":[175],"93.81%":[181],"98.41%":[183],"TCGA-NSCLC":[185],"TCGA-RCC":[187],"datasets,":[188],"respectively.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9}],"updated_date":"2026-04-27T08:22:11.395708","created_date":"2025-10-10T00:00:00"}