{"id":"https://openalex.org/W3106482466","doi":"https://doi.org/10.1109/tcst.2020.3038028","title":"Dynamic Model Reduction and Predictive Control of Hot-Melt Extrusion Applied to Drug Manufacturing","display_name":"Dynamic Model Reduction and Predictive Control of Hot-Melt Extrusion Applied to Drug Manufacturing","publication_year":2020,"publication_date":"2020-12-07","ids":{"openalex":"https://openalex.org/W3106482466","doi":"https://doi.org/10.1109/tcst.2020.3038028","mag":"3106482466"},"language":"en","primary_location":{"id":"doi:10.1109/tcst.2020.3038028","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2020.3038028","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103127148","display_name":"Jonathan Grimard","orcid":"https://orcid.org/0000-0003-4733-6866"},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jonathan Grimard","raw_affiliation_strings":["Systems, Estimation, Control and Optimization Group, Faculty of Engineering, University of Mons, Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-4733-6866","affiliations":[{"raw_affiliation_string":"Systems, Estimation, Control and Optimization Group, Faculty of Engineering, University of Mons, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079070585","display_name":"Laurent Dewasme","orcid":"https://orcid.org/0000-0002-1688-167X"},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laurent Dewasme","raw_affiliation_strings":["Systems, Estimation, Control and Optimization Group, Faculty of Engineering, University of Mons, Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-1688-167X","affiliations":[{"raw_affiliation_string":"Systems, Estimation, Control and Optimization Group, Faculty of Engineering, University of Mons, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030337733","display_name":"Alain Vande Wouwer","orcid":"https://orcid.org/0000-0001-7022-6126"},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alain Vande Wouwer","raw_affiliation_strings":["Systems, Estimation, Control and Optimization Group, Faculty of Engineering, University of Mons, Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-7022-6126","affiliations":[{"raw_affiliation_string":"Systems, Estimation, Control and Optimization Group, Faculty of Engineering, University of Mons, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8936,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.74914693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"29","issue":"6","first_page":"2366","last_page":"2378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11081","display_name":"Advanced Control Systems Design","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11749","display_name":"Iterative Learning Control Systems","score":0.984000027179718,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"Model predictive control","score":0.8270634412765503},{"id":"https://openalex.org/keywords/process-control","display_name":"Process control","score":0.5789116024971008},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5313060283660889},{"id":"https://openalex.org/keywords/pharmaceutical-manufacturing","display_name":"Pharmaceutical manufacturing","score":0.5260417461395264},{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.4885893762111664},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.47771143913269043},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.4391992688179016},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.4264662265777588},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3743162155151367},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.28681278228759766},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20659014582633972}],"concepts":[{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.8270634412765503},{"id":"https://openalex.org/C155386361","wikidata":"https://www.wikidata.org/wiki/Q1649571","display_name":"Process control","level":3,"score":0.5789116024971008},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5313060283660889},{"id":"https://openalex.org/C2778938233","wikidata":"https://www.wikidata.org/wiki/Q7180757","display_name":"Pharmaceutical manufacturing","level":2,"score":0.5260417461395264},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.4885893762111664},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.47771143913269043},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.4391992688179016},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.4264662265777588},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3743162155151367},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.28681278228759766},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20659014582633972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcst.2020.3038028","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2020.3038028","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"},{"id":"pmh:oai:orbi.umons.ac.be:20.500.12907/28384","is_oa":false,"landing_page_url":"https://orbi.umons.ac.be/handle/20.500.12907/28384","pdf_url":null,"source":{"id":"https://openalex.org/S7407055454","display_name":"ORBi UMONS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Transactions on Control Systems Technology, 29 (6), 2366-2378 (2020-12-07)","raw_type":"peer reviewed"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6100000143051147,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W168413054","https://openalex.org/W236078109","https://openalex.org/W1485426748","https://openalex.org/W1821949790","https://openalex.org/W1973216857","https://openalex.org/W1996139824","https://openalex.org/W2007149219","https://openalex.org/W2011847240","https://openalex.org/W2013841303","https://openalex.org/W2015983805","https://openalex.org/W2016461110","https://openalex.org/W2030215459","https://openalex.org/W2032376646","https://openalex.org/W2033887088","https://openalex.org/W2040657797","https://openalex.org/W2055032477","https://openalex.org/W2063062247","https://openalex.org/W2078384894","https://openalex.org/W2116107032","https://openalex.org/W2118436621","https://openalex.org/W2146132556","https://openalex.org/W2317739943","https://openalex.org/W2414456399","https://openalex.org/W2437373983","https://openalex.org/W2490132800","https://openalex.org/W2493782643","https://openalex.org/W2505479526","https://openalex.org/W2513937099","https://openalex.org/W2544637862","https://openalex.org/W2729873196","https://openalex.org/W4247631405","https://openalex.org/W4302436361"],"related_works":["https://openalex.org/W1990079087","https://openalex.org/W2101188133","https://openalex.org/W2165750643","https://openalex.org/W2638730922","https://openalex.org/W3155069932","https://openalex.org/W3111228260","https://openalex.org/W2102218006","https://openalex.org/W2752220042","https://openalex.org/W2138349465","https://openalex.org/W1599968825"],"abstract_inverted_index":{"This":[0],"study":[1,41,120],"aims":[2],"at":[3],"designing":[4],"model-based":[5],"controllers":[6],"for":[7,13],"a":[8,51,78,82,108],"hot-melt":[9],"extrusion":[10],"process":[11,102,109],"designed":[12],"the":[14,24,30,45,89],"manufacturing":[15],"of":[16,39,47,67,118,137],"pills.":[17],"The":[18,36,65,93,115,135],"control":[19,113,126,139],"objective":[20],"is":[21,42,95,141],"to":[22,101,111,132],"regulate":[23],"output":[25],"mass":[26,58],"flow":[27],"rate":[28],"and":[29,59,86,146,153],"active":[31],"pharmaceutical":[32],"ingredient":[33],"(API)":[34],"concentration.":[35],"first":[37],"part":[38,117],"this":[40,119],"concerned":[43],"with":[44,99],"derivation":[46],"reduced-order":[48,69],"models":[49,70],"from":[50,77,129],"detailed":[52,90],"distributed":[53],"parameter":[54],"(DP)":[55],"model":[56,124],"involving":[57],"energy":[60],"balance":[61],"partial":[62],"differential":[63],"equations.":[64],"parameters":[66],"these":[68,138],"are":[71],"estimated":[72],"based":[73],"on":[74,122],"experimental":[75],"data":[76],"laboratory":[79],"device":[80],"presenting":[81],"specific":[83],"screw":[84],"geometry,":[85],"validated":[87],"against":[88],"DP":[91],"model.":[92],"latter":[94],"too":[96],"computationally":[97],"expensive":[98],"regards":[100],"control,":[103],"but":[104],"can":[105],"serve":[106],"as":[107,150],"emulator":[110],"test":[112],"strategies.":[114],"second":[116],"focuses":[121],"several":[123],"predictive":[125],"strategies,":[127],"ranging":[128],"Smith":[130],"predictor":[131],"NEPSAC":[133],"controllers.":[134],"effectiveness":[136],"strategies":[140],"assessed":[142],"using":[143],"numerical":[144],"simulation":[145],"performance":[147],"indicators":[148],"such":[149],"disturbance":[151],"rejection":[152],"computational":[154],"cost.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}