{"id":"https://openalex.org/W2896732217","doi":"https://doi.org/10.1109/tcst.2018.2871962","title":"Closed-Loop MISO Identification of Propofol Effect on Blood Pressure and Depth of Hypnosis","display_name":"Closed-Loop MISO Identification of Propofol Effect on Blood Pressure and Depth of Hypnosis","publication_year":2018,"publication_date":"2018-10-11","ids":{"openalex":"https://openalex.org/W2896732217","doi":"https://doi.org/10.1109/tcst.2018.2871962","mag":"2896732217"},"language":"en","primary_location":{"id":"doi:10.1109/tcst.2018.2871962","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2018.2871962","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009577016","display_name":"Klaske van Heusden","orcid":"https://orcid.org/0000-0003-2763-5279"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Klaske van Heusden","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005548548","display_name":"Mahdi Yousefi","orcid":"https://orcid.org/0000-0002-6226-9254"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mahdi Yousefi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010534406","display_name":"J. Mark Ansermino","orcid":"https://orcid.org/0000-0001-8427-2035"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Mark Ansermino","raw_affiliation_strings":["Department of Anesthesiology, Pharmacology, and Therapeutics, The University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Pharmacology, and Therapeutics, The University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055045540","display_name":"Guy A. Dumont","orcid":"https://orcid.org/0000-0003-2048-4391"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Guy A. Dumont","raw_affiliation_strings":["Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, The University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5009577016"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":null,"apc_paid":null,"fwci":1.801,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.85205085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"28","issue":"1","first_page":"254","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.978600025177002,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9747999906539917,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"Propofol","score":0.7541841268539429},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5887693166732788},{"id":"https://openalex.org/keywords/outlier","display_name":"Outlier","score":0.5855249762535095},{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.5805822014808655},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4769634008407593},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46818649768829346},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.2983326315879822},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2951202094554901},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22391173243522644},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.1845468282699585},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18148455023765564},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.1692942976951599}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.7541841268539429},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5887693166732788},{"id":"https://openalex.org/C79337645","wikidata":"https://www.wikidata.org/wiki/Q779824","display_name":"Outlier","level":2,"score":0.5855249762535095},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.5805822014808655},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4769634008407593},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46818649768829346},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2983326315879822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2951202094554901},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22391173243522644},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.1845468282699585},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18148455023765564},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.1692942976951599},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tcst.2018.2871962","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2018.2871962","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3901587335","display_name":null,"funder_award_id":"PPP-141711","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G7273630271","display_name":null,"funder_award_id":"CHRP 446511-13","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W178056938","https://openalex.org/W1984528575","https://openalex.org/W1997629397","https://openalex.org/W1998440482","https://openalex.org/W2018146940","https://openalex.org/W2036246067","https://openalex.org/W2037348596","https://openalex.org/W2044321898","https://openalex.org/W2046012301","https://openalex.org/W2052952057","https://openalex.org/W2053331558","https://openalex.org/W2055618961","https://openalex.org/W2059926983","https://openalex.org/W2060357972","https://openalex.org/W2082419282","https://openalex.org/W2085501345","https://openalex.org/W2091046471","https://openalex.org/W2102176098","https://openalex.org/W2118389786","https://openalex.org/W2122645804","https://openalex.org/W2125370735","https://openalex.org/W2126318234","https://openalex.org/W2137826907","https://openalex.org/W2146438678","https://openalex.org/W2153685136","https://openalex.org/W2158522512","https://openalex.org/W2159171548","https://openalex.org/W2172008557","https://openalex.org/W2317422852","https://openalex.org/W2322826186","https://openalex.org/W2483698312","https://openalex.org/W2493756966","https://openalex.org/W2616427857","https://openalex.org/W2739927630","https://openalex.org/W2751546257","https://openalex.org/W2763864576","https://openalex.org/W2769460295","https://openalex.org/W2773562780","https://openalex.org/W6681769921"],"related_works":["https://openalex.org/W2428256220","https://openalex.org/W2405416670","https://openalex.org/W2369770283","https://openalex.org/W2354276920","https://openalex.org/W2313970103","https://openalex.org/W3179641435","https://openalex.org/W2235782953","https://openalex.org/W2806907687","https://openalex.org/W3182831328","https://openalex.org/W1996778921"],"abstract_inverted_index":{"Feasibility":[0],"of":[1,50,91,115,135,154,158,175],"closed-loop":[2,13,24,45,81,109,118],"propofol":[3,148],"anesthesia":[4,92],"has":[5],"been":[6],"demonstrated":[7],"in":[8,19,47,67],"clinical":[9,20,25,71],"trials;":[10],"however,":[11],"no":[12],"system":[14,31],"is":[15,53,96],"currently":[16],"routinely":[17],"used":[18],"practice.":[21],"Data":[22],"from":[23,70],"trials":[26],"provide":[27],"valuable":[28,43,168],"information":[29],"for":[30,106,150,162,170],"evaluation":[32,174],"prior":[33],"to":[34,57,83,87,147],"market":[35],"approval,":[36],"including":[37],"outlier":[38],"behavior.":[39],"To":[40],"exploit":[41],"this":[42,74,107,127],"data,":[44],"identification":[46,82,102,110,119],"the":[48,85,113,140,144,163,171],"presence":[49],"nonzero":[51],"disturbances":[52,88],"required.":[54],"Disturbances":[55],"due":[56],"stimulation":[58],"are":[59],"not":[60,122],"zero":[61],"mean":[62],"and":[63,112,131,143,173],"will":[64],"cause":[65],"bias":[66,105],"models":[68,136],"identified":[69],"data.":[72],"In":[73],"paper,":[75],"we":[76,129],"use":[77,114],"multiple-input":[78],"single-output":[79],"(MISO)":[80],"take":[84],"response":[86,146],"during":[89],"induction":[90],"into":[93],"account.":[94],"It":[95],"shown":[97],"that":[98,137],"direct":[99],"MISO":[100],"output-error":[101],"introduces":[103],"limited":[104],"specific":[108],"problem":[111],"more":[116],"complex":[117],"methods":[120],"does":[121],"improve":[123],"model":[124],"accuracy.":[125],"Using":[126],"approach,":[128],"identify":[130],"validate":[132],"a":[133,167],"set":[134],"describes":[138],"both":[139,159],"blood":[141],"pressure":[142],"depth-of-hypnosis":[145],"infusion":[149],"patients":[151,165],"at":[152],"risk":[153],"cardiovascular":[155],"suppression.":[156],"Quantification":[157],"these":[160],"responses":[161],"same":[164],"provides":[166],"basis":[169],"design":[172],"constrained":[176],"control":[177],"systems.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}