{"id":"https://openalex.org/W2998248873","doi":"https://doi.org/10.1109/tcst.2018.2861410","title":"Optimal Impulsive Control With Application to Antiangiogenic Tumor Therapy","display_name":"Optimal Impulsive Control With Application to Antiangiogenic Tumor Therapy","publication_year":2018,"publication_date":"2018-08-16","ids":{"openalex":"https://openalex.org/W2998248873","doi":"https://doi.org/10.1109/tcst.2018.2861410","mag":"2998248873"},"language":"en","primary_location":{"id":"doi:10.1109/tcst.2018.2861410","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2018.2861410","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10281/246791","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007661526","display_name":"Filippo Cacace","orcid":"https://orcid.org/0000-0003-1060-744X"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Cacace","raw_affiliation_strings":["Universit\u00e0 Campus Bio-Medico di Roma, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1060-744X","affiliations":[{"raw_affiliation_string":"Universit\u00e0 Campus Bio-Medico di Roma, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034312302","display_name":"Valerio Cusimano","orcid":"https://orcid.org/0000-0002-1965-9054"},"institutions":[{"id":"https://openalex.org/I197604219","display_name":"National Academies of Sciences, Engineering, and Medicine","ror":"https://ror.org/02eq2w707","country_code":"US","type":"government","lineage":["https://openalex.org/I197604219"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210162062","display_name":"Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti","ror":"https://ror.org/054ye0e45","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Valerio Cusimano","raw_affiliation_strings":["Institute of Systems Analysis and Computer Science \u201cA. Ruberti,\u201d National Research Council, Rome, Italy","Institute of Systems Analysis and Computer Science \"A. Ruberti,\" National Research Council, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1965-9054","affiliations":[{"raw_affiliation_string":"Institute of Systems Analysis and Computer Science \u201cA. Ruberti,\u201d National Research Council, Rome, Italy","institution_ids":["https://openalex.org/I197604219"]},{"raw_affiliation_string":"Institute of Systems Analysis and Computer Science \"A. Ruberti,\" National Research Council, Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069495460","display_name":"Pasquale Palumbo","orcid":"https://orcid.org/0000-0002-9371-2802"},"institutions":[{"id":"https://openalex.org/I197604219","display_name":"National Academies of Sciences, Engineering, and Medicine","ror":"https://ror.org/02eq2w707","country_code":"US","type":"government","lineage":["https://openalex.org/I197604219"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210162062","display_name":"Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti","ror":"https://ror.org/054ye0e45","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Pasquale Palumbo","raw_affiliation_strings":["Institute of Systems Analysis and Computer Science \u201cA. Ruberti,\u201d National Research Council, Rome, Italy","Institute of Systems Analysis and Computer Science \"A. Ruberti,\" National Research Council, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9371-2802","affiliations":[{"raw_affiliation_string":"Institute of Systems Analysis and Computer Science \u201cA. Ruberti,\u201d National Research Council, Rome, Italy","institution_ids":["https://openalex.org/I197604219"]},{"raw_affiliation_string":"Institute of Systems Analysis and Computer Science \"A. Ruberti,\" National Research Council, Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4248,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.89232283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"28","issue":"1","first_page":"106","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9593999981880188,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.6261375546455383},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.5875216126441956},{"id":"https://openalex.org/keywords/linear-quadratic-gaussian-control","display_name":"Linear-quadratic-Gaussian control","score":0.5402718186378479},{"id":"https://openalex.org/keywords/multivariate-normal-distribution","display_name":"Multivariate normal distribution","score":0.5254268646240234},{"id":"https://openalex.org/keywords/observer","display_name":"Observer (physics)","score":0.5200254917144775},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.476026326417923},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47113245725631714},{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.46537041664123535},{"id":"https://openalex.org/keywords/covariance","display_name":"Covariance","score":0.44295534491539},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.43987587094306946},{"id":"https://openalex.org/keywords/discrete-time-and-continuous-time","display_name":"Discrete time and continuous time","score":0.4282931983470917},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.4266570210456848},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.38489001989364624},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3544332981109619},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3368278741836548},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.29118672013282776},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.2887676954269409},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18835431337356567},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.1435902714729309},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10088267922401428},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.07938680052757263}],"concepts":[{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.6261375546455383},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.5875216126441956},{"id":"https://openalex.org/C204495892","wikidata":"https://www.wikidata.org/wiki/Q1798304","display_name":"Linear-quadratic-Gaussian control","level":3,"score":0.5402718186378479},{"id":"https://openalex.org/C177384507","wikidata":"https://www.wikidata.org/wiki/Q1149000","display_name":"Multivariate normal distribution","level":3,"score":0.5254268646240234},{"id":"https://openalex.org/C2780704645","wikidata":"https://www.wikidata.org/wiki/Q9251458","display_name":"Observer (physics)","level":2,"score":0.5200254917144775},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.476026326417923},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47113245725631714},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.46537041664123535},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.44295534491539},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43987587094306946},{"id":"https://openalex.org/C55689738","wikidata":"https://www.wikidata.org/wiki/Q15963867","display_name":"Discrete time and continuous time","level":2,"score":0.4282931983470917},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.4266570210456848},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.38489001989364624},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3544332981109619},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3368278741836548},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.29118672013282776},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.2887676954269409},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18835431337356567},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1435902714729309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10088267922401428},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07938680052757263},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tcst.2018.2861410","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tcst.2018.2861410","pdf_url":null,"source":{"id":"https://openalex.org/S133363738","display_name":"IEEE Transactions on Control Systems Technology","issn_l":"1063-6536","issn":["1063-6536","1558-0865","2374-0159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Control Systems Technology","raw_type":"journal-article"},{"id":"pmh:oai:boa.unimib.it:10281/246791","is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/246791","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:boa.unimib.it:10281/246791","is_oa":true,"landing_page_url":"http://hdl.handle.net/10281/246791","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.7799999713897705,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W139331474","https://openalex.org/W858884580","https://openalex.org/W1520892678","https://openalex.org/W1579297325","https://openalex.org/W1617532289","https://openalex.org/W1943173994","https://openalex.org/W1964231254","https://openalex.org/W1966362654","https://openalex.org/W1969002375","https://openalex.org/W1978139448","https://openalex.org/W1980040626","https://openalex.org/W1986837879","https://openalex.org/W1996027565","https://openalex.org/W2004356567","https://openalex.org/W2004710504","https://openalex.org/W2022434170","https://openalex.org/W2035722747","https://openalex.org/W2039948839","https://openalex.org/W2043943566","https://openalex.org/W2045510646","https://openalex.org/W2050240106","https://openalex.org/W2057463665","https://openalex.org/W2057526038","https://openalex.org/W2070941761","https://openalex.org/W2072928113","https://openalex.org/W2073009824","https://openalex.org/W2075780259","https://openalex.org/W2083651908","https://openalex.org/W2088929622","https://openalex.org/W2091513278","https://openalex.org/W2104430655","https://openalex.org/W2108786375","https://openalex.org/W2109474071","https://openalex.org/W2121929569","https://openalex.org/W2124441204","https://openalex.org/W2128011232","https://openalex.org/W2130321554","https://openalex.org/W2131798870","https://openalex.org/W2138405647","https://openalex.org/W2138471159","https://openalex.org/W2150478512","https://openalex.org/W2157642143","https://openalex.org/W2163741151","https://openalex.org/W2177000429","https://openalex.org/W2317728695","https://openalex.org/W2410521322","https://openalex.org/W2568702871","https://openalex.org/W2569066301","https://openalex.org/W2765553351","https://openalex.org/W2766975391","https://openalex.org/W2791864613","https://openalex.org/W4238086324","https://openalex.org/W4245893543","https://openalex.org/W6623855402","https://openalex.org/W6640822977","https://openalex.org/W6676155456","https://openalex.org/W6676306407","https://openalex.org/W6745269047","https://openalex.org/W7005231937"],"related_works":["https://openalex.org/W1999291921","https://openalex.org/W4245839115","https://openalex.org/W2111439273","https://openalex.org/W2144691561","https://openalex.org/W2107169685","https://openalex.org/W2115005925","https://openalex.org/W2101783086","https://openalex.org/W1998777431","https://openalex.org/W2466810109","https://openalex.org/W2621108323"],"abstract_inverted_index":{"An":[0],"optimal":[1],"control":[2,21,38,67],"algorithm":[3,90],"is":[4,40,49,91,118],"proposed":[5],"for":[6,42,75,85],"impulsive":[7],"differential":[8,16],"systems,":[9],"i.e.,":[10],"systems":[11,77],"evolving":[12],"according":[13],"to":[14,51,136],"ordinary":[15],"equations":[17],"between":[18],"any":[19],"two":[20],"actions,":[22],"occurring":[23],"impulsively":[24],"at":[25,33],"discrete-time":[26,34],"instants.":[27,35],"Measurements":[28],"are":[29,130],"as":[30],"well":[31],"acquired":[32],"A":[36],"model-based":[37],"law":[39,68],"conceived":[41],"medical":[43],"and":[44,115,132],"healthcare":[45],"frameworks":[46],"and,":[47],"indeed,":[48],"applied":[50],"synthesize":[52],"a":[53,70,101,109],"feedback":[54],"antiangiogenic":[55],"tumor":[56],"therapy.":[57],"To":[58],"cope":[59],"with":[60],"unavailable":[61],"or":[62],"temporally":[63],"sparse":[64],"measurements,":[65],"the":[66,125,134],"benefits":[69],"state":[71],"observer":[72],"properly":[73],"designed":[74],"continuous-discrete":[76],"by":[78,93],"suitably":[79],"exploiting":[80],"recent":[81],"results":[82,129],"on":[83,100],"observers":[84],"time-delay":[86],"systems.":[87],"The":[88],"closed-loop":[89],"validated":[92],"building":[94],"up":[95],"an":[96],"exhaustive":[97],"simulation":[98],"campaign":[99],"population":[102],"of":[103],"virtual":[104],"subjects,":[105],"each":[106],"sampled":[107],"from":[108,120,124],"multivariate":[110],"Gaussian":[111],"distribution":[112],"whose":[113],"mean":[114],"covariance":[116],"matrix":[117],"identified":[119],"experimental":[121],"data":[122],"taken":[123],"literature.":[126],"In":[127],"silico":[128],"encouraging":[131],"pave":[133],"way":[135],"further":[137],"clinical":[138],"verifications.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}